Protective Effect of Opuntia dillenii (Ker Gawl.) Haw. Seed Oil on Gentamicin-Induced Nephrotoxicity: A Biochemical and Histological Analysis by Mohamed Bouhrim, Noureddine Bencheikh, Hamada Imtara, Nour Elhouda Daoudi, Hamza Mechchate, Hayat Ouassou, Loubna Kharchoufa, Mostafa Elachouri, Hassane Mekhfi, Abderrahim Ziyyat, Abdelkhaleq Legssyer, Mohammed Aziz, Mohamed Bnouham

“…In addition, the results of the present study showed for the first time that Opuntia dillenii seed oil reduced renal toxicity in gentamicin-induced nephrotoxicity in rats. …”
Get full text

Impact of thoracic radiotherapy on first‐line treatment outcomes in ES‐SCLC patients by Xiaoli Mu, Yixin Zhou, Qing Liu, Jiantao Wang, Feng Xu, Feng Luo, Ke Wang, Lu Li, Panwen Tian, Yalun Li, Jiewei Liu, Yan Zhang, Jiyan Liu, Yan Li

“…Conclusions Thus, weconfirmed that the addition of tRT to the conventional regimen of first‐linechemotherapy and immunotherapy yields better survival outcomes without asignificant increase in toxicity.…”
Get full text

High-density lipoprotein nanoparticles spontaneously target to damaged renal tubules and alleviate renal fibrosis by remodeling the fibrotic niches by Shanshan He, Xiaoyang Li, Yuanyuan He, Ling Guo, Yunzhou Dong, Leilei Wang, Lan Yang, Lin Li, Shiyun Huang, Jiali Fu, Qing Lin, Zhirong Zhang, Ling Zhang

“…The bHDL vehicle also possesses high manufacturability, good safety and adequately reduces the toxicity of TP. Thus, this system is promising for the treatment of CKD and bHDL has good potential for delivering agents to damaged renal tubular epithelial cells.…”
Get full text

Potential Interaction of Pinocembrin with Drug Transporters and Hepatic Drug-Metabolizing Enzymes by Sirima Sangkapat, Rattiporn Boonnop, Jeerawat Pimta, Napason Chabang, Bodee Nutho, Promsuk Jutabha, Sunhapas Soodvilai

“…In addition, it attenuated the toxicity of tenofovir, a substrate of hOAT1, in cells overexpressing hOAT1. …”
Get full text

Combining In Vitro, In Vivo, and In Silico Approaches to Explore the Effect of <i>Ceratonia siliqua</i> and <i>Ocimum basilicum</i> Rich Phenolic Formula on Lipid Metabolism and Pl... by Mohammadine Moumou, Amani Tayebi, Abderrahmane Hadini, Omar M. Noman, Abdulsalam Alhalmi, Hamza Ahmoda, Souliman Amrani, Hicham Harnafi

“…Accordingly, the CBF prevented LRP oxidation in a concentration-dependent manner. This formula is not toxic in mice (LD₅₀ > 2000 mg/kg body weight). …”
Get full text

Assisted Egg White Biogenic Synthesis for Elaboration of ZnO Nanoparticles by Elena Andreea Vijan, Ecaterina Magdalena Modan, Sorin Georgian Moga, Denis Aurelian Negrea, Adriana-Gabriela Schiopu, Mihai Oproescu, Daniela Istrate

“…ZnO-based nanomaterials especially demonstrate versatility, accessibility, biocompatibility and low toxicity. In recent years, there has been a growing interest in developing eco-friendly and sustainable approaches for synthesizing nanomaterials. …”
Get full text

Immunogenicity in humans of a transdermal multipeptide melanoma vaccine administered with or without a TLR7 agonist by Craig L Slingluff, Gina R Petroni, Walter C Olson, Kimberly A Chianese-bullock, Donna Deacon, Mark Smolkin, William W Grosh, Max O Meneveau, Kevin T Lynch, Elise P Salerno, Elizabeth Woodson, James W Patterson

“…Every 3 weeks thereafter (x 6), the peptides were combined with GM-CSF and were injected into the dermis and subcutis in an emulsion with IFA. Toxicities were recorded and immune responses assayed by ELIspot.Results CD8+ T cell responses to transdermal vaccination in DMSO occurred in 83% of participants in group 3 and 86% in group 4, and responses to vaccination in IFA were observed in 29% of participants in group 1 and 14% in group 2. …”
Get full text

Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis by Ganesh Sharma, Neeraj Kumar, Chandra Shekhar Sharma, Taha Alqahtani, Yewulsew Kebede Tiruneh, Sharifa Sultana, Gabriel Vinícius Rolim Silva, Gabriela de Lima Menezes, Magdi E. A. Zaki, Jonas Ivan Nobre Oliveira

“…The physicochemical properties, pharmacokinetics, and ADMET (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiles were evaluated to determine drug similarity and safety. …”
Get full text

The Anthelmintic Activity of <i>Nepeta racemosa</i> Lam. Against Gastrointestinal Nematodes of Sheep: Rosmarinic Acid Quantification and In Silico Tubulin-Binding Studies by Büşra Karpuz Ağören, Mahmut Sinan Erez, Esma Kozan, Aydın Dağyaran, Mevlüt Akdağ, Eduardo Sobarzo-Sánchez, Esra Küpeli Akkol

“…The discovery of low-cost and low-toxicity anthelmintic compounds is very important.…”
Get full text

Safety of vancomycin-loaded cement spacers for treating gram-positive periprosthetic joint infections in two-stage resection arthroplasty among patients with renal insufficiency by Yu-Chih Lin, Chih-Hsiang Chang, Chih-Chien Hu, Yung-Chieh Liang, Pang-Hsin Hsieh, Sheng-Hsun Lee, Sheng-Hsuan Lin

“…RI patients displayed higher peak blood vancomycin levels (1.23–5.43 mg/L) but remained below toxicity thresholds. The infection-free interval, aseptic revision rates, and bacterial profiles specific to gram-positive species showed no significant differences between the groups. …”
Get full text

Consumption of Raw Herbal Medicines Is Associated with Major Public Health Risks amongst Ugandans by Fred, Ssempijja, Keneth Iceland, Kasozi, Ejike, Daniel Eze, Andrew, Tamale, Sylvia Anurika, Ewuzie, Kevin, Matama, Justine, Ekou, Paul, Bogere, Regan, Mujinya, Grace Henry, Musoke, Jovile Kasande, Atusiimirwe, Gerald, Zirintunda, Muhamudu, Kalange, Joel, Lyada, Ritah, Kiconco, Theophilus, Pius, Christopher, Nandala, Roland Mugisha, Kamugisha, Yunusu, Hamira, Edgar Mario, Fernandez, Simon Peter, Musinguzi

“…+e EDI was significantly higher in children than in adults, demonstrating an increased risk of toxicity in children. +e THQ and ILCR were over 1000 times higher in all Ugandans, demonstrating the undesirable health risks following oral consumption of Vernonia amygdalina due to very high Cr and Ni toxicities, respectively. …”
Get full text

Indigofera suffruticosa Mill. (Anil): Plant Profile, Phytochemistry, and Pharmacology Review by Janaina K. L. Campos, Tiago F. da S. Araújo, Thaíse G. da S. Brito, Ana P. S. da Silva, Rebeca X. da Cunha, Mônica B. Martins, Nicácio H. da Silva, Bianka S. dos Santos, César A. da Silva, Vera L. de M. Lima

“…This review aimed at providing important data on the botanical, distribution, ethnopharmacology, phytochemical, pharmacological, and toxicity of I. suffruticosa based on the scientific literature. …”
Get full text

Impaired RelA signaling and lipid metabolism dysregulation in hepatocytes: driving forces in the progression of metabolic dysfunction-associated steatotic liver disease by Yihuai He, Jinlian Jiang, Lili Ou, Yunfen Chen, Aikedaimu Abudukeremu, Guimei Chen, Weiwei Zhong, Zhigang Jiang, Nuerbiye Nuermaimaiti, Yaqun Guan

“…Impaired RelA signaling remodeled the ER stress response and lipid metabolism, and enhanced lipid accumulation and lipid toxicity. In conclusion, impaired RelA signaling and disrupted lipid metabolism form a detrimental feedback loop in hepatocytes that promotes MASLD progression. …”
Get full text

Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells by Cheng C, Sun M, Li J, Xue Y, Cai X, Liu J, Wang X, Xu S, Xie Y, Zhang J

“…Cell viability assays confirmed that aptamers did not induce cellular toxicity.Conclusion: AP4-2 and AP17-4 showed strong affinity and specificity for their target VLPs and represent promising candidates for HuNoV capture and detection. …”
Get full text

Unraveling the spatiotemporal trends and source attribution of polycyclic aromatic hydrocarbons and oxygenated derivatives in Guangzhou agricultural ditch sediment by Shaomin Li, Weisong Chen, Yichen Liu, Haoyu Wang, Yongtao Li, Zhen Zhang, Xingjian Yang

“…Oxygenated polycyclic aromatic hydrocarbons (OPAHs) have garnered significant scientific attention due to their heightened toxicity and mobility compared to their parent PAHs. …”
Get full text

Fatty acids from soybeans: compatibility with Panonychus citri (Acari: Tetranychidae) and its two predators☆ by Qayyoum Muhammad Asif, Khan Bilal Saeed, Song Zi-Wei, Yi Tian-Ci, Inayat Rehan, Akram Muhammad Irfan, Mobarak Syed Husne, Li Dun-Song

“…Soybean oil showed the least toxicity, with the highest LT50 (Lethal Time) values for N. californicus (LDM: 1.19 h, TSM: 1.27 h). …”
Get full text

Catalytic effect of Fe@Fe2O3 nanowires and Fenton process on carbamazepine removal from aqueous solutions using response surface methodology by M.M. Amin, S. Yousefinejad, M. Dehghani, S. Rahimi

“…Carbamazepine is one of the hydrophilic compounds identified in aquatic environments. Due to toxicity and bio-stability of this psychotropic pharmaceutical in the environment and humans, its removal efficiency and mineralization are important. …”
Get full text

<i>Sambucus nigra</i>-Lyophilized Fruit Extract Attenuated Acute Redox–Homeostatic Imbalance via Mutagenic and Oxidative Stress Modulation in Mice Model on Gentamicin-Induced Nephr... by Kamelia Petkova-Parlapanska, Ivaylo Stefanov, Julian Ananiev, Tsvetelin Georgiev, Petya Hadzhibozheva, Veselina Petrova-Tacheva, Nikolay Kaloyanov, Ekaterina Georgieva, Galina Nikolova, Yanka Karamalakova

“…<b>Objectives:</b> The present study aimed to investigate the nephroprotective and anti-inflammatory potential of lyophilized <i>Sambucus nigra</i> fruit extract (<i>S. nigra extract</i>) to reduce acute oxidative stress and residual toxicity of GM in a 7-day experimental model in Balb/c rodents. …”
Get full text

Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives by Basma T. Abd-Elhalim, Ghada G. El-Bana, Ahmed F. El-Sayed, Ghada E. Abdel-Ghani

“…Additionally, the computational ADMET “Absorption–distribution–metabolism–excretion–toxicity” analysis of these compounds revealed adherence to Lipinski’s rules, indicating favorable physicochemical characteristics. …”
Get full text

PD-1 cis-targeted IL-2v in combination with radiotherapy inhibits lung cancer growth and remodels the immune microenvironment by Pedro J Romero, Sara Labiano, Gregory Verdeil, Christian Klein, Pablo Umana, Tania Wyss, Christine Trumpfheller, Marie-Catherine Vozenin, Céline Godfroid, Jackeline Romero, Vincent Roh, Genrich V Tolstonog, Chia-Hsien Chuang, Andrea Kelemen, Laura Codarri Deak

“…Importantly, this combination therapy was devoid of measurable toxicity. It induced remodeling of the immune contexture through the increase of CD8+ T and natural killer (NK) cells. …”
Get full text