A Novel Sesterterpenoid, Petrosaspongin and γ-Lactone Sesterterpenoids with Leishmanicidal Activity from Okinawan Marine Invertebrates by Takahiro Jomori, Nanami Higa, Shogo Hokama, Trianda Ayuning Tyas, Natsuki Matsuura, Yudai Ueda, Ryo Kimura, Sei Arizono, Nicole Joy de Voogd, Yasuhiro Hayashi, Mina Yasumoto-Hirose, Junichi Tanaka, Kanami Mori-Yasumoto

“…Current treatments face challenges such as high toxicity, side effects, cost, and growing drug resistance. …”
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Endocrine Adverse Events in Patients Treated with Immune Checkpoint Inhibitors: A Comprehensive Analysis by Meriç Dökmetaş, Harun Muğlu, Erkan Özcan, Buket Bayram Kuvvet, Kaan Helvacı, Ender Kalacı, Seda Kahraman, Musa Barış Aykan, İrfan Çiçin, Fatih Selçukbiricik, Ömer Fatih Ölmez, Ahmet Bilici

“…<i>Conclusions</i>: Endocrine dysfunction is a significant toxicity of ICI therapy. Early recognition, prompt diagnosis, and appropriate management are crucial to minimize their impact on patient health and quality of life. …”
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Imatinib Mesylate Effectiveness in Chronic Myeloid Leukemia with Additional Cytogenetic Abnormalities at Diagnosis among Black Africans by Tolo Diebkilé Aïssata, Duni Sawadogo, Clotaire Nanho, Boidy Kouakou, N'dogomo Meité, N'Dhatz Emeuraude, Ayémou Roméo, Sekongo Yassongui Mamadou, Paul Kouéhion, Konan Mozart, Gustave Koffi, Ibrahima Sanogo

“…Death was related in 40% to hematologic toxicity and in 30% to acutisation. The median survival was 40 months.…”
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Efficacy and safety of FOLFIRI/aflibercept in second‐line treatment of metastatic colorectal cancer in a real‐world population: Prognostic and predictive markers by Ana Fernández Montes, Nieves Martínez Lago, Marta Covela Rúa, Juan de la Cámara Gómez, Paula González Villaroel, José Carlos Méndez Méndez, Mónica Jorge Fernández, Mercedes Salgado Fernández, Margarita Reboredo López, Guillermo Quintero Aldana, María Luz Pellón Augusto, Begoña Graña Suárez, Jesús García Gómez

“…The most common grade 3/4 toxicities were neutropenia (15.3%), asthenia (10.3%), diarrhea and mucositis (6.4% each). …”
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TROPION-Breast04: a randomized phase III study of neoadjuvant datopotamab deruxtecan (Dato-DXd) plus durvalumab followed by adjuvant durvalumab versus standard of care in patients... by Heather L. McArthur, Sara M. Tolaney, Rebecca Dent, Peter Schmid, Jamil Asselah, Qiang Liu, Jane Lowe Meisel, Naoki Niikura, Yeon Hee Park, Gustavo Werutsky, Giampaolo Bianchini, Jay C. Andersen, Robert Kozarski, Nana Rokutanda, Barbara Pistilli, Sibylle Loibl

“…Background: Despite treatment advances for patients with early-stage triple-negative breast cancer (TNBC) and hormone receptor (HR)-low/human epidermal growth factor receptor 2-negative (HER2−) breast cancer, treatments that improve clinical outcomes while mitigating toxicity are needed. Datopotamab deruxtecan (Dato-DXd), a TROP2-directed antibody-drug conjugate consisting of a humanized IgG1 monoclonal antibody attached via a plasma-stable cleavable linker to a topoisomerase-I inhibitor payload, has shown efficacy alone or in combination with durvalumab, a selective, high-affinity anti-programmed cell death ligand 1 antibody, in early-phase clinical studies. …”
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Lysozyme-based spray for treatment of radiotherapy-induced oral mucositis by Zdenka Gojković, Jelena Rožić, Nataša Gašpar, Aziz Šukalo, Meliha Mehić, Amna Tanović Avdić, Una Glamočlija

“…Methods: A prospective, open-label study was conducted on patients with ulcerative inflammation of the oral cavity and pharynx mucous membranes clinically assessed for oral mucositis according to the World Health Organization (WHO) Oral Toxicity Scale. Patients were randomly divided into a lysozyme group (using a spray containing lysozyme + cetylpyridinium + lidocaine) and a control group (using a compounded preparation containing gentamicin + dexamethasone + lidocaine). …”
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Preclinical assessment of splicing modulation therapy for ABCA4 variant c.768G>T in Stargardt disease by Dyah W. Karjosukarso, Femke Bukkems, Lonneke Duijkers, Tomasz Z. Tomkiewicz, Julia Kiefmann, Andrei Sarlea, Sander Bervoets, Irene Vázquez-Domínguez, Laurie L. Molday, Robert S. Molday, Mihai G. Netea, Carel B. Hoyng, Alejandro Garanto, Rob W. J. Collin

“…No major safety concerns regarding off-targets, immunostimulation and toxicity are observed in transcriptomics analysis, cytokine stimulation assays in human primary immune cells, and cytotoxicity assays. …”
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Gastrointestinal Bleeding and Diffuse Skin Thickening as Kaposi Sarcoma Clinical Presentation by Sara Querido, Henrique Silva Sousa, Tiago Assis Pereira, Rita Birne, Patrícia Matias, Cristina Jorge, André Weigert, Teresa Adragão, Margarida Bruges, Domingos Machado

“…A renal allograft biopsy revealed interstitial fibrosis and tubular atrophy grade II. Toxicity of calcineurin inhibitor was assumed and, after a switch for everolimus, renal function improved. …”
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The effect of educational programs on parents’ knowledge, behavior, and practices regarding aluminum phosphide poisoning and its first-aid measures by Mabrouka Attia Ali Nada, Ahmed Kamal Eldin Elsayed Elfeky, Hamida Ahmed Mustafa Darweesh, Farida Khalil Ibrahim Mohamed, Loujain Saud Sharif, Faten Shawky Kandil, Fatma Ahmed Elsobky, Samah Abdallah Mohamed Amer

“…Management is primarily supportive, to control toxic symptoms and prevent the anticipated consequences. …”
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Maternal transfer and sex-differences in brain bioaccumulation for Northern bobwhite quail (Colinus virginianus) exposed to per- and poly-fluoroalkyl substances by Kenneth N. Kikanme, Adcharee Karnjanapiboonwong, Rameshkumar Angappan, Nicole M. Dennis, Farzana Hossain, Jamie G. Suski, Christopher J. Salice, Todd A. Anderson

“…We obtained archived samples of male-female pairs of Northern bobwhite quail (NBWQ) from chronic toxicity studies where adults were exposed to either individual PFAS or binary mixtures through drinking water for at least 60 days. …”
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Biological evaluation and interaction mechanism of beta-site APP cleaving enzyme 1 inhibitory pentapeptide from egg albumin by Zhipeng Yu, Sijia Wu, Wenzhu Zhao, Long Ding, David Shiuan, Fuping Zheng, Jianrong Li, Jingbo Liu

“…To find natural products for the treatment of Alzheimer's disease, absorption, distribution, metabolism, excretion and toxicity (ADMET) properties and in vitro BACE1 inhibitory activity of the peptides isolated from egg albumin were evaluated. …”
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Species of Sulfur in Sour Gas Reservoir: Insights from In Situ Raman Spectroscopy of S–H2S–CH4–H2O System and Its Subsystems from 20 to 250°C by Yifan Yu, Wenxuan Hu, I-Ming Chou, Lei Jiang, Ye Wan, Yiqun Li, Yang Xin, Xiaolin Wang

“…However, experimental studies on S species in sour gas are limited due to the toxicity and corrosion of S and H2S. Fused silica capillary capsules (FSCCs) are inert to S and H2S and, therefore, were employed in this study as microreactors containing the S–H2S–CH4–H2O system and its subsystems, representing the composition of sour gas. …”
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Exogenous organic acids promoted phytoremediation by Hydrangea macrophylla in cadmium‑contaminated soil by Yunjing Song, Qian Cheng, Bing Zhao

“…Cadmium (Cd) contaminants with high toxicity and mobility seriously threatens the ecological environment and human safety. …”
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Sustainability assessment of pectin extraction from Citrus paradisi peel to support the encapsulation of lactic acid bacteria by Natalia A. Di Clemente, Enzo La Cava, Sonia Sgroppo, Andrea Gomez-Zavaglia, Esteban Gerbino

“…The main impact categories were climate change, human toxicity with carcinogenic effects and depletion of water resources contributing to deionized water and electricity consumption. …”
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A targeted and synergetic nano-delivery system against Pseudomonas aeruginosa infection for promoting wound healing by Chang Ni, Xisheng Li, Haiye Jiang, Shumin Gui, Heng Yin, Xinmin Nie

“…The wound healing potential and in vivo toxicity of the nanosystems were evaluated in a mouse skin wound model. …”
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Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health by Yan Zuo, Zhilan Bai, Kaixuan Yang, Ziyuan Lin, Xiaolin Hu, Huaqin Sun

“…This study aimed to address this gap by using zebrafish embryos at the 1-cell stage as a model to assess the toxicity of sine waves, following OECD Test No. 236. …”
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Analysis of thyroid function and structure and serum metabolomics in pregnant rats exposed to airborne contaminants: Combined perchlorate, thiocyanate, and nitrate exposure by Chenchen Wang, Xiaohui Xu, Jiangling Yuan, Ran An, Aierken Taxitiemuer, Yan Zhang, Tao Luo, Jing Zhou, Chang Wang, Ling Zhang, Shunhua Wu

“…Conclusions: Mixed thiocyanate, nitrate, and perchlorate exposure can result in subchronic toxicity in rats, affecting thyroid function and structure.…”
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Amrubicin Monotherapy for Patients with Platinum-Refractory Gastroenteropancreatic Neuroendocrine Carcinoma by Takayuki Ando, Ayumu Hosokawa, Hiroki Yoshita, Akira Ueda, Shinya Kajiura, Hiroshi Mihara, Sohachi Nanjo, Haruka Fujinami, Jun Nishikawa, Kohei Ogawa, Takahiko Nakajima, Johji Imura, Toshiro Sugiyama

“…Among 22 patients with advanced gastroenteropancreatic NEC, 10 received amrubicin monotherapy between September 2007 and May 2014 after failure of platinum-based chemotherapy. The efficacy and toxicity of the treatment were analyzed retrospectively. …”
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The Utilization of <i>Gracilaria</i> sp. as Raw Material for Cellulose in Cellulose Acetate-Nickel Oxide (CA-NiO) as Electrode for Energy Storage Technology by Abdul Karim, Ahyar Ahmad, Rugaiyah Andi Arfah, Riksfardini Annisa Ermawar, Harningsih Karim, Andi Erwin Eka Putra, Suriati Eka Putri, Satria Putra Jaya Negara, Siti Halimah Larekeng

“…Composites with CA can be an environmentally friendly alternative electrode with low toxicity. The results show that the cellulose has been successfully synthesized from the algae Gracilaria sp., which was proven by FTIR spectra analysis. …”
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A multifunctional mesoporous silica drug delivery nanosystem that ameliorates tumor hypoxia and increases radiotherapy efficacy by Yanhong Chu, LiFeng Wang, Yaohua Ke, Xiaoyu Feng, Wenmei Rao, Wei Ren, Kai Xin, Yan Wang, Lixia Yu, Baorui Liu, Qin Liu

“…Safety assessments confirmed the absence of MSN@R837-Mn/ZnO2 toxicity, highlighting its potential as a promising approach with dual functionality for the diagnostic imaging and treatment of cancer.…”
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