Network pharmacology: a crucial approach in traditional Chinese medicine research by Yiyan Zhai, Liu Liu, Fanqin Zhang, Xiaodong Chen, Haojia Wang, Jiying Zhou, Keyan Chai, Jiangying Liu, Huiling Lei, Peiying Lu, Meiling Guo, Jincheng Guo, Jiarui Wu

“…The application of network pharmacology in TCM is widespread, covering areas such as identifying the material basis of TCM efficacy, unraveling mechanisms of action, and evaluating toxicity, safety, and novel drug development. However, challenges remain, such as the lack of standardized data collection across databases and insufficient consideration of processed herbs in research. …”
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Growth and viability of juvenile humpback grouper (Cromileptes altivelis) supplemented with inorganic and organic selenium by Muhaimin Hamzah, Muhammad Agus Suprayudi, Nur Bambang Priyo Utomo, Wasmen Manalu

“…On the contrary, supplementation of selenomethionine up to 4 mg Se/kg did not show any signs of toxicity and the survival was on 86.11 to 97.22%. Feed efficiency, protein retention, lipid retention, and Se retention indicated that a dosage of 4 mg Se/kg selenomethionine supplementation was the best dosage. …”
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The effect of ozone exposure on the release of eicosanoids in guinea-pig BAL fluid in relation to cellular damage and inflammation by H. J. M. Van Hoof, F. J. Zijlstra, H-P. Voss, I. M. Garrelds, J. A. M. A. Dormans, L. Van Bree, A. Bast

“…We hypothesized that depending on the O3 exposure protocol, mainly either an oxidant damage or an inflammation will determine the O3 toxicity. We compared two different ozone exposure protocols: an acute exposure (3 ppm 2 h) for studying the oxidant damage and an exposure (1 ppm 12 h) where an inflammatory component is also probably involved. …”
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Anti-Inflammatory Activities of Some Plants of Genus Alpinia: Insights from In Vitro, In Vivo, and Human Studies by Yuliawati KM, Febriyanti RM, Sumiwi SA, Levita J

“…These plants did not show toxicity toward numerous normal cell lines (RAW 264.7, IEC-6, HepG2, MT-4, NIH-3T3, Vero cells, human peripheral blood mononuclear cells, and HaCaT) but were toxic to cancer cell lines (HT29). …”
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Investigation study of face mask consumption in Malaysia and its impact on environment by Low Chung-Yu, Bee Soo-Tueen, Law Yung-Siang, Lee Tin-Sin, Bee Soo-Ling

“…In overall, RFL washable face mask is found to provide a lower environmental impact when compared to 3-ply surgical face mask in terms of the ReCiPe midpoint and endpoint indicator, which included Global Warming Potential, Photochemical Oxidant Formation Potential, Toxicity Potential, Ecosystem Quality, Human Health and Resource Depletion.…”
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Applications of cell penetrating peptide-based drug delivery system in immunotherapy by Jing-Jing Du, Ru-Yan Zhang, Shangchi Jiang, Shanshan Xiao, Yiting Liu, Yongheng Niu, Wen-Xiang Zhao, Dongyuan Wang, Dongyuan Wang, XianShi Ma

“…Besides, inappropriate chemical modification can lead to membrane disruption and nonspecific toxicity. In this paper, we first reviewed recent advances in the CPP applications for cancer therapy via covalent or non-covalent manners. …”
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Hypoglycemic natural products with in vivo activities and their mechanisms: a review by Wenyi Ma, Longgao Xiao, Haiyang Liu, Xiaojiang Hao

“…Natural products (NPs) are a reservoir of diverse structures and bioactivities with low toxicity and less side effects. And some of them show effects on diabetic complications, which is a significant idea for drug development. …”
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Effect of Nano-Silica on Mechanical Properties and Cytotoxicity of Calcium-Silicate-Based Root Canal Filling Materials by Hao He, Bolang Hao, Xiang Xiong, Yi Cheng, Jia Lou, Zheyu He, Dongyang Li, Zhihuan Wang, Jian Qin

“…The findings of this study demonstrate that the early compressive strength of calcium-silicate-based root canal filling materials exhibits a substantial increase in response to the incorporation of NS, and that calcium-silicate-based root canal filling materials do not manifest significant levels of toxicity. NS improved hydration product formation and made efficient pore filling possible.…”
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Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review by Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

“…Persistent organic pollutants (POPs) are pervasive organic chemicals with significant environmental and ecological ramifications, extending to adverse human health effects due to their toxicity and persistence. The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, mucosal chemistry, and cellular immunity, shields the host from external threats and fosters a symbiotic relationship with intestinal bacteria. …”
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Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes by Rauda A. Mohamed, Keat K. Ong, Noor Azilah M. Kasim, Norhana A. Halim, Siti Aminah M. Noor, Victor F. Knight, Nurul Najwa Ab. Rahman, Wan Md Zin W. Yunus

“…However, many questions remain unanswered regarding the efficacy and toxicity of this reactivator. Pralidoxime, MMB-4, TMB-4, obidoxime, and HI-6 are the examples of the established oximes, yet they are of insufficient effectiveness in some poisonings and only a limited spectrum of the different nerve agents and pesticides are being covered. …”
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Assessment of Health Risks in Wheat Crop Irrigated by Manka Canal, Dera Ghazi Khan, Pakistan by Muhammad Anwar ul Hassan, Sabiha Javied, Umair Riaz, Muneera A. Saleh, Khalid H. Alamer, Naila Siddique, Ambreen Aslam, Nabeela Noor, Qamar uz Zaman

“…Prior to irrigating crops like wheat and vegetables, it is strongly advised to treat municipal wastewater to prevent soil and dietary toxicity from heavy metals.…”
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4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies by Ashanul Haque, Khalaf M. Alenezi, Mohd. Saeed Maulana Abdul Rasheed, Md. Ataur Rahman, Saleha Anwar, Shahzaib Ahamad, Dinesh Gupta

“…The drug-likeness feature and toxicity of the molecules were evaluated using QikProp and other tools.ResultsCompounds were synthesized following a multi-step approach and characterized using multi-nuclear magnetic resonance (1H/13C-NMR) and mass spectrometry. …”
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Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA by Tobias Solli Iveland, Lars Hagen, Mirta Mittelstedt Leal de Sousa, Nina Beate Liabakk, Per Arne Aas, Animesh Sharma, Bodil Kavli, Geir Slupphaug

“…Contrary to the conventional model of antifolate toxicity, which implicates futile cycles of uracil incorporation and excision in DNA, we propose that ribonucleotide incorporation in nuclear and mitochondrial DNA significantly contributes to the cytotoxicity of antifolates like pemetrexed, and likely also of fluorinated pyrimidine analogs. …”
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Neurovascular bundle sparing in hypofractionated radiotherapy maintained with realistic treatment uncertainties by Roel C. Kwakernaak, Victor J. Brand, Jesús Rojo-Santiago, Femke E. Froklage, Mischa S. Hoogeman, Steven J.M. Habraken, Maaike T.W. Milder

“…Background and purpose: Erectile dysfunction is a common side effect of radiotherapy for prostate cancer. To mitigate this toxicity, it has been suggested to limit the dose to critical nerves and vessels. …”
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Sources of Lipopeptides and Their Applications in Food and Human Health: A Review by Shuyi Chen, Sumin Chen, Xin Yu, Caijing Wan, Ying Wang, Lianxin Peng, Qiang Li

“…Lipopeptides (LPs) are widely sourced surface-active natural products with a wide range of functions and low toxicity, high potency, and good biodegradability. …”
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Electrochemical sensor doped with core-shell structured molecularly imprinted polymer proposed for therapeutic drug monitoring of trazodone hydrochloride by Amr M. Mahmoud, Nariman A. El-Ragehy, Maha A. Hegazy, Samia A. Tawfik, Ghada A. Sedik

“…Its detection is significant for ensuring effective therapeutic drug monitoring as it has a narrow therapeutic window in addition to optimize dosages, prevent toxicity, and enhance treatment outcomes. MIP with a uniform core shell structure was prepared where the shell was combined onto the surface of silica nanoparticles by copolymerizing ethylene glycol dimethacrylate together with methacrylic acid in the presence of trazodone hydrochloride. …”
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Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product by Afolabi C. Akinmoladun, Kehinde O. Oguntunde, Lawrence O. Owolabi, Omotayo B. Ilesanmi, Joan O. Ogundele, M.Tolulope Olaleye, Afolabi A. Akindahunsi

“…In this study, Trévo™, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in acetaminophen-induced hepatic toxicity in Wistar rats. Animals received Trévo™ (1.5 mL/kg, 3.0 mL/kg or 4.5 mL/kg) orally for 14 days. …”
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Design and In Silico and In Vitro Evaluations of a Novel Nicotinamide Derivative as a VEGFR-2 Inhibitor by Ibrahim H. Eissa, Muhammad Abd ElGayed Bkrah, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Dalal Z. Husein

“…Furthermore, compound 10 demonstrated a lower level of toxicity towards Vero cell lines, with an IC50 value of 127.3 μM. …”
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Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer by Brock J. Sishc, Janapriya Saha, Elizabeth M. Alves, Lianghao Ding, Huiming Lu, Shih-Ya Wang, Katy L. Swancutt, James H. Nicholson, Angelica Facoetti, Arnold Pompos, Mario Ciocca, Todd A. Aguilera, Michael D. Story, Anthony J. Davis

“…These findings suggest that PDAC tumors with HR pathway mutations or high replication stress are more likely to benefit from CIRT while minimizing normal tissue toxicity.…”
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Safety assessment of the substance 2,2′‐oxydiethylamine for use in plastic food contact materials by EFSA Panel on Food Contact Materials (FCM), Claude Lambré, Riccardo Crebelli, Maria deSilva, Konrad Grob, Evgenia Lampi, Maria Rosaria Milana, Marja Pronk, Mario Ščetar, Georgios Theodoridis, Els Van Hoeck, Nadia Waegeneers, Claudia Bolognesi, Ronan Cariou, Laurence Castle, Emma Di Consiglio, Roland Franz, Eric Barthélémy, Remigio Marano, Gilles Rivière

“…Based on these data, the Panel excluded genotoxicity concerns for the substance and its oligomers. From a 90‐day toxicity study on the 1‐oxa‐4,11,18‐triazacycloeicosane‐5,10,17‐trione, the Panel identified a NOAEL of 1040 mg/kg bw per day. …”
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