Toxicological Assessment of Pseudospondias microcarpa (A. Rich.) Engl. Hydroethanolic Leaf Extract in Rats: Haematological, Biochemical, and Histopathological Studies by Donatus Wewura Adongo, Priscilla Kolibea Mante, Kennedy Kwami Edem Kukuia, Charles Kwaku Benneh, Robert Peter Biney, Eric Boakye-Gyasi, Nicholas Akinwale Titiloye, Eric Woode

“…However, although parts of the plant are extensively used in African traditional medicine, no scientific study has been reported on its toxicity. Therefore, this study evaluated the acute and subacute toxicity studies of the ethanolic extract of P. microcarpa in rats. …”
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Prevalence, Dispersion and Nature of Bioaerosols over a Solid Landfill Site in Central India by Priyanka D. Bhoyar, Pooja Kamdi, Amit Bafana, Panuganti C. S. Devara, Saravanadevi Sivanesan, Amrit Kumar, Kannan Krishnamurthi

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Temperature effects on the hormetic response of Myzus persicae after sublethal exposure to insecticides by Ana Paula Nascimento Silva, Camila Faria Chagas, Emanuel Lucas de Andrade Alves, Vinícius de Castro Carvalho, Khalid Haddi

“…It can also affect the toxicity and relative efficacy of insecticides that are used in agricultural fields. …”
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Diversity and functions of fungal VOCs with special reference to the multiple bioactivities of the mushroom alcohol by Guohua Yin, Geromy G. Moore, Joan Wennstrom Bennett

“…When Drosophila was cultivated in an atmosphere shared with VOC mixtures released from growing cultures of several medically important fungi, including Aspergillus fumigatus, toxicity was observed. Additionally, we propose that components of the genetic immune system of D. melanogaster are engaged in the toxicity of fungal VOCs mainly via the elicitation of the Toll pathway. …”
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A Bayesian phase 2 model based adaptive design to optimise antivenom dosing: Application to a dose-finding trial for a novel Russell's viper antivenom in Myanmar. by James A Watson, Thomas Lamb, Jane Holmes, David A Warrell, Khin Thida Thwin, Zaw Lynn Aung, Min Zaw Oo, Myat Thet Nwe, Frank Smithuis, Elizabeth A Ashley

“…The design formalises the optimal initial dose of antivenom as the dose closest to that giving a pre-specified desired efficacy, but resulting in less than a pre-specified maximum toxicity. For Daboia siamensis envenoming, efficacy is defined as the restoration of blood coagulability within six hours, and toxicity is defined as anaphylaxis. …”
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Delphi study to identify consensus on patient selection for hydrogel rectal spacer use during radiation therapy for prostate cancer in the UK by Amit Bahl, Suneil Jain, Albert Edwards, Rhodri Saunders, Clive Peedell, Heather Ann Payne, James Andrew Thomas, Prantik Das, Amanda Hansson Hedblom, Emily Woodward

“…There was agreement that despite meeting rectal dose constraints, too many patients experience rectal toxicity and that rectal hydrogel spacers in eligible patients significantly reduces toxicity-related adverse events. …”
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Optimization of anthracene biodegradation by indigenous Trichoderma lixii and Talaromyces pinophilus using response surface methodology by Samson O. Egbewale, Ajit Kumar, Mduduzi P. Mokoena, Ademola O. Olaniran

“…Despite reduced toxicity, both strains were classified as harmful based on effective concentration (EC50) and toxicity unit (TU) (20.92±1.32 mg/L and 4.78 % for TlFLU1 and 35.29±1.55 mg/L and 2.83 % for TpFLU12). …”
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Comprehensive Insight of Neurodegenerative Diseases and The Role of Neurotoxin Agents — Glutamate by Hui-Min Yap, Kwan-Liang Lye, Loh Teng-Hern Tan

“…Whereas non-receptor mediated oxidative toxicity involved the breakdown of the cystine/glutamate antiporter (xc - ) mechanism, which leads to the depletion of glutathione (GSH) and causes oxidative stress and cell death. …”
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Systematic Review of Focal Prostate Brachytherapy and the Future Implementation of Image-Guided Prostate HDR Brachytherapy Using MR-Ultrasound Fusion by M. Sean Peach, Daniel M. Trifiletti, Bruce Libby

“…Further, we wanted to determine if focal treatment results in less toxicity. Utilizing the Medline repository, dosimetric papers comparing whole gland to partial gland brachytherapy and clinical papers that reported toxicity of focal brachytherapy were selected. …”
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Accounting for microorganisms yields stricter water quality criteria and elevated ecological risks of antibiotics: A case study of sulfonamides in the Yangtze River Delta by Xinyang Zhang, Xiao Yun, Ye Huang, Guofeng Shen, Nan Lin

“…The derivation of water quality criteria (WQC) for antibiotics is influenced by the inclusion of various organisms' toxicity data, including microbial data, though no definitive conclusions have been reached. …”
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Antihyperlipidemic Potential of Polyphenol and Glycoside Rich Nerium oleander Flower against Triton WR-1339-Induced Hyperlipidemia in Experimental Sprague Dawley Rats by V. Gayathri, S. Ananthi, Hannah R. Vasanthi

“…In the present study, we have evaluated the toxicity profile of the 50% hydroethanolic extracts of Nerium oleander flowers (ENO) using in vitro brine shrimp lethality assay and MTT cytotoxicity assay and in vivo acute toxicity test as per the OECD guidelines. …”
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How to use monoclonal antibody-based therapy in ALL by Erica Brivio, Sujith Samarasinghe

“…Acute Lymphoblastic Leukemia (ALL) represents a significant challenge in haematology, particularly due to its aggressive nature, high relapse rates in adults and toxicity of treatment. Over the past decade, monoclonal antibody (MoAb)-based therapies have emerged as a promising approach to target specific antigens on leukemic cells, offering higher specificity, reduced toxicity, and improved response rates. …”
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Study on the Application of Doxorubicin-Loaded Magnetic Nanodrugs in Targeted Therapy of Liver Cancer by Lei Wang, Liping Liang, Shuzhen Shi, Chao Wang

“…Doxorubicin (DOX) has been widely recognized as effective in anticancer therapy; however, the additional organ toxicity and low targeting of DOX in antitumor activity remains unaddressed. …”
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Stereotactic Body Radiotherapy for Metastatic Lung Cancer as Oligo-Recurrence: An Analysis of 42 Cases by Wataru Takahashi, Hideomi Yamashita, Yuzuru Niibe, Kenshiro Shiraishi, Kazushige Hayakawa, Keiichi Nakagawa

“…To investigate the outcome and toxicity of stereotactic body radiotherapy (SBRT) in patients with oligo-recurrence cancer in the lung (ORCL). …”
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Antimicrobial and Cytotoxicity Activities of Medicinal Plants against Salmonella gallinarum Isolated from Chickens by Mwanaisha Mkangara, Fulgence N. Mpenda

“…For the safety of chickens against the toxicity of plants, the cytotoxicity assay was determined using a brine shrimp lethality test. …”
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Macrofilaricidal Activity, Acute and Biochemical Effects of Three Lichen Species Found on Mount Cameroon by Thierry Roland Kang, Jerome Nyhalah Dinga, Ayuk Elizabeth Orock, Elvis Monya, Moses Njutain Ngemenya

“…No mortality and no adverse effects were recorded in the acute toxicity test. These two most active extracts had no significant effect on liver enzymes, alanine aminotransferase, and aspartate (P values < 0.05), but a high AST : ALT ratio (2.59) for Pammet indicates likely reversible adverse hepatic toxicity. …”
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Immunosuppressants in modern approaches to treatment of inflammatory bowel diseases by O. B. Schukina, A. G. Kharitonov, A. M. Kharitidis, T. E. Ivashchenko, Yu. A. Nasykhova, T. V. Gabrusskaya, A. Yu. Baranovsky

“…In case of intolerance or bone marrow toxicity at intake of thiopurines methotrexate should be prescribed.…”
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A critical assessment of ionic liquid-based aqueous biphasic systems for biomolecules extraction and CO2 absorption by Viggy Wee Gee Tan, Yazan Abuhasheesh, Doris Ying Ying Tang, Yongyu Zhang, Zengling Ma, Lin Chen, Rambabu Krishnamoorthy, Pau Loke Show

“…The prospects of ILs as green solvents and their toxicity and applicability in carbon dioxide (CO2) capture are discussed. …”
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Evaluation of Type III Adhesive Mortar (ACIII) and Gypsum as Precipitating Agents of Copper and Lead by Jefferson Luiz Alves Marinho, Henrique Douglas Melo Coutinho, Raimundo Nonato Pereira Teixeira, Jorge Marcell Coelho Menezes, Francisco José de Paula Filho, Francisco Assis Bezerra da Cunha

“…Heavy metals exhibit characteristics such as nonbiodegradable nature, toxic character, bioaccumulation capability, and ability to transit over long distances. …”
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Corrigendum to “Zeaxanthin: Review of Toxicological Data and Acceptable Daily Intake” by James A. Edwards, Dirk Cremer

“…Also in 2018, JECFA raised the group ADI of lutein and zeaxanthin to “not specified,” due to the low toxicity of these substances.…”
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