Showing 2,401 - 2,420 results of 3,629 for search '"Toxicity"', query time: 0.07s Refine Results
  1. 2401

    Investigation of the optimal platinum-based regimen in the postoperative adjuvant chemotherapy setting for early-stage resected non-small lung cancer: a Bayesian network meta-analy... by Li Zhang, Wen-Feng Fang, Yi Lv, Lan-Lan Pang, Jia-Di Gan, Yi-Hua Huang, Jun Liao, Wael Abdullah-Sultan Ali

    Published 2022-06-01
    “…The secondary outcome was the rate of grade 3–4 toxicity assessments. Cochrane Handbook (V.5) was used for the risk of bias assessment. …”
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  2. 2402

    Manual of Clinical anesthesiology :

    Published 2021
    Table of Contents: “…-- Hemodynamic collapse following a mainstem intubation -- Hypoxemia during tracheostomy -- Anesthetic depth and mask ventilation in the prone position -- Jet ventilation through a cookgas airway exchange catheter -- End of case evaluation and management of a patient post airway mass excision -- Possible recurrent laryngeal nerve injury -- Obstructive sleep apnea, and dead in bed -- Bilevel positive air pressure, decreased sensorium, aspiration and capnography -- Perioperative management of a patient previously treated with bleomycin undergoing thoracic surgery -- Intra-operative airway fire -- Obesity hypoventilation syndrome -- Circulation-related cases -- Hemorrhage during endovascular repair of thoracic aorta -- Pacemakers and automatic implantable cardioverter defibrillators -- Acute myocardial infarction during laparoscopic surgery -- Sickle cell and preeclampsia -- Dysrhythmias in a patient with Crohn's disease -- Hematologic disorders: hemophilia and disseminated intravascular coagulation -- Blood transfusion and the Jehovah's Witness patient -- Cardiac and pulmonary contusions -- Intraoperative coagulopathy -- Hypotension in chronic methamphetamine user -- Venous air embolism during arteriovenous malformation repair -- Cardiac tamponade -- Case of intraoperative new-onset atrial fibrillation -- Valvular disease -- Obstetrics-related cases -- Labor epidural with unrecognized dural puncture, causing high sensory block, hypotension, fetal bradycardia and post dural puncture headache -- Acute pulmonary dysfunction immediately after cesarean delivery under general anesthesia -- Jehovah's Witness with placenta previa and increta for cesarean hysterectomy -- A pregnant patient with mitral stenosis -- Unrecognized uterine hyperstimulation due to oxytocin and combined spinal-epidural analgesia -- Super morbidly obese patient for elective repeat cesarean section -- Probable amniotic fluid embolus -- Emergent cesarean section -- Pregnancy plus atrial septal defect vs Eisenmenger Syndrome -- Uterine abruption -- Pediatric-related cases -- Neonatal resuscitation following spontaneous vaginal delivery -- Anxious, coughing and bound to obstruct -- Special diseases/conditions/situations -- Hypothermia during laparoscopic nephrectomy -- Operating room management case scenarios -- Anaphylaxis reactions -- Autonomic dysreflexia -- Porphyrias -- Monitored anesthesia care: medical implications; and wrong-sided operations: legal implications -- Diabetic ketoacidosis in the urgent anesthesia setting -- Fever, altered mental status, and rigidity in the perioperative course -- Neuro/neuromuscular-related cases -- Emergent craniotomy for evacuation of epidural hematoma -- Hyperkalemia and residual neuromuscular blockade after kidney transplantation -- A defasciculating dose of nondepolarizing neuromuscular blocker -- Postoperative monocular vision loss -- Delayed emergence after aneurysm clipping -- Pain and regional anesthesia related cases -- Unintentional dural puncture in a patient with severe preeclampsia -- Complex regional pain syndrome -- Vascular absorption of local anesthetic producing systemic toxicity -- Inadvertent high spinal in parturient -- Outpatient surgery-related cases -- Plastic surgery in a surgeon's office -- Orthopedic surgery in an ambulatory surgicenter -- Eye surgery at an outpatient surgicenter -- Endoscopic sinus surgery at an outpatient sugicenter.…”
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  3. 2403

    A first evaluation of the efficacy of minibeam radiation therapy combined with an immune check point inhibitor in a model of glioma-bearing rats by Lorea Iturri, Emmanuel Jouglar, Cristèle Gilbert, Julie Espenon, Marjorie Juchaux, Yolanda Prezado

    Published 2025-03-01
    “…The combination of CRT plus ICI appeared to be toxic. MBRT + ICI surpassed the survival rate with respect to ICI alone. …”
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  4. 2404
  5. 2405

    IFN-γ reprograms cardiac microvascular endothelial cells to mediate doxorubicin transport and influences the sensitivity of mice to doxorubicin-induced cardiotoxicity by Haoyu Ji, Wenya Ma, Xu Liu, Hongyang Chen, Yining Liu, Zhongyu Ren, Daohong Yin, Ao Cai, Zizhen Zhang, Xin Wang, Wei Huang, Leping Shi, Yanan Tian, Yang Yu, Xiuxiu Wang, Yang Li, Yu Liu, Benzhi Cai

    Published 2025-01-01
    “…Abstract Doxorubicin (DOX) is a first-line chemotherapy agent known for its cardiac toxicity. DOX-induced cardiotoxicity (DIC) severely limits the use for treating malignant tumors and is associated with a poor prognosis. …”
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  6. 2406

    Spireoside Controls Blast Disease by Disrupting Membrane Integrity of Magnaporthe oryzae by Xu Liting, He Kaiwei, Guo Chunyu, Quan Cantao, Ma Yahuan, Zhang Wei, Ren Lifen, Wang Long, Song Li, Ouyang Qing, Yin Junjie, Zhu Xiaobo, Tang Yongyan, He Min, Chen Xuewei, Li Weitao

    Published 2025-01-01
    “…Plant secondary metabolites typically exhibit broad-spectrum antifungal activity without selective toxicity against pathogens. However, only a small fraction of antifungal metabolites have been identified from the tens of thousands of known plant secondary metabolites. …”
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  7. 2407

    Production of ACE inhibitory peptides via ultrasonic-assisted enzymatic hydrolysis of microalgal Chlorella protein: Process improvement, fractionation, identification, and in silic... by Jeeraporn Pekkoh, Apiwit Kamngoen, Antira Wichaphian, May Thu Zin, Supakit Chaipoot, Kamon Yakul, Wasu Pathom-aree, Wageeporn Maneechote, Benjamas Cheirsilp, Kuan Shiong Khoo, Sirasit Srinuanpan

    Published 2025-06-01
    “…More importantly, in silico structure-activity relationship analysis proved the non-toxicity of the identified LMW peptides. The result indicates a potential link between 47 LMW peptides and the inhibition of ACE activity, suggesting that microalgae protein hydrolysate and peptides could be developed into new treatments for CVD and hypertension. …”
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  8. 2408

    Hepatoprotection and Phytochemistry of the Vietnamese Herbs Cleome chelidonii and Cleome viscosa Stems by Nhat Minh Phan, Thi Hong Tuoi Do, Le Thanh Tuyen Nguyen, Trong Tuan Nguyen, Quoc Luan Ngo, Trong Duc Tran, Quan Hien Nguyen, Bui Linh Chi Huynh, Diep Xuan Ky Nguyen, Trong Dat Bui, Dinh Tri Mai, Tan Phat Nguyen

    Published 2021-01-01
    “…The study aims to determine the hepatoprotective effect of n-hexane, ethyl acetate, and methanol extracts of the leaves and stems of two Cleome species against carbon tetrachloride- (CCl4-) induced liver toxicity both in vitro using human hepatoma (HepG2) cells and in vivo in rats as well as the hepatoprotective property of all isolated compounds on HepG2. …”
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  9. 2409

    Mechanisms underlying the effects of cyanogenesis on development and reproduction of Tetranychus urticae: Insights from enzyme activity and gene expression aspects by Mufeng Wu, Xiao Liang, Ying Liu, Chunling Wu, Xingkui An, Zihua Zhao, Guifeng Hao, Ijiti Oluwole Gregory, Zhihong Li, Qing Chen

    Published 2025-01-01
    “…Numerous studies have speculated this CNG-mediated toxicity by a plant-pest interaction manner. However, the specific toxic effect of HCN was not well-demonstrated because of the interference of other ingested metabolites. …”
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  10. 2410
  11. 2411

    Self-propelled ferroptosis nanoinducer for enhanced cancer therapy by Wenxin Xu, Hao Tian, Yanzhen Song, Hanfeng Qin, Junbin Gao, Yichi Chen, Weichang Huang, Lin Lin, Haixin Tan, Yicheng Ye, Xiaoting Zhang, Daniela A Wilson, Guang Yang, Fei Peng, Yingfeng Tu

    Published 2025-01-01
    “…However, the development of ferroptosis-based nanotherapeutics is generally hindered by the limited penetration depth in tumors, poor active pharmaceutical ingredient (API) loading content and the systemic toxicity. Herein, self-propelled ferroptosis nanoinducers composed of two endogenous proteins, glucose oxidase and ferritin, are presented to show enhanced tumor inhibition via ferroptosis while maintaining high API and biocompatibility. …”
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  12. 2412
  13. 2413

    Analytical methods for nanomaterials investigation in food and food-related materials by Daniele Passeri, Pierfrancesco Atanasio, Anacleto Proietti, Chiara Mancini, Flavio Cognigni, Giancarlo La Penna, Luca Buccini, Marco Rossi, Anna Chiara Turco, Marilena D'Amato, Angela Sorbo, Simone Dinarelli, Giulia D'Ettorre, Federica Aureli

    Published 2025-06-01
    “…All these improvements, however, need to be achieved in a ‘safe’ way, thus there is a wide and constantly updated legislation that deals with the possible toxicity of these additions by posing some limitation to the percentage of nanosized elements added and to their composition. …”
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  14. 2414

    3-methyl-4-nitrophenol disturbs the maternal-to-zygotic transition of early embryos by damaging mitochondrial function and histone modification by Fan Chen, An-Feng Luo, Kai-Xin Pan, Hao Gu, Chang-Fan Zhou, Wei Zeng, Song Liu, Adrian Molenaar, Hong-Yan Ren, Li-Jun Huo, Yan-Zhen Bi

    Published 2025-01-01
    “…Despite its global recognition as an endocrine disruptor with documented reproductive toxicity, its detrimental impact on preimplantation embryonic development has yet to be thoroughly investigated. …”
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  15. 2415

    Ginger-Derived Exosome-Like Nanoparticles Loaded With Indocyanine Green Enhances Phototherapy Efficacy for Breast Cancer by Guo Z, Li G, Shen L, Pan J, Dou D, Gong Y, Shi W, Sun Y, Zhang Y, Ma K, Cui C, Li W, Liu Q, Zhu X

    Published 2025-01-01
    “…Furthermore, in vivo studies demonstrated that engineered GDNPs@ICG significantly inhibited breast tumor growth and presented limited toxicity. Moreover, by detecting the expression of CD31, N-cadherin, IL-6, IFN-γ, CD8, p16, p21, and p53 in tumor tissues, we found that GDNPs@ICG substantially reduced angiogenesis, inhibited metastasis, activated the anti-tumor immune response, and promoted cell senescence in breast tumor.Conclusion: Our study demonstrated that the novel bio-nanoplatform GDNPs@ICG enhanced the photo-mediated therapeutic effect in breast tumor. …”
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  16. 2416

    Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Laetitia Fend, Eric Quemeneur, Monika Semmrich, Jean-Baptiste Marchand, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Björn Frendeus, Petra Holmkvist, Carolin Svensson, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén

    Published 2022-01-01
    “…Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) is one of few clinically validated targets for ICB, but toxicities linked to efficacy in approved αCTLA-4 regimens have restricted their use and precluded full therapeutic dosing. …”
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  17. 2417

    Chemical Composition of Mexicali Propolis and Its Effect on Gastric Repair in an Indomethacin-Induced Gastric Injury Murine Model by Pilar Dominguez-Verano, Nadia Jacobo-Herrera, Andrés Castell-Rodríguez, Octavio Canales-Alvarez, Maria Margarita Canales-Martinez, Marco Aurelio Rodriguez-Monroy

    Published 2025-01-01
    “…Prior to the evaluation, MeEEP was found to exhibit low oral toxicity, as determined under the Organisation for Economic Co-operation and Development (OECD) 425 guidelines. …”
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  18. 2418

    Metabolic reprogramming and immunological changes in the microenvironment of esophageal cancer: future directions and prospects by Zhi-Xun Guo, Jia-Li Ma, Jin-Qiu Zhang, Ling-Ling Yan, Ying Zhou, Xin-li Mao, Xin-li Mao, Xin-li Mao, Shao-Wei Li, Shao-Wei Li, Shao-Wei Li, Xian-Bin Zhou, Xian-Bin Zhou, Xian-Bin Zhou

    Published 2025-01-01
    “…Current treatment modalities for esophageal cancer primarily include encompass chemotherapy and a limited array of targeted therapies, which are hampered by toxicity and drug resistance issues. Immunotherapy, particularly immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 pathway, has exhibited promising results; however, a substantial proportion of patients remain unresponsive. …”
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  19. 2419

    Metformin exerted tumoricidal effects on colon cancer tumoroids via the regulation of autophagy pathway by Roya Shabkhizan, Çığır Biray Avci, Sanya Haiaty, Marziyeh Sadat Moslehian, Fatemeh Sadeghsoltani, Ahad Bazmani, Mahdi Mahdipour, Leila Sabour Takanlou, Maryam Sabour Takanlou, Arezoo Rezaie Nezhad Zamani, Reza Rahbarghazi

    Published 2025-02-01
    “…Despite slight changes in released LDH contents, no statistically significant differences were achieved in terms of cell toxicity in MTF-exposed groups compared to the control tumoroids, indicating the insufficiency of MTF in the induction of tumor cell death (p > 0.05). …”
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  20. 2420