VsMATE1-Mediated Citrate Efflux Is Involved in Al Resistance in Common Vetch (<i>Vicia sativa</i> L.) by Wenhui Yan, Jia Shi, Ling He, Zigang Hou, Zhenfei Guo, Haifeng Zhu

“…Under Al toxicity, 418 accumulated less Al in both roots and shoots. …”
Get full text

The Anti-Cytokine Storm Activity of Quercetin Zinc and Vitamin C Complex by Hayder B. Sahib, Omer Abid Kathum, Rafal Shakeeb Alanee, Rehab A. M Jawad, Ahmed Majeed Al-Shammari

“…Thirty mice were used to investigate the acute toxicity; mice were distributed into six groups: one control group and five treated groups; then several serial dilutions from the complex have been prepared for different concentrations from 5 g/kg to 0.312 g/kg. …”
Get full text

Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat by Caroline E. Rasmussen, Jette Nowak, Julie M. Larsen, Emma Moore, David Bell, Kai Chiu Liu, Nanna Skall Sorensen, Wendela A. Kappers, Thomas Krogh-Meibom, Hanne Offenberg

“…Conducting long-term toxicity studies in animals using human proteins can be complicated by anti-drug antibody (ADA) development. …”
Get full text

Effects of Cu(Ⅱ) stress on embryonic development, oxidative stress response, cholinergic system and energy metabolism in the Sepiella maindroni by Qilong Huang, Jiawen Yu, Ruibing Peng, Maowang Jiang, Qingxi Han, Xiamin Jiang

“…In conclusion, when the concentration of Cu(Ⅱ) in the environment is ≥ 0.01 mg/L, it causes significant lethality toxicity, developmental toxicity and teratogenicity in S. maindroni embryos. …”
Get full text

Salicylic acid confers cadmium tolerance in wheat by regulating photosynthesis, yield and ionic homeostasis by Umer Hayat, Kaleem ul din, Muhammad Ahmad, Usman Zulfiqar, Maryium Sajjad, Muhammad Faisal Maqsood, Walid Soufan, P. V. Vara Prasad, Ivica Djalovic

“…Further, SPAD value and chlorophyll fluorescence decreased under Cd toxicity in both wheat cultivars as compared to non-stress conditions. …”
Get full text

Antagonistic Effects of Sublethal Concentrations of Certain Mixtures of Metal Oxide Nanoparticles and the Bulk (Al2O3, CuO, and SiO2) on Gill Histology in Clarias gariepinus by Amaeze Henry Nnamdi, Tam-Miette Dawarri Briggs, Oluwaseun Olusola Togunde, Henry Ebele Obanya

“…The joint actions of nano Al2O3 and CuO with SiO produced a low toxic effect, unlike the high toxicity of their single trials; this also indicates that nano Al2O3 and CuO are antagonists. …”
Get full text

Toxicological effects of the environmental pollutant perfluoronanoic acid on the ground-dwelling arthropod Solenopsis invicta by Wenxuan Wang, Mingrong Liang, Yangting Ou, Xiangrui Wang, Yunbo Song, Huimei Chen, Jingxin Hong, Yuling Liang, Yongyue Lu

“…Perfluorononanoic acid (PFNA), widely employed in surfactants, coatings, plastics, corrosion inhibitors, and fire-extinguishing agents, is less regulated than PFOS or PFOA but displays higher bioaccumulation and potential toxicity. Most toxicity assessments have focused on mammals, fish, and algae, with limited research on ground-dwelling arthropods, especially ants. …”
Get full text

Safety Evaluation of Artocarpus altilis as Pharmaceutical Agent in Wistar Rats by Sudha Sairam, Asna Urooj

“…This study was designed to elucidate the acute toxicity of Artocarpus altilis leaf and bark extracts. …”
Get full text

A Case of Trastuzumab-Associated Cardiomyopathy Presenting as an Acute Coronary Syndrome: Acute Trastuzumab Cardiotoxicity by Sylvana Hidalgo, Carol A. Albright, Gretchen L. Wells

“…Trastuzumab is a monoclonal antibody highly effective in the treatment of several cancers, but its use is associated with cardiac toxicity which usually responds to cessation of the drug and/or medical therapy. …”
Get full text

Characteristics of Hepatitis C Virus Infection in HIV-Infected People by Curtis L Cooper, Andrew D Badley, Jonathan B Angel

“…Adverse consequences of highly active antiretroviral therapy in co-infected patients include hepatic toxicity and, in a minority of patients, an 'immune restoration syndrome'. …”
Get full text

Stationary Distribution and Periodic Solution of Stochastic Toxin-Producing Phytoplankton–Zooplankton Systems by Chunjin Wei, Yingjie Fu

“…The results show that weaker white noise and/or toxicity will strengthen the stability of system, while stronger white noise and/or toxicity will result in the extinction of one or two populations.…”
Get full text

Research Progress of Programmed Cell Death Induced by Acrylamide by Jing Wang, Jinfeng Yu, Man Wang, Liangliang Fang, Wenjuan Yang, Wenbo Yao, Nan Li, Pin Gong

“…This review may provide basic data for further research of acrylamide and prevention of its toxicity.…”
Get full text

Three-Dimensional Conformal Radiotherapy for Hepatocellular Carcinoma in Patients Unfit for Resection, Ablation, or Chemotherapy: A Retrospective Study by Vassilis Kouloulias, Eftychia Mosa, John Georgakopoulos, Kalliopi Platoni, Ilias Brountzos, Anna Zygogianni, Christos Antypas, Paraskevas Kosmidis, Kyriaki Mystakidou, Maria Tolia, Ivelina Beli, Athanasios Gouliamos, John Kouvaris, Nikoalos Kelekis

“…The purpose is to evaluate the feasibility, efficacy, and the toxicity of three-dimensional conformal radiotherapy (3DCRT) in patients with advanced hepatocelluar carcinoma (HCC) and inferior vena cava tumor thrombosis (IVCTT). …”
Get full text

The pharmacology, toxicology, and detoxification of Aconitum kusnezoffii Reichb., traditional and modern views by Kenneth Happy, Sungyu Yang, Chang Ho Kang, Youngmin Kang

“…Abstract Aconitum kusnezoffii Reichb. is a medicinal plant widely used in traditional Asian medicine, especially in Korea, for its potent pharmacological effects. However, its toxic alkaloids pose significant risk, making careful processing essential to reduce its toxicity. …”
Get full text

Safety Evaluation of Multiple Strains of Lactobacillus plantarum and Pediococcus pentosaceus in Wistar Rats Based on the Ames Test and a 28-Day Feeding Study by Cheng-Chih Tsai, Sew-Fen Leu, Quan-Rong Huang, Lan-Chun Chou, Chun-Chih Huang

“…In the short-term oral toxicity study, rats received a normal dosage of 390 mg/kg/d (approximately 9×109 CFU/kg/d) or a high dosage of 1950 mg/kg/d (approximately 4.5×1010 CFU/kg/d) for 28 d. …”
Get full text

Integrated multi-omics analysis reveals the underlying molecular mechanism for the neurotoxicity of triclosan in zebrafish by Shasha Zhao, Yuhang Ling, Baohua Zhang, Danting Wang, Limei Sun

“…As a new type of environmental endocrine disruptor, it causes range of toxicities, including hepatotoxicity and reproductive toxicity. …”
Get full text

Relaxin inhibits 177Lu-EDTMP associated cell death in osteosarcoma cells through notch-1 pathway by Xu Junhua, Wan Song, Chen Wei, Zhang Yi, Ji Zhenzhong

“…We reported that RLXH2 significantly declined cellular toxicity and apoptosis associated with 177Lu-EDTMP in MG63 and Saos-2 cells through the notch-1 pathway.…”
Get full text

Effect of <I>Andrographis paniculata</I> Leaf Crude Extract Against <I>Edwardsiella tarda</I> Bacteria and Histopathological Profile of the Liver of <I>Osphronemus gouramy</I> Juve... by Giri Pratama, Arief Prajitno, Titik Dwi Sulistiyati

“…The Lethal Dosage (LD50) was 106 CFU/ml, and a toxicity test showed a dose of 250 mg/L caused the most death compared to other treatments. …”
Get full text

Galectin-1-Dependent Mitochondria Apoptosis Plays an Essential Role in the Potential Protein Targets of DBDCT-Induced Hepatotoxicity as Revealed by Quantitative Proteomic Analyses by Jiayu Song, Yuan Ren, Lihua Liu, Yixin Wang, Chuandao Shi, Xiaoqing Ji, Yunlan Li, Qingshan Li

“…Similar to platinum compounds, it also showed toxicity. However, the effective targets and mechanisms for specific toxicity and biological activity are still unclear. …”
Get full text

Irisin Exerts Neuroprotective Effects on Cultured Neurons by Regulating Astrocytes by Kexin Wang, Hongyan Li, Hongxing Wang, Jun-hui Wang, Feng Song, Yu Sun

“…Neurons suffer detrimental effects from β-amyloid toxicity in Alzheimer’s disease. The exercise hormone, irisin, is found to induce a neuroprotective gene program and facilitates the beneficial effects on cognitive function. …”
Get full text