Optimised extraction of antioxidant components from Calophyllum inophyllum L. seeds using response surface methodology by L. Fitriyana, M.D. Supardan, Y. Aisyah, Irfan .

“…The lotion produced from the C. inophyllum seed extract contained high antioxidant activity with a 50 per cent inhibition concentration of 4.621 part per million; the toxicity text showed it was safe to be used (50 per cent lethal concentration of 789 grams per millilitre).CONCLUSION: The results showed the effectiveness of this approach in determining the optimal conditions to maximise antioxidant content. …”
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A novel approach for unveiling co-occurrence patterns of UV filter mixtures in sunscreens: Prioritization for hazard and risk assessment by Ah-Reum Jo, Ba Reum Kwon, Inae Lee, Jieun Min, Sohyeon Choi, Na-Youn Park, Younglim Kho, Jeongim Park, Ho Kim, Kyungho Choi

“…In recent years, concerns regarding the toxicity of organic UV filters in sunscreen products have increased. …”
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Source attribution, health risk analysis, and policy implications of PAHs and NPAHs in PM $$_{10}$$ in Northern Mexico by Lucy T. González, Ilse María Hernández-Romero, Alberto Mendoza, Aldo I. Ramirez, Yasmany Mancilla, Boris Kharissov, Michael Pérez-Rodríguez, Juan Manuel Alfaro Barbosa, Daniel López Serna, Oxana Kharissova, Andrea Nucamendi, Jesús Abraham Díaz Paéz, Francisco E. Longoria

“…Significantly, 3-nitrofluoranthene (3N-FLA) and 1-nitropyrene (1N-PYR), known for their potent toxicity, were among the most prominent NPAHs, with total concentrations in MMA, CHI, and CDJ at 470.32 pg/m $$^3$$ , 247.26 pg/m $$^3$$ , and 193.20 pg/m $$^3$$ , respectively. …”
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Dual in vivo T cell depleted haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide and anti-thymocyte globulin as a third salvage transplant... by Azadeh Kiumarsi, Amirarsalan Alaei, Mohsen Nikbakht, Saeed Mohammadi, Mohammad Reza Ostad-Ali, Zahra Rasti, Tahereh Rostami

“…BackgroundWith recent advances in clinical practice, including the use of reduced-toxicity conditioning regimens and innovative approaches such as ex vivo TCRαβ/CD19 depletion of haploidentical donor stem cells or post-transplant cyclophosphamide (PTCY), hematopoietic stem cell transplantation (HSCT) has emerged as a curative treatment option for a growing population of patients with inborn errors of immunity (IEI). …”
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Antiplasmodial and Cytotoxic Activities of Extracts of Selected Medicinal Plants Used to Treat Malaria in Embu County, Kenya by Bibianne Waiganjo, Gervason Moriasi, Jared Onyancha, Nelson Elias, Francis Muregi

“…Further focused studies geared towards isolation of active constituents and determination of in vivo toxicities to ascertain their safety are warranted.…”
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The Effects of Subchronic Exposure to Metribuzin on Danio rerio by Lucie Plhalova, Stanislava Stepanova, Eva Praskova, Lucie Chromcova, Lenka Zelnickova, Lenka Divisova, Misa Skoric, Vladimira Pistekova, Iveta Bedanova, Zdenka Svobodova

“…The effects of subchronic exposure to metribuzin on fish growth and the development of histopathological changes in selected organs (gill, kidney, liver) and on activity of some biochemical markers (CYP450, EROD) in Danio rerio were investigated during a 28-day toxicity test. Juvenile growth tests were performed on D. rerio according to OECD method number 215. …”
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Density functional theory calculation for understanding the roles of biochar in immobilizing exchangeable Al3 + and enhancing soil quality in acidic soils by Debo He, Xinyi Liu, Dongni Hu, Ping Lei, Jinbo Zhang, Zhixin Dong, Bo Zhu

“…These findings collectively highlight the potential of biochar as a sustainable and effective amendment to reduce Al toxicity in acidic soils, thereby promoting soil quality and sustainable agricultural and ecological practices.…”
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Exercise medicine as adjunct therapy during RADIation for CAncer of the prostaTE to improve treatment efficacy – protocol for the ERADICATE study: a phase II randomised controlled... by Oliver Schumacher, Robert U. Newton, Colin Tang, Raphael Chee, Sjoerd B. Vos, Ronny S. Low, David Joseph, Dennis R. Taaffe, Daniel A. Galvão

“…Secondary outcomes will include acute and chronic changes in tumour perfusion and hypoxia, treatment-related toxicity, body composition, physical function, and quality of life. …”
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The role of oxidized non-coding RNAs of the epigenome in the development of human diseases (literature review) by S.S. Ostrovska, Ye.N. Dychko, T.Ye. Shumna, G.I. Titov, O.S. Trushenko, P.G. Gerasymchuk, I.Y. Burega

“…The results of the study showed that cadmium manifests its toxicity by oxidizing micro RNAs and long RNAs that regulate gene expression without changing DNA/histone complexes. …”
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Phase I Trial of Upamostat Combined With Gemcitabine in Locally Unresectable or Metastatic Pancreatic Cancer: Safety and Preliminary Efficacy Assessment by Xiuping Lai, Di Cheng, Huixin Xu, Jingshu Wang, Xiaozhi Lv, Herui Yao, Liuning Li, Junyan Wu, Suiwen Ye, Zhihua Li

“…Pharmacokinetic analysis revealed a dose‐related increase in LH011 and its metabolite WX‐UK1 exposure from 100 to 400 mg but not in the 600 mg group. Hematological toxicity, mainly attributable to gemcitabine, was the predominant grade 3 or 4 adverse event, with additional occurrences of loss of appetite, rash, and interstitial lung disease. …”
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Reactivity in cell culture medium and in vitro anticancer activity of 3,5-di-tert-butylcatechol: link to metal-catechol interactions by Aviva Levina, Debbie C. Crans, Peter A. Lay

“…The resultant adduct is likely to be responsible for the high toxicity of dtbH2 and dtbQ in GSH-rich cancer cells via oxygen-dependent radical chain reactions. …”
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RNA m6A involves in regulation of oxidative stress and apoptosis may via NF-kB pathway in cadmium-induced lung cells by Nan Zhang, Jie Yang, Yuan Zhao, Wenhong Li, Bo Zhao, Rongxian Li, Zuoshun He, Shiyan Gu

“…In conclusion, our study provides a scientific foundation for understanding cadmium toxicity and offers novel insights for treating cadmium-induced lung diseases.…”
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Chalcogenide perovskites: enticing prospects across a wide range of compositions and optoelectronic properties for stable photodetector devices by Shilpa Mariam Samuel, Sadasivan Shaji, David Avellaneda Avellaneda, Bindu Krishnan

“…Inspired by the perovskite structure, intense investigation in search of highly stable, non-toxic and earth abundant materials with superior optoelectronic features has led to the discovery of chalcogenide perovskites (CPs). …”
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Potential of Liposomal FTY720 for Bone Regeneration: Proliferative, Osteoinductive, Chemoattractive, and Angiogenic Properties Compared to Free Bioactive Lipid by Mouzoura P, Marazioti A, Gkartziou F, Metsiou DN, Antimisiaris SG

“…FTY720 demonstrated the ability to increase cell proliferation at 10– 300nM doses but was cytotoxic at doses> 400nM while the corresponding liposomal-FTY720 doses were non-cytotoxic, proving its reduced toxicity. In several cases (cells and doses), FTY720 liposomes demonstrated increased osteogenic differentiation of cells, proliferation, and migration compared to free FTY720, whereas both FTY720 forms demonstrated substantial angiogenic activity. …”
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Antileishmanial Activity of Warifteine: A Bisbenzylisoquinoline Alkaloid Isolated from Cissampelos sympodialis Eichl. (Menispermaceae) by Eliete Cavalcanti da Silva, Cynthia Dias Rayol, Paloma Lys Medeiros, Regina Célia Bressan Queiroz Figueiredo, Márcia Regina Piuvezan, José Maria Brabosa-Filho, Alexsandro Fernandes Marinho, Teresinha Gonçalves Silva, Gardenia Carmen Gadelha Militão, Ana Paula Pimentel Cassilhas, Paulo Paes de Andrade

“…The treatment is difficult due to the high toxicity of the available drugs, high costs, and emergence of resistance in the parasites. …”
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Phytomedicinal armamentarium: A review of inula racemosa-derived alantolactones and isoalantolactones in anticancer therapy by Joshi Gaurav Santoshrao, Smriti Jamwal, Rakesh Kumar, Ekta Bisht, Bisen Harsh Krishnakumar, Shreya Katoch, R.K. Asrani

“…The compounds have demonstrated efficacy in vitro and in vivo, affecting various cancer cell lines with minimal toxicity to normal cells. Conclusion: Alantolactone and isoalantolactone from Inula racemosa show promising potential as anti-cancer agents. …”
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Compost as an eco-friendly alternative to mitigate salt-induced effects on growth, nutritional, physiological and biochemical responses of date palm by Mohamed Ait-El-Mokhtar, Abdessamad Fakhech, Raja Ben-Laouane, Mohamed Anli, Abderrahim Boutasknit, Youssef Ait-Rahou, Said Wahbi, Abdelilah Meddich

“…The presence of compost mitigated these effects by improving the concentrations of the essential elements (P, K+, N and Ca2+) in both plant shoots and roots and by limiting salt ion (Na+ and Cl-) toxicity and thereby induced higher K/Na and Ca/Na ratios. …”
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Clinical Characteristics of Neuropathic Pain and Its Relationship with Cancer in Different Corporal Areas—A Systematic Review by Fernanda Danés-López, Cristóbal Diaz-Palominos, Anggie Ortiz Domínguez, Alanna Silva Rodriguez, Constanza Astorga, Daniela Martínez-Hernández, Juan Jose Valenzuela-Fuenzalida, Juan Sanchis-Gimeno, Pablo Nova-Baeza, Alejandra Suazo-Santibáñez, Gustavo Oyanedel-Amaro, Mathias Orellana-Donoso, Héctor Gutiérrez Espinoza

“…Causes of neuropathic cancer pain (NCP) include direct nerve invasion or compression by the tumor, as well as neural toxicity associated with treatments. This type of pain is classified into several categories, such as plexopathy, radiculopathy, and peripheral neuropathies. …”
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Lipid-encapsulated gold nanoparticles: an advanced strategy for attenuating the inflammatory response in SARS-CoV-2 infection by Sanjeevram Dhandapani, Yujeong Ha, Rongbo Wang, Tae Woo Kwon, Ik-Hyun Cho, Yeon-Ju Kim

“…To address safety and toxicity concerns associated with nanoparticles, lipid-nanocarrier-based drug delivery systems have emerged as a promising approach for developing next-generation smart nanomedicines. …”
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Solid Self-Microemulsifying Drug Delivery System for Improved Oral Bioavailability of Relugolix: Preparation and Evaluation by Li ZL, Deng GX, Fang CZ, Zhao YQ, Yuan J, Chen L, Zhong HJ, Guo F

“…There was no apparent cardiac, hepatic, splenic, pulmonary or renal toxicity on the surface discovered by pathological analysis after oral administration.Conclusion: It is evident that S-SMEDDS may be a safe and effective method to improve oral absorption of drugs with low oral bioavailability. …”
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