A phase I study of the CDK4/6 inhibitor ribociclib combined with gemcitabine in patients with advanced solid tumors by Aurora Norman, Mahesh Seetharam, Jacob Allred, Jianping Kong, Mateusz Opyrchal, Wen Wee Ma, Yanyan Lou, Grace K. Dy, Amit Mahipal, S. John Weroha, Andrea E. Wahner Hendrickson, Joel M. Reid, Alex A. Adjei

“…Abstract Background Based on preclinical data showing addition of CDK4/6 inhibitors to gemcitabine was synergistic, ribociclib was evaluated in combination with gemcitabine to determine the maximum tolerated dose (MTD) and dose limiting toxicities (DLT). Methods In this single arm multicohort phase I trial, we evaluated the safety and efficacy of ribociclib plus gemcitabine in patients with advanced solid tumors. …”
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Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade by Chun-Bing Chen, Shuen-Iu Hung, John Wen-Cheng Chang, Chan-Keng Yang, David Hui-Kang Ma, Yu-Chuan Teng, Chun-Wei Lu, Wei-Ti Chen, Hsiao-Yin Yang, Cheng-Chang Tsai, Chih Liang Wang, Pin-Hsuan Chiang, Jennifer Wu, Ya-Wen Tsai, Lai-Ying Lu, Yang Yu-Wei Lin, Rosaline Chung-Yee Hui, Fu-Mei Hsieh, Chao-Kai Hsu, Chaw-Ning Lee, Yi-Ju Chen, Chih-Chiang Chen, Yilei Cui, Hung-Chih Hsu, Ya-Ching Chang, Chih-Jung Chang, Ho-Chen Lin, Chee Jen Chang, Yu-Jr Lin, Cheng-Lung Ku, Chuang-Wei Wang, Wen-Hung Chung

“…However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), hindering continuous ICI therapy. …”
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Nematicidal potential of Microbacterium maritypicum Sneb159 against Heterodera glycines and the complete genome sequence analysis by Jing Zhao, Jing Zhao, Jing Zhao, Zhifu Xing, Aatika Sikandar, Yuxi Duan

“…The volatiles produced by M. maritypicum Sneb159 are toxic to H. glycines for both juveniles and eggs. …”
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Microplastics in water, sediment and salts from traditional salt producing ponds by A. Tahir, P. Taba, M.F. Samawi, S. Werorilangi

“…With microplastics abundance reached over 53 microplastics items/kg salt, it is believed that continuous consumption by people will end up with possible accumulation of potentially absorbed of various toxic chemical pollutants which present in sea water as salt raw materials. …”
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Column Study for Adsorption of Copper and Cadmium Using Activated Carbon Derived from Sewage Sludge by Najib Al-mahbashi, S.R.M Kutty, A.H. Jagaba, Ahmed Al-Nini, Mujahid Ali, A.A.H. Saeed, A.A.S Ghaleb, Upaka Rathnayake

“…Among the water-polluting substances, heavy metals stand out due to their carcinogenic and toxic effects on the creatures and environment. This study aimed to scrutinize the effectiveness of sewage sludge-based activated carbon in the removal of copper and cadmium from aqueous solutions in column study. …”
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The Effect of the Increasing Doses of Vermicompost Applications to Soil on Some Nutrient Concentrations in Olive (Olea europaea L.) Leaves by Ayşe Nur Coşkun, Ali Sümer

“…Micro nutrient elements remained under the limit of toxic effect upon all the applications. The dose 2 kg tree-1 was determined to be the most suitable one in terms of both macro and micro element concentrations under such trial circumstances.…”
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Severe Cutaneous Adverse Drug Reactions at a Tertiary Care Center in Saudi Arabia by Mohammed I. AlJasser

“…SCARs include drug reaction with eosinophilia and systemic symptoms (DRESS), Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), and acute generalized exanthematous pustulosis (AGEP). …”
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How to get over with medication errors underestimation? Improving indices of medication errors with focus on intravenous medications in hematopoietic stem cell transplantation sett... by Ava Mansouri, Kiana Moazzeni, Maryam Valeh, Kazem Heidari, Molouk Hadjibabaie

“…Especially, in the hematopoietic stem cell transplantation (HSCT) setting where toxic drugs are frequently used and patients are in critical immunocompromised conditions, medication errors (ME) can have catastrophic reactions and devastating outcomes such as death. …”
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Human Islet Amyloid Polypeptide Fibril Binding to Catalase: A Transmission Electron Microscopy and Microplate Study by Nathaniel G. N. Milton, J. Robin Harris

“…Human IAPP fibrils are toxic in a similar manner to Alzheimer's amyloid-β (Aβ) and prion protein (PrP) fibrils. …”
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Application of central composite design to optimization of Yellow Tartarazine and Methylene Blue environmentally clean adsorption by untreated walnut shells by Mahmoud Trachi, Moussa Abbas, Mohamed Trari

“…Climate change poses a real threat to the water security by altering the precipitation patterns and other weather variables, desirability function (df) was used to determine the interactive effects and optimize with the Central Composite Design (CCD) of important variables such as initial dyes concentration (C o : 20–100 mg L –1 ), solution pH (1.5–11), temperature (20–60 °C) and adsorbent dosage (0.1–1.3 g L –1 ) for the removal of toxic Yellow Tartarazine (YT) and Methylene Blue (MB) onto Untreated Walnut Shells (UWS). …”
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Experience in the management of patients with HTLV-1 positive adult T-cell leukemia/lymphoma in a Latin American center by Danielle Floyd-Aristizábal, Cristian Alonso Barreiro García, Oriana Arias-Valderrama, Catalina Proaño Millán, Nhora María Silva Perez, Joaquín Donaldo Rosales Martinez, Elizabeth Arrieta López

“…However, the overall response rate to chemotherapy was low, and most patients experienced complications and toxicities associated with treatment. Conclusion: This study provides insights into the clinical course and management of ATL in a Colombian population. …”
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Delayed Acetaminophen Absorption Resulting in Acute Liver Failure by Huiling Tan, Paul Stathakis, Benoj Varghese, Nicholas A. Buckley, Angela L. Chiew

“…Acetaminophen metabolites were measured, including nontoxic glucuronide and sulfate conjugates and toxic cytochrome P450 (CYP) metabolites. The metabolite data demonstrated increasing CYP metabolites in occurrence with the delayed acetaminophen peak concentration. …”
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Release of apoptosis inhibitor of macrophage (AIM) from pentameric IgM in serum predicts prognosis after hemodialysis initiation by Keisuke Yasuda, Akemi Nishijima, Tomoko Inoue, Toshio Takagi, Kazunari Tanabe, Jun Minakuchi, Satoko Arai, Toru Miyazaki

“…Patients at dialysis initiation with high proportion of serum IgM-free AIM (fAIM%) show elevated uremic toxins and other toxic metabolites, higher mortality, and increased cardiovascular risk compared to those with low fAIM%. …”
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RELATIONSHIP BETWEEN ADSORPTION-RHEOLOGICAL PROPERTIES OF SERUM IN HEMORRHAGIC VASCULITIS AND ECOLOGY IN REGIONS OF PATIENTS’ RESIDENCE by T.B. Bevzenko, I.Yu. Golovach, M. V. Yermolaieva, V.Ya. Mikuksts, O.V. Syniachenko

“…Adsorption-rheological properties of serum of patients with HV depend on the integrated degree of pollution by xenobiotics of air and drinking water (but not of soil by chemical elements), the degree of emissions and accumulation of industrial waste in it, the nature of the impact of modernization of agriculture, metallurgical, chemical and engineering industries in the regions, levels of 3,4-benzpyrene (ST2, PA), phenol (BV, PA), ammonia (SCIA), nitrogen dioxide (ST1, ST2, ST3), carbon dioxide (SE, RT, ST1, ST2, ST4) in the breathing air, the degree of mineralization and hardness of drinking water (MV), the parameters of toxic microelements and essential zinc (ST3) in the soil. …”
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The use of Kutikulin for treatment and prevention of gastrointestinal diseases in calves and piglets by M. V. Koryukina, V. N. Makarova, O. B. Badeeva, I. N. Simanova

“…The paper presents  the results of tests of Kutikulin, a product made at the Vologda Branch of the FSC VIEV, which consists of chicken gizzard cuticle containing a keratoid secretion and a number of biologically active enzymes. It is a non-toxic, water-insoluble, odourless yellow-green powder with a bitterish taste. …”
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Fabrication of composite ceramic polymeric membranes for agricultural wastewater treatment by Neamatalla M. Azzam, Sahar S. Ali, Gehad G. Mohamed, Mohamed M. Omar, Shereen K. Amin

“…The study examined how effectively the membranes removed toxic substances from wastewater. The findings exhibited an excellent removal of > 80% and up to 97.02%, > 80% and up to 99.97% of the heavy metals, and optimum fluxes of 341.07 and 276.35 L h−1 m−2 were achieved in the cases of M2 and M4, respectively. …”
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Surface hardening of MIM porous metals by ultrasonic vibration assisted pressing by Shimaoka Ryo, Yin Zidong, Tanaka Shigeo, Yang Ming

“…This surface strengthening method uses an ultrasonically vibrating punch to work-harden the surface, enabling localised hardening in a short time without using highly toxic chemicals or large-scale equipment. In addition, porous metals have the properties of absorbing sound and shock, which allows them to efficiently absorb the energy of ultrasonic vibrations and effectively harden the surface. …”
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Cyanin Chloride Inhibits Hyperbaric Pressure-Induced Decrease of Intracellular Glutamate-Aspartate Transporter in Rat Retinal Müller Cells by Xiaomin Chen, Yue Wang, Fangfang Han, Min Ke

“…High concentrations of extracellular glutamate are toxic to the optic nerve. The glutamate-aspartate transporter (GLAST) in retinal Müller cells is involved in the development of glaucoma. …”
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New genetic tools for plant defense against parasitic nematodes by A. V. Kochetov, T. A. Gavrilenko, O. S. Afanasenko

“…The biological characteristics of sedentary nematodes makes their agrotechnical control problematic, i.e. the GPCN cysts remain dormant in soil for many years until a susceptible host appears, whereas nematicides are either toxic or inefficient. Introgression of resistance genes (R-genes) from related cultivated or wild species is likely to be the most appropriate way for their biocontrol. …”
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Pollution Characteristics of Sb, As, Hg, Pb, Cd, and Zn in Soils from Different Zones of Xikuangshan Antimony Mine by Saijun Zhou, Andrew Hursthouse, Tengshu Chen

“…Sixty soil samples from the four zones were taken for experimental work, and the contents and morphological characteristics of the six potentially toxic elements (PTEs) such as Sb, As, Hg, Pb, Cd, and Zn in the soil samples were measured by using a hydride generation atomic fluorescence spectrometer (AFS-9700). …”
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