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2941
Propylene glycol-based deep eutectic solvent as an alternative to Ethaline for electrometallurgy
Published 2024-11-01“…However, if ChCl can be considered as a “green” reactant, this is not the case for EG. A DES with a lower toxicity can be obtained by replacing EG by propylene glycol (PG), widely used in cosmetics and pharmacology, yielding a DES called Propeline. …”
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2942
A Systematic Review on Poisoned Patients as Potential Organ Donors
Published 2024-12-01“…Evidence strongly indicates that outcomes of transplants from poisoned donors and nonpoisoned donors are comparable, with complications not attributable to the toxicity of the substance. While there’s no single answer to all questions posed by transplant surgeons regarding poisoned patients, it is evident that harvesting organs from poisoned/intoxicated donors is no longer experimental but founded on robust scientific evidence and ample experience. …”
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2943
Sulforaphane as a promising anti-caries agents: inhibitory effects on Streptococcus mutans and caries control in a rat model
Published 2025-01-01“…Further investigation using a rat caries model displayed a prominent caries control in the SFN-treated group with no observed toxicity. The notable results demonstrated in this study highlight the potential of SFN as a natural substitute for current anti-caries agents, while also providing valuable insights into the potential applications of SFN in caries control.…”
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2944
CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium
Published 2025-01-01“…IntroductionCadmium (Cd) and polystyrene microplastics (PS-MPs), two ubiquitous environmental contaminants, produce unique synergistic toxicity when co-existing. Key unanswered questions include specific effects on liver function and potential mechanisms.MethodsIn this study, C57BL/6 mice and AML12 cells were used to establish in vivo and in vitro models to elucidate the effects of combined exposure to PS-MPs and Cd on the liver and their mechanisms.ResultsThe results showed that the combined effects of PS-MPs and Cd caused significantly more liver damage than exposure alone. …”
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2945
Surgical resection, radiotherapy and percutaneous thermal ablation for treatment of stage 1 non-small cell lung cancer: protocol for a systematic review and network meta-analysis
Published 2022-06-01“…The primary outcomes will include cancer-specific survival, lung disease-free survival, locoregional recurrence, death, toxicity and non-target organ injury. We will also search published and unpublished studies in trial registries and will review references of included studies for possible inclusion. …”
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2946
Investigation of the optimal platinum-based regimen in the postoperative adjuvant chemotherapy setting for early-stage resected non-small lung cancer: a Bayesian network meta-analy...
Published 2022-06-01“…The secondary outcome was the rate of grade 3–4 toxicity assessments. Cochrane Handbook (V.5) was used for the risk of bias assessment. …”
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2947
Manual of Clinical anesthesiology :
Published 2021Table of Contents: “…-- Hemodynamic collapse following a mainstem intubation -- Hypoxemia during tracheostomy -- Anesthetic depth and mask ventilation in the prone position -- Jet ventilation through a cookgas airway exchange catheter -- End of case evaluation and management of a patient post airway mass excision -- Possible recurrent laryngeal nerve injury -- Obstructive sleep apnea, and dead in bed -- Bilevel positive air pressure, decreased sensorium, aspiration and capnography -- Perioperative management of a patient previously treated with bleomycin undergoing thoracic surgery -- Intra-operative airway fire -- Obesity hypoventilation syndrome -- Circulation-related cases -- Hemorrhage during endovascular repair of thoracic aorta -- Pacemakers and automatic implantable cardioverter defibrillators -- Acute myocardial infarction during laparoscopic surgery -- Sickle cell and preeclampsia -- Dysrhythmias in a patient with Crohn's disease -- Hematologic disorders: hemophilia and disseminated intravascular coagulation -- Blood transfusion and the Jehovah's Witness patient -- Cardiac and pulmonary contusions -- Intraoperative coagulopathy -- Hypotension in chronic methamphetamine user -- Venous air embolism during arteriovenous malformation repair -- Cardiac tamponade -- Case of intraoperative new-onset atrial fibrillation -- Valvular disease -- Obstetrics-related cases -- Labor epidural with unrecognized dural puncture, causing high sensory block, hypotension, fetal bradycardia and post dural puncture headache -- Acute pulmonary dysfunction immediately after cesarean delivery under general anesthesia -- Jehovah's Witness with placenta previa and increta for cesarean hysterectomy -- A pregnant patient with mitral stenosis -- Unrecognized uterine hyperstimulation due to oxytocin and combined spinal-epidural analgesia -- Super morbidly obese patient for elective repeat cesarean section -- Probable amniotic fluid embolus -- Emergent cesarean section -- Pregnancy plus atrial septal defect vs Eisenmenger Syndrome -- Uterine abruption -- Pediatric-related cases -- Neonatal resuscitation following spontaneous vaginal delivery -- Anxious, coughing and bound to obstruct -- Special diseases/conditions/situations -- Hypothermia during laparoscopic nephrectomy -- Operating room management case scenarios -- Anaphylaxis reactions -- Autonomic dysreflexia -- Porphyrias -- Monitored anesthesia care: medical implications; and wrong-sided operations: legal implications -- Diabetic ketoacidosis in the urgent anesthesia setting -- Fever, altered mental status, and rigidity in the perioperative course -- Neuro/neuromuscular-related cases -- Emergent craniotomy for evacuation of epidural hematoma -- Hyperkalemia and residual neuromuscular blockade after kidney transplantation -- A defasciculating dose of nondepolarizing neuromuscular blocker -- Postoperative monocular vision loss -- Delayed emergence after aneurysm clipping -- Pain and regional anesthesia related cases -- Unintentional dural puncture in a patient with severe preeclampsia -- Complex regional pain syndrome -- Vascular absorption of local anesthetic producing systemic toxicity -- Inadvertent high spinal in parturient -- Outpatient surgery-related cases -- Plastic surgery in a surgeon's office -- Orthopedic surgery in an ambulatory surgicenter -- Eye surgery at an outpatient surgicenter -- Endoscopic sinus surgery at an outpatient sugicenter.…”
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2948
A first evaluation of the efficacy of minibeam radiation therapy combined with an immune check point inhibitor in a model of glioma-bearing rats
Published 2025-03-01“…The combination of CRT plus ICI appeared to be toxic. MBRT + ICI surpassed the survival rate with respect to ICI alone. …”
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2949
Novel and potent MICA/B antibody is therapeutically effective in KRAS LKB1 mutant lung cancer models
Published 2025-01-01“…We show that in two KL mutant NSCLC xenograft models and a KL mutant PDX model, treatment with AHA-1031 monotherapy significantly inhibits tumor growth compared with vehicle-treated animals with no observable toxicity. Tumor tissues from treated mice exhibit significantly increased immune cell infiltrates and activated NK cell populations.Conclusions Activating NK cells through MICA/B stabilization and inducing ADCC offers an alternative and potent therapy option in KL tumors. …”
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2950
Safety assessment of a novel marine multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 according to phenotype and whole genome-sequencing analysis
Published 2024-07-01“…Virulence enzymes, such as gelatinase, DNase, hemolytic, lecithinase, and thrombin were absent. Acute toxicity test with mice demonstrated that GXDK6 is safe. …”
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2951
The anti-PD-L1/CTLA-4 bispecific antibody KN046 plus lenvatinib in advanced unresectable or metastatic hepatocellular carcinoma: a phase II trial
Published 2025-02-01“…The primary endpoints were safety, tolerability, dose-limiting toxicity (DLT), and objective response rate (ORR) according to RECIST v1.1. …”
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2952
IFN-γ reprograms cardiac microvascular endothelial cells to mediate doxorubicin transport and influences the sensitivity of mice to doxorubicin-induced cardiotoxicity
Published 2025-01-01“…Abstract Doxorubicin (DOX) is a first-line chemotherapy agent known for its cardiac toxicity. DOX-induced cardiotoxicity (DIC) severely limits the use for treating malignant tumors and is associated with a poor prognosis. …”
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2953
Spireoside Controls Blast Disease by Disrupting Membrane Integrity of Magnaporthe oryzae
Published 2025-01-01“…Plant secondary metabolites typically exhibit broad-spectrum antifungal activity without selective toxicity against pathogens. However, only a small fraction of antifungal metabolites have been identified from the tens of thousands of known plant secondary metabolites. …”
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2954
Production of ACE inhibitory peptides via ultrasonic-assisted enzymatic hydrolysis of microalgal Chlorella protein: Process improvement, fractionation, identification, and in silic...
Published 2025-06-01“…More importantly, in silico structure-activity relationship analysis proved the non-toxicity of the identified LMW peptides. The result indicates a potential link between 47 LMW peptides and the inhibition of ACE activity, suggesting that microalgae protein hydrolysate and peptides could be developed into new treatments for CVD and hypertension. …”
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2955
LC-MS based analysis reveal antimicrobial compounds from Gabonese pharmacopoeia: chemical characterisation and cytotoxicity evaluation
Published 2025-01-01“…In addition, we assessed the toxicity of the three extracts that showed antimicrobial activity using an invertebrate model, Galleria mellonella (GM). …”
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2956
Hepatoprotection and Phytochemistry of the Vietnamese Herbs Cleome chelidonii and Cleome viscosa Stems
Published 2021-01-01“…The study aims to determine the hepatoprotective effect of n-hexane, ethyl acetate, and methanol extracts of the leaves and stems of two Cleome species against carbon tetrachloride- (CCl4-) induced liver toxicity both in vitro using human hepatoma (HepG2) cells and in vivo in rats as well as the hepatoprotective property of all isolated compounds on HepG2. …”
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2957
Mechanisms underlying the effects of cyanogenesis on development and reproduction of Tetranychus urticae: Insights from enzyme activity and gene expression aspects
Published 2025-01-01“…Numerous studies have speculated this CNG-mediated toxicity by a plant-pest interaction manner. However, the specific toxic effect of HCN was not well-demonstrated because of the interference of other ingested metabolites. …”
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2958
Safety and efficacy of trifluridine/tipiracil +/− bevacizumab plus XB2001 (anti-IL-1α antibody): a single-center phase 1 trial
Published 2025-01-01“…No patient exhibited dose-limiting toxicity at any dose. The most common treatment-related adverse events (TRAE) of any grade (G) were diarrhoea (35.3%), nausea (47.1%) and anaemia (35.3%). …”
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2959
Deep learning on CT scans to predict checkpoint inhibitor treatment outcomes in advanced melanoma
Published 2024-12-01“…Abstract Immune checkpoint inhibitor (ICI) treatment has proven successful for advanced melanoma, but is associated with potentially severe toxicity and high costs. Accurate biomarkers for response are lacking. …”
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2960
Self-propelled ferroptosis nanoinducer for enhanced cancer therapy
Published 2025-01-01“…However, the development of ferroptosis-based nanotherapeutics is generally hindered by the limited penetration depth in tumors, poor active pharmaceutical ingredient (API) loading content and the systemic toxicity. Herein, self-propelled ferroptosis nanoinducers composed of two endogenous proteins, glucose oxidase and ferritin, are presented to show enhanced tumor inhibition via ferroptosis while maintaining high API and biocompatibility. …”
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