Pharmacogenomics predictors of aromatic antiepileptic drugs-induced SCARs in the Iraqi patients by Ali Fadhel Ahmed, Dzul Azri Mohamed Noor, Majeed Arsheed Sabbah, Nur Fadhlina Musa, Nur Aizati Athirah Daud

“…Common types of SCARs include Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS). …”
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Bacterial flora of the eyelids and conjunctiva in the development of inflammatory pathology in the anterior part of the eye by E.A. Kleshcheva, G.M. Chernakova, N.V. Melnikova, A.E. Kleshchev

“…Its efficacy, safety, and broad-spectrum activity make it well-suited for cases wh ere a powerful and non-toxic antibiotic is required. </p> <p> <b>Keywords</b>: conjunctival microflora, eyelid microflora, bacterial infection, conjunctivitis, endophthalmitis, antibiotics, netilmicin. …”
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Primary Terminal Haemochromatosis in a 50 Year-Old Patient by M. I. Gonik, M. S. Zharkova, O. Yu. Kiseleva, E. V. Berezina, Sh. A. Ondos, Yu. V. Lerner, E. A. Kogan, V. T. Ivashkin

“…The patient had a history of long-term alcohol consumption at toxic doses, putative cirrhosis, paroxysmal atrial fibrillation, type 2 diabetes mellitus. …”
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Buffalo milk quality in southern Italy: trace elements & endocrine disruptors. A One Health analysis by Luigi Jacopo D’Auria

“…Regarding the presence of metals, of the twenty trace elements analysed, only lead is regulated in the EU and no sample exceeded the maximum limit (LM = 0.02 mg/kg). Potentially toxic elements such as chromium (< 0.141 mg/kg), cobalt (< 0.008 mg/kg), manganese (< 0.035 mg/kg), selenium (< 0.044 mg/kg), vanadium (< 0.016 mg/kg), zinc (<4.31 mg/kg) and strontium (< 0.947 mg/kg) have been found in milk at levels that do not constitute a health risk; furthermore their presence could be related to the geographical origin. …”
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Phase 1, open-label, dose-escalation study on the safety, pharmacokinetics, and preliminary efficacy of intravenous Coxsackievirus A21 (V937), with or without pembrolizumab, in pat... by Christy Ralph, Sumati Gupta, Matthew Zibelman, Brendan D Curti, Kevin J Harrington, Steven J O'Day, Andrew G Hill, David C Campbell, Gavin M Wright, David E Gerber, Jonathan E Rosenberg, Jaime R Merchan, Charles M Rudin, Hardev S Pandha, Wallace L Akerley, Daphne Day, Timothy D Clay, Ross R Jennens, Yixin Ren, Emmett V Schmidt, Lisa Guttman

“…Dose-escalation proceeded if no dose-limiting toxicities (DLTs) occurred in cycle 1 of the previous cohort. …”
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Anlotinib in combination with metronomic chemotherapy in HER2-negative metastatic breast cancer: an observational and retrospective study by Jiaxuan Liu, Jiayang Zhang, Huiping Li, Guohong Song, Lijun Di, Hanfang Jiang, Ying Yan, Huan Wang, Jing Wang, Xiaoran Liu, Bin Shao, Qiao Li

“…Metronomic chemotherapy (MCT) provides antiangiogenic effects without increased toxicities, making it good partner for antiangiogenic therapy. …”
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Preparation of oat galactolipid and anti-liver cancer effects of oat galactolipid–modified curcumin-loaded liver targeting vesicle by Huiying Ren, Nuo Chen, Yanqing Liu, Meimei Wu, Meimei Wu, Meimei Wu, Jingsong Yan, Jingsong Yan, Jingsong Yan, Mingxiang Chang, Mingxiang Chang, Mingxiang Chang, Hanmin Li, Hanmin Li, Hanmin Li

“…IntroductionThe mortality rate for liver cancer is extremely high but clinical treatments have not made much progress, so it is necessary to develop anticancer agents with lower toxicities and more effective liver-targeting drug delivery systems (LTDDSs). …”
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Fedratinib combined with ropeginterferon alfa-2b in patients with myelofibrosis (FEDORA): study protocol for a multicentre, open-label, Bayesian phase II trial by Graham McIlroy, Charlotte Gaskell, Aimee Jackson, Emily Yafai, Rachel Tasker, Catherine Thomas, Sonia Fox, Rebecca Boucher, Fitsum Ghebretinsea, Claire Harrison, Adam J. Mead, Mary Frances McMullin

“…The primary outcome is tolerability, whereby the combination is deemed intolerable in a patient if drug-related toxicities in the first four months of treatment lead to: either drug being discontinued; delays in treatment exceeding 28 consecutive days; or death. …”
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Systematic preclinical evaluation of CD33-directed chimeric antigen receptor T cell immunotherapy for acute myeloid leukemia defines optimized construct design by Haiying Qin, Nirali N Shah, Terry J Fry, Lila Yang, John A Chukinas, Samiksha Tarun, Marie Pouzolles, Christopher D Chien, Lisa M Niswander, Anthony R Welch, Sarah K Tasian, Naomi A Taylor

“…Gemtuzumab-based CD33CARTs were unexpectedly toxic in vivo in animal models despite observed in vitro anti-leukemia activity. …”
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Assessment of Health Risks from Agricultural Soils Contaminated with Polycyclic Aromatic Hydrocarbons (PAHs) Across Different Land-Use Categories of Bangladesh by Sumaya Sharmin, Qingyue Wang, Md. Rezwanul Islam, Weiqian Wang, Yanyan Wang, Christian Ebere Enyoh, Md. Sohel Rana

“…Polycyclic aromatic hydrocarbons (PAHs) are a matter of deep concern as they pose significant environmental and health hazards due to their persistence, bioaccumulation, and toxic effects. In soils, PAHs accumulate, contaminating ecosystems, entering food chains, and posing threats to plant and human health. …”
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Neuroprotective role of epigallocatechin-3-gallate, albeginin and melanoxetin in alzheimer's disease by Arif Malik, Mehreen Hassan, Sulayman Waquar, Muhammad Wasim, Anam Naz, Faryal M. Awan, Muhammad T. Khan, Ali I. Khawaja, Sumera Zaib, Jamshed Iqbal, Ayesha Zahid, Marvi Marvi, Javeid Iqbal, Heng Wang, Dong-Qing Wei

“…Melanoxetin, a phenolic molecule, chelates toxic metals, lowers ROS, and protects neurons at 15–40 mg/kg/day in animal models and 50–150 mg/day in humans. …”
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Ligilactobacillus salivarius LZZAY01 accelerated autophagy and apoptosis in colon cancer cells and improved gut microbiota in CAC mice by Wenhong Yang, Tao Li, Shixiang An, Rong Chen, Yuxin Zhao, Jiaxian Cui, Mingyu Zhang, Jingkun Lu, Yunpeng Tian, Lili Bao, Pengwei Zhao

“…However, these treatments are associated with a high recurrence rate, poor prognosis, and highly toxic side effects. The probiotics have the potential to prevent CRC, and they display a favorable safety performance. …”
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Molecular docking and molecular dynamics simulation studies of inhibitor candidates against Anopheles gambiae 3-hydroxykynurenine transaminase and implications on vector control by Eunice O. Adedeji, Olubanke O. Ogunlana, Gbolahan O. Oduselu, Rainer Koenig, Ezekiel Adebiyi, Opeyemi S. Soremekun, Segun Fatumo

“…These compounds were predicted to be less toxic than temephos, a standard larvicide and more biodegradable than previously reported inhibitors. …”
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Ibrutinib disrupts blood-tumor barrier integrity and prolongs survival in rodent glioma model by Sanghee Lim, Minhye Kwak, Jeonghan Kang, Melissa Cesaire, Kayen Tang, Robert W. Robey, William J. E. Frye, Baktiar Karim, Donna Butcher, Martin J. Lizak, Mahalia Dalmage, Brandon Foster, Nicholas Nuechterlein, Charles Eberhart, Patrick J. Cimino, Michael M. Gottesman, Sadhana Jackson

“…Our results motivate the need to identify other BTB modifiers, all with the intent of improving survival and reducing systemic toxicities.…”
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A New CYP2E1 Inhibitor, 12-Imidazolyl-1-dodecanol, Represents a Potential Treatment for Hepatocellular Carcinoma by Torsten Diesinger, Alfred Lautwein, Sebastian Bergler, Dominik Buckert, Christian Renz, Radovan Dvorsky, Vyacheslav Buko, Siarhei Kirko, Edith Schneider, Florian Kuchenbauer, Mukesh Kumar, Cagatay Günes, Felicitas Genze, Berthold Büchele, Thomas Simmet, Martin Haslbeck, Kai Masur, Thomas Barth, Dieter Müller-Enoch, Thomas Wirth, Thomas Haehner

“…This antitumour effect was not associated with tumour cachexia. I-ol was not toxic to healthy tissues or organs. This study demonstrates for the first time the therapeutic effect of the specific CYP2E1 inhibitor I-ol on the tumorigenesis of HCC. …”
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First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

“…Secondary objectives were to assess safety and pharmacokinetics (PK), and exploratory objectives included evaluating preliminary efficacy.ResultsFifty-seven patients enrolled in the dose escalation: 23 in monotherapy cohorts and 34 in combination therapy cohorts. Dose-limiting toxicities were limited, no maximum tolerated dose was reached, and the maximum administered dose of 1500mg was selected for dose expansion. …”
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Potential impact and mechanism of aged polyethylene microplastics on nitrogen assimilation of Lactuca sativa L. by Xiaoli Mou, Hedong Zhu, Renrui Dai, Li Lu, Shengqi Qi, Min Zhu, Yuyang Long, Nan Ma, Chao Chen, Jiali Shentu

“…Possible mechanisms included inhibition of carbon assimilation, photosynthesis, and Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco). The toxic effect of aged MNPs on growth and N assimilation in lettuce was much greater than that of the particle size, which was attributed to the carbonyl and hydroxyl groups caused by aging. …”
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Green synthesis of titanium dioxide photocatalyst using Lactobacillus bulgaricus for processing palm oil mill effluent by L. Agustina, M. Romli, P. Suryadarma, S. Suprihatin

“…Testing the titanium dioxide photocatalyst to treat palm oil mill secondary effluent yielded in elimination efficiency of 16.16-27.27 percent for chemical oxygen demand and 11.05-21.95 percent for biological oxygen demand. Phenol, which is toxic and difficult to degrade biologically, could eliminated significantly (up to 81.12 percent) using a photocatalyst dose of 1 gram per liter at a time irradiation of 2.5 hour.CONCLUSION: The biological synthesis of nano titanium dioxide photocatalysts is affected by temperatures and metal oxide concentrations. …”
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