Artemisinin-Based Combination Therapy Depressed Mitosis and Induced Chromosome Aberration in Onion Root Cells by J. I. Raji, C. K. Onwuamah, P. G. C. Odeigah

“…The toxicity on the mitotic index varies with the duration of exposure and dose tested. …”
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Synthesis and Evaluation of Some New Isoquine Analogues for Antimalarial Activity by Chandra Nath Saha, Sanjib Bhattacharya, Dipak Chetia

“…Amodiaquine is a 4-aminoquinoline antimalarial that can cause adverse side effects including hepatic and haematological toxicity. The drug toxicity involves the formation of an electrophilic metabolite, amodiaquine quinoneimine (AQQI), which binds to cellular macromolecules leading to hepatotoxicity and agranulocytosis. …”
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COX-2 Inhibitors and Gastric Cancer by Zhen Wang, Jun-qiang Chen, Jin-lu Liu

“…However, enthusiasm is thwarted by the potential toxicity, that is, gastrointestinal toxicity of nonselective COX-2 inhibitors and cardiovascular risk of selective COX-2 inhibitors. …”
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Review on Cement Stabilization/Solidification of Municipal Solid Waste Incineration Fly Ash by Chengcheng Fan, Baomin Wang, Tingting Zhang

“…Municipal solid waste incineration (MSWI) fly ash must be treated properly prior to being disposed in the security landfill due to its serious pollution toxicity. Nowadays, lots of studies have demonstrated that cement-based stabilization/solidification could reduce the toxicity pollution effectively by encapsulating the heavy metals into cement matrix, which leads to greater capacity and weight. …”
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Research Progress on Zearalenone Biodegradation and Its Detoxification Mechanism by LI Kailong, LIU Kunlun, XIN Ying, YANG Chenxian, WANG Zikun

“…Zearalenone (ZEN) has been detected at high rates in moldy corn, wheat, and other grains, and exposure to ZEN pollution can induce reproductive, hepatic, and renal toxicity. Due to its widespread contamination and severe hazards, ZEN has become a major hidden danger to food safety. …”
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Gonadal health benefits of black cumin (Nigella sativa) seed oil on chronic lead-exposed male Wistar rats by Afrina Mustari, Mahabub Alam, Samia Rashid, A.G.M.Sofi Uddin Mahamud, Mohammad Alam Miah, Emdadul Hauqe Chowdhury

“…Lead (Pb) is a highly toxic heavy metal that can cause harm even at extremely low concentrations and damage various organs, including those of reproduction. …”
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Toxicologic Assessment of a Commercial Decolorized Whole Leaf Aloe Vera Juice, Lily of the Desert Filtered Whole Leaf Juice with Aloesorb by Inder Sehgal, Wallace D. Winters, Michael Scott, Andrew David, Glenn Gillis, Thaya Stoufflet, Anand Nair, Konstantine Kousoulas

“…We tested a decolorized whole leaf (DCWL) aloe vera, treated with activated charcoal to remove the latex portion of the plant, for genotoxicity in bacteria, acute/subacute toxicity in B6C3F1 mice, and subchronic toxicity in F344 rats. …”
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Cytotoxicity and Exposure Assessment of PM2.5 in a Residential Home during COVID-19 Lockdown by Ummi Sabariah Mahamud, Armania Nurdin, Eliani Ezani

“…Abstract As individuals become more confined to their homes, especially during the COVID-19 lockdown and the post-pandemic era, human activities will continue to generate more indoor particles. However, the toxicity effects of indoor particles remain unknown during residents’ occupancy time. …”
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Humanising nanotoxicology: replacement of animal-derived products in the application of integrated approaches to testing and assessment of nanomaterial inhalation hazard by Roma Fraser, Keira Campbell, Pawel Pokorski, Eve MacKinnon, Katie McAllister, Karla B. Neves, Fiona Murphy

“…Further investigation is needed to support a shift toward more ethical toxicity testing that does not rely on animal-derived materials.…”
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Comparative efficacy of plant derived extracts with the insecticide mospilan on two whitefly species Bemisia tabaci biotype B and Trialeurodes ricini by Hanaa S. Hussein, Mamdouh H. Idriss, Farouk H. El-Gayar, Hebatullah Yehia Saad Mousa, Mohamed Z. M. Salem

“…The HEs of weeping willow and garlic showed the maximum toxicity against B. tabaci, while the HEs of thyme and garlic showed the highest toxicity against T. ricini. …”
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Time dependence effect of metal toxicology and application in WQC derivation of main water basins in China by Tianxin Li, Yao Wang, Ning Qin, Wenjing Zhao, He Huang

“…The exposure time in acute toxicology experiments can affect not only the accuracy of toxicity data such as lethal concentration 50 (LC50) at the species level, but also the dose-effect relationship establishment of pollutants at the community level. …”
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Flavouring group evaluation 418 (FGE. 418): 3‐[3‐(2‐isopropyl‐5‐methyl‐cyclohexyl)‐ureido]‐butyric acid ethyl ester by EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Romualdo Benigni, Kevin Chipman, Eugenia Cordelli, Gisela Degen, Karl‐Heinz Engel, Paul Fowler, Maria Carfí, Gabriele Gagliardi, Agnieszka Mech, Salvatore Multari, Carla Martino

“…In a prenatal developmental toxicity study, no maternal or fetal toxicity was observed in rats dosed up to 1000 mg/kg body weight (bw) per day. …”
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Flavouring group evaluation 420 (FGE.420): Hesperetin dihydrochalcone by EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, Gisela Degen, Karl‐Heinz Engel, Paul Fowler, Maria Carfí, Consuelo Civitella, Borana Dino, Gabriele Gagliardi, Agnieszka Mech, Panagiota Zakidou, Carla Martino

“…In a prenatal developmental toxicity study, no maternal or foetal toxicity was observed. …”
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Fermented Ofada rice (A Nigerian recipe) attenuates renal and hepatic dysfunction induced by crude oil poisoning in Wistar Rats by E Aganbi, B. O. Odeghe, ORORORO OSUVWE, E. T. Ojugbeli, J. C. Mordi

“…Short-term crude oil toxicity was conducted for seven days. Groups A (positive control) were exempted and devoid of the toxicant while B (negative control) to D were administered 4ml BLCO/kg bwt. …”
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Safety of a change of specifications of phytosterols/phytostanols as a novel food pursuant to Regulation (EU) 2015/2283 by EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Marina Heinonen, Monika Neuhäuser‐Berthold, Helle Katrine Knutsen, Morten Poulsen, Miguel Prieto Maradona, Josef Rudolf Schlatter, Alexandros Siskos, Henk vanLoveren, Wolfgang Gelbmann, Harry J. McArdle

“…No evidence was found from the literature for the genotoxicity, subchronic toxicity, chronic toxicity and carcinogenicity, and reproductive toxicity of four phytosterols which have been identified by the applicant in the NF when produced from sunflower oil. …”
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Kinomic profiling to predict sunitinib response of patients with metastasized clear cell Renal Cell Carcinoma by Jeannette C. Oosterwijk-Wakka, Liesbeth Houkes, Loes F.M. van der Zanden, Lambertus A.L.M. Kiemeney, Kerstin Junker, Anne Y Warren, Tim Eisen, Ulrich Jaehde, Marius T Radu, Rob Ruijtenbeek, Egbert Oosterwijk

“…With modest OS improvement and variable response and toxicity predictive and/or prognostic biomarkers are needed to personalize patient management: Prediction of individual TKI therapy response and resistance will increase successful treatment outcome while reducing unnecessary drug use and expense. …”
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Pancreatic Cancer: What the Oncologist Can Offer for Palliation by Malcolm J Moore

“…This drug is more effective than 5-fluorouracil (5-FU), can be used in patients who fail to respond to 5-FU and has only modest toxicity. Combination therapies including gemcitabine and other agents are being tested. …”
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Antifungal Activity of Coumarin Mammeisin Isolated from Species of the Kielmeyera Genre (Family: Clusiaceae or Guttiferae) by Helcio Cassemiro Marcondes, Tânia T. de Oliveira, Jason G. Taylor, Moisés Hamoy, Arman do Leonel Neto, Vanessa Joia de Mello, Tanus J. Nagem

“…Coumarin mammeisin isolated from Kielmeyera elata was evaluated for its toxicity and antifungal activities. The toxicity of mammeisin was investigated by utilizing the Artemia salina methodology to determine its LD50 value. …”
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EGFR inhibitors in the treatment of colorectal cancer by M. В. Zabelin, A. D. Kaprin, A. A. Kostin, E. V. Gameeva, S. E. Varlamova

“…The correla on between toxicity and effi  cacy of these drugs is discussed separately. …”
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Multisystemic Side Effects of an Indispensable Old Drug: A Case Report of Chronic Lithium Use (A Patient with Multiple Side Effects of Lithium) by Levent Demirtas, Emin Murat Akbas, Husnu Degirmenci, Ali Gurel, Eren Duzgun

“…Health care professionals should keep in mind that lithium-related side effects might trigger or exacerbate each other. To avoid toxicity, close follow-up and clinical supervision are important for the early diagnosis and treatment of these side effects, due to the narrow therapeutic index and obscure clinical signs and symptoms of toxicity.…”
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