Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends by Prateek Uttreja, Indrajeet Karnik, Ahmed Adel Ali Youssef, Nagarjuna Narala, Rasha M. Elkanayati, Srikanth Baisa, Nouf D. Alshammari, Srikanth Banda, Sateesh Kumar Vemula, Michael A. Repka

“…While challenges such as scalability and excipient toxicity persist, emerging technologies and multidisciplinary collaborations are paving the way for next-generation SEDDS. …”
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Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms by Mohammad Yasin Zamanian, Hamidreza Zafari, Maria K. Osminina, Alla A. Skakodub, Raed Fanoukh Aboqader Al‐Aouadi, Maryam Golmohammadi, Nikta Nikbakht, Iman Fatemi

“…Liposomal delivery of DEX, particularly when liposomes are surface‐modified with targeting ligands like peptides or sialic acid, can improve drug efficacy by enhancing its distribution to inflamed joints and minimizing toxicity. This study investigates the potential of liposomal drug delivery systems to enhance the efficacy and targeting of DEX in the treatment of RA. …”
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Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin by Jeonghyun Oh, Christy Catherine, Eun Seon Kim, Kwang Wook Min, Hae Chan Jeong, Hyojin Kim, Mijin Kim, Seung Hae Ahn, Nataliia Lukianenko, Min Gu Jo, Hyeon Seok Bak, Sungsu Lim, Yun Kyung Kim, Ho Min Kim, Sung Bae Lee, Hyunju Cho

“…Abstract Toxic protein aggregates are associated with various neurodegenerative diseases, including Huntington’s disease (HD). …”
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Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection by Romain Vial, Christine Zandotti, Sophie Alain, Alexandre Decourt, Noémie Jourde-Chiche, Raj Purgus, Charleric Bornet, Laurent Daniel, Valérie Moal, Tristan Legris

“…Clinical and virological remission was observed after a 21-day course of BCV, despite mild and reversible liver toxicity. However, a new relapse could not be effectively cured by BCV due to a new mutation in the UL54 gene, which is known to confer resistance to cidofovir. …”
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Unlocking biochar impacts on abiotic stress dynamics: a systematic review of soil quality and crop improvement by Periyasamy Rathinapriya, Theivanayagam Maharajan, Ravi Jothi, Mayakrishnan Prabakaran, Mayakrishnan Prabakaran, In-Bog Lee, Pyoung-Ho Yi, Seung Tak Jeong

“…Although its benefits for improving soil properties are well-documented, the potential of BC to mitigate various abiotic stresses-such as drought, salinity, and heavy metal toxicity-and its effect on plant traits need further exploration. …”
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Mild hyperthermia with magnetic resonance- guided high intensity focused ultrasound combined with salvage chemoradiation for recurrent rectal cancer by Jonathan Peng, Ari Partanen, Samuel Pichardo, Robert Staruch, Kaitlyn Perry, Merrylee McGuffin, Yuexi Huang, Kelvin KW. Chan, Shun Wong, Greg Czarnota, Kullervo Hynynen, William Chu

“…There were no complications on the day of the MR-HIFU procedure and all acute toxicities (no grade >/=3 toxicities) resolved after completion of treatment. …”
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C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity by Diksha Agnihotri, Chi-Chang Lee, Po-Chao Lu, Ruei-Yu He, Yung-An Huang, Hung-Chih Kuo, Joseph Jen-Tse Huang

“…Summary: The toxicity of C9ORF72-encoded polyproline-arginine (poly-PR) dipeptide is associated with its ability to disrupt the liquid-liquid phase separation of intrinsically disordered proteins participating in the formation of membraneless organelles, such as the nucleolus and paraspeckles. …”
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Rational design of novel phenol ether derivatives as non-covalent proteasome inhibitors through 3D-QSAR, molecular docking and ADMET prediction by Miao Yuan, Hanwen Ji, Fengxin Sun, Qiang Chen, Ping Cheng

“…Therefore, potentially attractive non-covalent proteasome inhibitors with low toxicity could be found as anticancer drugs. Methods: In this work, computer-aided drug design methods, including quantitative structure-activity relationship (QSAR), molecular docking, absorption, distribution, metabolism, excretion, and toxicology (ADMET) prediction, and drug-likeness prediction methods were performed. …”
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Influence of substituted quinones on the excretory function of the rat kidney and evaluation of the prospects of their use as potential diuretics by K.V. Sokolova, O.A. Podpletnya, S.О. Konovalova, A.P. Avdeenko, S.I. Kovalenko

“…The search for diuretics that would be aimed at inhibiting a key target molecule that is involved in the regulation of salt or water balance in the kidney, and certainly have a low level of toxicity and side effects, is an urgent task for researchers. …”
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Plant protein-derived anti-breast cancer peptides: sources, therapeutic approaches, mechanisms, and nanoparticle design by Deju Zhang, Deju Zhang, Deju Zhang, Ying Yuan, Ying Yuan, Qingdong Zeng, Qingdong Zeng, Juan Xiong, Juan Xiong, Yiming Gan, Kai Jiang, Kai Jiang, Ni Xie

“…Consequently, there is an urgent need for low-cost, low-toxicity and effective therapeutic methods to prevent or mitigate breast cancer progression. …”
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Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Fac... by Qie Guo, Xiao Li, Meng-Na Cui, Yu Liang, Xiang-Peng Li, Jun Zhao, Li-Na Wei, Xiao-Lei Zhang, Xiang Hua Quan

“…In recent years, although MMC has proven useful for the treatment of pterygium, its application has been controversial because of its clear toxicity and the possibility of ocular complications. …”
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Cellular EMT-status governs contact guidance in an electrospun TACS-mimicking in vitro model by Lorenz Isert, Mehak Passi, Benedikt Freystetter, Maximilian Grab, Andreas Roidl, Christoph Müller, Aditi Mehta, Harini G. Sundararaghavan, Stefan Zahler, Olivia M. Merkel

“…The biocompatibility of these fibers was enhanced by collagen coating, ensuring minimal toxicity and improved cell attachment. Various breast cancer cell lines (MCF7, HCC1954, MDA-MB-468, and MDA-MB-231) were cultured on these fibers to assess epithelial-to-mesenchymal transition (EMT) markers, cellular morphology, and migration.Aligned fibers (TACS5) significantly influenced EMT-related changes, promoting cellular alignment, spindle-shaped morphology and a highly migratory phenotype in mesenchymal and hybrid EMT cells (MDA-MB-468, MDA-MB-231). …”
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Ocular Findings in COVID-19 Patients: A Review of Direct Manifestations and Indirect Effects on the Eye by Federica Bertoli, Daniele Veritti, Carla Danese, Francesco Samassa, Valentina Sarao, Nicolò Rassu, Tommaso Gambato, Paolo Lanzetta

“…Among the array of drugs that have shown positive results, the use of hydroxychloroquine and chloroquine has raised a concern due to their well-known retinal toxic effects. However, the risk of retinal toxicity with short-term high-dose use of antimalarials is still unknown. …”
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Identification of antibiotic use patterns in poultry farms in the southwest region of Bangladesh by Sarder Safiqul Islam, Ratna Ghosh, Md. Shafiqul Islam, Minhazul Abedin Sun, Mustajabur Rahman, Dhiman Mondol

“…The majority of the farmers did not know about the negative impacts of antibiotic use in poultry farming (87.8%), among the remaining 7.8% of farmers said it was carcinogenic, 3.3% stated it was toxicity in humans and only 1.1% said it had no effect of antibiotics in human health. …”
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Liquid chromatography-high resolution mass spectrometry based analysis of persistent mobile organic compounds in aqueous samples: Method development and optimization by Kyriaki Anagnostopoulou, Vasileios Alampanos, Eleni Evgenidou, Dimitra A. Lambropoulou

“…Persistent Mobile Organic Compounds (PMOCs) represent a critical threat to water resources due to their high solubility, resistance to degradation, and potential toxicity, posing risks to human health and ecosystems. …”
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Identification and Quality Evaluation of Raw and Processed Asarum Species Using Microscopy, DNA Barcoding, and Gas Chromatography-Mass Spectrometry by Guangzhe Yao, Wenjuan Ma, Xuhua Huang, Qi Jia, Jiayuan Shen, Yanxu Chang, Huizi Ouyang, Jun He

“…Some volatile components of Asarum which have toxic effect may cause adverse reactions such as headache, general tension, unconsciousness, and respiratory paralysis. …”
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Insights into depolymerization of chitosan using acid hydrolysis, direct photolysis, and photocatalysis: A review by Nurul Amanina A. Suhaimi, Nur Batrisyia Amirul, Alessandra Anne Hasman, Nurulizzatul Ningsheh M. Shahri, Nur Nabaahah Roslan, Harry Lik Hock Lau, Cristina Pei Ying Kong, Eny Kusrini, Anwar Usman

“…This review summarizes physical, chemical, and biological properties of chitosan, and applications of this biopolymer especially in pharmaceutical formulation, medicine, biomedicine, agriculture, and wastewater treatment, and insights into methodology, mechanism, and advantages of depolymerization of chitosan using acid hydrolysis, direct photolysis, and photocatalysis, as well as their challenges and limitations in terms of environmental concerns, chemical structure conservation, controllability, and toxicity. The challenges in scaling up the photocatalytic depolymerization process is also discussed based on recovery, reusability, and regeneration of the photocatalysts along with a use of specific facet and morphology of photocatalysts, nanometer-sized multi-phase photocatalysts, and proper photoreactor design and parameters optimization in the photocatalytic depolymerization of chitosan in the future.…”
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Antiviral Activity of Pistacia atlantica subsp. Kurdica Extract Against Herpes Simplex Virus Type 1 by Shahin Gavanji, Hojjat Baghshahi, Azizollah Bakhtari, Ali Mohamadi, Zahra Hamami Chamgordani, Mojtaba Khandan, Javaher Sinaei

“…Kurdica was tested for toxicity. Furthermore, 50% cytotoxic and inhibitory concentrations (CC50 and IC50) were identified. …”
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Assessment of targets of antibody drug conjugates in SCLC by Abhishek Ajay, Han Wang, Ali Rezvani, Omid Savari, Brandon J. Grubb, Karen S. McColl, Suzy Yoon, Peronne L. Joseph, Shelby R. Kopp, Adam M. Kresak, Craig D. Peacock, Gary M. Wildey, Minh Lam, Masaru Miyagi, Hung-Ying Kao, Afshin Dowlati

“…However, significant challenges remain, including systemic toxicity, acquired resistance, and the lack of reliable biomarkers for patient selection. …”
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Multi-target gene therapy AUP1602-C to improve healing and quality of life for diabetic foot ulcer patients: a phase I, open-label, dose-finding study by Christoph Schindler, Jacek Mikosiński, Pawel Mikosiński, Hanna-Riikka Kärkkäinen, Mirka Sanio, Jere Kurkipuro, Igor Mierau, Wesley Smith, Aki Vartiainen, Laurent Décory, Dirk Weber, Thomas Wirth, Juha Yrjänheikki, Sebastian Schellong, Haritha Samaranayake

“…No serious adverse reactions, systemic toxicity, deaths, or side effects suggestive of immunogenicity, hypersensitivity, allergic reaction, or dose-limiting toxicities related to treatment were reported. …”
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