Green synthesis of silver nanoparticles derived from algae and their larvicidal properties to control Aedes aegypti by Matheus Alves Siqueira de Assunção, Douglas Dourado, Daiane Rodrigues dos Santos, Gabriel Bezerra Faierstein, Mara Elga Medeiros Braga, Severino Alves Junior, Rosângela Maria Rodrigues Barbosa, Herminio José Cipriano de Sousa, Fábio Rocha Formiga

“…In addition, assessment of toxicity of these nanomaterials in non-target species is discussed.…”
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Sulforaphane acutely activates multiple starvation response pathways by Kendra S. Plafker, Constantin Georgescu, Nathan Pezant, Atul Pranay, Scott M. Plafker

“…Collectively, these data support that the fasting-mimetic properties of SFN could underlie both the therapeutic efficacy and potential toxicity of this phytochemical.…”
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Application of Fly Ash and Slag Generated by Incineration of Municipal Solid Waste in Concrete by Cong Zeng, Yan Lyu, Dehong Wang, Yanzhong Ju, Xiaoyu Shang, Luoke Li

“…The leaching concentrations of Cu, Zn, Pb, Cr, and Cd in MSWI concrete samples are determined to be less than the identification value of solid waste leaching toxicity. Based on scanning electron microscopy (SEM) and X-ray diffraction (XRD) analyses, MSWI fly ash has certain dispersion. …”
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Enhanced antitumor efficacy through sustained release of 5-fluorouracil from poly(trimethylene carbonate) membranes by Zongheng Wang, Zhipeng Hou, Shuguang Zhang, Shuangyi Ren, Liqun Yang, Qianshi Zhang

“…IntroductionCancer remains one of the deadliest diseases worldwide. 5-Fluorouracil (5-FU) is one of the most commonly used chemotherapeutic agents in clinical practice today, but its effectiveness is often hampered by rapid drug metabolism and systemic toxicity. To address these limitations, the development of novel drug delivery systems for sustained drug release is essential to improve therapeutic outcomes.MethodsThis study aimed to develop a poly(trimethylene carbonate) (PTMC) membrane capable of sustained drug release of 5-FU to enhance its antitumor activity. …”
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Regulatory mechanism analysis of signal transduction genes during rapeseed (Brassica napus L.) germination under aluminum stress using WGCNA combination with QTL by Chenyang Li, Ruili Wang, Jiana Li, Qingyuan Zhou, Cui Cui

“…As soil becomes more acidic, aluminum toxicity has emerged as a key issue impacting seed germination and crop productivity in such environments. …”
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Non-target effects of ten essential oils on the egg parasitoid Trichogramma evanescens by van Oudenhove, Louise, Cazier, Aurélie, Fillaud, Marine, Lavoir, Anne-Violette, Fatnassi, Hicham, Perez, Guy, Calcagno, Vincent

“…Results highlight the fumigant toxicity of EOs on parasitoid development. Anise, Fennel, Basil, Coriander, Oregano, Peppermint and Thyme EOs are particularly toxic and drastically reduce the emergence rate of T. evanescens. …”
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Knowledge on Chemical Pesticide use among Farmers Exposed to Pesticides in Panchkhal Municipality, Kavrepalanchok, Nepal by Leela Paudel, Rajendra Neupane, Lochana Shrestha, Lee Budhathoki, Keshav Raj Paudel

“…This study aims to assess the knowledge and evaluate the relationship between pesticide use knowledge and pesticide toxicity symptoms among farmers in Panchkhal Municipality. …”
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Zinc Oxide Nanoparticles Enhance the Tolerance and Remediation Potential of Bacillus spp. against Heavy Metal Stress by Nazneen Akhtar, Sehresh Khan, Shafiq Ur Rehman, Zia Ur Rehman, Zia Ur Rehman Mashwani, Eui Shik Rha, Muhammad Jamil

“…This study suggested that synergistic treatment of Bacillus spp. with lower concentrations of ZnO NPs enhances the tolerance potential and significantly reduces the HM toxicity.…”
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Sequential Therapy of Linezolid and Contezolid to Treat Hematogenous Lung Abscess Caused by Staphylococcus aureus in a Congenital Cerebral Hypoplasia Patient: A Case Report by Zhou S, Xin C, Liu W

“…Contezolid may ameliorate the hematologic toxicity associated with linezolid. Here, we report the case of a patient with congenital cerebral hypoplasia who was hospitalized due to fever and multiple abscesses in both lungs. …”
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Plant-Mediated Green Synthesis of Ag NPs and Their Possible Applications: A Critical Review by Darbin Kumar Poudel, Purushottam Niraula, Himal Aryal, Biplab Budhathoki, Sitaram Phuyal, Rishab Marahatha, Kiran Subedi

“…This review focuses on the contribution of plant-mediated Ag NPs in different applications and their toxicity in the aquatic system.…”
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Effect of selected catechins on doxorubicin antiproliferative efficacy and hepatotoxicity in vitro by Rudolfová Petra, Hanušová Veronika, Skálová Lenka, Bártíková Hana, Matoušková Petra, Boušová Iva

“…Moreover, EGCG at 25 μmol L-1 increased the viability of isolated hepatocytes and significantly protected these cells against DOX-induced toxicity and ROS production. Consumption of EGCG during DOX therapy seems to be safe and beneficial, since EGCG does not decrease DOX anticancer efficacy and could ameliorate DOX hepatotoxicity…”
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Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation by Michela Staderini, Lara Mannelli, Elisabetta Antonioli, Benedetta Puccini, Valentina Berti, Francesco Mungai, Federica Vergoni, Valentina Carrai, Luigi Rigacci, Alberto Bosi

“…Simultaneous onset can be challenging for clinicians as both diseases may have an aggressive course requiring multiple treatments with increased risk of toxicity and complicated management.…”
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Hypericum Perforatum-Derived Exosomes-Like Nanovesicles: A Novel Natural Photosensitizer for Effective Tumor Photodynamic Therapy by Ma X, Chen N, Zeng P, He Y, Zhang T, Lu Y, Li Z, Xu J, You J, Zheng Y, Wang L, Luo M, Wu J

“…In vivo, HPDEN-mediated PDT significantly suppressed tumor growth and induced extensive tumor necrosis, with no observable toxicity to major organs.Conclusion: HPDENs represent a novel plant-derived photosensitizer with dual ROS generation pathways and significant therapeutic efficacy, providing a promising platform for enhancing photodynamic therapy.Keywords: Hypericum perforatum-derived exosomes-like nanovesicles, photosensitizer, photodynamic therapy, reactive oxygen species, apoptosis…”
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Differential Effects of Chronic Pulsatile versus Chronic Constant Maternal Hyperglycemia on Fetal Pancreatic β-Cells by Mackenzie S. Frost, Aqib H. Zehri, Sean W. Limesand, William W. Hay, Paul J. Rozance

“…These results indicate that late gestation constant maternal hyperglycemia leads to significant β-cell toxicity (increased apoptosis and decreased GSIS). …”
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Natural Enrichment of Trace Elements in Surface Horizons of Calcareous Soils (La Mancha, Spain) by Sandra Bravo Martín-Consuegra, Jose A. Amorós Ortíz-Villajos, Caridad Pérez-de-los-Reyes, Francisco J. García Navarro, Rolando Ruedas Luna, Raimundo Jiménez Ballesta

“…Soil quality does not indicate toxicity although surficial enrichment suggests a weak threat from consuming crops.…”
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Layer-by-Layer Biopolymer-Coated Deformable Liposomes–In Situ Gel: A Hybrid Strategy for Enhanced Ocular Delivery of Itraconazole: In Vitro and In Vivo Appraisal by Mohamed M. Badran, Areej Alsubaie, Mounir M. Salem Bekhit, Abdullah H. Alomrani, Aliyah Almomen

“…Its oral administration is associated with systemic toxicity, and its efficacy in ocular formulations is limited. …”
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Targeted delivery of curcumin and CM11 peptide against hepatocellular carcinoma cells based on binding affinity of PreS1-coated chitosan nanoparticles to SB3 protein by Danial Rahmani, Ramezan Ali Taheri, Mehrdad Moosazadeh Moghaddam

“…The MTT assay showed that PreS1-Cur-CM11-CS NPs act in a targeted and specific manner with the highest toxicity on the HepG2 cells compared to the control by a decrease in viability of about 26% after 48 h based on cell apoptosis. …”
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2’-Fucosyllactose alleviate immune checkpoint blockade-associated colitis by reshaping gut microbiota and activating AHR pathway by Shikai Yan, Leilei Yu, Fengwei Tian, Jianxin Zhao, Wei Chen, Qixiao Zhai

“…Immune checkpoint blockade (ICB) therapeutics are highly effective in cancer immunotherapy, but gastrointestinal toxicity limited the application. Intestinal microbiota plays a crucial role in ICB-associated colitis. 2’-Fucosyllactose (2’FL) is most abundance prebiotic in human milk that can reshape gut microbiota and exert immune regulatory effect. …”
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An Open‐Label Phase II Trial of Pembrolizumab, an Immune Checkpoint Inhibitor Alone or in Combination With Oral Azacitidine as Second‐Line Therapy for Advanced Head and Neck Squamo... by Vinod K. Ramani, Srimonta Gayen, Radheshyam Naik

“…To evaluate the clinical effectiveness endpoints and toxicity of oral azacytidine when combined with pembrolizumab. ii. …”
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Breaking the shield of solid tumors: a combined approach for enhanced efficacy of CAR-T cells by Marat Khaliulin, Aygul Valiullina, Alexey Petukhov, Youyong Yuan, Sheila Spada, Emil Bulatov

“…Furthermore, concerns exist regarding tumor antigen loss and therapy-associated toxicity. Currently, scientists are working to enhance the structure of the CAR and improve the survival and efficiency of CAR-T cells in recognizing tumor antigens in solid tumors. …”
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