Effects of aluminum on metabolism of reactive oxygen species and reactive nitrogen species in root tips of different Eucalyptus species by Zilong Ouyang, Bing Liu, Tangkan Li, Tiandao Bai, Weichao Teng

“…The tolerance of E. urophylla and E. urophylla × E. grandis to Al stress was stronger than that of E. grandis and E. tereticornis. Differences in Al toxicity tolerance were related to long-term selection of the original habitat of the species; moreover, the Al tolerance was hereditary. …”
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Identifying common pathways for doxorubicin and carfilzomib-induced cardiotoxicities: transcriptomic and epigenetic profiling by Conagh Kelly, Dylan J. Kiltschewskij, Angeline J.W. Leong, Tatt Jhong Haw, Amanda J. Croft, Lohis Balachandran, Dongqing Chen, Danielle R. Bond, Heather J. Lee, Murray J. Cairns, Aaron L. Sverdlov, Doan T. M. Ngo

“…Abstract Cancer therapy-related cardiovascular toxicity (CTR-CVT) is now recognised as one of the leading causes of long-term morbidity and mortality in cancer patients. …”
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DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities by Wen-yu Cai, Xin-xian Cai, Yi-ran Fei, Rui Ye, Ding-ming Song, Dan Hu, Wan-wan Zhang, Ming-fei Xia, Xiao-xiao Yang

“…We discuss the underlying mechanisms that enable these therapeutic synergies, preclinical and clinical evidence supporting the approach, and the challenges posed by tumor heterogeneity, drug resistance, and toxicity. Finally, we explore the potential for personalized treatment strategies incorporating multi-omics data to optimize therapeutic outcomes. …”
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Leveraging computational approaches in identifying novel HER-2 + breast cancer potential therapeutics: integrating virtual screening and molecular dynamics simulation by Olawale Quadri Bolaji, Temitope Isaac Adelusi, Taiwo Ooreoluwa Ojo, Ibrahim Damilare Boyenle, Abdul-Quddus Kehinde Oyedele, Taiwo Temitope Ogunjobi, Adegboye Oyewole Oyaronbi, Sukurat Oluwatoyin Ayoola, Abdeen Tunde Ogunlana

“…Additionally, binding free energy calculations, ADME and toxicity profiling, and molecular dynamics simulations presented these compounds as lead-like. …”
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Determination of the Selected Heavy Metal Content and Its Associated Health Risks in Selected Vegetables Marketed in Bahir Dar Town, Northwest Ethiopia by Biset Asrade, Gebremariam Ketema

“…However, they are a major source of heavy metals, which contain both essential and toxic heavy metals over a wide range of concentrations. …”
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Analysing the effect of Quinalphos pesticide on fish health through molecular docking studies and their eradication by photocatalytic degradation using Fe/S/TiO2 nanocomposite by Anisha Russelraj, Sibmah Stalin, Kirupa Jino

“…Furthermore, the reduction in toxicity level of the effluent was examined by using aquatic organisms. …”
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Outcome of Very Late Relapse in Patients with Hodgkin's Lymphomas by Francesco Gaudio, Annamaria Giordano, Vincenzo Pavone, Tommasina Perrone, Paola Curci, Domenico Pastore, Mario Delia, Clara de' Risi, Alessandro Spina, Vincenzo Liso, Giorgina Specchia

“…The aim of this study is to report a single centre experience of the clinical characteristics, outcome, and toxicity of pts who experienced very late relapses, defined as relapses that occurred 5 or more years after the achievement of first complete remission. …”
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Ameliorated Impact of Fenugreek Seed Extract on Some Blood Cellular and Biochemical Parameters in Female Albino Rats Exposed to Lead Acetate by Rozhya Abduljalil Naser, Rabar Yousif Mameik, Nazar M. Shareef Mahmood, Kurdo Bapir Chato

“…It has a several diverse-organ toxicant effect in various healthy issues included diseases of the hepatic, renal, and other body systems. …”
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Computational and GC-MS screening of bioactive compounds from Thymus Vulgaris targeting mycolactone protein associated with Buruli ulcer by Muhammad Naveed, Imran Ali, Tariq Aziz, Ayesha Saleem, Zeerwah Rajpoot, Sameera Khaleel, Ayaz Ali Khan, Mitub Al-harbi, Thamer H. Albekairi

“…The leads identified in the study have demonstrated encouraging outcomes with regard to their efficacy, toxicity, pharmacokinetics, and safety. Further experimental investigations can be conducted to evaluate their anti-bacterial activity, and their molecular frameworks could be utilized as a valuable foundation for designing new drugs for the treatment of Buruli ulcer.…”
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Cytopenia among CML Patients on Imatinib in Kenya: Types, Grades, and Time Course by Angela McLigeyo, Jamilla Rajab, Mohammed Ezzi, Peter Oyiro, Yatich Bett, Andrew Odhiambo, Matilda Ong’ondi, Sitna Mwanzi, Mercy Gatua, NAOthieno- Abinya

“…Patients on imatinib treatment may develop cytopenia due to drug toxicity. This study aimed to determine the types, grades, and time course of cytopenia in CML patients on imatinib at a Nairobi hospital. …”
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Effects of fiber engraving laser on metallurgical, surface topography, and corrosion properties of AZ80 magnesium-based alloy by Narges Ahmadi, Homam Naffakh-Moosavy, Seyed Mohammad Mahdi Hadavi, Fatemeh Bagheri

“…Magnesium, a lightweight metal similar to natural bone, shows no toxicity and can aid in hard tissue recovery when implanted in the human body. …”
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From guideline to practice: three years of ICH S11 insights and recommendations by Diana Tavares, Hsiao-Tzu Chien, Hsiao-Tzu Chien, Maria Elzbieta Sheean, Peter Theunissen, Peter Theunissen, Peter van Meer, Peter van Meer, Peter van Meer, Karen Van Malderen

“…A thorough consideration of developmental aspects of the product’s pharmacological target, the clinical relevance of notable toxicity findings, and the clinical context of the medicine’s use fosters effective dialogue and improves regulatory alignment. …”
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Rationale and design of the multicenter, national, randomized, open labeled phase III trial: allogeneic stem cell transplantation as a potential curative treatment for patients wit... by Annemarie Glöckner, Stefan Schönland, Hermann Einsele, Nicolaus Kröger

“…Discussion The present clinical study is designed to evaluate the superiority of allogeneic stem cell transplantation compared to conventional therapy (triplet chemotherapy) for the difference in overall survival at 5 years, toxicity and quality of life in patients with multiple myeloma who have relapsed or progressed after first-line autologous stem cell therapy. …”
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A rare case of acute myocardial infarction with heart failure following hump-nosed viper bite in a Sri Lankan female by W. M. D. A. S. Wanninayake, Tilan Aponso, Manohari Seneviratne, Dhanapala Dissanayake

“…However, recent reports have indicated severe systemic envenomation incidents, which include hemostatic dysfunction, microangiopathic hemolysis, kidney injury, myocardial toxicity, and even death. The literature rarely reports cardiac manifestations from hump-nosed viper bites, and all reported cases show cardiac manifestations within hours of the snake bite. …”
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Development and Validation of an RP-HPLC Method for the Quantitative Analysis of Triclosan in Human Urine by Prince Karikari, James Oppong-Kyekyeku, Edmund Ekuadzi, Samuel Oppong Bekoe, Rita Opoku, Daniel Nimako Amprako, Emmanuel Addo-Yobo, Sandra Kwarteng Owusu, Bernard Arhin, Adegoke G. Falade, Ganiyu Arinola, Adeleye S. Bakarey, John I. Anetor, Kevin J. Mortimer

“…TCS has sparked widespread awareness because of its toxicity and possible negative effect on public health in recent years. …”
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Sublethal effects of copper nanoparticles on the histology of gill, liver and kidney of the Caspian roach, Rutilus rutilus caspicus by Sh. Aghamirkarimi, A. Mashinchian Moradi, I. Sharifpour, Sh. Jamili, P. Ghavam Mostafavi

“…The current study has determined the toxicity effects of copper nanoparticles on the some vital organs such as gill, liver and kidney of Caspian Roach; Rutillus rutillus caspicus. …”
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An integrated strategy for sequential nitrite removal and methane recovery: Sludge fermentation driven by nitrite reduction by Xiaodi Li, Mengxue Sun, Bo Wang, Wei Zeng, Yongzhen Peng

“…With the nitrite concentrations increasing from 200 to 800 mg/L methane production decreased from 128.7 to 0 mg/L at the digestion time of 15 d. The toxicity of nitrite to methanogenic microorganisms and the nitrite reduction process competing with methanogens for carbon sources may lead to the inhibition of methane production by excessive nitrite. …”
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Molecular Dynamics Insights into Peptide-Based Tetrodotoxin Delivery Nanostructures by Shenghan Song, Xinyu Xia, Temair Shorty, Tongtong Li, Amy O. Stevens, Chao Zhao, Yi He

“…To fully leverage TTX’s capabilities as a local anesthetic, it is crucial to develop a drug delivery system that balances its systemic toxicity with its therapeutic efficacy. Recent studies have shown that peptide mixtures, derived from fragments of Site-1 sodium channel proteins and enhanced with hydrophobic tails (designated MP1 and MP2), can self-assemble into nanostructures that exhibit remarkable sustained-release capabilities for TTX. …”
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Application of Novel Amino-Functionalized NZVI@SiO2 Nanoparticles to Enhance Anaerobic Granular Sludge Removal of 2,4,6-Trichlorophenol by Zeyu Guan, Jinquan Wan, Yongwen Ma, Yan Wang, Yajie Shu

“…Moreover, adding the appropriate concentration of NZVI@SiO2-NH2 in anaerobic granular sludge treatment system can decrease the toxicity of 2,4,6-TCP to anaerobic microorganisms and improved the cumulative amount of methane production and electron transport system activity. …”
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Nanoplastics induces arrhythmia in human stem-cells derived cardiomyocytes by Shirley Pei Shan Chia, Jeremy Kah Sheng Pang, Winanto Winanto, Boon-Seng Soh

“…Further research is needed to fully elucidate the mechanisms underlying NP-induced toxicity and to develop strategies for mitigating their adverse effects. …”
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