Combining solubilization and controlled release strategies to prepare pH-sensitive solid dispersion loaded with albendazole: in vitro and in vivo studies by Dehai Su, Mingyang Bai, Chaoqun Wei, Xiangyang Long, Xuezhen Liu, Xiangguang Shen, Huanzhong Ding

“…Additionally, high dosing regimens of ABZ pose risks of developmental toxicity in animal models. This study developed a pH-sensitive solid dispersion of albendazole (ABZ-pHs-SD) using Glyceryl Monostearate (GM) in conjunction with Hypromellose Acetate Succinate (HPMC-AS). …”
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Transcriptional Targeting of Mature Dendritic Cells with Adenoviral Vectors via a Modular Promoter System for Antigen Expression and Functional Manipulation by Ilka Knippertz, Andrea Deinzer, Jan Dörrie, Niels Schaft, Dirk M. Nettelbeck, Alexander Steinkasserer

“…As this involves overexpressing mHSF1, we first evaluated the resulting effects on DCs regarding upregulation of heat shock proteins and maturation markers, toxicity, cytokine profile, and capacity to induce antigen-specific CD8+ T cells. …”
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Potassium-pillared Na4FeV(PO4)3@C cathode for high-performance sodium-ion batteries by Jiafeng Zhou, Wei Zhang, Jin Bai, Qingqing Wang, Bo Ding, Hao Gong

“…However, it still suffers from the toxicity and high cost of vanadium elements, coupled with low electronic conductivity. …”
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Formulation and evaluation of hyaluronic acid and adipic acid dihydrazide modified graphene quantum dot-based nanotherapeutics for paclitaxel-targeted delivery in breast cancer by Dilip O. Morani, Pravin O. Patil

“…Thus, this research paper aimed to develop PAC-loaded nanoparticles to lessen toxicity and boost PAC's solubility in water. In this case, hyaluronic acid (HA), graphene quantum dots (GQDs), and adipic acid dihydrazide (ADH) have been combined in a unique way to suggest pH-responsive nanoconjugates that can improve the therapeutic effect of medicinal molecule PAC with fluorescence and breast cancer targeting. …”
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Morphology of Welding Fume Derived from Stainless Steels Arc Welding by J. Wyciślik-Sośnierz, J. Matusiak, J. Adamiec, M. Lemanowicz, R. Kusiorowski, A. Gerle

“…The combined analysis of these factors determines the toxicity of fume and its impact on the human body. …”
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Protective effects of resveratrol on the expression of catalase, glutathione peroxidase, and superoxide dismutase genes in the ovary and their activity in the serum of rats exposed... by Mohammad Karimian, Mozhdeh Ghadiri, Seyedeh Mahsa Poormoosavi, Hossein Najafzadehvarzi

“… Background: Lead (Pb) could be toxic to the female reproductive system, and resveratrol (Res) may overcome this toxicity. …”
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A Combined Computational and Experimental Study on Nanoparticle Transport and Partitioning in the Human Trachea and Upper Bronchial Airways by Jiawei Ma, Wei-Chung Su, Yi Chen, Yidan Shang, Jingliang Dong, Jiyuan Tu, Lin Tian

“…Abstract In the past few decades, the transport and deposition of aerosol in the human respiratory tract has been a crucial area of research, resulting in the identification of the toxicity pathways of inhaled pollutants and facilitating the design of efficient drug delivery systems for targeted treatment. …”
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Biological Effect of Organically Coated Grias neuberthii and Persea americana Silver Nanoparticles on HeLa and MCF-7 Cancer Cell Lines by Lizeth Salazar, María José Vallejo López, Marcelo Grijalva, Luis Castillo, Alexander Maldonado

“…Cell viability assays along with gene expression levels in treated MCF-7 cells support a cancer cell population undergoing cell cycle arrest. The selective toxicity of biosynthesized piton/avocado AgNPs on MCF-7 cells might be of value for novel therapeutics.…”
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Gengnianchun Recipe Protects Ovarian Reserve of Rats Treated by 4-Vinylcyclohexene Diepoxide via the AKT Pathway by Fangui Zhao, Wenjun Wang

“…Taken together, these findings suggest that high-dose GNC could protect ovarian reserve against VCD-induced toxicity via the activation of the AKT signaling pathway and reduced cell apoptosis in SD Rats. …”
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In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice by Hana Biruk, Biruk Sentayehu, Yonatan Alebachew, Wondmagegn Tamiru, Abebe Ejigu, Solomon Assefa

“…Results. The in vivo acute toxicity test indicated that both extracts of T. brownii did not cause mortality. …”
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Preparation, characterisation, and in vitro cancer‐suppression function of RNA nanoparticles carrying miR‐301b‐3p Inhibitor by Junjie Zhao, Niu Niu, Fan Yang, Haitao Liu, Weibo Qi

“…Cell internalisation, toxicity, proliferation, migration, invasion, and apoptosis were assayed by confocal laser scanning microscope, CCK8, colony formation assay, Transwell, western blot, and flow cytometry. …”
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Investigation of Gamma Radiation Shielding in NiMnGa-Doped Multifunctional Smart Polymer Composites Using Geant4 and WinXCOM by Mediha Kök, Mustafa Ersin Pekdemir, Seçil Niksarlıoğlu, Serpil Yalçın Kuzu, Mustafa Kaya

“…These findings highlight the potential of NiMnGa-doped polymer composites as eco-friendly, cost-effective alternatives to lead-based shields for medical and industrial applications, offering enhanced protection with reduced toxicity and environmental impact.…”
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Life cycle assessment of heat, CO2 from composting for greenhouse applications by Jiamin Wang, BiChen Tian, Rui Li, Jianming Li

“…Sensitivity analysis revealed that the system is most sensitive to freshwater ecotoxicity, toxicity equivalent, and marine ecotoxicity. The impact of AW processing is minimal, contributing only 1.09 % of the total impact. …”
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A Comparative Analysis of 2-(Thiocyanomethylthio)-Benzothiazole Degradation Using Electro-Fenton and Anodic Oxidation on a Boron-Doped Diamond Electrode by Armando Vázquez, Lucía Alvarado, Isabel Lázaro, Roel Cruz, José Luis Nava, Israel Rodríguez-Torres

“…The results showed that both AO and EF processes could be useful strategies for TCMTB toxicity reduction in wastewaters.…”
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Deciphering the Molecular Mechanism of Peracetic Acid Response in Listeria monocytogenes by Marianna Arvaniti, Ahmed Gaballa, Renato H. Orsi, Panagiotis Skandamis, Martin Wiedmann

“…In detail, the organic peroxide toxicity protection (OhrA-OhrR) system, the metal homeostasis genes fur and zurM, the SbrE-regulated lmo0636-lmo0637 operon and a carbohydrate phosphotransferase system (PTS) operon component were induced under exposure of L. monocytogenes to PAA. …”
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Intravitreal Melphalan for Vitreous Seeds: Initial Experience in China by Xunda Ji, Peiyan Hua, Jing Li, Jiakai Li, Junyang Zhao, Peiquan Zhao

“…Intravitreal melphalan achieved a high local control rate for vitreous seeds without extraocular extension and with acceptable toxicity in Chinese retinoblastoma patients.…”
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Trace elements‐based Auroshell gold@hematite nanostructure: Green synthesis and their hyperthermia therapy by Hadil M. Alahdal, Sumya Ayad Abdullrezzaq, Hawraz Ibrahim M. Amin, Sitah F. Alanazi, Abduladheem Turki Jalil, Mehrdad Khatami, Marwan Mahmood Saleh

“…Auroshell gold@hematite nanoparticles with minimal toxicity are safe against normal cells. The gold shell around the magnetic core of magnetite caused the environmental and cellular biocompatibility of these Auroshell nanoparticles. …”
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Recent insights into the transformative role of Graphene‐based/TiO2 electron transport layers for perovskite solar cells by T. Sewela, R. O. Ocaya, T. D. Malevu

“…The high interest in TiO2 is due to its low toxicity, chemical stability, and the potential to enhance its excitonic performance through doping with many materials. …”
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Comparative Transcriptome Analysis Reveals Molecular Defensive Mechanism of Arachis hypogaea in Response to Salt Stress by Hao Zhang, Xiaobo Zhao, Quanxi Sun, Caixia Yan, Juan Wang, Cuiling Yuan, Chunjuan Li, Shihua Shan, Fengzhen Liu

“…Abiotic stresses comprise all nonliving factors, such as soil salinity, drought, extreme temperatures, and metal toxicity, posing a serious threat to agriculture and affecting the plant production around the world. …”
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Tenascin C-Guided Nanosystem for Precision Delivery of Obeticholic Acid in Liver Fibrosis Therapy by Yawen Wang, Lei Yang, Qing Xu, Taiyu Liu, Hongliang He, Lisha Liu, Lifang Yin

“…<b>Methods:</b> We designed a liposomal delivery system functionalized with the GBI-10 aptamer and encapsulating obeticholic acid (OCA lips@Apt) to enhance selective delivery to fibrotic liver tissue while minimizing systemic toxicity. <b>Results:</b> Both in vitro and in vivo studies demonstrated that the aptamer-modified OCA liposomes effectively treated hepatic fibrosis through dual mechanisms: modulation of abnormal bile acid metabolism and attenuation of inflammation. …”
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