How to use monoclonal antibody-based therapy in ALL by Erica Brivio, Sujith Samarasinghe

“…Acute Lymphoblastic Leukemia (ALL) represents a significant challenge in haematology, particularly due to its aggressive nature, high relapse rates in adults and toxicity of treatment. Over the past decade, monoclonal antibody (MoAb)-based therapies have emerged as a promising approach to target specific antigens on leukemic cells, offering higher specificity, reduced toxicity, and improved response rates. …”
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Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer by Lei Wang, Liping Liang, Shuzhen Shi, Chao Wang

“…Doxorubicin (DOX) has been widely recognized as effective in anticancer therapy; however, the additional organ toxicity and low targeting of DOX in antitumor activity remains unaddressed. …”
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Stereotactic Body Radiotherapy for Metastatic Lung Cancer as Oligo-Recurrence: An Analysis of 42 Cases by Wataru Takahashi, Hideomi Yamashita, Yuzuru Niibe, Kenshiro Shiraishi, Kazushige Hayakawa, Keiichi Nakagawa

“…To investigate the outcome and toxicity of stereotactic body radiotherapy (SBRT) in patients with oligo-recurrence cancer in the lung (ORCL). …”
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Antimicrobial and Cytotoxicity Activities of Medicinal Plants against Salmonella gallinarum Isolated from Chickens by Mwanaisha Mkangara, Fulgence N. Mpenda

“…For the safety of chickens against the toxicity of plants, the cytotoxicity assay was determined using a brine shrimp lethality test. …”
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Macrofilaricidal Activity, Acute and Biochemical Effects of Three Lichen Species Found on Mount Cameroon by Thierry Roland Kang, Jerome Nyhalah Dinga, Ayuk Elizabeth Orock, Elvis Monya, Moses Njutain Ngemenya

“…No mortality and no adverse effects were recorded in the acute toxicity test. These two most active extracts had no significant effect on liver enzymes, alanine aminotransferase, and aspartate (P values < 0.05), but a high AST : ALT ratio (2.59) for Pammet indicates likely reversible adverse hepatic toxicity. …”
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Immunosuppressants in modern approaches to treatment of inflammatory bowel diseases by O. B. Schukina, A. G. Kharitonov, A. M. Kharitidis, T. E. Ivashchenko, Yu. A. Nasykhova, T. V. Gabrusskaya, A. Yu. Baranovsky

“…In case of intolerance or bone marrow toxicity at intake of thiopurines methotrexate should be prescribed.…”
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Evaluation of the Hepatoprotective Properties of Traditional Formulations Based on Cochlospermum tinctorium Used in Benin by Appolinaire K. Dossa, Jean Robert Klotoé, Victorien Dougnon, Eric Agbodjento, Rémi Akotègnon, Fréjus Ohouko, Manoir Hounkanrin, Kévine Vodounnon, Luc V. C. Brun, Fréderic Loko

“…The results revealed an absence of acute oral toxicity for the 10 recipes. The hepatoprotective tests conducted indicated that the hepatoprotective effect of C. tinctorium is dose dependent. …”
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A critical assessment of ionic liquid-based aqueous biphasic systems for biomolecules extraction and CO2 absorption by Viggy Wee Gee Tan, Yazan Abuhasheesh, Doris Ying Ying Tang, Yongyu Zhang, Zengling Ma, Lin Chen, Rambabu Krishnamoorthy, Pau Loke Show

“…The prospects of ILs as green solvents and their toxicity and applicability in carbon dioxide (CO2) capture are discussed. …”
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Evaluation of Type III Adhesive Mortar (ACIII) and Gypsum as Precipitating Agents of Copper and Lead by Jefferson Luiz Alves Marinho, Henrique Douglas Melo Coutinho, Raimundo Nonato Pereira Teixeira, Jorge Marcell Coelho Menezes, Francisco José de Paula Filho, Francisco Assis Bezerra da Cunha

“…Heavy metals exhibit characteristics such as nonbiodegradable nature, toxic character, bioaccumulation capability, and ability to transit over long distances. …”
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Corrigendum to “Zeaxanthin: Review of Toxicological Data and Acceptable Daily Intake” by James A. Edwards, Dirk Cremer

“…Also in 2018, JECFA raised the group ADI of lutein and zeaxanthin to “not specified,” due to the low toxicity of these substances.…”
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VsMATE1-Mediated Citrate Efflux Is Involved in Al Resistance in Common Vetch (<i>Vicia sativa</i> L.) by Wenhui Yan, Jia Shi, Ling He, Zigang Hou, Zhenfei Guo, Haifeng Zhu

“…Under Al toxicity, 418 accumulated less Al in both roots and shoots. …”
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The Anti-Cytokine Storm Activity of Quercetin Zinc and Vitamin C Complex by Hayder B. Sahib, Omer Abid Kathum, Rafal Shakeeb Alanee, Rehab A. M Jawad, Ahmed Majeed Al-Shammari

“…Thirty mice were used to investigate the acute toxicity; mice were distributed into six groups: one control group and five treated groups; then several serial dilutions from the complex have been prepared for different concentrations from 5 g/kg to 0.312 g/kg. …”
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Colibactin-induced damage in bacteria is cell contact independent by Emily Lowry, Amir Mitchell

“…We used Escherichia coli as a model system to study colibactin toxicity in neighboring bacteria and directly tested if cell-cell contact is required for toxicity, as has previously been proposed. …”
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Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat by Caroline E. Rasmussen, Jette Nowak, Julie M. Larsen, Emma Moore, David Bell, Kai Chiu Liu, Nanna Skall Sorensen, Wendela A. Kappers, Thomas Krogh-Meibom, Hanne Offenberg

“…Conducting long-term toxicity studies in animals using human proteins can be complicated by anti-drug antibody (ADA) development. …”
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Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroni by Qilong Huang, Jiawen Yu, Ruibing Peng, Maowang Jiang, Qingxi Han, Xiamin Jiang

“…In conclusion, when the concentration of Cu(Ⅱ) in the environment is ≥ 0.01 mg/L, it causes significant lethality toxicity, developmental toxicity and teratogenicity in S. maindroni embryos. …”
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Salicylic acid confers cadmium tolerance in wheat by regulating photosynthesis, yield and ionic homeostasis by Umer Hayat, Kaleem ul din, Muhammad Ahmad, Usman Zulfiqar, Maryium Sajjad, Muhammad Faisal Maqsood, Walid Soufan, P. V. Vara Prasad, Ivica Djalovic

“…Further, SPAD value and chlorophyll fluorescence decreased under Cd toxicity in both wheat cultivars as compared to non-stress conditions. …”
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Antagonistic Effects of Sublethal Concentrations of Certain Mixtures of Metal Oxide Nanoparticles and the Bulk (Al2O3, CuO, and SiO2) on Gill Histology in Clarias gariepinus by Amaeze Henry Nnamdi, Tam-Miette Dawarri Briggs, Oluwaseun Olusola Togunde, Henry Ebele Obanya

“…The joint actions of nano Al2O3 and CuO with SiO produced a low toxic effect, unlike the high toxicity of their single trials; this also indicates that nano Al2O3 and CuO are antagonists. …”
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Toxicological effects of the environmental pollutant perfluoronanoic acid on the ground-dwelling arthropod Solenopsis invicta by Wenxuan Wang, Mingrong Liang, Yangting Ou, Xiangrui Wang, Yunbo Song, Huimei Chen, Jingxin Hong, Yuling Liang, Yongyue Lu

“…Perfluorononanoic acid (PFNA), widely employed in surfactants, coatings, plastics, corrosion inhibitors, and fire-extinguishing agents, is less regulated than PFOS or PFOA but displays higher bioaccumulation and potential toxicity. Most toxicity assessments have focused on mammals, fish, and algae, with limited research on ground-dwelling arthropods, especially ants. …”
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Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats by Sudha Sairam, Asna Urooj

“…This study was designed to elucidate the acute toxicity of Artocarpus altilis leaf and bark extracts. …”
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A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab Cardiotoxicity by Sylvana Hidalgo, Carol A. Albright, Gretchen L. Wells

“…Trastuzumab is a monoclonal antibody highly effective in the treatment of several cancers, but its use is associated with cardiac toxicity which usually responds to cessation of the drug and/or medical therapy. …”
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