The influence of external factors on the development of olfactory disorders in patients with the coronavirus disease 2019: an immunomorphological assessment by I.S. Shponka, O.M. Usova

“…The main risk factors for the development of olfactory disorders are old age, male gender, head injuries, exposure to toxic substances and infectious diseases of the upper respiratory tract. …”
Get full text

Importance of benzoyltransferase GcnE and lysine benzoylation of alcohol dehydrogenase AdhB in pathogenesis and aflatoxin production in Aspergillus flavus by Xuan Chen, Lihan Wu, Yuqi Zhang, Sen Wang, Shihua Wang

“…Meanwhile, it points out the important role of Kbz in the pathogenicity of pathogenic fungi.IMPORTANCEAspergillus flavus is a ubiquitous opportunistic pathogen of plants and animals, which produces carcinogenic and toxic secondary metabolite aflatoxin. A. flavus and aflatoxin contamination have emerged as a global food safety concern. …”
Get full text

Transition metal-based MOFs for Fenton-like photocatalytic degradation of organic pollutants: Performance, stability, and biocompatibility by S.M. Tikhanova, Yu.A. Tishchenko, E.Yu. Stovpiaga, M. Timofeeva, D.V. Lipin, S.A. Povarov, V.A. Milichko, A.S. Timin, S.A. Shipilovskikh, V.I. Popkov

“…By reducing reliance on toxic chemical treatments, this study highlights MeBDC MOFs as highly efficient, biocompatible, and sustainable photocatalysts, with significant potential for industrial and domestic water purification applications.…”
Get full text

Computer-guided identification of novel inhibitors of apoptosis-signaling kinase 1 from Spondia mombim bioactive compounds against colorectal cancer by Olusola Olalekan Elekofehinti, Hannah Oluwaseun Popoola, Adedotun Olayemi Oluwatuyi, Opeyemi Iwaloye, Moses Orimoloye Akinjiyan, Oluwamodupe Cecilia, Frank Abimbola Ogundolie, Olalekan Isaac Olatunde, Oussama Abchir, Samir Chtita, Joao Batista Texeira Rocha

“…The oral bioavailability and toxicities of these compounds are promising as compounds obeyed the Lipinski rule of five. …”
Get full text

Larvicidal Effectiveness of Azolla pinnata against Aedes aegypti (Diptera: Culicidae) with Its Effects on Larval Morphology and Visualization of Behavioural Response by Nor Shaida Husna Zulkrnin, Nurul Nadiah Rozhan, Nur Amanina Zulkfili, Nik Raihan Nik Yusoff, Mohd Sukhairi Mat Rasat, Nor Hakimin Abdullah, Muhammad Iqbal Ahmad, Rajiv Ravi, Intan H. Ishak, Mohamad Faiz Mohd Amin

“…The extensive use of chemical insecticides has led to severe health problems, environmental pollution, toxic hazards to human and nontarget species, and development of insecticide resistance on mosquitoes. …”
Get full text

Gestational exposure to environmental chemical mixtures and cognitive abilities in children: A pooled analysis of two North American birth cohorts by Jagadeesh Puvvula, Wei-Ting Hwang, Lawrence McCandless, Changchun Xie, Joseph M. Braun, Ann M. Vuong, Youssef Oulhote, Enrique F. Schisterman, Russell T. Shinohara, Linda Booij, Maryse F. Bouchard, Kristin Linn, Michael M. Borghese, Jean R. Seguin, Angelika Zidek, Christine Till, William Fraser, Kimberly Yolton, Kim M. Cecil, Jillian Ashley-Martin, Tye E. Arbuckle, Bruce Lanphear, Aimin Chen

“…Background: Gestational exposures to single toxic chemicals have been associated with cognitive deficits in children, but few studies have explored chemical mixtures. …”
Get full text

Phase Ib study of pembrolizumab in combination with trastuzumab emtansine for metastatic HER2-positive breast cancer by Sara M Tolaney, Tianyu Li, Edward T Richardson, Judith Agudo, Elizabeth A Mittendorf, Beth Overmoyer, Eric P Winer, Adrienne G Waks, Tanya E Keenan, Nabihah Tayob, Gerburg M Wulf, Victoria Attaya, Leilani Anderson, Ian E Krop, Eliezer M Van Allen

“…There were no dose-limiting toxicities. The RP2D was 3.6 mg/kg T-DM1 every 21 days plus 200 mg pembrolizumab every 21 days. 85% of patients experienced treatment-related adverse events (AEs) ≥grade 2, 20% of patients experienced grade 3 AEs, and no patients experienced grade >4 AEs. …”
Get full text

Testing of Retail Cheese, Butter, Ice Cream, and Other Dairy Products for Highly Pathogenic Avian Influenza in the US by David L. Suarez, Iryna V. Goraichuk, Lindsay Killmaster, Erica Spackman, Nicole J. Clausen, Tristan J. Colonius, Cynthia L. Leonard, Monica L. Metz

“…Trial studies were conducted with different cheese types with spiked-in avian influenza virus to show that inoculation of the liquified cheese into embryonating chicken eggs was not toxic to the embryos and allowed virus replication. …”
Get full text

iMulch: an investigation of the influence of polymers on a terrestrial ecosystem using the example of mulch films used in agriculture by Carmen Wolf, Mike Wenzel, Björn Fischer, Ralf Bertling, Erich Jelen, Dieter Hennecke, Karlheinz Weinfurtner, Martina Roß-Nickoll, Henner Hollert, Antonia Weltmeyer, Kristina Bitter, Pauline Ruiz, Dusica Banduka, Jochen Tuerk, Lars M. Blank

“…In the ecotoxicological tests, both film types showed no acute toxic effects in the earthworm Eisenia fetida and the springtail Folsomia candida. …”
Get full text

Exposure of wild mammals to glyphosate, AMPA, and glufosinate: a case for “emerging organic contaminants”? by Fritsch, Clémentine, Appenzeller, Brice M. R., Bertrand, Colette, Coeurdassier, Michael, Driget, Vincent, Hardy, Emilie M, Palazzi, Paul, Schaeffer, Charline, Goydadin, Anne-Claude, Gaba, Sabrina, Bretagnolle, Vincent, Pelosi, Céline

“…Accumulating evidence shows that GLY and its metabolite aminomethylphosphonic acid (AMPA) are more persistent and toxic than expected, but little is known about the risks to wildlife. …”
Get full text

The Effect of Lipotoxicity on Renal Dysfunction in a Nonobese Rat Model of Metabolic Syndrome: A Urinary Proteomic Approach by Irena Markova, Denisa Miklankova, Martina Hüttl, Petr Kacer, Jelena Skibova, Jan Kucera, Radislav Sedlacek, Tereza Kacerova, Ludmila Kazdova, Hana Malinska

“…The development of metabolic syndrome-associated renal dysfunction is exacerbated by a number of factors including dyslipidemia, ectopic deposition of lipids and their toxic metabolites, impairment of lipid metabolism, and insulin resistance. …”
Get full text

Research Progress on Animal Models of Sepsis-Related Organ Injury by YANG Jiahao, DING Chunlei, QIAN Fenghua, SUN Qi, JIANG Xusheng, CHEN Wen, SHEN Mengwen

“…This article first summarizes classic modeling methods for sepsis related organ injury, including the destruction of intestinal barrier tissue integrity and the implantation of pathogens or toxic drugs. The former mainly includes cecal ligation and puncture, ascending colon stent implantation, and cecal ligation incision. …”
Get full text

Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy by Qin Si, Lu Yang, Jie Liu, Hui Liu, Ruifang Bu, Na Cui

“…Furthermore, M2 macrophage suppresses the toxic effect of CAR-T cells on OC cells, while silencing the P2X7 receptor nullifies the immunosuppressive effect of M2 macrophages on CAR-T cells. …”
Get full text

Neuropsychiatric manifestations following chimeric antigen receptor T cell therapy for cancer: a systematic review of clinical outcomes and management strategies by Max Topp, Michael Hudecek, Hermann Einsele, Imad Maatouk, Leo Rasche, Johannes Duell, Anna Fleischer, Sophia Kurth, Patrick-Pascal Strunz, Julia Mersi, Carmen Sanges

“…As the application of CAR-T cell therapy expands to treat a broader range of diseases, it becomes increasingly important to devise effective strategies for handling the associated toxicities. Challenges in treating patients with CAR-T cells include addressing complications such as cytokine release syndrome, immune effector cell-associated neurotoxicity syndrome, and cytopenias. …”
Get full text

Validation of heavy metals in geothermal to support water management practices and mitigation strategies by G.M. Idroes, D.P. Rezeki, K. Khairi, K. Khairan, R. Idroes, E. Suhartono, R. Prasetio, S.A. Rahman, S. Suhendrayatna

“…Preventive measures, such as water filtration and public health advisories, should be implemented to safeguard the local population from the potential long-term exposure to these toxic metals.…”
Get full text

Cadmium and lead uptake by wild swamp eel in the populous river by N. Nurhasanah, L. Sulistyowati, E. Riani, M. Cordova

“…BACKGROUND AND OBJECTIVES: For enhanced environmental management of the Ciliwung River, toxic pollutions such as cadmium dan lead data are required. …”
Get full text

A STUDY OF THE INFLUENCE OF EXTRACELLULAR VESICLES ON THE MORPHOFUNCTIONAL STATE OF THE ENDOMETRIUM IN VITRO by Оксана Александровна Мелкозерова, Ирина Викторовна Крутинь, Александра Юрьевна Храмцова, Мария Валерьевна Улитко, Алсу Фармутовна Мустафина

“…It was noted that extracellular vesicles do not have a toxic effect on cell culture. Under the influence of vesicles, the number of cell nuclei increases. …”
Get full text

Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma by Lawrence G Lum, Parameswaran Hari, Aniko Szabo, Michele Donato, Jee Hyun Park, Daniel H Fowler, Binod Dhakal, Saurabh Chhabra, Deborah D Glass, David S Siegel, Tania C Felizardo

“…Median progression-free survival was 6.0 months (range, 2.1 to>16.8 months). There were no toxicities of any grade attributable to RAPA-201, including no cytokine release syndrome and no immune effector cell-associated neurotoxicity syndrome. …”
Get full text

Photochemical oxidation and landfarming as remediation techniques for oil-contaminated soil by M. Mambwe, K.K. Kalebaila, T. Johnson

“…Natural attenuation takes too long to produce positive results, whereas landfarming can produce toxic intermediates due to the organisms’ inability to degrade other oil components. …”
Get full text

The effect of endosulfan bioaccumulation on the growth of carp, Cyprinus carpio LINN. by Imam Taufik, E. Supriyono, K. Nirmala

“…This study resulted that endosulfan was very toxic to the carp with LC50-96h value was 2.42 (2.206-2.652) mg/l. …”
Get full text