Synergistic action between a synthetic cannabinoid compound and tramadol in neuropathic pain rats by Quiñonez-Bastidas Geovanna Nallely, Osuna-Martínez Ulises, Reda-Licea Ana Laura, López-Ortíz Manuel, Regla Ignacio, Navarrete Andrés

“…In the present study the interaction of cannabinoid, PhAR-DBH-Me [(R, Z)-18-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl)-18-oxooctadec-9-en-7-ylphenyl-acetate] and tramadol in two neuropathy models, as well as their possible toxic effects, was analyzed. The anti-allodynic effect of PhAR-DBH-Me, tramadol, or their combination, were evaluated in neuropathic rats. …”
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Dynamic non-coding RNA biomarker reveals lung injury and repair induced by polystyrene nanoplastics by Sheng Yang, Yiling Ge, Tianyi Zhang, Lihong Yin, Yuepu Pu, Zaozao Chen, Geyu Liang

“…Therefore, this study aims to provide new insights into the pulmonary toxicity of PS-NPs using mice and organoid models. …”
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Improvement of engineering properties and environmental impact of fired clay bricks utilizing industry sludge waste by Amir Detho, Aeslina Abdul Kadir, Ahmad Shayuti, Bin Abdul Rahim, Nejib Ghazouani, Abdelkader Mabrouk, Ahmed Babeker Elhag, Hesham Hussein Rassem

“…Various leachability assessments, including the Toxicity Characteristic Leaching Procedure (TCLP), Synthetic Precipitation Leaching Procedure (SPLP), and Static Leachate Test (SLT), confirm that bricks containing up to 30% BS and PS comply with United States Environmental Protection Agency (USEPA) and Environment Protection Authority Victoria (EPAV) standards for heavy metals, making them environmentally safe for use. …”
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Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa persister cells and biofilms by Mona Mahmoud, Peter Richter, Philipp Arnold, Michael Lebert, Andreas Burkovski

“…Nevertheless, the addition of BP did not enhance the efficacy of CHL against biofilms; CHL (500 µg/ml) reduced biofilm viability by 2.6 log10 at 791 J/cm2. No toxicity has been observed in darkness. This study highlights the potential antimicrobial effect of CHL against P. aeruginosa.…”
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Radiation decreases bronchial epithelial progenitor function as assessed by organoid formation by Merian E. Kuipers, Dennis K. Ninaber, Krista C.J. van Doorn-Wink, Annelies M. Slats, Pieter S. Hiemstra

“…Results and discussion IR increased the number of γH2Ax-foci (marker of double stranded DNA breaks) in ALI-PBEC, but did not affect markers of toxicity (LDH-release or TEER). IR did also not affect mRNA markers for inflammation or epithelial-mesenchymal transition (EMT), but did increase mRNA levels of the cell cycle inhibitor P21/CDKN1A and resulted in downregulation of the proliferation markers MKI67 and E2F1. …”
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Etiologies and Outcomes of Acute Liver Failure in a Spanish Community by Emilio Fábrega, Miguel Ángel Mieses, Alvaro Terán, Irene Moraleja, Fernando Casafont, Javier Crespo, Fernando Pons-Romero

“…Previous retrospective study (1992 to 2000) performed in Spain showed that drug toxicity, viral hepatitis, and indeterminate etiology were the most prevalent causes of acute liver failure (ALF). …”
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Assessment of slag incorporation in cold recycled mixtures emulsified asphalt: Mechanical performance and environmental impact by Putri Adhitana Paramitha, Shih-Huang Chen, Emil Adly, Handy Prasetyo, Wei-Lun Tsai

“…The environmental impact was assessed using the Toxicity Characteristic Leaching Procedure (TCLP) and volume expansion tests. …”
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Dietary Flaxseed Oil Protects against Bleomycin-Induced Pulmonary Fibrosis in Rats by Joshua Lawrenz, Betty Herndon, Afrin Kamal, Aaron Mehrer, Daniel C. Dim, Cletus Baidoo, David Gasper, Jonathan Nitz, Agostino Molteni, Richard C. Baybutt

“…Bleomycin, a widely used antineoplastic agent, has been associated with severe pulmonary toxicity, primarily fibrosis. Previous work has shown a reduction in bleomycin-induced lung pathology by long-chain omega-3 fatty acids. …”
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An overview of RE-Mg-based alloys for hydrogen storage: Structure, properties, progresses and perspectives by Dongsheng Zhou, Chunling Zheng, Yanghuan Zhang, Hanfeng Sun, Peng Sheng, Xin Zhang, Jun Li, Shihai Guo, Dongliang Zhao

“…RE-Mg-based hydrogen storage materials with high magnesium content are considered to be one of the most promising hydrogen storage materials for application due to their high mass/volume hydrogen storage density, moderate required hydrogen pressure, good reversibility, non-toxicity, and harmlessness. Furthermore, RE-Mg-based materials with low magnesium content and superlattice structure show great potential for application in the field of solid-state hydrogen storage. …”
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Value of Plasma NGAL and Creatinine on First Day of Admission in the Diagnosis of Cardiorenal Syndrome Type 1 by Hao Phan Thai, Bao Hoang Bui, Tien Hoang Anh, Minh Huynh Van

“…Neutrophil gelatinase-associated lipocalin (NGAL) in the blood and urine is one of the earliest biomarkers of acute kidney injury due to ischemia or renal toxicity. This study was aimed to evaluate the diagnostic efficacy of plasma NGAL in the diagnosis of CRS1. …”
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Experimental and computational studies of Schiff bases derived from 4-aminoantipyrine as potential antibacterial and anticancer agents by Johana Zúñiga-Miranda, Rebeca González-Pastor, Saskya E. Carrera-Pacheco, Cristina Rodríguez-Pólit, Carlos Barba-Ostria, Antonio Machado, Linda P. Guamán, Christian D. Alcivar-León, Jorge Heredia-Moya

“…Six compounds demonstrated anticancer activity, though some exhibited toxicity to non-tumor cells. Compounds 3b, 3f, and 3h showed notable anticancer potential, while 3f and 3h also exhibited strong antibacterial effects, with 3f being the most effective against multidrug-resistant bacteria strains. …”
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Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

“…In addition, the predicted absorption, distribution, metabolism, excretion, and toxicity properties of these lead compounds remarkably demonstrated their considerable drug-like and non-toxic qualities. …”
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Self-Emulsifying Drug Delivery Systems (SEDDS): Transition from Liquid to Solid—A Comprehensive Review of Formulation, Characterization, Applications, and Future Trends by Prateek Uttreja, Indrajeet Karnik, Ahmed Adel Ali Youssef, Nagarjuna Narala, Rasha M. Elkanayati, Srikanth Baisa, Nouf D. Alshammari, Srikanth Banda, Sateesh Kumar Vemula, Michael A. Repka

“…While challenges such as scalability and excipient toxicity persist, emerging technologies and multidisciplinary collaborations are paving the way for next-generation SEDDS. …”
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Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms by Mohammad Yasin Zamanian, Hamidreza Zafari, Maria K. Osminina, Alla A. Skakodub, Raed Fanoukh Aboqader Al‐Aouadi, Maryam Golmohammadi, Nikta Nikbakht, Iman Fatemi

“…Liposomal delivery of DEX, particularly when liposomes are surface‐modified with targeting ligands like peptides or sialic acid, can improve drug efficacy by enhancing its distribution to inflamed joints and minimizing toxicity. This study investigates the potential of liposomal drug delivery systems to enhance the efficacy and targeting of DEX in the treatment of RA. …”
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Engineering a membrane protein chaperone to ameliorate the proteotoxicity of mutant huntingtin by Jeonghyun Oh, Christy Catherine, Eun Seon Kim, Kwang Wook Min, Hae Chan Jeong, Hyojin Kim, Mijin Kim, Seung Hae Ahn, Nataliia Lukianenko, Min Gu Jo, Hyeon Seok Bak, Sungsu Lim, Yun Kyung Kim, Ho Min Kim, Sung Bae Lee, Hyunju Cho

“…Abstract Toxic protein aggregates are associated with various neurodegenerative diseases, including Huntington’s disease (HD). …”
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Brincidofovir Use after Foscarnet Crystal Nephropathy in a Kidney Transplant Recipient with Multiresistant Cytomegalovirus Infection by Romain Vial, Christine Zandotti, Sophie Alain, Alexandre Decourt, Noémie Jourde-Chiche, Raj Purgus, Charleric Bornet, Laurent Daniel, Valérie Moal, Tristan Legris

“…Clinical and virological remission was observed after a 21-day course of BCV, despite mild and reversible liver toxicity. However, a new relapse could not be effectively cured by BCV due to a new mutation in the UL54 gene, which is known to confer resistance to cidofovir. …”
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Rational design of novel phenol ether derivatives as non-covalent proteasome inhibitors through 3D-QSAR, molecular docking and ADMET prediction by Miao Yuan, Hanwen Ji, Fengxin Sun, Qiang Chen, Ping Cheng

“…Therefore, potentially attractive non-covalent proteasome inhibitors with low toxicity could be found as anticancer drugs. Methods: In this work, computer-aided drug design methods, including quantitative structure-activity relationship (QSAR), molecular docking, absorption, distribution, metabolism, excretion, and toxicology (ADMET) prediction, and drug-likeness prediction methods were performed. …”
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Low-Dose Mitomycin C Decreases the Postoperative Recurrence Rate of Pterygium by Perturbing NLRP3 Inflammatory Signalling Pathway and Suppressing the Expression of Inflammatory Fac... by Qie Guo, Xiao Li, Meng-Na Cui, Yu Liang, Xiang-Peng Li, Jun Zhao, Li-Na Wei, Xiao-Lei Zhang, Xiang Hua Quan

“…In recent years, although MMC has proven useful for the treatment of pterygium, its application has been controversial because of its clear toxicity and the possibility of ocular complications. …”
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Ocular Findings in COVID-19 Patients: A Review of Direct Manifestations and Indirect Effects on the Eye by Federica Bertoli, Daniele Veritti, Carla Danese, Francesco Samassa, Valentina Sarao, Nicolò Rassu, Tommaso Gambato, Paolo Lanzetta

“…Among the array of drugs that have shown positive results, the use of hydroxychloroquine and chloroquine has raised a concern due to their well-known retinal toxic effects. However, the risk of retinal toxicity with short-term high-dose use of antimalarials is still unknown. …”
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Identification of antibiotic use patterns in poultry farms in the southwest region of Bangladesh by Sarder Safiqul Islam, Ratna Ghosh, Md. Shafiqul Islam, Minhazul Abedin Sun, Mustajabur Rahman, Dhiman Mondol

“…The majority of the farmers did not know about the negative impacts of antibiotic use in poultry farming (87.8%), among the remaining 7.8% of farmers said it was carcinogenic, 3.3% stated it was toxicity in humans and only 1.1% said it had no effect of antibiotics in human health. …”
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