Nanoparticles for Biomedical Use Derived from Natural Biomolecules: Tannic Acid and Arginine by Mehtap Sahiner, Selin S. Suner, Nurettin Sahiner

“…Furthermore, all p(TA-co-ARG) particles at 1000 mg/mL concentration showed >80% toxicity on L929 fibroblast cells and increased as ARG content of p(TA-co-ARG) particles is increased. …”
Get full text

Novel (±)-trans-β-lactam ureas: Synthesis, in silico and in vitro biological profiling by Jurin Mladenka, Stepanić Višnja, Bojanić Krunoslav, Vadlja Denis, Kontrec Darko, Dražić Tonko, Roje Marin

“…The tools PASS and SwissTargetPrediction could not predict biological targets for compounds 4a–t with high probability, pointing to the novelty of their structure. Considering low toxicity risk, molecules 4a and 4f can be selected as the most promising candidates for further structure modifications.…”
Get full text

Impact of Agroindustrial Waste Fermented with Bacteria and Yeasts and Their Effect on Productive, Hematological, and Microbiota Indicators in Guinea Pigs (<i>Cavia porcellus</i>) by José E. Miranda-Yuquilema, Juan Taboada-Pico, Daniel Luna-Velasco, Mercy Cuenca-Condoy, Wilfrido Briñez

“…Results: The parameters evaluated were toxicity, productive parameters, occurrence of diarrhea and mortality, and blood profile. …”
Get full text

Evolution of drug therapy in patients with resectable gastric and esophageal‑gastric junction cancer by M. V. Sedova, M. A. Batov, V. S. Tretyak, A. A. Kolomeytseva, V. M. Khomyakov, N. N. Volchenko, A. A. Fedenko, A. D. Kaprin

“…However, according to statistics, less than half of patients complete all adjuvant courses of FLOT chemotherapy due to the high toxicity of the regimen and a decrease in the functional status of patients in the postoperative period. …”
Get full text

Mycosynthesis of chitosan-selenium nanocomposite and its activity as an insecticide against the cotton leafworm Spodoptera littoralis by Sohila A. Ibrahiem, Fifi M. Reda, Eman M. Abd-ElAzeem, Mostafa S. Hashem, Hala A. Ammar

“…Selenium nanoparticles (SeNPs) are metalloid nanomaterial, with extensive biological activities. They have low toxicity and can be used safely in plant disease management. …”
Get full text

Antifungal, toxicological, and colorimetric properties of Origanum vulgare, Moringa oleifera, and Cinnamomum verum essential oils mixture against Egyptian Prince Yusuf Palace deter... by Asmaa Alhussein Mohamed, Mahgoub A. Ahmed, Abdallah S. Korayem, Samah H. Abu-Hussien, Wael Bakry Rashidy

“…Cytotoxicity testing on human skin fibroblasts (HSF) showed minimal toxicity of EOs mixture with 87.64% cell viability at 100 µg/ml. …”
Get full text

Development and validation of an LC-MS/MS method for the simultaneous estimation of tadalafil and macitentan in rat plasma: Greenness assessment and design of experiment approach by Sravanthi Gandu, Kumaraswamy Gandla, Lalitha Repudi

“…Environmental assessment using green analytical chemistry tools confirmed the eco-friendly design of the method, characterized by reduced solvent consumption and low toxicity. This validated LC-MS/MS method provides a robust and sustainable analytical solution for preclinical pharmacokinetic studies, delivering reliable data to inform safe and effective dosing of tadalafil and macitentan.…”
Get full text

Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE) by Jennifer Clough, Peter Irving, A Toby Prevost, Graham M Lord, Joana Vasconcelos, James B Canavan, Beverley Rodger, D Macallan

“…The primary endpoint is defined as the occurrence of dose-limiting toxicity occurring within 5 weeks post-infusion.Ethics and dissemination The study protocol and related documents have been approved by a NHS Research Ethics Committee, the Health Research Authority and the Medicines and Healthcare products Regulatory Agency for Clinical Trial Authorisation. …”
Get full text

Functionalization of collagen fiber with nano-islands of silver via atomic layer deposition to promote bone healing by Sarah Hashemi Astaneh, Leonardo P. Faverani, Harshdeep Bhatia, Eduardo Dallazen, Monique Gonçalves Costa, Edilson Ervolino, Valentim A.R. Barão, Cortino Sukotjo, Christos G. Takoudis

“…Comparison of gingival cells cultured on pristine collagen, and silver-coated collagen, demonstrated that the attained silver nanoparticle size and concentration are below the toxicity level of silver. In vivo assessment in rat model showed the biocompatibility of the Ag/Collagen, and greater new bone formation compared to control. …”
Get full text

Status Epilepticus due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats by Evon S. Ereifej, Seth M. Meade, Cara S. Smith, Keying Chen, Nanette Kleinman, Jeffrey R. Capadona

“…These findings are consistent with oral and intravenous administration of propylene glycol toxicity as previously reported in other species, including humans. …”
Get full text

Investigation of Heavy Metal Effects on the Anaerobic Co-Digestion Process of Waste Activated Sludge and Septic Tank Sludge by Quang-Minh Nguyen, Duy-Cam Bui, Thao Phuong, Van-Huong Doan, Thi-Nham Nguyen, Minh-Viet Nguyen, Thien-Hien Tran, Quang-Trung Do

“…These results indicated that Cu(II) had more inhibiting effect on the anaerobic digestion of the sludge mixture than Zn(II), Cr(VI), and Pb(II). The relative toxicity of these heavy metals to the co-digestion process was as follows: Cu (the most toxic) > Zn > Cr > Pb (the least toxic). …”
Get full text

Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i> by María Paz González-Troncoso, Catalina Landeta-Salgado, Javiera Munizaga, Ruth Hornedo-Ortega, María del Carmen García-Parrilla, María Elena Lienqueo

“…Crude extracts of fungal biomass were analyzed for total phenolic content (TPC), antioxidant capacity (TAC), toxicity, and phenolic compound identification using ultra-high-performance liquid chromatography coupled with high-resolution electrospray ionization mass spectrometry (UHPLC-MS/MS). …”
Get full text

Genomic Insight into <i>Vibrio</i> Isolates from Fresh Raw Mussels and Ready-to-Eat Stuffed Mussels by Artun Yibar, Muhammed Duman, Hilal Ay, Nihed Ajmi, Gorkem Tasci, Fatma Gurler, Sabire Guler, Danny Morick, Izzet Burcin Saticioglu

“…Overall, this study provides a comprehensive understanding of the genomic diversity of <i>Vibrio</i> spp. isolated from FRM and RTE-SM samples, shedding light on the prevalence, pathogenicity, and toxicity mechanisms of <i>Vibrio</i>-induced gastroenteritis.…”
Get full text

Survival after aluminum phosphide poisoning with cardiotoxicity: a case report by Habtamu Mesele Gebray, Addisu Liknaw Chekol

“…Because it is freely available on the market, it is one of the commonly used agents for self-poisoning in different parts of the developing world. Early signs of toxicity are manifested by shock and circulatory failure. …”
Get full text

Assessment of the Knowledge, Attitude, and Perception (KAP) of Sheep Farmers Regarding Ticks and Tick-Borne Pathogens in Tunisia, North Africa by Médiha Khamassi Khbou, Syrine Rekik, Rihab Romdhane, Limam Sassi, Felicitas Bergmann, Martin H. Groschup, Mourad Rekik, Mohamed Gharbi

“…As acaricides were perceived to be efficient for fighting ticks, according to 97.7% of the sheep farmers, they were used for both the animals and their sleeping areas. Although the toxicity of acaricides is known, 59.3% of the respondents did not use personal protection equipment when applying these products. …”
Get full text

Cytotoxicity Potentials of Eleven Bangladeshi Medicinal Plants by Amina Khatun, Mahmudur Rahman, Tania Haque, Md. Mahfizur Rahman, Mahfuja Akter, Subarna Akter, Afrin Jhumur

“…All the extracts showed potent to moderate cytotoxicity ranging from LC50 2 to 115 µg/mL. The highest toxicity was shown by Hygrophila spinosa seeds (LC50=2.93 µg/mL) and the lowest by Litsea glutinosa leaves (LC50=114.71 µg/mL) in comparison with standard vincristine sulphate (LC50=2.04 µg/mL). …”
Get full text

Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances by Chong Ning, Yuhan Jiao, Jiaqi Wang, Weiwei Li, Jingqiu Zhou, Yi-Chieh Lee, Dik-Lung Ma, Chung-Hang Leung, Rugang Zhu, Hui-Min David Wang

“…Natural substances have the characteristics of low toxicity and few side effects and may be key to the development of diabetic health products and preventive treatments. …”
Get full text

Gaps in cancer care in a multi-ethnic population in Sarawak, Borneo: A central referral centre study. by Melissa Siaw Han Lim, Pei Jye Voon, Adibah Ali, Fitri Suraya Mohamad, Lin Lin Jong, Lee Ping Chew, Mohamad Adam Bujang, Yolanda Augustin, Yuong Kang Cheng

“…Many patients face financial toxicity following a cancer diagnosis, particularly when diagnosed with advanced cancer requiring complex multi-modality treatment.…”
Get full text

Development of Solid Nanosystem for Delivery of Chlorhexidine with Increased Antimicrobial Activity and Decreased Cytotoxicity: Characterization and In Vitro and In Ovo Toxicologic... by Alexandra-Ioana Dănilă, Mihai Romînu, Krisztina Munteanu, Elena-Alina Moacă, Andreea Geamantan-Sîrbu, Iustin Olariu, Diana Marian, Teodora Olariu, Ioana-Cristina Talpoş-Niculescu, Raluca Mioara Cosoroabă, Ramona Popovici, Ştefania Dinu

“…After the characterization of the CHX-NPS nanosystem through infrared spectroscopy and electronic microscopy, the in vitro results showed that the CHX antimicrobial efficacy was enhanced when delivered through a nanoscale system, with improved bioavailability and reduced toxicity when this was tested as the newly CHX-NPS nanosystem. …”
Get full text

Synergistic attenuation of complete freund’s adjuvant-induced inflammation in mice using shinbaro-pelubiprofen: a novel therapeutic complex by Hyunseong Kim, Jin Young Hong, Wan-Jin Jeon, Hyun Kim, Changhwan Yeo, Junseon Lee, Yoon Jae Lee, In-Hyuk Ha

“…Additionally, while 1.5 mg/kg of Pel alone increases levels of liver and kidney toxicity markers, such as aspartate aminotransferase, alanine aminotransferase, and creatinine, combining it with SBR at a reduced dosage of 0.5 mg/kg maintains these markers at normal levels. …”
Get full text