Pain in pancreatitis: issue and ways out by A. V. Okhlobystin

“…Medical treatment of pain includes, first of all, elimination of toxic factors and stimulations of pancreatic secretion. …”
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The formulated microbicide RC-101 was safe and antivirally active following intravaginal application in pigtailed macaques. by Alexander M Cole, Dorothy L Patton, Lisa C Rohan, Amy L Cole, Yvonne Cosgrove-Sweeney, Nicole A Rogers, Deena Ratner, Alexandra B Sassi, Carol Lackman-Smith, Patrick Tarwater, Bharat Ramratnam, Piotr Ruchala, Robert I Lehrer, Alan J Waring, Phalguni Gupta

“…<h4>Background</h4>RC-101 is a congener of the antiretroviral peptide retrocyclin, which we and others have reported is active against clinical HIV-1 isolates from all major clades, does not hemagglutinate, and is non-toxic and non-inflammatory in cervicovaginal cell culture. …”
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Release of tumour necrosis factor alpha into bronchial alveolar lavage fluid following antigen challenge in passively sensitized guinea-pigs by D. E. Kelly, M. Denis, D. F. Biggs

“…BAL fluid from OA sensitized animals that inhaled OA aerosols contained no detectable TNF-α at 30 min, but it was found in increasing amounts at 60, 90 and 120 min; TNF-α was not detected in fluid from any of the animals that inhaled saline. As BAL fluids were toxic to the cells used in the assays, neither IL-1 nor IL-6 could be measured. …”
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Ecological and genetic assessment of the consequences of radiation influence on contaminated areas by A. B. Bigaliev, K. Z. Shalabaeva, B. E. Shimshikov, S. S. Kobegenova, L. M. Adilova, A. N. Kozhakhmetova, S. Sharakhmetov, M. N. Burkhanova

“…A reconnaissance and radioecological examination of environmental objects was carried out using analytical methods, which made it possible to determine the quantitative content of toxic components, the content of priority pollutants and radioactive isotopes. …”
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The evolving roles of geophysics in environmental assessment, monitoring, and management of landfill leachate contaminant plumes: An overview by Joseph Omeiza Alao

“…Landfill leachate, a toxic brew of pollutants, poses a silent threat to water resources, ecosystems, and public health. …”
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Comparative analysis of the efficacy and safety of fixed-dose combinations versus their individual components for open-angle glaucoma by Z.M. Nagornova, A.V. Kuroyedov, A.V. Seleznev

“…Moreover, IOP-lowering effect of fixed-dose combinations is similar or even greater than that of individual components due to the lack of washout phenomenon and less toxic effect of preservatives on the ocular surface. …”
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Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity by Eman Aly Khalifa, Ahmed Nabil Ahmed, Khalid Shaaban Hashem, Ahmad Gad Allah

“…However, despite intense efforts to develop less toxic and equally effective alternatives, cisplatin continues to be widely prescribed. …”
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ACTIVITY OF NITRO-OXIDATIVE PROCESSES IN PREGNANT WOMEN WITH IDIOPATHIC ARTERIAL HYPOTENSION by Leonid Markin, Olena Popovych, Alla Popovych

“…High levels of nitrites and nitrates in pregnant women with IAH form the basis for the development of nitrosatous stress, which is accompanied by increasing concentration of highly toxic peroxynitrite. Significant increase in peroxynitrite is one of the causes of endothelial dysfunction. …”
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Deterrent Effects of Clary Sage Oil and Two Major Constituents against <em>Drosophila suzukii</em> (Diptera: Drosophilidae) by Yu Wang, Fengyi Wen, Xiangyi Zhou, Guoxing Chen, Chunxia Tian, Jiali Qian, Huiming Wu, Mengli Chen

“…Essential oils, considered potential alternatives to pesticidal strategies, exhibit potent toxic and sublethal behavioral effects against numerous pests, including <i>D. suzukii</i>. …”
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Association between exposure to environmental pollutants and increased oral health risks, a comprehensive review by Li Zhu, Mengchen Tang, Yinyin Cai, Yinyin Cai, Panpan Wang, Panpan Wang

“…The review also explores potential mechanisms underlying these impacts, including microorganism, inflammation, oxidative stress, genetic influences, and toxicant exposures from heavy metals and other pollutants. …”
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Angel or devil: the dual roles of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucopyranoside in the development of liver injury based on integrating pharmacological techniques: a system... by Jiajie Jiang, Jiajie Jiang, Qixiu Wang, Qiang Wu, Bobin Deng, Cui Guo, Jie Chen, Jinhao Zeng, Yaoguang Guo, Xiao Ma

“…The histological analysis of liver tissue confirmed the regulatory effects of TSG, and a comprehensive analysis revealed the optimal protective dosage range was 27.27–38.81 mg/kg/d and the optimal toxic dosage range was 51.93–76.07 mg/kg/d. TSG exerts the dual effects on liver injury (LI) through the network of Keap1/Nrf2/HO-1/NQO1, NF-κB, PPAR, PI3K/Akt, JAK/STAT and TGF-β pathways.ConclusionTSG could mediate the pathways of oxidation, inflammation, and metabolism to result in hepatoprotection (27.27–38.81 mg/kg/d) and hepatotoxicity (51.93–76.07 mg/kg/d).…”
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A Comparative Analysis of the Antioxidant Profiles Generated by the RoXsta^TM System for Diverse Biological Fluids Highlights the Powerful Protective Role of Human Semina... by Robert J. Aitken, Alexandra Wilkins, Natasha Harrison, Mohammad Bahrami, Zamira Gibb, Kaitlin McIntosh, Quan Vuong, Sarah Lambourne

“…The purpose of this study was to examine its performance utilizing a diverse array of biological fluids including semen, blood plasma, serum, urine, saliva, follicular fluid and plant extracts. (2) Methods: The RoXsta^TM system was used to assess the ability of different fluids to suppress free radical formation as well as scavenge a variety of toxic oxygen metabolites including free radicals and both hydrogen and organic peroxides. (3) Results: Human semen was shown to have significantly (<i>p</i> < 0.001) more peroxide scavenging power than any other fluid tested (10–14 mM vitamin C equivalent compared with 1–2 mM for blood serum or plasma), while urine was particularly effective in scavenging free radicals and preventing free radical formation (<i>p</i> < 0.001). …”
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Bismuth-Immobilized Optical Fiber-Based SPR Nanosensor for Detection of Zinc Nitrate Contamination in Aquaculture Industry by Yesudasu Vasimalla, Nasih Hma Salah, Baljinder Kaur, Hogr M. Rasul, Chella Santhosh, Ramachandran Balaji, S.R. Srither, Santosh Kumar

“…Zinc nitrate, a toxic substance usually found in industrial waste and agricultural residues, poses a serious threat to the aquaculture industry due to the poor water quality and harmful aquatic life. …”
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Tailoring traditional Chinese medicine in cancer therapy by Shuiquan Li, Xi Chen, Hui Shi, Ming Yi, Bing Xiong, Tianye Li

“…Through comprehensive analysis, we demonstrated that TCM not only potentially increases the efficacy of conventional cancer treatments, but also significantly mitigates their toxic side effects, thereby prolonging patients’ prognosis and improving their living quality. …”
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Optimizing Microwave-Assisted Extraction of Carbohydrate from Scenedesmus sp. Cultivated in Domestic Wastewater by Yeong Hwang Tan, Mee Kin Chai, Ling Shing Wong, Mei Yin Ong, Ranjithkumar Rajamani

“…Conventional methods of extraction include long energy-intensive heating processes with toxic solvents because carbohydrates are packed inside the microalga cell wall. …”
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Health Risk Assessment of Chemicals: From Bulk to Nano by Soqrat Omari Shekaftik, Jamal Biganeh, Maedeh Hosseinzadeh, Hamidreza Jafari Nodoushan, Neda Mehrparvar

“…Introduction: Workplaces often contain potential risks, such as exposure to toxic chemicals. Conducting a thorough health risk assessment helps employers recognize these dangers and implement necessary controls. …”
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Chemical Composition, In Vivo, and In Silico Molecular Docking Studies of the Effect of <i>Syzygium aromaticum</i> (Clove) Essential Oil on Ochratoxin A-Induced Acute Neurotoxicity by Mostapha Brahmi, Djallal Eddine H. Adli, Imane Kaoudj, Faisal K. Alkholifi, Wafaa Arabi, Soumia Sohbi, Kaddour Ziani, Khaled Kahloula, Miloud Slimani, Sherouk Hussein Sweilam

“…These results highlight the therapeutic potential of EOC in combating the toxic effects of OTA and pave the way for future research into the mechanisms of action and therapeutic applications of natural compounds in the prevention and treatment of poison-induced diseases.…”
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Efficacy and Safety of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting Transforming Growth Factor-β and Programmed Death-Ligand 1, Plus Chemotherapy in Patients With Stage... by Christian Rolfo, MD, PhD, Laurent Greillier, MD, PhD, Remi Veillon, MD, PhD, Firas Badin, MD, MBA, Francois Ghiringhelli, MD, PhD, Nicolas Isambert, MD, PhD, Astrid Paulus, MD, PhD, Surendra Pal Chaudhary, MD, Yulia Vugmeyster, PhD, Masashi Sato, MSc, Sandrine Hiret, MD, PhD

“…Results: Four serious and one nonserious treatment-emergent adverse events were considered dose-limiting toxicities, none of which were assessed as related to bintrafusp alfa by the investigator. …”
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Brodifacoum causes coagulopathy, hemorrhages, and mortality in rainbow trout (Oncorhynchus mykiss) at environmentally relevant hepatic residue concentrations by Hannah Schmieg, Hermann Ferling, Karina Annika Bucher, Stefanie Jacob, Julia Regnery, Hannah Schrader, Julia Schwaiger, Anton Friesen

“…Widely used second-generation anticoagulant rodenticides like brodifacoum are classified as persistent, bioaccumulative, and toxic. Widespread exposure of terrestrial and avian non-target species is well-known and recently hepatic anticoagulant rodenticide residues have been detected in wild fish. …”
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Boanmycin overcomes bortezomib resistance by inducing DNA damage and endoplasmic reticulum functional impairment in multiple myeloma by Jin-Xing Wang, Ling Zhang, Peng-Wei Zhang, Luo-Wei Yuan, Jian Jiang, Xiao-Hui Cheng, Wei Zhu, Yong Lei, Fa-Qing Tian

“…Furthermore, boanmycin significantly suppressed MM cell growth in immunodeficient mouse xenograft models without inducing distinct toxic side effects. Notably, boanmycin markedly killed patient-derived MM cells ex vivo. …”
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