Organ-specific immune-related adverse events and prognosis in cancer patients receiving immune checkpoint inhibitors by Xinyue Han, Yingcui Chen, Hong Xie, Yuekai Zhang, Yu Cui, Yaping Guan, Weiwei Nie, Qi Xie, Jisheng Li, Baocheng Wang, Bicheng Zhang, Jun Wang

“…Furthermore, only skin or endocrine toxicities were associated with improved OS and PFS. …”
Get full text

Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…Novel engineered IL-2 agonists strive to increase the therapeutic window of aldesleukin (human IL-2) by increasing selectivity toward effector over regulatory T cells and reducing dose-limiting toxicities. Here we describe ANV419, an IL-2/anti-IL2 antibody fusion protein designed for selective IL-2 receptor βγ (IL-2 Rβγ) activation by sterically hindering IL-2 from binding to IL-2 Rα. …”
Get full text

Chemical Composition, Source Appointment and Health Risk of PM2.5 and PM2.5-10 during Forest and Peatland Fires in Riau, Indonesia by Sepridawati Siregar, Nora Idiawati, Puji Lestari, Abiyu Kerebo Berekute, Wen-Chi Pan, Kuo-Pin Yu

“…Clearly, more attention should be devoted to reducing the noncarcinogenic and carcinogenic health risks caused by particulate-bound toxic elements through inhalation exposure.…”
Get full text

Harmful Effects of Nanoparticles on Animals by Jean-Marie Exbrayat, Elara N. Moudilou, Emmanuel Lapied

“…It has been already shown that NPs could be toxic to bacteria, algae, invertebrates, and vertebrates. …”
Get full text

Effect of storage time on histamine content in fish by O. Cenap Tekinşen, Suzan Yalçın, Mustafa Nizamlıoğlu

“…<p> Based on this study, it is concluded that the histamine levels in mackerel, bonito and anchovy fish during sforage at 4°C even after 3 days were below toxic leve!.…”
Get full text

Contaminants in the Urban Environment: Microplastics by Maia McGuire, Yun-Ya Yang, Ignacio A. Rodriguez-Jorquera, Gurpal S. Toor, Alexander J. Reisinger

“…This series is intended to give state and local government officials, soil and water scientists, consulting engineers, Extension agents, and citizens (1) a basic understanding of the occurrence, toxic effects and source of various contaminants in the environment and (2) provide guidance on ways to protect human and environmental health. …”
Get full text

The Role of Eosinophils in Liver DiseaseSummary by Linxi Xie, Hejiao Zhang, Long Xu

“…Previously, eosinophils were primarily regarded as effector toxic cells involved in allergic diseases and parasitic infections. …”
Get full text

Preparation and Characterization of Reduced Graphene Oxide Sheets via Water-Based Exfoliation and Reduction Methods by Vorrada Loryuenyong, Krit Totepvimarn, Passakorn Eimburanapravat, Wanchai Boonchompoo, Achanai Buasri

“…Finally, the oxygen functional groups on exfoliated graphite oxide or graphene oxide were eliminated by stirring in hot distilled water at 95°C, as a replacement for highly toxic and dangerously unstable hydrazine. The results assured that stirring in hot distilled water could give the product of graphene or reduced graphene oxide. …”
Get full text

Clinical Outcome of a Novel Anti-CD6 Biologic Itolizumab in Patients of Psoriasis with Comorbid Conditions by Vinay Singh

“…However, long term uses of these agents are associated with unwanted effects and toxicities. Recently, Itolizumab has been developed as world’s first anti-CD6 humanized monoclonal IgG1 antibody for the management of moderate-to-severe chronic plaque psoriasis in India. …”
Get full text

Emerging targeted therapies in oral oncology: Focus on EGFR inhibition by Vishnu Priya Veeraraghavan, Shikhar Daniel, Arun Kumar Dasari, Kaladhar Reddy Aileni, Chaitra patil, Santosh R. Patil

“…However, challenges, such as the development of resistance mechanisms and treatment-related toxicities, pose obstacles to their clinical utility. …”
Get full text

Contaminants in the Urban Environment: Microplastics by Maia McGuire, Yun-Ya Yang, Ignacio A. Rodriguez-Jorquera, Gurpal S. Toor, Alexander J. Reisinger

“…This series is intended to give state and local government officials, soil and water scientists, consulting engineers, Extension agents, and citizens (1) a basic understanding of the occurrence, toxic effects and source of various contaminants in the environment and (2) provide guidance on ways to protect human and environmental health. …”
Get full text

Photocatalytic Degradation of Thiram (Fungicides) under Visible Light Irradiation by Sanjay R. Thakare, N. S. Bhave

“…Pesticides in the different form are toxic to the environment and removal of its form the various sources is a difficult task. …”
Get full text

Effect of Oxygen and Redox Potential on Glucose Fermentation in Thermotoga maritima under Controlled Physicochemical Conditions by Raja Lakhal, Richard Auria, Sylvain Davidson, Bernard Ollivier, Alain Dolla, Moktar Hamdi, Yannick Combet-Blanc

“…However, although oxygen was toxic, our experiment unambiguously proved that T. maritima was able to consume it during a 12-hour exposure period. …”
Get full text

Catalytic Activity of Porous Phosphate Heterostructures-Fe towards Reactive Black 5 Degradation by Marco S. Lucas, Manuel Algarra, José Jiménez-Jiménez, Enrique Rodríguez-Castellón, José A. Peres

“…This study can provide a simple, effective, and economic system ideal for the treatment of toxic and nonbiodegradable azo dyes.…”
Get full text

Food Processing and Maillard Reaction Products: Effect on Human Health and Nutrition by Nahid Tamanna, Niaz Mahmood

“…Depending on the way the food is being processed, both beneficial and toxic MRPs can be produced. Therefore, there is a need to understand the different types of MRPs and their positive or negative health effects. …”
Get full text

Pollution, colonialité et droit international de l'environnement : Une étude de la situation palestinienne by Joni Aasi

“…In this colonization, natural resources are exploited, and Palestinian lands are transformed into a tame for toxic and dangerous wastes. It seems that international environmental law provides some means of struggle for Palestinians, but it is still limited when it comes to non-state and non-dominant group rights. …”
Get full text

Design of a Banana Fiber-Extracting Machine. by Lejoruku, David Desire

“…Banana fiber offers a superior alternative to synthetic and natural fibers, boasting eco-friendliness, chemical-free, non-toxic, and odorless properties. However, traditional extraction methods can be labor-intensive and yield variable results. …”
Get full text

Management of Spittlebugs in Limpograss Pasture by Martin B. Adjei, Richard Sprenkel, Jim Selph

“…The adults also inject toxic saliva into leaf tissue while feeding, which causes streaking on the leaves. …”
Get full text

Climate Change and the Occurrence of Harmful Microorganisms in Florida’s Ocean and Coastal Waters by Karl Havens

“…These include algae that form noxious or toxic blooms, including red tides, and bacteria and other pathogens. …”
Get full text

Management of Spittlebugs in Limpograss Pasture by Martin B. Adjei, Richard Sprenkel, Jim Selph

“…The adults also inject toxic saliva into leaf tissue while feeding, which causes streaking on the leaves. …”
Get full text