Identification and pharmacokinetics of saponins in Rhizoma Anemarrhenae after oral administration to rats by HPLC-Q-TOF/MS and HPLC-MS/MS by Wang Hai-Qiao, Lan Fen, Zhang Yi-Han, Xia Jin-Er, Gong Xiao-Mei, Liu Min

“…It is essential to classify the properties of saponins which are associated with their toxicity and efficacy. In this study, 25 compounds were identified by HPLC-Q-TOF/MS in the extract of Rhizoma Anemarrhenae and 8 saponins were detected in rat plasma by HPLC-MS/MS after oral administration of this extract. …”
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99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as an auspicious tumour targeting by Adli A. Selim, Tamer M. Sakr, Basma M. Essa, Galal H. Sayed, Kurls E. Anwer

“…Gold nanoparticles (AuNPs) offer precise cancer treatment through targeted delivery, boasting high drug-loading capacity and low toxicity. This study aimed to develop and evaluate 99mTc-labeled benzenesulfonamide derivative-entrapped gold citrate nanoparticles as a tumor-targeting agent. …”
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Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance by Paulina Ruiz, Paula Maldonado, Yessia Hidalgo, Alejandra Gleisner, Daniela Sauma, Cinthia Silva, Juan Jose Saez, Sarah Nuñez, Mario Rosemblatt, Maria Rosa Bono

“…Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs. To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression. …”
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A Prospective Study to Assess the Best Optimal Dose of Tacrolimus before Renal Transplantation and Its Impact on Graft Survival and Patient Outcome in Renal Transplant Recipients by Niranjan Gogoi, Charu Jain, Megha Agarwal, Dhananjay Agarwal, Ajay Gupta, Munesh Kumar

“…One patient showed TAC-related toxicity in biopsy. Conclusion: Optimizing the dose of TAC before renal transplantation may facilitate individualization of immunosuppression and can improve graft outcome.…”
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Phytochemical Profiling, Bioactivity, and Insecticidal Effectiveness of <i>Mammea americana</i> L. Leaf Extracts Against <i>Ferrisia</i> sp. by Mike Vázquez-Torres, Nilka Rivera-Portalatín, Irma Cabrera-Asencio

“…Potential cytotoxicity was assessed using brine shrimp lethality tests, where all extracts displayed high toxicity to <i>Artemia salina</i>. The dichloromethane extract (MAD) had the lowest LC₅₀ value (8.39 μg/mL), followed by methanol extract (MAM, 11.66 μg/mL) and chloroform extract (MAC, 12.67 μg/mL). …”
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Indomethacin-Induced Gastric Ulcer in Rats: Gastroprotectivity of <i>Muscari neglectum</i> in Water by Menekse Soydan, Gulnur Arabaci, Necati Utlu, Mesut Bünyami Halici, Esra Aktas Senocak, Metin Kiliçlioglu

“…<b>Methods:</b> 60 male Sprague Dawley rats were utilized for the purposes of evaluating the acute toxicity and gastric ulcer models, with a total of 36 rats employed for these experiments (n = 6). …”
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Adsorption of phenol on activated carbon obtained from date palm branches by Sameh Ahmed, E. S. Gogina, N. A. Makisha

“…However, the discharge of wastewater containing phenol is a priority due to its high toxicity to humans and animals, even at low concentrations. …”
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Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/LPA6 Receptors by Yifan Yang, Jing Xu, Qingxin Su, Yiran Wu, Qizheng Li, Zongren Ma, Tao Ding

“…Recently, LPA has been reported to be involved in spinal cord neuronal injury and toxicity, promoting the pathogenesis of LSS. However, the exact effects of LPA on spinal cord neurons remain unknown. …”
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Comparison of inhaled versus intravenous anesthesia for laryngoscopy and laryngeal electromyography in a rat model by M. Gazzaz, J. Saini, S. Pagliardini, B. Tsui, C. Jeffery, H. El-Hakim

“…Three mortalities were encountered, one of which was due to lidocaine toxicity and two were during anesthetic induction. …”
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Lyophilized powder of calf bone marrow hydrolysate liposomes improved renal anemia: In vitro and in vivo evaluation. by Li Li, Shasha Zhao, Xiaodun Liu, Zhe Xu, Dong Li, Xiaoyu Dai

“…The results of lyophilized powder of CBMHL co-culture with human adipose mesenchymal stem cells (MSCs) and human cytokine-induced killer (CIK) cells showed that the lyophilized powder of CBMHL had no potential toxicity and allergic reaction in vitro. Compared with the Model Group, the red blood cell (RBC) count, hemoglobin (HB) content and hematokrit (HCT) of rats blood routine in the Model+high doses of CBMHL Group (Model+H-CBMHL Group) increased significantly (P < 0.05). …”
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Nonclinical Similarity of the Biosimilar Candidate ABP 938 with Aflibercept Reference Product by Neungseon Seo, Scott Kuhns, Dina A. Andrews, Alexander Colbert, Vincent Chow, Jennifer Liu

“…Additionally, there was no evidence of ocular or systemic toxicity associated with IVT administration of ABP 938 in a repeat-dose, 1-month toxicology study in cynomolgus monkeys; toxicokinetic and toxicology profiles were similar to aflibercept RP. …”
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Assessing Redox Properties of Natural Organic Matters with regard to Electron Exchange Capacity and Redox-Active Functional Groups by Zhiyuan Xu, Zhen Yang, Hongping Wang, Jie Jiang

“…Redox processes in groundwater play an important role in bioavailability, toxicity, and mobility of redox-active elements and contaminants. …”
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Nanoparticle-based drug delivery system for Oral Cancer: Mechanism, challenges, and therapeutic potential by Nurhasni Hasan, Maryam Aftab, Muneeb Ullah, Phuong Tram Nguyen, Rina Agustina, Yulia Yusrini Djabir, Theofilus A. Tockary, Satoshi Uchida

“…Recent advancements in nanotechnology provide innovative, targeted therapeutic strategies that enhance bioavailability and decrease toxicity. This review provides an overview of nanoparticle applications in oral cancer therapy, outlining mechanisms, advantages, limitations, and potential clinical impacts. …”
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Silver Nanoparticles: Biosynthesis Using an ATCC Reference Strain of Pseudomonas aeruginosa and Activity as Broad Spectrum Clinical Antibacterial Agents by Melisa A. Quinteros, Ivana M. Aiassa Martínez, Pablo R. Dalmasso, Paulina L. Páez

“…In addition, these Ag-NPs showed negligible cytotoxic effect in human neutrophils suggesting low toxicity to the host.…”
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Biological Response Modifiers in Combination with Antivirals against Experimentally-Induced Virus Infections by Robert W Sidwell, John H Huffman, Donald F Smee, John Gilbert, Roland K Robins, Meir Kende, John Huggins

“…In each experiment. multiple dosages of both BRM and ribavirin were selected to range from ineffective levels to, in certain cases with ribavirin, lethally toxic levels. Ribavirin was always administered orally twice daily for three days starting 24 h after virus inoculation. …”
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Influence of Heat Treatment on Biocorrosion and Hemocompatibility of Biodegradable Mg-35Zn-3Ca Alloy by Jeong-Hui Ji, Il-Song Park, Yu-Kyoung Kim, Sook-Jeong Lee, Tae-Sung Bae, Min-Ho Lee

“…The hemolysis value was ≤5% in all groups, indicating no toxicity during short-term blood reaction.…”
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Evaluation of Toxicological Risks and Effects of Microplastics on Nile Tilapia (Oreochromisniloticus) under in Vitro Laboratory Conditions by Macarius Pancras Mtega, Matobola Joel Mihale, Kessy Fidel Kilulya

“…The objective of research was to determine the toxicity of microplastics to Nile tilapia (Oreochromis niloticus). …”
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Decitabine Increases the Transcription of <i>RIG-I</i> Gene to Suppress the Replication of Feline Calicivirus and Canine Influenza Virus by Shaotang Ye, Zhen Wang, Aolei Chen, Ying Chen, Gaoming Lou, Qingmei Xie, Gang Lu, Shoujun Li

“…A preliminary screening from a natural product library was conducted, with subsequent assessments to ascertain their toxicity levels and antiviral capabilities. The results showed that decitabine and alprostadil were effective in reducing FCV replication. …”
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Tolerance of Chemoorganotrophic Bioleaching Microorganisms to Heavy Metal and Alkaline Stresses by Annick Monballiu, Nele Cardon, Minh Tri Nguyen, Christel Cornelly, Boudewijn Meesschaert, Yi Wai Chiang

“…The plate diffusion method was performed for each metal to determine the toxicity effect. Liquid batch cultures were set up for more quantitative evaluation as well as for studying the influence of basicity. …”
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Examining the Chemical and Optical Properties of Biomass-burning Aerosols and their Impact on Oxidative Potential by Suman Yadav, Taveen Singh Kapoor, Pradnya Vernekar, Harish C. Phuleria

“…Our findings suggest that emissions from biomass cooking may pose a substantial risk to a large population, in particular to women and young children in rural areas and that the toxicity of the emitted PM from biomass cooking is likely due to soot and the absorbing OC in PM.…”
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