Nucleic Acid-Based Therapy Approaches for Huntington's Disease by Tatyana Vagner, Deborah Young, Alexandre Mouravlev

“…Huntington's disease (HD) is caused by a dominant mutation that results in an unstable expansion of a CAG repeat in the huntingtin gene leading to a toxic gain of function in huntingtin protein which causes massive neurodegeneration mainly in the striatum and clinical symptoms associated with the disease. …”
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Treatment of Acquired von Willebrand Syndrome and Prevention of Bleeding Postautologous Stem Cell Transplant during Severe Pancytopenia with IVIG by Behyar Zoghi, Paul Shaughnessy, Roger M. Lyons, Richard Helmer, Carlos Bachier, C. Frederick LeMaistre

“…Patients with myeloma and Acquired von Willebrand Syndrome (AVWS) undergoing autologous stem cell transplant (ASCT) are at significant risk of bleeding due to the profound thrombocytopenia, low Factor VIII levels, fever, and toxicities associated with the preparative regimen. …”
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Ribosomal Alteration-Derived Signals for Cytokine Induction in Mucosal and Systemic Inflammation: Noncanonical Pathways by Ribosomal Inactivation by Yuseok Moon

“…Although the primary effect of ribosomal inactivation in cells is the functional inhibition of global protein synthesis, early responsive gene products including proinflammatory cytokines are exclusively induced by toxic stress in highly dividing tissues such as lymphoid tissue and epithelia. …”
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How to Obtain an Aldicarb Application Permit for Florida Cotton or Peanut by Zane J. Grabau, Ethan Carter, Libbie Johnson, Jay Ferrell, Dale Dubberly, Tamara James

“… This publication is intended to guide growers through the process of applying for a free permit to use aldicarb, an insecticide/nematicide subject to particular restrictions because of its highly toxic nature and concerns about groundwater contamination when it is improperly applied. …”
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Natural Products for Managing Landscape and Garden Pests in Florida by Eileen A. Buss, Sydney G. Park Brown

“… This publication describes “natural” pesticides: alternatives that are usually less toxic to non-target organisms and the environment and that, when used correctly, can be effective substitutes for synthetic products. …”
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Baiting the Nine-banded Armadillo by Holly K. Ober, Lucas W. DeGroote, Russell F. Mizell

“…There are no repellents, toxicants, or fumigants registered for use with them. …”
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Climate Change and the Occurrence of Harmful Microorganisms in Florida’s Ocean and Coastal Waters by Karl Havens

“…These include algae that form noxious or toxic blooms, including red tides, and bacteria and other pathogens. …”
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Baiting the Nine-banded Armadillo by Holly K. Ober, Lucas W. DeGroote, Russell F. Mizell

“…There are no repellents, toxicants, or fumigants registered for use with them. …”
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Régulation, verrous technologiques et transition écologique : le cas des formaldéhydes by Nicolas Béfort

“…The present change towards the use of renewable resources is activating production regimes in which economic actors are trying to use as an opportunity the social contestation of toxic molecules. In this context, our aim is to analyze the use of formaldehyde, an emblematic and carcinogenic molecule widely used in the production of resins and adhesives.Starting with a review of the regulation literature analyzing innovation, we discuss here the 'evolutionist theory of environmental innovations' in order to highlight an analytical framework that aims to analyze from a historical perspective the dynamics of acquiring knowledge. …”
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Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion by Mirjana Babić Leko, Vera Župunski, Jason Kirincich, Dinko Smilović, Tibor Hortobágyi, Patrick R. Hof, Goran Šimić

“…The proposed molecular mechanisms by which C9orf72 repeat expansions induce neurodegenerative changes are C9orf72 loss-of-function through haploinsufficiency, RNA toxic gain-of-function, and gain-of-function through the accumulation of toxic dipeptide repeat proteins. …”
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Chemical Composition, Source Appointment and Health Risk of PM2.5 and PM2.5-10 during Forest and Peatland Fires in Riau, Indonesia by Sepridawati Siregar, Nora Idiawati, Puji Lestari, Abiyu Kerebo Berekute, Wen-Chi Pan, Kuo-Pin Yu

“…Clearly, more attention should be devoted to reducing the noncarcinogenic and carcinogenic health risks caused by particulate-bound toxic elements through inhalation exposure.…”
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Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos by Hong-Ling Zhou, Bei-Bei Wang, Xu-Li Fan, Xiao-Min Zhang, Ying Song

“…Moreover, PC12 cells treated with Nrf2 inhibitors failed to exhibit any improvement in survival rate when treated with CAA after a toxic insult. Furthermore, ROS and MDA levels were not significantly reduced, SOD enzyme activity did not increase, and mitochondrial membrane potential and mtDNA copy number did not improve. …”
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Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…Novel engineered IL-2 agonists strive to increase the therapeutic window of aldesleukin (human IL-2) by increasing selectivity toward effector over regulatory T cells and reducing dose-limiting toxicities. Here we describe ANV419, an IL-2/anti-IL2 antibody fusion protein designed for selective IL-2 receptor βγ (IL-2 Rβγ) activation by sterically hindering IL-2 from binding to IL-2 Rα. …”
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Enhanced Interleukin 6 Trans-Signaling Modulates Disease Process in Amyotrophic Lateral Sclerosis Mouse Models by Carol Milligan, Dale O. Cowley, William Stewart, Alyson M. Curry, Elizabeth Forbes, Brian Rector, Annette Hastie, Liang Liu, Gregory A. Hawkins

“…Intense research efforts have provided insight into unique neuroanatomical regions, specific neuronal populations and genetic associations for ALS and other neurodegenerative diseases; however, the experimental results also suggest a convergence of these events to common toxic pathways. We propose that common toxic pathways can be therapeutically targeted, and this intervention will be effective in slowing progression and improving patient quality of life. …”
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Propionate metabolism in a human pathogenic fungus: proteomic and biochemical analyses by Luiz Paulo Araújo Santos, Leandro do Prado Assunção, Patrícia de Souza Lima, Gabriel Brum Tristão, Matthias Brock, Clayton Luiz Borges, Mirelle Garcia Silva-Bailão, Célia Maria de Almeida Soares, Alexandre Melo Bailão

“…Paracoccidioides spp. cells also induce transcripts/enzymes of the methylcitrate cycle (MCC), a pathway responsible for propionyl-CoA metabolism. Propionyl-CoA is a toxic compound formed during the degradation of odd-chain fatty acids, branched chain amino acids and cholesterol. …”
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Identification of key chromium resistance genes in Cellulomonas using transcriptomics by Hongmei Sun, Yongdong Li, Shengchao Gao, Guangchuan Shi, Lianbin Cao, Xinya Li, Tong Li, Tongbiao Li, Mingcheng Wang, Enzhong Li, Junhe Liu, Hongxia Ni, Yi Chen, Ying Liu

“…Cellulomonas fimi Clb-11 can reduce high toxic Cr(VI) to less toxic Cr(III), and transcriptomics was used to reveal the key Cr(VI) uptake and reduction genes of C. fimi Clb-11 in this study. …”
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Novel role of FTO in regulation of gut–brain communication via Desulfovibrio fairfieldensis-produced hydrogen sulfide under arsenic exposure by Ruonan Chen, Xiaoqin Chai, Yunxiao Zhang, Tianxiu Zhou, Yinyin Xia, Xuejun Jiang, Bo Lv, Jun Zhang, Lixiao Zhou, Xin Tian, Ruonan Wang, Lejiao Mao, Feng Zhao, Hongyang Zhang, Jun Hu, Jingfu Qiu, Zhen Zou, Chengzhi Chen

“…However, there is no specific treatment for its toxic effects due to the uncovered mechanisms. We previously revealed that exposure to arsenic increased the level of m6A via down-regulation of FTO, which might serve as a potential target for intervention against arsenic-related disorders. …”
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Organ-specific immune-related adverse events and prognosis in cancer patients receiving immune checkpoint inhibitors by Xinyue Han, Yingcui Chen, Hong Xie, Yuekai Zhang, Yu Cui, Yaping Guan, Weiwei Nie, Qi Xie, Jisheng Li, Baocheng Wang, Bicheng Zhang, Jun Wang

“…Furthermore, only skin or endocrine toxicities were associated with improved OS and PFS. …”
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Harmful Effects of Nanoparticles on Animals by Jean-Marie Exbrayat, Elara N. Moudilou, Emmanuel Lapied

“…It has been already shown that NPs could be toxic to bacteria, algae, invertebrates, and vertebrates. …”
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Contaminants in the Urban Environment: Microplastics by Maia McGuire, Yun-Ya Yang, Ignacio A. Rodriguez-Jorquera, Gurpal S. Toor, Alexander J. Reisinger

“…This series is intended to give state and local government officials, soil and water scientists, consulting engineers, Extension agents, and citizens (1) a basic understanding of the occurrence, toxic effects and source of various contaminants in the environment and (2) provide guidance on ways to protect human and environmental health. …”
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