IONPs-induced neurotoxicity via cascade of neuro-oxidative stress, parthanatos-mediated cell death, neuro-inflammation and neurodegenerative changes: Ameliorating effect of rosemar... by Arwa A. Elsheikh, Noha Ali Abd-Almotaleb, Mona Mostafa Ahmed, Eman El-Sayed Khayal

“…Iron oxide nanoparticles (IONPs) are widely used in various fields, particularly in medicine, where they can be directly injected for diagnostic and therapeutic purposes, although they may induce certain types of toxicity. Therefore, the present work aimed to estimate the potential protective role of the oral extract of rosemary (RO)against the toxic effects of injected IONPs on the brain tissues of adult male rats, and to explore the potential underlying mechanisms involved in reversing such toxicity. …”
Get full text

Novel tetracycline hybrids: synthesis, characterization, docking studies and in-vitro evaluation of antibacterial activity by Mansi Shah, Bhanubhai Suhagia, Sunita Goswami, Sneha Sagar, Arpit Patwari

“…Molecular dynamic simulation studies and in silico pharmacokinetic and toxicity prediction studies were done to determine in silico pharmacokinetics and toxicity of compounds. …”
Get full text

Complications and Influential Perioperative Factors Associated with SpaceOAR Hydrogel Placement by Kerith R. Wang, Rishabh K. Simhal, Cassra B. Clark, Mark J. Mann, James R. Mark, Costas D. Lallas, Robert Den, Edouard J. Trabulsi

“…Overall, the hydrogel placement was well tolerated with low incidence of mild and transient procedure-related toxicity.…”
Get full text

Enhancement of in vitro antitumour activity of epirubicin in HER2+ breast cancer cells using immunoliposome formulation by Farnaz Khaleseh, Abbas Hemmati Azandaryani, Fatemeh Fathian Kolahkaj, Mozafar Khazaei, Katayoun Derakhshandeh

“…The preparation process of liposomes was a modified ethanol injection method followed by Herceptin conjugation. The in vitro cell toxicity and cellular uptake of optimum formulation against HER2+ and HER2− cancer cell lines were evaluated. …”
Get full text

Safety evaluation of the food enzyme α‐amylase from the non‐genetically modified Aspergillus sp. strain FUA by EFSA Panel on Food Enzymes (FEZ), Holger Zorn, José Manuel Barat Baviera, Claudia Bolognesi, Francesco Catania, Gabriele Gadermaier, Ralf Greiner, Baltasar Mayo, Alicja Mortensen, Yrjö Henrik Roos, Marize L. M. Solano, Monika Sramkova, Henk Van Loveren, Laurence Vernis, Cristina Fernàndez‐Fraguas, Magdalena Andryszkiewicz, Natalia Kovalkovicova, Eleonora Marini, Yi Liu

“…Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90‐day oral toxicity study in rats. …”
Get full text

Antifilarial Activity of the Methanolic Extract of Indigofera tinctoria (Fabaceae) on Bovine Parasites (Onchocerca ochengi) by Enock Enock Rakwa, Benoît Bargui Koubala, Bertrand Ndou Mando, Mathieu Djongra, Francis Nveikoueing, Dieudonné Ndjonka

“…The promising plant extract’s acute and subacute oral toxicity were evaluated on both mice and rats. The result revealed a highest antifilarial activity of the methanolic extract (LC50=12.28 μg/mL) compared to ivermectin (LC50=26.50 μg/mL) after 72 h of treatment. …”
Get full text

Optimizing Bioaugmentation for Pharmaceutical Stabilization of Sewage Sludge: A Study on Short-Term Composting Under Real Conditions by Gabriela Angeles-De Paz, Juan Cubero-Cardoso, Clementina Pozo, Concepción Calvo, Elisabet Aranda, Tatiana Robledo-Mahón

“…Their uncomplete removal and lack of monitoring during composting neglects their potentially toxic effects when used as a soil organic amendment. …”
Get full text

Treatment With Avacopan in Patients With Respiratory Tract Manifestations of Antineutrophil Cytoplasmic Antibody–Associated Vasculitis by Ulrich Specks, Robert F. Spiera, Lynn A. Fussner, Robert Lebovics, Sarah Bray, Rachel E. Gurlin, Darcy Trimpe, David R. W. Jayne, Peter A. Merkel, for the ADVOCATE Study Group

“…The relapse rate, glucocorticoid toxicity, and measures of HRQoL favored avacopan for both respiratory tract manifestation groups. …”
Get full text

Determination of Crizotinib in Mouse Tissues by LC-MS/MS and Its Application to a Tissue Distribution Study by Fang Zhao, Yuan Wei, Yiming Yan, Han Liu, Sitong Zhou, Bo Ren, Ruijuan Liu

“…Toxicity induced by crizotinib, a small-molecule tyrosine kinase inhibitor, is a significant clinical issue during treatment. …”
Get full text

Nanoformulation of Polymyxin E Through Complex Coacervation: A Pharmacokinetic Analysis by Xiaobao Chen, Li Liu, Weidan Wang, Yuan Yuan, Wei Wang

“…The positive charge inherent in PME causing its toxicity was mitigated after complex coacervation.…”
Get full text

Proliferative and viability effects of two cyanophages on freshwater bloom-forming species Microcystis aeruginosa and Raphidiopsis raciborskii vary between strains by Nada Tokodi, Antonia Łobodzińska, Barbara Klimczak, Adam Antosiak, Sara Młynarska, Sigitas Šulčius, Sarit Avrani, Takashi Yoshida, Dariusz Dziga

“…The high variability in responses observed with a limited subset of cyanophage-cyanobacteria combinations not only highlights the intricate role of viral infections in microbial ecosystems but also underscores the significant challenges in predicting the composition, toxicity, and dynamics of cyanobacterial blooms.…”
Get full text

Pretreatment with serine protease inhibitors impairs Leishmania amazonensis survival on macrophages by Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Elaine Soares Coimbra, Herbert Leonel de Matos Guedes

“…The current chemotherapy available for the treatment of leishmaniasis presents several problems, such as adverse effects, toxicity, long treatment time, and parasite resistance. …”
Get full text

Neoadjuvant programmed death ligand-1 with chemotherapy versus chemotherapy alone for limited-stage small-cell lung cancer: a retrospective study by Zhi Yang, Yan-qing Wang, Xiujun Chang

“…There were no perioperative deaths.ConclusionsNeoadjuvant immunotherapy shows lower toxicity and fewer perioperative complications. ICI combined chemotherapy can achieve more pathological relief and clinical benefits in the neoadjuvant treatment of LS-SCLC without increased irAE and perioperative complications. …”
Get full text

Investigating the research landscape of chlorinated paraffins over the past ten decades by Chinemerem Ruth Ohoro, Chijioke Olisah, Victor Wepener

“…Despite having similar toxicity to short-chain chlorinated paraffin (SCCP), long-chain chlorinated paraffin (LCCP) has received less attention. …”
Get full text

The triphenylmethane dye brilliant blue G is only moderately effective at inhibiting amyloid formation by human amylin or at disaggregating amylin amyloid fibrils, but interferes w... by Rehana Akter, Alexander Zhyvoloup, Bingqian Zheng, Surita R Bhatia, Daniel P Raleigh

“…BBG also remodels preformed h-amylin amyloid fibrils if added in excess, however BBG has no significant effect on h-amylin induced toxicity towards cultured β-cells or cultured CHO-T cells except at high concentrations. …”
Get full text

Cytotoxic and Antioxidant Effects of Antimalarial Herbal Mixtures by Isaac Dadzie, Shaibu Adams Avorgbedo, Regina Appiah-Opong, Obed Cudjoe

“…The herbal mixtures may be potential sources of toxic agents to host cells. Therefore, further toxicity studies must be performed to safeguard health of the public. …”
Get full text

Insecticides Used in the Urban Environment: Mode of Action by S.M. Valles, P.G. Koehler

“…The article details how different chemicals, such as pyrethroids, carbamates, and organophosphates, disrupt insect physiology, leading to toxicity and death. It also highlights the specific mechanisms through which these insecticides operate, providing a comprehensive understanding of their biological impacts. …”
Get full text

Common Pokeweed by Brent Sellers, Jason Ferrell, Curtis Rainbolt

“… SS-AGR-123, a 2-page illustrated fact sheet by Brent Sellers, Jason Ferrell, and Curtis Rainbolt, provides key information on the biology, toxicity, cultural uses, and control of common pokeweed (Phytolacca americana) -- also called poke berry, pigeon berry, inkberry coakum, pocan bush, scoke, poke salad, and American nightshade. …”
Get full text

Renal Aspects of Peptic Ulcer Pharmacology by Daniel Muruve, Ellen Burgess

“…The older agents, antacids and sucralfate, allow absorption of cations (calcium, magnesium and aluminum) which may result in toxicity. Newer medications (H2 blockers and omeprazole) appear to have fewer side effects and be better tolerated with appropriate dosage adjustments.…”
Get full text

Bismuth as Smart Material and Its Application in the Ninth Principle of Sustainable Chemistry by Ayodele Temidayo Odularu

“…The study also entails a green element called bismuth. Bismuth’s low toxicity and low cost have made researchers focus on its wide applications in catalysis. …”
Get full text