Haemophagocytic lymphohistiocytosis in patients treated with immune checkpoint inhibitors: analysis of WHO global database of individual case safety reports by Alessandro Ceschi, Roberta Noseda, Raffaela Bertoli, Laura Müller

“…ICI-related haemophagocytic lymphohistiocytosis (HLH) has been recently outlined in single case reports, raising a concern about the need of increasing our knowledge on this rare yet life threatening ICI haematological toxicity.Methods To determine ICI-related HLH clinical, haematological, and coagulation features, its timing and outcome, concurrent irAEs and concomitant infections, we performed a retrospective observational cross-sectional study and queried VigiBase, the WHO global database of suspected adverse drug reactions (ADRs), on September 30th, 2018. …”
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CAR T-cell detection scoping review: an essential biomarker in critical need of standardization by Naomi Taylor, Nirali N Shah, David P Turicek, Victoria M Giordani, Josquin Moraly

“…The expansion and persistence of chimeric antigen receptor (CAR) T-cells in patients are associated with response, toxicity, and long-term efficacy. As such, the tools used to detect CAR T-cells following infusion are fundamental for optimizing this therapeutic approach. …”
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Cobalt oxide nanoparticles induce cytotoxicity and excessive ROS mediated mitochondrial dysfunction and p53-independent apoptosis in melanoma cells by Hanan R. H. Mohamed, Basma A. Mohamed, George M. Hakeem, Shahd H. Elnawasani, Maria Nagy, Rawan Essam, Ayman Diab, Gehan Safwat

“…Abstract Nanotherapy has emerged as a promising strategy for the targeted and efficient treatment of melanoma, the most aggressive and lethal form of skin cancer, with minimized systemic toxicity. However, the therapeutic efficacy of cobalt oxide nanoparticles (Co3O4NPs) in melanoma treatment remains unexplored. …”
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Decarboxylase mediated oxalic acid metabolism is important to antioxidation and detoxification rather than pathogenicity in Magnaporthe oryzae by Chang Liu, Yi Wei, Yuejia Dang, Wajjiha Batool, Xiaoning Fan, Yan Hu, Zhengquan He, Shihong Zhang

“…M. oryzae OxdC (MoOxdC) is an oxalate decarboxylase that appears to play a role in relieving oxalic acid toxicity. Loss of Mooxdc does not affect mycelial growth, conidiophore development, or appressorium formation in M. oryzae; however, the antioxidant and pathogenic abilities of the mutant were enhanced. …”
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Synthesis and characterization of a magnetic bacterial cellulose-chitosan nanocomposite and evaluation of its applicability for osteogenesis by Nahid Rezazadeh, Effat Alizadeh, Somaieh Soltani, Soodabeh Davaran, Neda Esfandiari

“…Magnetic nanocomposites have low toxicity (P < 0.0001) and higher osteogenic potential compared to other scaffolds. …”
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Ecotoxicological insight of phytochemicals, toxicological informatics, and heavy metal concentration in Tridax procumbens L. in geothermal areas by N.B. Maulydia, R. Idroes, K. Khairan, T.E. Tallei, F. Mohd Fauzi

“…Toxicological analysis showed that the compounds in the ethanolic extract of Tridax procumbens were nontoxic or inactive in five toxicity parameters. The other results of the heavy metal analysis showed the dominance of chromium among the other six metals tested (copper, not detected; cadmium, 0.91 ± 0.03 milligram per kilogram; zinc, 3.50 ± 0.03 milligram per kilogram; iron, 4.65 ± 0.02 milligram per kilogram; lead, 6.42 ± 0.05 milligram per kilogram; and chromium, 13.81 ± 0.07 milligram per kilogram.CONCLUSION: This study highlights the unique secondary metabolite composition of Tridax procumbens under such extreme conditions and underscores the potential implications of heavy metal accumulation in plants in geothermal areas.…”
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Antifungal, Insecticidal, and Repellent Activities of Rosmarinus officinalis Essential Oil and Molecular Docking of Its Constituents against Acetylcholinesterase and β-Tubulin by Ghizlane Houzi, Youness El abdali, Ghada Beniaich, Mohamed Chebaibi, Mohamed Taibi, Amine Elbouzidi, Samiha Kaioua, Abdeslam Asehraou, Mohamed Addi, Khalid Chaabane, Rachid Flouchi, Aimad Allali, Soad Khal-Layoun

“…Repellent capacity and toxicity were evaluated through inhalation and contact tests on Callosobruchus maculatus. …”
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Combination of ataxia telangiectasia and Rad3-related inhibition with ablative radiotherapy remodels the tumor microenvironment and enhances immunotherapy response in lung cancer by Jenny Ling-Yu Chen, Chun-Kai Pan, Li-Cheng Lin, Yu-Sen Huang, Tsung-Hsuan Huang, Shu-Jyuan Yang, Sung-Hsin Kuo, Yu-Li Lin

“…Safety analysis showed minimal toxicity. ATR inhibition enhanced the efficacy of ablative radiotherapy and immunotherapy in lung cancer. …”
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Antistripping potential of cement kiln dust on recycled asphalt pavement. Innovative Infrastructure Solutions by Usman, Kabiru Rogo, Ali, Atheer Muhammed, Wakawa, Yakubu Mamman, Usman, Abbas

“…In addition to the physical, mechanical, chemical, and structural/morphological tests, the safe inclusion of CKD in terms of heavy metals was evaluated by applying toxicity characteristic leaching procedure (TCLP) test. …”
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Jiedu Xiaozheng Decoction Augments 5-fluorouracil Induced Anti-hepatic Carcinoma Effect <italic>in Vitro</italic> and <italic>in Vivo</italic> by Zhiyun CAO, Liangpu ZHENG, Wei LIN, Xuzheng CHEN, Xiaoqin ZHU, Jiumao LIN, Wei LIN, Jian DU

“…However with the bigger dosage of 5-FU applying the more severely toxicity and side-effects have limited it's widely clinical use. …”
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Curcumin-Loaded Lipid Nanoparticles: A Promising Antimicrobial Strategy Against <i>Enterococcus faecalis</i> in Endodontic Infections by Sónia Ferreira, Liliana Grenho, Maria Helena Fernandes, Sofia A. Costa Lima

“…The CUR-loaded SLNs showed good cytocompatibility with human fibroblasts up to 2.5 μg/mL, suggesting low toxicity. <b>Conclusions:</b> CUR-loaded SLNs demonstrate significant antimicrobial activity against <i>E. faecalis</i>, along with good cytocompatibility, indicating their potential as an effective adjunct therapy in endodontic treatments.…”
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P(AN-co-MMA) nanofiber membrane decorated with greenly synthesized nanoparticles for heavy metal removal: a competitive study by Abeer Syed, Enshirah Da’na, Amel Taha, Mohamed R El-Aassar, Adnan M Aldughaish

“…Heavy metal contamination is a serious threat to water resources as it has been associated with carcinogenicity, mutagenicity, and toxicity. With the presence of heavy metals in water bodies reported from all over the globe, there is an urgent need for innovative water treatment strategies. …”
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Evaluating a Soil Amendment for Cadmium Mitigation and Enhanced Nutritional Quality in Faba Bean Genotypes: Implications for Food Safety by Liping Cheng, Jiapan Lian, Xin Wang, Mehr Ahmed Mujtaba Munir, Xiwei Huang, Zhenli He, Chengjian Xu, Wenbin Tong, Xiaoe Yang

“…Notably, SA treatment reduced Cd concentration in seeds by 60% and significantly mitigated Mn and Al toxicity. Additionally, SA treatment enhanced levels of essential macronutrients (Ca, Mg, P, S) and micronutrients (Mo, Cu) while lowering Phytate (Phy)/Ca, Phy/Mg, and Phy/P ratios, thus improving mineral nutrient bioavailability. …”
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Removal of Di (2-ethylhexyl) phthalate from groundwater by sodium persulfate activated by hollow micron zero-valent iron: Reaction mechanism and degradation path by Chunyang Gao, Bing Wang, Jingjing Zhao, Jvfeng Li, Xianyuan Du, Jin Zheng, Quanwei Song, Jiacai Xie

“…There were three degradation pathways of DEHP in H-mZVI/PS system, and the toxicity of DEHP degradation products was significantly lower than that of the parent.…”
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Trifluridine/tipiracil regimen in combination with bevacizumab for metastatic colorectal cancer in the third line: an expert opinion by Carmine Pinto, Sara Lonardi, Evaristo Maiello, Erika Martinelli, Michele Prisciandaro, Lisa Salvatore, Lisa Salvatore, Andrea Sartore-Bianchi, Andrea Sartore-Bianchi, Mario Scartozzi, Giuseppe Aprile, Chiara Cremolini, Alberto Sobrero

“…The prolongation of survival along with the preservation of quality of life, possibly avoiding harmful cumulative toxicities, is the primary therapeutic aim for patients with metastatic colorectal cancer (mCRC) in the third-line setting. …”
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Ultrastructural Analysis of Leishmania infantum chagasi Promastigotes Forms Treated In Vitro with Usnic Acid by João S. B. da Luz, Erwelly B. de Oliveira, Monica C. B. Martins, Nicácio H. da Silva, Luiz C. Alves, Fábio A. B. dos Santos, Luiz L. S. da Silva, Eliete C. Silva, Paloma L. de Medeiros

“…Pentavalent antimonials used for treatment of this disease are limited and new phytochemicals emerge as an alternative to existing treatments, due to the low toxicity and cost reduction. Usnic acid is uniquely found in lichens and is especially abundant in genera such as Alectoria, Cladonia, Evernia, Lecanora, Ramalina, and Usnea. …”
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Lumbosacral Plexopathy After Carbon-ion Radiation Therapy for Postoperative Pelvic Recurrence of Rectal Cancer: Subanalysis of a Prospective Observational Study (GUNMA 0801) by Takuya Kumazawa, MD, PhD, Shintaro Shiba, MD, PhD, Yuhei Miyasaka, MD, PhD, Masahiko Okamoto, MD, PhD, Daijiro Kobayashi, MD, PhD, Tatsuya Ohno, MD, PhD

“…The incidence of all RILSP (grades 1 and 2) and grade 2 RILSP was 22.5% (9/40) and 10% (4/40) of 40 lumbosacral plexuses in 20 patients, respectively, and no grade ≥ 3 toxicity was observed. Throughout the dose range, the volumes of the irradiated lumbosacral plexuses were significantly higher in patients with RILSP than in patients without RILSP (P < .001 for Dmax, D0.5 cm3 − D2 cm3, V20 Gy(RBE) − V70 Gy(RBE)). …”
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Rescue RM/CS-AKI by blocking strategy with one-dose anti-myoglobin RabMAb by Xinyue Wang, Ning Li, Lu Han, Ou Qiao, Xin Chen, Pengtao Wang, Lancao Zhang, Yingjie Hou, Fengjiao Bao, Herui Hao, Sania Saeed, Li Zhang, Zizheng Li, Xiaohong Duan, Shuquan Rao, Zichuan Liu, Yanhua Gong

“…The optimal administration strategy, pharmacokinetic analysis, toxicity evaluation for anti-Mb RabMAb, and the distribution of its immune complexes in RM/CS-AKI mice are investigated. …”
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Anticancer activity of Ilex khasiana, a rare and endemic species of holly in Northeast India, against murine lymphoma by Charles Lalnunfela, Pawi Bawitlung Lalthanpuii, Hmar Tlawmte Lalremsanga, Zothansiama, Chhaihlo Lalmuansangi, Mary Zosangzuali, Nachimuthu Senthil Kumar, Tochhawng Lalhriatpuii, Kholhring Lalchhandama

“…An alkylated phenol, 2,6-di-tert-butylphenol, was the predominant compound. Acute toxicity test indicated that the plant extract was non-toxic even at the highest dosage tested, i.e., 2000 mg/kg body weight. …”
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A Case Report of Accidental Intoxication following Ingestion of Foxglove Confused with Borage: High Digoxinemia without Major Complications by Maria Silvia Negroni, Arianna Marengo, Donatella Caruso, Alessandro Tayar, Patrizia Rubiolo, Flavio Giavarini, Simone Persampieri, Enrico Sangiovanni, Franca Davanzo, Stefano Carugo, Maria Laura Colombo, Mario Dell’Agli

“…Plasma samples at day 11 were analysed by LC-MS spectrometry, and gitoxin was identified suggesting that this compound may be responsible for the clinical toxicity rather than digoxin. In the case of Digitalis spp. poisoning, laboratory data should be interpreted according to the clinical picture and method of analysis used since a variety of glycosides, which are chemically similar to the cardioactive glycosides but without or with fewer cardiac effects, may be incorrectly recognized as digoxin by the test, giving misleading results.…”
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