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2941
Coronary Artery and Peripheral Vascular Disease in a Patient with Poorly Differentiated Thyroid Cancer Treated with the Tyrosine Kinase Inhibitor Lenvatinib
Published 2023-01-01“…However, in the phase III SELECT trial of the drug in thyroid cancer, 5.4% of patients on lenvatinib experienced arterial thromboembolic events, with 2.7% experiencing severe grade ≥3 toxicities associated with arterial vascular events. …”
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2942
Influence of Chronic Alcohol Use on Osteoblastic Differentiation of Bone Marrow Cells, Bone Properties, and Hepatic and Renal Morphology of Rats
Published 2018-01-01“…Chronic alcohol exposure can affect the osteoblastic activity and the proliferation and differentiation of cells due to its toxic effect, which can affect negatively bone repair and bone microarchitecture. …”
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2943
Characterization of mineral composition of leaves and flowers of wild-growing Sambucus nigra
Published 2024-03-01“…The concentration of heavy metals and toxic elements (Pb, Cd, and Hg) was within the permissible concentrations according to Eur. …”
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2944
The Role of Air Pollution and Olfactory Dysfunction in Alzheimer’s Disease Pathogenesis
Published 2025-01-01“…AD is recognised for its characteristic deposition of toxic proteins within the brain, leading to a steady deterioration of cognitive capabilities, memory failure, and, ultimately, death. …”
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2945
Health and Safety Considerations of Fermented Sausages
Published 2017-01-01“…Over the last years, eating fermented sausages has been associated with potential health hazards due to their high contents of saturated fats, high NaCl content, presence of nitrite and its degradation products such as nitrosamines, and use of smoking which can lead to formation of toxic compounds such as polycyclic aromatic hydrocarbons. …”
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2946
Successful Treatment of Cisplatin Overdose with Plasma Exchange
Published 2010-01-01“…On day 4, he experienced frank cisplatin toxicities and emergency plasma exchange was initiated. …”
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2947
Rutin attenuates zearalenone-induced ferroptosis of endometrial stromal cells in piglets through the p53 signaling pathway
Published 2025-01-01“…Zearalenone (ZEA) is an environmentally widespread mycotoxin capable of posing a serious threat to food safety and public health, and porcine endometrial stromal cells (ESCs) are particularly sensitive to the toxic effects of ZEA. We hypothesized that Rutin, a flavonoid antioxidant, could significantly alleviate ZEA-induced ferroptosis through the p53 signaling pathway. …”
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2948
Fatty Acid Accumulation and Resulting PPARα Activation in Fibroblasts due to Trifunctional Protein Deficiency
Published 2012-01-01“…To examine fatty acid accumulation and its toxic effects in cells, we analyzed skin fibroblasts from six patients with mitochondrial trifunctional protein deficiency, who had abnormalities in the second through fourth reactions in fatty acid β-oxidation system. …”
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2949
Research and application of advanced oxidation technology for low carbon and harmless treatment of hospital wastewater
Published 2024-02-01“…However, the high cost, substantial energy consumption, and the potential generation of additional toxic by-products limit the widespread application of advanced oxidation technologies in practical engineering. …”
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2950
Physicochemical Characterization and Asymmetric Catalytic Properties of New Biobased Organocatalytic Surfactants
Published 2025-01-01“…However, conventional solvents are often toxic and dangerous for the environment, and an interesting alternative is to replace them by water. …”
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2951
Analysis of Slow-Released Fertilisers as a Source of Microplastics
Published 2024-12-01“…Therefore, the solution to the problem of increasing the efficiency of agricultural production through the use of fertilisers with slow or controlled release of nutrients leads to environmental pollution by microplastics remaining in the soil after fertiliser application, which are also capable of adsorbing from the soil various toxic pollutants.…”
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2952
Hepatic Differentiation of Murine Disease-Specific Induced Pluripotent Stem Cells Allows Disease Modelling In Vitro
Published 2011-01-01“…In this study, we focused on three murine models for metabolic liver disorders: the copper storage disorder Wilson's disease (toxic-milk mice), tyrosinemia type 1 (fumarylacetoacetate-hydrolase deficiency, FAH−/− mice), and alpha1-antitrypsin deficiency (PiZ mice). …”
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2953
Effect of Adsorption Characteristics of Rhodamine 6G Dye Solution in Fe3O4 Magnetic Nanoparticles on Fluorescence Quantum Yield
Published 2019-01-01“…We believe that our study makes a significant contribution to the literature because Fe3O4 magnetic nanoparticles were found to be able to quench rhodamine 6G dye molecules, which will aid in eliminating toxic and hazardous pollutants from dye wastewater, which are otherwise detrimental to the environment and human health.…”
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2954
Oncolytic Virotherapy for Hematological Malignancies
Published 2012-01-01“…The ideal ex vivo purging agent would selectively target the contaminating cancer cells while spare normal stem and progenitor cells and would be applied quickly without toxicities to the recipient. One agent which meets these criteria is oncolytic viruses. …”
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2955
Proteomic profiling identifies muscle-invasive bladder cancers with distinct biology and responses to platinum-based chemotherapy
Published 2025-02-01“…Abstract Platinum-based neoadjuvant chemotherapy prior to radical cystectomy is the preferred treatment for muscle-invasive bladder cancer despite modest survival benefit and significant associated toxicities. Here, we profile the global proteome of muscle-invasive bladder cancers pre- and post-neoadjuvant chemotherapy treatment using archival formalin-fixed paraffin-embedded tissue. …”
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2956
Virgin and photo-degraded microplastics induce the activation of human vascular smooth muscle cells
Published 2025-02-01“…In conclusion, MPs can induce harmful activation of VSMCs, posing potential health risks through inflammation, cell damage, and phenotypic changes. Understanding these toxic mechanisms may reveal critical pathways for intervention and prevention.…”
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2957
Experimental Investigation of the Use of Expansive Materials to Increase Permeability in Coal Seams through Expansive Fracturing
Published 2020-01-01“…Hydration reactions of expansive materials are typically very safe, easy to induce, and low in cost, while the crushing of such materials is typically free from noise, dust, vibration, and toxic gases. In the present study, to realize the application of expansive materials in the prevention of coal seam gas disasters, the microstructure, heat release rate, and expansive pressure of expansive materials were investigated for different degrees of hydration based on temperature and pressure measurements and using a scanning electron microscope (SEM); fracture characteristics were determined based on fracture tests of coal-like materials. …”
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2958
Liver diseases (<i>Review of the Seventeenth Russian Gastroenterological Week proceedings, October, 10–12, 2011, Moscow</i>)
Published 2012-06-01“…The most of publications (70,5%) has been devoted to etiopathogenesis, features of clinical pattern, diagnostics and treatment of acute and chronic viral hepatitis (2542 patients), liver cirrhoses (1338 patients), non-alcoholic fatty liver disease (1145 patients), toxic liver diseases (834 patients) that indicates medical and social impact of these diseases. …”
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2959
Diphenhydramine as a Cause of Drug-Induced Liver Injury
Published 2017-01-01“…A thorough workup of liver injury ruled out viral hepatitis (including A, B, C, and E), autoimmune, toxic, ischemic, and metabolic etiologies including Wilson’s disease. …”
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2960
The Nephroprotective Effect of Andrographis Paniculata Ethanol Extract Chitosan Nanoparticles on Vero cells
Published 2025-01-01“…Chitosan-based ethanol extract nanoparticles of Andrographis paniculata are non-toxic and have nephroprotective abilities in both recovery and protection tests.…”
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