Dynamics of REL, RELA and IRF1 transcription factor expression in U937 macrophages after dioxin exposure by E. V. Kashina, D. Y. Oshchepkov, E. V. Antontseva, M. Y. Shamanina, D. P. Furman, V. A. Mordvinov

“…The aryl hydrocarbon receptor (AhR), a ligand- activated transcription factor, participates in a wide range of critical cellular events in response to endogenous signals or xenobiotic chemicals. 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) is one of the AhR ligands with a very high binding affinity for the AhR. TCDD is the most toxic among the dioxin xenobiotics and induces a broad spectrum of biological responses, including immunotoxicity and cancer. …”
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Recovery of gold from refractory ore employing pressure oxidation by Flávio de Almeida Lemos, Marisa Nascimento, Gaspar Rodrigues Moreira Júnior, Vanessa Resende de Andrade, Paul Cezanne Pinto, Afonso José Guedes Salles

“…However, it has a high energy cost and environmental issues due to the release of toxic gases containing arsenic. In the treatment of refractory gold ores containing arsenic, pressure oxidation (POX) represents an attractive approach for arsenic immobilization, since the conditions are suitable for both sulfide oxidation and the formation of stable arsenates. …”
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Molecular identification and phylogenetic relationship of Bangladeshi pufferfish based on mitochondrial COI and 16S rRNA genes by Md Sagir Ahmed, Nafisa Islam, Durjoy Raha Antu, Mysha Mahjabin, Sujan Kumar Datta, Osamu Arakawa

“…Pufferfish poisoning sporadically occurs due to the consumption of toxic pufferfish throughout the country. Identification of pufferfish is challenging and/or misleading, based on only morphometric characteristics. …”
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A qualitative exploration of the enablers of and barriers to conformance with antibiotic withdrawal periods on smallholding, peri-urban pig farms in Kiambu County, Kenya. by Claire Scott, Nicholas Bor, Kristen K Reyher, Alex J Tasker, Henry Buller, Irene Bueno, Lian F Thomas

“…Non-conformance with antibiotic withdrawal period guidelines represents a food safety concern, with potential for antibiotic toxicities and allergic reactions as well as selecting for antibiotic resistance. …”
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A parallel bioreactor strategy to rapidly determine growth-coupling relationships for bioproduction: a mevalonate case study by Alec Banner, Joseph Webb, Nigel Scrutton

“…However, this process also led to the formation of the toxic byproduct acetate, which can slow growth and cause problems during downstream processing. …”
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Synthesis, in vitro safety and antioxidant activity of new pyrrole hydrazones by Tzankova Diana, Vladimirova Stanislava, Aluani Denitsa, Yordanov Yordan, Peikova Lily, Georgieva Maya

“…The initial in vitro safety screening for cytotoxicity (on HepG2 cells) and hemocompatibility (hemolysis assay) showed good safety of the new compounds, where ethyl 5-(4-bromophenyl)-1-(1-(2-(4-hydroxy-3-methoxybenzylidene)-hydrazineyl)-1-oxo-3-phenylpropan-2-yl)-2-methyl-1H-pyr-role-3-carboxylate (4d) and ethyl 5-(4-bromophenyl)-1-(1-(2-(2-hydroxybenzylidene)hydrazineyl)-1-oxo-3-phenylpropan--2-yl)-2-methyl-1H-pyrrole-3-carboxylate (4a) were the least toxic. The antioxidant activity in terms of radical scavenging activity (DPPH test) and reducing ability (ABTS) was also evaluated. …”
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Histopathological and Biochemical Assessment of Neuroprotective Effects of Sodium Valproate and Lutein on the Pilocarpine Albino Rat Model of Epilepsy by Aziza Rashed Al-Rafiah, Khlood Mohammed Mehdar

“…Sodium valproate (SVP) is a commonly used antiepileptic drug (AED); however, it has toxic effects. Lutein (L), a carotenoid, has potent antioxidant and anti-inflammatory properties. …”
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Characteristics and Clinical Course of Patients with Acute Myocardial Infarction and ST-segment Elevation with and without Interatrial Block by Francisco de Jesús Valladares Carvajal, Verónica Mercedes Carretero Acosta, Raimundo Carmona Puerta, Aymara Marcia Hernández Cardoso, Ernesto Julio Bernal Valladares

“…Demographic variables were analyzed: age, sex, skin color and between clinics: toxic habits; (smoker, ex-smoker); medical history (myocardial infarction, angina, peripheral arterial disease, arterial hypertension, type 2 diabetes mellitus, chronic kidney disease; infarct location (anterior, inferior, left bundle branch block); complications: heart failure, atrial fibrillation, ventricular tachycardia/ventricular fibrillation, atrioventricular conduction disorders, mechanical complication, post infarction angina, arterial embolism) and discharge status (alive or deceased). …”
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Analysis of Benzene-Induced Effects on Rhodococcus sp. 33 Reveals that Constitutive Processes Play a Major Role in Conferring Tolerance by Tony Gutiérrez, Robert Learmonth, Iain Couperwhite

“…Most studies investigating mechanisms that confer microorganisms with tolerance to solvents have often focused on adaptive responses following exposure, while less attention has been given to inherent, or constitutive, processes that prevail at the onset of exposure to a toxic solvent. In this study, we investigated several properties of the highly solvent-tolerant bacterium Rhodococcus sp. 33 that confer it with a tolerance to high concentrations of benzene. …”
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Synthesis of ZrO2:Dy3+ Nanoparticles: Photoluminescent, Photocatalytic, and Electrochemical Sensor Studies by K. Gurushantha, K. S. Anantharaju, Nagaraju Kottam, K. Keshavamurthy, C. R. Ravikumar, B. S. Surendra, A. Murugan, H. C. Ananda Murthy

“…The electrochemical sensor studies on ZrO2:Dy3+ NPs exhibited potentiality towards sensing of highly toxic metals like mercury and lead.…”
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Melanin production and laccase mediated oxidative stress alleviation during fungal-fungal interaction among basidiomycete fungi by Samim Dullah, Dibya Jyoti Hazarika, Gunajit Goswami, Tanushree Borgohain, Alokesh Ghosh, Madhumita Barooah, Ashok Bhattacharyya, Robin Chandra Boro

“…Moreover, the fungal–fungal interaction also led to increase in the production of laccase, a group of multicopper oxidases involved in detoxification of toxic compounds. Further, increased activity of superoxide dismutase, an enzyme that catalyzes the dismutation of the superoxide anion to hydrogen peroxide was also recorded during fungal–fungal interaction. …”
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The different response of PM2.5 stimulated nasal epithelial spheroids in control, asthma and COPD groups by Paulina Misiukiewicz-Stępień, Elwira Zajusz-Zubek, Katarzyna Górska, Rafał Krenke, Magdalena Paplińska-Goryca

“…The impairment of airway epithelium in asthma and COPD changes their response to toxic environmental stimuli. This physiological dysfunction might be associated with diseases exacerbation of obstructive lung diseases.…”
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Elritercept, a modified activin receptor IIA ligand trap, increased erythropoiesis and thrombopoiesis in a phase 1 trial by Jennifer Lachey, Christopher Rovaldi, Suresh Bobba, Jared Tur, Harveen Natarajan, Ben Snyder, Jasbir Seehra

“…Elritercept was generally well tolerated at all dose levels, with no dose-limiting toxicities observed. There were no severe or serious adverse events or clinically significant changes in safety laboratory measures. …”
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Characterization of some selected macroalgae extracts and assessment of their insecticidal and genotoxicity in Culex pipiens L. mosquito larvae by Dina A. Refaay, Mostafa M. El-Sheekh, Yasmin M. Heikal, Ahmed A. Rashed

“…The larvicidal activity results revealed that J. rubens methylene chloride extract was the most toxic for C. pipiens larvae with LC50 = 9.30 ppm followed by C. sinuosa acetone extract with LC50 = 82.58 ppm after 72 h of exposure. …”
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Effect of Phosphogypsum Amendment on Chemical Properties of Sodic Soils at Different Incubation Periods by Haile Hasana, Sheleme Beyene, Alemayehu Kifilu, Selamyihun Kidanu

“…The application of phosphogypsum (PG) on sodic soils provides nutrients to the soil, reduces the toxic effect of Na+, and improves soil properties. …”
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Biosorption of hexavalent chromium in a tannery industry wastewater using fungi species by D. Sivakumar

“…This study suggested that one could select the type of fungi species, ion concentration level, selection of treatment period, quantity of biomass to be used, and pH level of the medium, to achieve the highest reduction of any toxic metals from any contaminated water, wastewater and soil environment.…”
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How do lifestyle and environmental factors influence the sperm epigenome? Effects on sperm fertilising ability, embryo development, and offspring health by Ayazhan Akhatova, Celine Jones, Kevin Coward, Marc Yeste

“…DNA methylation is correlated with alterations in sperm quality and the ability to fertilise oocytes, possibly via a differentially regulated MAKP81IP3 signalling pathway. Paternal exposure to toxic endocrine-disrupting chemicals (EDCs) is also linked to the transgenerational transmission of increased predisposition to disease, infertility, testicular disorders, obesity, and polycystic ovarian syndrome (PCOS) in females through epigenetic changes during gametogenesis. …”
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A wireless sensor network for coal mine safety powered by modified localization algorithm by Hafiz Zameer ul Hassan, Anyi Wang, Ghulam Mohi-ud-din

“…In coal mines, gas leaks pose a serious safety risk, often leading to explosions or toxic exposure. Temperature control is difficult due to fluctuating underground conditions, potentially causing heat stress or equipment malfunction. …”
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Simultaneous Quantification of Dexpanthenol and Resorcinol from Hair Care Formulation Using Liquid Chromatography: Method Development and Validation by Amit Kumar De, Partha Pratim Chowdhury, Shyamaprasad Chattapadhyay

“…On the other hand resorcinol is mainly prescribed for the treatment of seborrheic dermatitis of scalp. The toxic side effects of resorcinol limit its use in dermatological preparations. …”
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Single-center experience of venetoclax combined with azacitidine in young patients with newly diagnosed acute myeloid leukemia by Xuezhu Xu, Rui Liu, Hongli Chen, Ruoyu Yang, Gongzhizi Gao, Aili He, Fangxia Wang

“…Conclusion: In conclusion, our study indicated that VEN + AZA with a higher MRD-negative remission rate and less toxic appeared to be a therapy option for young patients with ND AML. …”
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