Effect of Monotherapy and Combination Therapy of Pantoprazole and Aprepitant in Gastric Esophageal Reflux Disease in Albino Rats by Kamleshwar Shukla, Prince Raj, Arun Kumar, Mukesh Kumar, Gaurav Kaithwas

“…Groups of rats, fasted overnight, received normal saline (3 mL/kg, sham control) or toxic control (3 mL/kg) or pantoprazole (30 mg/kg) or aprepitant (10 mg/kg), or their combinations and were subjected to pylorus and forestomach ligation. …”
Get full text

Low dose DNA methyltransferase inhibitors potentiate PARP inhibitors in homologous recombination repair deficient tumors by Romain Pacaud, Scott Thomas, Sibapriya Chaudhuri, Ann Lazar, Luika A. Timmerman, Pamela N. Munster

“…However, clinical responses are often not durable and treatment may be detrimental in advanced cancer due to excessive toxicities. Thus we are seeking alternative therapeutics to enhance PARP-directed outcomes. …”
Get full text

Real-World Experience with Dolutegravir-Based Two-Drug Regimens by Douglas Ward, Moti Ramgopal, David J. Riedel, Cindy Garris, Shelly Dhir, John Waller, Jenna Roberts, Katie Mycock, Alan Oglesby, Bonnie Collins, Megan Dominguez, James Pike, Joseph Mrus

“…The most common physician-reported reasons for initiating DTG 2DR were treatment simplification/streamlining (30%) and avoidance of potential long-term toxicities (20%). Before starting DTG 2DR, 42% of patients were virologically suppressed; of those, 95% maintained suppression while on DTG 2DR. …”
Get full text

Bioinorganic Synthesis of Polyrhodanine Stabilized Fe3O4/Graphene Oxide in Microbial Supernatant Media for Anticancer and Antibacterial Applications by Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Ahmad Gholami, Navid Omidifar, Maryam Zarei, Sonia Bahrani, Khadije Yousefi, Wei-Hung Chiang, Aziz Babapoor

“…Consequently, based on the results, it can be concluded that this novel polyrhodanine-based nanocompound can act as drug carriers due to their low toxic effects and may open a new window on the antibacterial agents.…”
Get full text

Fast and Slow Roasting of Alcohol- and Honey-infused Coffee Blends: A Comparative Study of PAH and N-PAH Emissions by Hsin-Chieh Kung, Chung-Hsien Hung, Kun-Hui Lin, Bo-Wun Huang, Nicholas Kiprotich Cheruiyot, Guo-Ping Chang-Chien

“…The fast roasting of green coffee resulted in mass and toxic concentrations approximately 1.6 and 3.2 times higher than in the slow roasting method (5,069 ng Nm−3 and 14.1 ng BaP-TEQ Nm−3, respectively). …”
Get full text

Motion Trajectory Planning and Design of Material Spraying Service Robot by Gang Wang, Hongyuan Wen, Jun Feng, Jun Zhou

“…The application of robots reduces repetitive and dangerous tasks for humans, especially the spraying robot, because many spraying materials are corrosive, toxic, and harmful. This paper designs the motion trajectory planning of the material spraying service robot. …”
Get full text

Viral Response to Specifically Targeted Antiviral Therapy for Hepatitis C and the Implications for Treatment Success by Curtis L Cooper

“…The attrition rate of agents within this class has been high due to various toxicities. Regardless, several STAT-C molecules are poised to become the standard of care for HCV treatment in the foreseeable future. …”
Get full text

Treatments for Severe Cutaneous Adverse Reactions by Yung-Tsu Cho, Chia-Yu Chu

“…It consists of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and generalized bullous fixed drug eruptions (GBFDE). …”
Get full text

Interaction between 𝛼-Synuclein and Other Proteins in Neurodegenerative Disorders by Kurt A. Jellinger

“…Protein aggregation is a common characteristic of many neurodegenerative disorders, and the interaction between pathological/toxic proteins to cause neurodegeneration is a hot topic of current neuroscience research. …”
Get full text

Current Status of Alginate in Drug Delivery by Dewi Melani Hariyadi, Nazrul Islam

“…The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed.…”
Get full text

Food waste in Indonesia: Assessing readiness for valorization by Taufiq Immawan

“…Key processes include contaminant removal and safety assessments, though limited studies address physicochemical, microbiological, and toxic contaminant evaluations. Identified gaps in Indonesian regulations, particularly regarding safety standards, highlight the need for clearer guidelines and support for eco-friendly technologies. …”
Get full text

Contaminants in the Urban Environment: Dioxins by Yun-Ya Yang, Gurpal S. Toor

“… Dioxins are among the most toxic chemicals on the earth. They are by-products of a number of human activities such as combustion of fuels and wastes containing polyvinyl chloride (PVC), chlorine bleaching of paper products, and selected industrial processes. …”
Get full text

Utility of renal replacement therapy in poisoning and drug overdosage by Rohit Bhowmick, Sasidaran Kandasamy

“…Toxic and prescribed drug ingestions are a significant cause of pediatric morbidity and mortality. …”
Get full text

Distribution and Fate of Military Explosives and Propellants in Soil: A Review by John Pichtel

“…When released to the biosphere, energetics are xenobiotic contaminants which pose toxic hazards to ecosystems, humans, and other biota. …”
Get full text

Contaminants in the Urban Environment: Dioxins by Yun-Ya Yang, Gurpal S. Toor

“… Dioxins are among the most toxic chemicals on the earth. They are by-products of a number of human activities such as combustion of fuels and wastes containing polyvinyl chloride (PVC), chlorine bleaching of paper products, and selected industrial processes. …”
Get full text

Natural products for managing landscape and garden pests in Florida by Matthew A. Borden, Eileen A. Buss, Sydney G. Park Brown, Adam G. Dale

“…This publication describes natural products used in residential landscapes and gardens that are generally less toxic to non-target organisms and the environment, and when used correctly, can be effective tools for plant protection. …”
Get full text

Development and study of iron-based nanoadsorbents by Deliyanni E., Bakoyannakis D., Zouboulis A., Matis K.

“…Main aim of this study was to evaluate the efficiency of the prepared material in the removal of heavy and toxic metal cations, like Cd(II), from aqueous solutions; cadmium constitutes a priority pollutant. …”
Get full text

Interleukin 2-Based Fusion Proteins for the Treatment of Cancer by Alana MacDonald, T.-C. Wu, Chien-Fu Hung

“…Over the past three decades, efforts have focused on circumventing IL-2-related toxicities by engineering methods to localize IL-2 to the tumor or secondary lymphoid tissue, preferentially activate CD8+ T cells and NK cells, and alter pharmacokinetic properties to increase bioavailability. …”
Get full text

Design and Construction of an Electronic Mosquito Repellant by Isaac, Kwesiga

Get full text

Natural products for managing landscape and garden pests in Florida by Matthew A. Borden, Eileen A. Buss, Sydney G. Park Brown, Adam G. Dale

“…This publication describes natural products used in residential landscapes and gardens that are generally less toxic to non-target organisms and the environment, and when used correctly, can be effective tools for plant protection. …”
Get full text