MAT2A inhibitor AG-270/S095033 in patients with advanced malignancies: a phase I trial by Mrinal Gounder, Melissa Johnson, Rebecca S. Heist, Geoffrey I. Shapiro, Sophie Postel-Vinay, Frederick H. Wilson, Elena Garralda, Gerburg Wulf, Caroline Almon, Salah Nabhan, Elia Aguado-Fraile, Peng He, Mathilde Romagnoli, Mohammad Hossain, Rohini Narayanaswamy, Amel Sadou-Dubourgnoux, Michael Cooper, Vasileios Askoxylakis, Howard A. Burris, Josep Tabernero

“…Reversible increases in liver function tests, thrombocytopenia, anemia and fatigue were common treatment-related toxicities. Two partial responses were observed; five additional patients achieved radiographically confirmed stable disease for ≥16 weeks. …”
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Comparative anti-methanogenic ability of green algae (C. reinhardtii) with/without nanoparticles: in vitro gas and methane production by Valiollah Palangi, Adem Kaya, Muhlis Macit, Hayrunnisa Nadaroglu, Hayrullah Bora Ünlü, Ali Kaya, Ashkan Fekri, Ayaz Mammadov, Maximilian Lackner

“…The green algal plant (C. reinhardtii), which has many non-toxic antioxidants, was used as a carbon source to produce carbon quantum dots (CQD). …”
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Effect of fungicides on soil respiration, microbial community, and enzyme activity: A global meta-analysis (1975–2024) by Zikai Wang, Shourong Yun, Yuli An, Liulingqian Shu, Shunjin Li, Kai Sun, Wei Zhang

“…Overall, fungicides inhibit the abundance, diversity, and enzyme activity of soil microorganisms; however, precise control of fungicide dosage is essential to minimize their toxic effects on soil.…”
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Sorption behavior of pomegranate polyphenols on surfactant-modified clays in aqueous solution by Houda Saad, Thouraya Turki, Mondher Srasra, Ezzeddine Srasra

“…They can be present at high concentrations in the bulk effluents generated by the agro-food industries which can be toxic and have an impact on microbial processing in wastewater treatment plants. …”
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UEF-HOCUrdu: Unified Embeddings Ensemble Framework for Hate and Offensive Text Classification in Urdu by Kifayat Ullah, Muhammad Aslam, Muhammad Usman Ghani Khan, Faten S. Alamri, Amjad Rehman Khan

“…Hate speech and other forms of hostile communication on social media have several implications such as; fostering violence, promoting social divide, and negative psychological effects. Since such toxic language is becoming more and more common, it is imperative to have a proper way of identifying it, especially in low resource language like Urdu. …”
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Sub-ppb H₂S Sensing with Screen-Printed Porous ZnO/SnO₂ Nanocomposite by Mehdi Akbari-Saatlu, Masoumeh Heidari, Claes Mattsson, Renyun Zhang, Göran Thungström

“…Hydrogen sulfide (H₂S) is a highly toxic and corrosive gas commonly found in industrial emissions and natural gas processing, posing serious risks to human health and environmental safety even at low concentrations. …”
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Inhibitory Effect of PRMT5/MTA Inhibitor on MTAP‐Deficient Glioma May Be Influenced by Surrounding Normal Cells by Yunjie Wang, Xiaohui Sun, Runchen Ma, Xiaofan Zhang, Shengmin Ji, Zhaofeng Liu, Gangqiang Yang, Hongbo Wang, Peng Zhang, Jianzhao Zhang, Jingwei Tian

“…In vitro and in vivo experiments have demonstrated that MRTX1719, a small molecule that selectively binds PRMT5/MTA complex, significantly inhibits the proliferation of MTAP‐deficient tumors and has a weak toxic effect on normal cells. However, it has been reported that MTAP‐deleted tumors did not significantly accumulate MTA in vivo due to metabolism of MTA by MTAP‐expressing stroma, which might lead to a diminished anti‐cancer effect of MRTX1719. …”
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NMR metabolic profiling of the liver following administrationof alcohol andthemushroom Ganoderma lucidum in rats by M. S. Krestina, O. B. Shevelev, I. V. Koptyug, L. A. Gerlinskaya, S. E. Peltek, A. E. Akulov

“…We have evaluated the efficiency of a metabonomic approach to metabolic phenotyping and detection of early metabolic changes under a toxic influence. For this purpose, a metabolic profiling of rat liver was performed with 1H NMR spectroscopy. …”
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Preventive treatment with guarana powder (Paullinia cupana) mitigates acute paracetamol-induced hepatotoxicity by modulating oxidative stress by Clécia Dias Teixeira, Priscila Oliveira Barbosa, Wanderson Geraldo Lima, Gustavo Silveira Breguez, Miliane Martins de Andrade Fagundes, Daniela Caldeira Costa, Cintia Lopes de Brito Magalhães, Joana Ferreira Amaral, Melina Oliveira de Souza

“…This study assessed the preventive effects of guarana powder on redox status in a rat model of acute hepatotoxicity induced by a toxic dose of paracetamol. Male Wistar rats were divided into four groups: control (C), guarana (G), paracetamol (P), and guarana + paracetamol (GP). …”
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Immune Thrombocytopenia in a worker exposed to toluene: a case report by Eric Slawka, Margarida Lourenço Castelló, Gabriel Machado Romão da Silva, Angelica dos Santos Vianna

“…Although several substances may cause ITP, little attention has been paid to the role of toxicants such as benzene, a well-known hematotoxic agent.Conclusion: This case highlights the role of benzene-contaminated toluene in ITP. …”
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Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids by Su-Jin Lee, Eunji Kim, Yeeun Jeong, Jae Boum Youm, Hyoung Kyu Kim, Jin Han, Elena A. Vasileva, Natalia P. Mishchenko, Sergey A. Fedoreyev, Valentin A. Stonik, Sung Joon Kim, Hyang-Ae Lee

“…EchA treatment induced no significant changes in these parameters, confirming its non-toxic electrophysiological profile. Cellular viability and lactate dehydrogenase (LDH) assays revealed no cytotoxic effects of EchA across tested concentrations. …”
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Associations of prenatal urinary melamine, melamine analogues, and aromatic amines with gestational duration and fetal growth in the ECHO Cohort by Giehae Choi, Xiaoshuang Xun, Deborah H. Bennett, John D. Meeker, Rachel Morello-Frosch, Sheela Sathyanarayana, Susan L Schantz, Leonardo Trasande, Deborah Watkins, Edo D. Pellizzari, Wenlong Li, Kurunthachalam Kannan, Tracey J. Woodruff, Jessie P. Buckley

“…While these chemicals have identified toxicities, little is known about their influences on fetal development. …”
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Ibuprofen-Induced Multiple Fixed Drug Eruption Confirmed by Re-Challenge: A Case Report and Literature Review by Yoshihito Mima, Masako Yamamoto, Hiyo Obikane, Yuta Norimatsu, Ken Iozumi

“…However, in multiple FDE, CD8-positive T cell activity may outweigh that of regulatory T cells, causing uncontrolled inflammation and leading to the spread of poorly-demarcated lesions that can progress to severe drug reactions such as Stevens–Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). We reviewed 13 cases of ibuprofen-induced multiple FDE. …”
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Validation of devices for characterization of hybrid 3D printed embroidery TENG for energy harvesting by HASAN TAHIR, Benny Malengier, Carla Hertleer, Lieva Van Langenhove

“…These threads have non-toxic, non-skin irritation properties, which makes them suitable for smart wearable energy harvesting applications. …”
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Enhanced biocidal efficacy of alcohol based disinfectants with salt additives by Euna Oh, Hyerin Shin, Sumin Han, Soo Jee Do, Younseo Shin, Ji Hee Pi, Youngjin Kim, Dae-Hong Ko, Kyu Hyoung Lee, Hyo-Jick Choi

“…This method, which employs mild salt instead of toxic materials, offers a simpler, more cost-effective, and safer alternative to conventional alcohol-based disinfectants. …”
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Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review by Hongcai Li, Jingjing Liang, Mengzhen Han, Zhenpeng Gao

“…Single drug therapy may have toxic side effects and disrupt gut microbiota balance. …”
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Addressing challenges in vector control: a review of current strategies and the imperative for novel tools in India’s combat against vector-borne diseases by Kuldeep Singh, Amit Sharma, Manju Rahi, Sanjeev Kumar Gupta, Gaurav Kumar, Rajendra Baharia, Sam Joy

“…The promising new vector control tools are insecticide-treated nets with synergist and/or pyrrole chlorfenapyr, alternatives/additions to synthetic pyrethroids like neonicotinoids, clothianidin for indoor residual spray, newer formulations such as Bacillus sphaericus for use in larvicides, attractive toxic sugar baits, especially to curtail outdoor transmission, endectocides like ivermectin for use in animals/humans, insecticidal paints, spatial repellents, insecticide-treated wearables and others. …”
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An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors by Russell J. Schilder, Drew Rasco, Manish R. Sharma

“…Three dose-limiting toxicities, all grade 3 nausea, were reported (n = 1, 500 mg; n = 2, 700 mg). …”
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Total flavonoids isolated from Eucommia ulmoides can alleviate bone loss and regulate intestinal microbiota in ovariectomized rats by Baocang Yin, Baocang Yin, Mingzhen Yang, Mingzhen Yang, Bowen Wang, Bowen Wang, Yun Zhang, Yun Zhang, Ningli Li, Ningli Li, Qin Li, Yingying Li, Cory J. Xian, Tiejun Li, Tiejun Li, Yuankun Zhai, Yuankun Zhai

“…High-throughput sequencing indicated that TFEL may regulate the composition of intestinal flora and intestinal microecology.ConclusionTFEL can prevent osteoporosis in OVX rats and has no toxic side effects. Meanwhile, TFEL can increase the diversity and improve the composition of intestinal flora in OVX rats.…”
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Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance by Tianming Qiu, Yu Zhi, Jingyuan Zhang, Ningning Wang, Xiaofeng Yao, Guang Yang, Liping Jiang, Li Lv, Xiance Sun

“…This discovery could provide novel insights into therapeutic strategies for T2D provoked by environmental toxicants.…”
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