TClC effectively suppresses the growth and metastasis of NSCLC via polypharmacology by Jing Lu, Ying Zhang, Chunyan Yan, Jingwen Liu, Dan Qi, Yue Zhou, Qinwen Wang, Juechen Yang, Jing Jiang, Benhao Wu, Meiling Yang, Weiwei Zhang, Xin Zhang, Xiaoyu Shi, Yan Zhang, Kun Liu, Yongcai Liang, Chaoyang Wang, Hanyu Yang, Yuqing Gao, Yuping Sun, Ronghu Ke, Jason H. Huang, Min Wu, Hongbo Wang, Chunlei Li, Shuang Zhou, Bin Guo, Erxi Wu, Guoying Zhang

“…In response, we synthesized a novel bioactive compound, ethyl 6-chlorocoumarin-3-carboxylyl L-theanine (TClC), which significantly inhibited NSCLC growth, epithelial mesenchymal transition (EMT), migration, and invasion in vitro and tumor growth and metastasis in vivo without inducing toxicity. TClC disrupts autocrine loops that promote tumor progression, particularly in stem-like CD133-positive NSCLC (CD133+ LC) cells, which are pivotal in tumor metastasis. …”
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Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy by Laura Grunewald, Lena Andersch, Konstantin Helmsauer, Silke Schwiebert, Anika Klaus, Anton G. Henssen, Teresa Straka, Marco Lodrini, Sebastian G. Wicha, Steffen Fuchs, Falk Hertwig, Frank Westermann, Alice Vitali, Carlotta Caramel, Gabriele Büchel, Martin Eilers, Kathy Astrahantseff, Angelika Eggert, Uta E. Höpken, Johannes H. Schulte, Thomas Blankenstein, Kathleen Anders, Annette Künkele

“…Combining MLN8237 and L1CAM-CAR T cell treatment synergistically enhanced MYCN-overexpressing tumor cytotoxicity in vitro and in vivo concomitant with severe in vivo toxicity. We identify target antigen downregulation as source of resistance against L1CAM-CAR T cells in MYCN-driven neuroblastoma cells. …”
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Nebulized aminoglycosides for ventilator-associated pneumonia: Methodological considerations and lessons from experimental studies by Jean-Jacques Rouby, Jing Xia, Jayesh Dhanani, Gianluigi Li Bassi, Antoine Monsel, Antoni Torres, Kostoula Arvaniti, Mona Assefi, Matteo Bassetti, Stijn Blot, Matthieu Boisson, Adrien Bouglé, Jean-Michel Constantin, Jayesh Dhanani, George Dimopoulos, Jonathan Dugernier, Pauline Dureau, Stephan Ehrmann, Timothy Felton, Marin Kollef, Antonia Koutsoukou, Anna Kyriakoudi, Pierre-François Laterre, Marc Leone, Victoria Lepère, Gianluigi Li Bassi, Xuelian Liao, Shakti Bedanta Mishra, Olivier Mimoz, Antoine Monsel, Girish B Nair, Michael Niederman, Lucy B Palmer, Jose Manuel Pereira, Konstantinos Pontikis, Garyphalia Poulakou, Jérôme Pugin, Chuanyun Qian, Jie-ming Qu, Jordi Rello, Jason Roberts, Jean-Jacques Rouby, Christina Routsi, Gerald C. Smaldone, Antoni Torres, Melda Türkoğlu, Tobias Welte, Michel Wolff, Xia Jing, Li Yang, Ting Yang, Ying-gang Zhu

“…Based on experimental data obtained in animals with inoculation pneumonia, it challenges the classical belief that nebulization protects against systemic toxicity. Loss of lung aeration decreases the lung penetration of nebulized aminoglycosides. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…The goals of phase I research are primarily to collect short-term safety, toxicity, dosing, and pharmacologic data, not to provide efficacious treatment.…”
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Florida Solid and Hazardous Waste Regulation Handbook: Pollution Prevention Act (PPA) by Michael T. Olexa, Aaron Leviten, Kelly Samek

“… The primary purpose of the Pollution Prevention Act is to discourage the disposal of recyclable toxic substances. Under this statute, EPA conducts a yearly audit of the major users of toxic substances and producers of toxic wastes. …”
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Florida Solid and Hazardous Waste Regulation Handbook: Pollution Prevention Act (PPA) by Michael T. Olexa, Aaron Leviten, Kelly Samek

“… The primary purpose of the Pollution Prevention Act is to discourage the disposal of recyclable toxic substances. Under this statute, EPA conducts a yearly audit of the major users of toxic substances and producers of toxic wastes. …”
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Combination of High-Dose Intravenous Immunoglobulins and Itraconozole in Treating Chronic Mycotic Demyelinating Optic Neuritis by Andrew W. Campbell, Ebere C. Anyanwu, Aristo Vojdani

“…Mycotic demyelinating optic neuritis is a neurological disorder of the visual system caused by mycotoxins released by indoor toxic molds. Although the health effect of indoor toxic mold on the population worldwide is now one of the �emerging diseases�, its involvement in chronic demyelinating optic neuritis has not been reported. …”
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NeuTox 2.0: A hybrid deep learning architecture for screening potential neurotoxicity of chemicals based on multimodal feature fusion by Xudi Pang, Xuejun He, Ying Yang, Ling Wang, Yuzhen Sun, Huiming Cao, Yong Liang

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Prediction-based prompt levothyroxine replacement to prevent a hypothyroid state after immune-related adverse events involving the thyroid gland by Ichiro Yamauchi, Takuro Hakata, Taku Sugawa, Daisuke Kosugi, Haruka Fujita, Kentaro Okamoto, Yohei Ueda, Toshihito Fujii, Daisuke Taura, Norio Harada, Nobuya Inagaki

“…The Toxic-Hypo group developed thyroid irAEs earlier than the Toxic group (26 vs. 91 days; p < 0.001), and had higher serum free T4 levels (3.210 vs. 1.880 ng/dL; p = 0.011). …”
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Methotrexate Induced Pancytopenia by Fernando Gonzalez-Ibarra, Sahar Eivaz-Mohammadi, Shiri Surapaneni, Hazem Alsaadi, Amer K. Syed, Simon Badin, Valentin Marian, Mazhar Elamir

“…The well-reported methotrexate (MTX) toxicities are based on the duration and cumulative dosing of drug. …”
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Recovery of the Dye Intermediate DNDS from Aqueous Solution by Adsorption onto Resins by Wei-Ben Yang, Jun Fan, Aimin Li, Quanxing Zhang

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An Initial Evaluation on the Adsorption of SO2 and NO2 over Porous Fe3O4 Nanoparticles Synthesized by Facile Scalable Method by Xuan-Manh Pham, Duy Linh Pham, Nguyen Thi Hanh, Tuyet Anh Dang Thi, Le Nhat Thuy Giang, Hoang Thi Phuong, Nguyen Tuan Anh, Hac Thi Nhung, Giang Truong Le, Mai Ha Hoang, Tuyen Van Nguyen

“…In this study, Fe3O4 nanoparticles used as an adsorbent for the removal of toxic gases were successfully synthesized via the facile coprecipitation method. …”
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Clinical Practice Guidelines for Exogenous Poisoning. by Alexis Díaz Mesa, Eddy Pereira Valdés, Alba Enseñat Álvarez, Carlos Alberto Rodríguez Armada

“…It includes the classification of toxic substances, clinical diagnosis (main syndromes), and description of therapeutic variations (vital support, antidotes, absorption measurements and increase of elimination and depuration of the toxic substance). …”
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Dynamics of two phytoplankton populations under predation by Jean-Jacques Kengwoung-Keumo

“…The aim of this paper is to investigate the manner in which predation and single-nutrient competition affect the dynamics of a non-toxic and a toxic phytoplankton species in a homogeneous environment (such as a chemostat). …”
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The mechanisms of fiber flax adaptation to high soil acidity (a review) by N. V. Kishlyan, N. V. Melnikova, T. A. Rozhmina

“…On strongly acid soils (pHKCl less than 4.5) with threshold values of the toxic aluminum (Al3+) content, 10–11 mg/100 g, a decrease in the flax yield is over 50%. …”
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Effect of Mercury on Seed Germination and Seedling Growth of Mungbean (<i>Vigna radiata</i> (L.) Wilczek) by ZI Muhammad, KS Maria, A Mohammad, S Muhammad, F Zia-ur-Rehman, K Muhammad

“…Among the toxic elements release in the environment, mercury is considered highly toxic to the growth of plants. …”
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Effect of Mercury on Seed Germination and Seedling Growth of Mungbean (<i>Vigna radiata</i> (L.) Wilczek) by ZI Muhammad, KS Maria, A Mohammad, S Muhammad, F Zia-ur-Rehman, K Muhammad

“…Among the toxic elements release in the environment, mercury is considered highly toxic to the growth of plants. …”
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What Do We Know of Childhood Exposures to Metals (Arsenic, Cadmium, Lead, and Mercury) in Emerging Market Countries? by Lindsey M. Horton, Mary E. Mortensen, Yulia Iossifova, Marlena M. Wald, Paula Burgess

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Variations in the composition and frequency of celiac disease epitopes among synthetic wheat lines by Rahman Ebrahimzadegan, Ghader Mirzaghaderi

“…In this way, the Ae. tauschii derived lines 5 and 6 contained higher levels of toxic alpha-gliadin epitopes, while lines 3, 4, and 7 (derived from Ae. crassa) contained the lowest levels of toxic peptides. …”
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Autoriser pour interdire. La fabrique des savoirs sur les molécules et leurs risques dans le règlement européen REACH by Henri Boullier

“…How can toxic chemicals be regulated with limited and incomplete data on their properties? …”
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