Efficient and Rapid Microfluidics Production of Bio-Inspired Nanoparticles Derived from <i>Bombyx mori</i> Silkworm for Enhanced Breast Cancer Treatment by Muhamad Hawari Mansor, Zijian Gao, Faith Howard, Jordan MacInnes, Xiubo Zhao, Munitta Muthana

“…In vitro studies demonstrated sustained cytotoxic effects, and cell cycle arrest at the G2/M phase in breast cancer cell lines, with minimal toxicity in non-cancerous cells. Cellular uptake assays confirmed efficient drug delivery to the cytoplasm. …”
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A Toxicological Evaluation of Methylliberine (Dynamine®) by Timothy S. Murbach, Róbert Glávits, John R. Endres, Amy E. Clewell, Gábor Hirka, Adél Vértesi, Erzsébet Béres, Ilona Pasics Szakonyiné

“…A (1) bacterial reverse mutation test, (2) in vitro mammalian chromosomal aberration test, (3) in vivo mammalian micronucleus test, and (4) 90-day repeated-dose oral toxicity study in rats with a 28-day recovery period were conducted. …”
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In silico design of an epitope-based vaccine ensemble for fasliolopsiasis by Ruchishree Konhar, Ruchishree Konhar, Kanhu Charan Das, Kanhu Charan Das, Aiboklang Nongrum, Rohan Raj Samal, Shailesh Kumar Sarangi, Devendra Kumar Biswal, Devendra Kumar Biswal

“…The creation of large omics datasets for F. buski by our group has accelerated the discovery of key molecules involved in intestinal fluke biology, toxicity, and virulence that can be targeted for vaccine development. …”
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THE BIOSYNTHESIS REGULATION OF POTATO STEROIDAL GLYCOALKALOIDS by K. A. Ivanova, S. V. Gerasimova, E. K. Khlestkina

“…Some of their modified variants are toxic to humans. In the course of potato domestication, plants with a lower SGA level were selected. …”
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Assessing molecular changes underlying isopropylated phenyl phosphate (IPP)-induced larval sensorimotor response deficits in zebrafish by Sunil Sharma, Alfredo Rojas, Abhishek Gour, Rosemaria Serradimigni, Connor Leong, Abhisheak Sharma, Subham Dasgupta

“…Notably, these impacts occur at concentrations within environmental relevance where overt toxic morphological phenotypes are not recorded. …”
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Exploring nanocomposite materials in clinical dermatology: Innovations for treating skin diseases by Sandipan Dasgupta, Subhasundar Maji, Sanjay Dey, Moitreyee Chattopadhyay, Ananya Chanda, Satarupa Acharjee, Kousik Santra, Kazi Asraf Ali

“…Despite these promising benefits, concerns about biocompatibility, toxicity, and legal challenges remain, necessitating further research to develop standardized protocols for clinical use. …”
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Application of Purified Botulinum Type A Neurotoxin to Treat Experimental Trigeminal Neuropathy in Rats and Patients with Urinary Incontinence and Prostatic Hyperplasia by Yoshizo Matsuka, Teruhiko Yokoyama, Yumiko Yamamoto, Tomonori Suzuki, Ni Nengah Dwi Fatmawati, Atsushi Nishikawa, Tohru Ohyama, Toshihiro Watanabe, Takuo Kuboki, Atsushi Nagai, Keiji Oguma

“…Type A neurotoxin (NTX) of Clostridium botulinum was purified by a simple procedure using a lactose gel column. The toxicity of this purified toxin preparation was retained for at least 1 year at −30°C by supplementation with either 0.1% albumin or 0.05% albumin plus 1% trehalose. …”
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Assessing the role of selenium in Minamata disease through reanalysis of historical samples by Mineshi Sakamoto, Masumi Marumoto, Koichi Haraguchi, Takashi Toyama, Yoshiro Saito, Steven J. Balogh, Chiharu Tohyama, Masaaki Nakamura

“…Subsequent animal studies indicated that Se mitigates MeHg toxicity; however, its role in Minamata disease remains unexplored. …”
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Structure-Based Virtual Screening, Docking, ADMET, Molecular Dynamics, and MM-PBSA Calculations for the Discovery of Potential Natural SARS-CoV-2 Helicase Inhibitors from the Tradi... by Ahmed M. Metwaly, Alaa Elwan, Abdul-Aziz M. M. El-Attar, Sara T. Al-Rashood, Ibrahim H. Eissa

“…Then, the most appropriate 26 compounds were subjected to in silico ADMET and toxicity studies to select the most convenient inhibitors to be: (1R,2S)-ephedrine (57), (1R,2S)-norephedrine (59), 2-(4-(pyrrolidin-1-yl)phenyl)acetic acid (84), 1-phenylpropane-1,2-dione (195), 2-methoxycinnamic acid (246), 2-methoxybenzoic acid (364), (R)-2-((R)-5-oxopyrrolidin-3-yl)-2-phenylacetic acid (405), (Z)-6-(3-hydroxy-4-methoxystyryl)-4-methoxy-2H-pyran-2-one (533), 8-chloro-2-(2-phenylethyl)-5,6,7-trihydroxy-5,6,7,8-tetrahydrochromone (637), 3-((1R,2S)-2-(dimethylamino)-1-hydroxypropyl)phenol (818), (R)-2-ethyl-4-(1-hydroxy-2-(methylamino)ethyl)phenol (5159), and (R)-2-((1S,2S,5S)-2-benzyl-5-hydroxy-4-methylcyclohex-3-en-1-yl)propane-1,2-diol (5168). …”
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Unraveling the Anti-Cancer Mechanisms of Antibiotics: Current Insights, Controversies, and Future Perspectives by Nikolaos Nektarios Karamanolis, Dimitris Kounatidis, Natalia G. Vallianou, Krystalia Dimitriou, Eleni Tsaroucha, Georgios Tsioulos, Ioanna A. Anastasiou, Evangelos Mavrothalassitis, Irene Karampela, Maria Dalamaga

“…Challenges such as drug resistance, toxicity, and suboptimal efficacy underscore the need for novel treatment paradigms. …”
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Enhancing immunotherapy efficacy with synergistic low-dose radiation in metastatic melanoma: current insights and prospects by Zahid Rafiq, Mingyo Kang, Hampartsoum B. Barsoumian, Gohar S. Manzar, Yun Hu, Carola Leuschner, Ailing Huang, Fatemeh Masrorpour, Weiqin Lu, Nahum Puebla-Osorio, James W. Welsh

“…Moreover, the dose-related toxicities of immunotherapies may be reduced by synergistic amplification of antitumor efficacy with LDRT.…”
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Case report of the first use of a hydrogel rectal spacer for prostate cancer reirradiation via LDR brachytherapy: applications and technical notes by Amina Lazrek, Sebastiano Finocchi Ghersi, Adeline Petre, Sarah Houabes, Anne-Agathe Serre, Frederic Gassa, Magali Sandt, Cecile Laude, Camille Roukoz, Salvatore Cozzi

“…Salvage iodine-125 brachytherapy with the placement of a rectal spacer provided precise radiation delivery while minimizing rectal toxicities. The significant biochemical response observed underscores the efficacy of this approach in controlling disease progression. …”
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Atomic Force Microscopy (AFM) nanomechanical characterization of micro- and nanoplastics to support environmental investigations in groundwater by Massimiliano Galluzzi, Michele Lancia, Chunmiao Zheng, Viviana Re, Valter Castelvetro, Shifeng Guo, Stefano Viaroli

“…Micro and nanoplastic (MNP) pollution is a severe environmental issue, posing potential risks to environmental and human health due to the intrinsic toxicity of plastic particles and their capacity to adsorb other pollutants. …”
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Continuous-flow columns packed with zero-valent iron and iron sulfide as a feasible strategy to remediate the persistent contaminant nitroguanidine by Youngjae Yu, Erika E. Rios-Valenciana, Robert A. Root, Reyes Sierra-Alvarez, Jon Chorover, Jim A. Field

“…However, NQ also represents an emerging contaminant whose environmental emissions can cause toxicity toward aquatic organisms, indicating the need for effective remediation strategies. …”
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Biochar Derived from Domestic Sewage Sludge: Influence of Temperature Pyrolysis on Biochars’ Chemical Properties and Phytotoxicity by Rahma Inès Zoghlami, Sarra Hechmi, Rihab Weghlani, Naceur Jedidi, Mohamed Moussa

“…The raw sewage sludge and the produced biochars have been analyzed to determine their volatile organic matter (VOM), mineral content (MC), nutrients’ level (total nitrogen TN, available phosphorus P, and potassium K), alkalinity (pH), and salinity (electrical conductivity EC and Na). The toxic effect of biochars derived from SS has been evaluated through the analysis of trace metals (Pb, Cr, Cd, Cu, and Zn) and their toxicity by measuring root elongation inhibition (REI). …”
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Synthetic Hydrogel Dilutes <i>Serratia plymuthica</i> Growth— Promoting Effect on <i>Brassica napus</i> L. Under Drought Conditions by Grażyna B. Dąbrowska, Daniel Krauklis, Milena Kulasek, Magdalena Nocny, Marcel Antoszewski, Agnieszka Mierek-Adamska, Beata Kaliska

“…Moreover, the hydrogel did not show toxicity towards tested bacterial strains. Field trials during the drought demonstrated that inoculation with <i>S. plymuthica</i> significantly increased the number of siliques (16.48%) and yield (19.93%), compared to controls. …”
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Efficacy and safety of pembrolizumab in patients with advanced endometrial cancer: a systematic review and meta-analysis by Biqiong Pan, Xiaojun Lai, Jiefang Lu, Xiaoyan Bao, Zengke Fan, Jie Sun

“…Two randomized controlled trials (RCTs) found that the pembrolizumab group had a higher incidence of grade 3 or 4 AEs compared to the control group (OR: 2.23; 95% CI: 1.23, 4.04; p = 0.008).ConclusionPembrolizumab monotherapy or combination significantly improves survival in recurrent or advanced EC and has manageable toxicity albeit with a relatively high incidence of treatment-related AEs.…”
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Reduction of bioavailability and leachability of heavy metals during agitated pile composting of Salvinia natans weed of Loktak lake by W. Roshan Singh, Shashi Kumar Pankaj, Ajay S. Kalamdhad

“…The study also revealed that the total concentrations of Zn (211â254 mg/ kg), Ni (310â345 mg/kg) and Pb (805â891 mg/kg) of the final composts were higher than that of Cr (140â207 mg/ kg) but the water-soluble forms of Zn (3.6â4.7 % of total Zn), Ni (NIL) and Pb (0.7â1.0 % of total Pb) were lower than that of Cr (13.3â19.3 % of total Cr) indicating that Cr in the composts had higher toxicity potential. The leachable heavy metals were within the threshold limits prescribed for agricultural application. …”
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Regulation of adipocyte differentiation and lipid metabolism by novel synthetic chromenes exploring anti-obesity and broader therapeutic potential by Kewalin Inthanon, Natthawut Wong-a-nan, Srisulak Dheeranupattana, Andres Garcia Guerra, Neal M. Davies, Chatchai Kesornpun, Sasithorn Sangher, Prasat Kittakoop

“…Among them, 14 chromenes demonstrated a lack of toxicity to pre-adipocytes (PAs) and mature adipocytes (MAs) of 3T3-L1 cells. …”
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Computational analysis of Allium sativum compounds to identify thermolabile hemolysin inhibitors against Vibrio alginolyticus in shrimp by Sayed Mashequl Bari, Nafees Bin Reza, Meamaching Marma, Sk. Foisal Ahmed, Md Arif Hussain, Md Naimuddin Jabed, Md Alomgir Hossain, Maria Manzoor, Md Saiful Alam

“…Pharmacokinetic and toxicity analyses showed favorable drug-like properties for gibberellin A7 and gibberellic acid with no violations. …”
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