Transplacental Transfer of Primaquine and Neurobehavioral Development of Prenatally Exposed Rats by Klaus M. Becker, Lorenna Rosa, Manoella S. B. Fernandes, Rosangela R. de Carvalho, Ana Cecilia X. De-Oliveira, Davyson L. Moreira, Francisco J. R. Paumgartten

“…Although PQ has been used for over 70 years, its toxicological database has gaps such as the absence of studies on its reproductive and developmental toxicity and kinetics in pregnancy. This study investigated the transplacental transfer of PQ and the effects of intrauterine exposure on the postnatal growth, survival, and neurobehavioral development of the offspring. …”
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Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2 by Yuchen Li, Jiayi Zhou, Tianxin Zhang, Xiaocong Li, Cheng Wu, Ziyi Zhao, Jianyuan Tang, Xiaoyu Tan, Qiongying Hu, Wenhao Liao

“…In conclusion, AS-IV could protect the kidney from heavy metal-induced toxicity and could be used as a nephroprotective agent.…”
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The Effects of Adverse Events and Associated Costs on Value-Based Care for Metastatic Pancreatic Ductal Adenocarcinoma by Prachi Bhatt, Jared Hirsch, Paul Cockrum, George Kim, Gabriela Dieguez

“…We compared the incidence of clinically significant AEs, TCOC, components of TCOC, and costs related to AEs/treatment toxicity. **Results:** Patient AE rates ranged from 6.2% to 51.7%. …”
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Activities of Some Medicinal Plants on the Proliferation and Invasion of Brain Tumor Cell Lines by Saidu I. Ngulde, Umar K. Sandabe, Roger Abounader, Ying Zhang, Isa M. Hussaini

“…Anticancer drugs are often expensive, have narrow spectrum of activities, and are associated with toxicities and side effects such as myelosuppression, immunosuppression, gastrointestinal disturbance, alopecia, skin toxicity, and hepatotoxicity. …”
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Environmental behavior of per- and polyfluoroalkyl substances (PFASs) and the potential role of biochar for its remediation: a review by Haiyan Wang, Haiyan Zhang, Lizhi He, Jie Wang, Shuo Wang, Xiaoyu Shi, Xiaokai Zhang, Hailong Wang, Feng He

“…Abstract Per- and polyfluoroalkyl substances (PFASs), commonly known as ‘‘forever chemicals’’, are persistent organic pollutants that are widely distributed in the environment. Due to their toxicity and resistance to degradation, PFASs are classified as emerging contaminants, and increasing attention is being paid to their remediation. …”
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Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects by Zi-Han Xu, Ming-Min Xie, Chun-Lan Xie, Xian-Wen Yang, Jun-Song Wang

“…Compounds derived from deep-sea fungi exhibit low toxicity and potent neuroprotective effects, offering a promising source for drug development. …”
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64Cu-chelated InP/ZnSe/ZnS QDs as PET/fluorescence dual-modal probe for tumor imaging by Ziyu Zhao, Ayaka Otsuka, Noriko Nakamura, Toshifumi Tatsumi, Kazuhiro Nakatsui, Taiki Tsuzukiishi, Tomo Sakanoue, Kenji Shimazoe, Seiichi Ohta

“…Among these QDs, heavy metal-free InP-based QDs have emerged as a promising candidate, addressing concerns regarding heavy metal-related toxicity. However, to the best of our knowledge, PET/fluorescence dual-modal imaging of InP QDs has yet to be explored. …”
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IgD Multiple Myeloma Paraproteinemia as a Cause of Myositis by I. Colombo, M. E. Fruguglietti, L. Napoli, M. Sciacco, E. Tagliaferri, A. Della Volpe, V. Crugnola, N. Bresolin, M. Moggio, A. Prelle

“…He underwent both muscle and peripheral nerve biopsy to discriminate between myositis (paraproteinemia versus GVHD), amyloidosis, and thalidomide toxicity. The first muscle biopsy showed an inflammatory pattern with necrotic fibres, macrophagical invasion (CD68 positive), rare interstitial cellular infiltrates (CD8 positive and CD4 negative), widespread anti-HLA positivity and negative antiMAC. …”
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Simultaneously delivery of functional gallium ions and hydrogen sulfide to endow potentiated treatment efficacy in chemo- and PARPi-resistant ovarian cancer by Sangsang Tang, Yangyang Li, Yifeng Fang, Mengyan Tu, Shenglong Wu, Yixuan Cen, Junfen Xu

“…More importantly, the therapeutic efficacy of Ga2S3-BSA NMs and their ability to enhance the sensitivity to carboplatin and fluzoparib with negligible toxicity were further confirmed in a platinum-resistant OC animal model. …”
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Screening of six medicinal plant species for antileishmanial activity by Ferreira Fabiana Borges Padilha, Cabral Márcia Regina Pereira, Sarragiotto Maria Helena, Fernandez Carla Maria Mariano, Gazim Zilda Cristiani, Junior Ranulfo Piau, Demarchi Izabel Galhardo, Silveira Thaís Gomes Verzignassi, Lonardoni Maria Valdrinez Campana

“…After isolation and analysis of chemical components by ultra-high performance liquid chromatography-high-resolution tandem mass spectrometry (UHPLC-HRMS/MS), the extracts were also tested for toxicity in J774.A1 macrophages and human erythrocytes. …”
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Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review by Smarika Chauhan, Eswar Marcharla, Sneha Hariharan, Saranya Vinayagam, Thanigaivel Sundaram, Priya SD, Swamynathan Ganesan, Maximilian Lackner

“…Accurate detection continues to be difficult and conventional therapies, such as radiation, surgery, and chemotherapy, frequently encounter problems with poor absorption, toxicity, and a lack of specificity. This review aims to explore the role of nanoparticles in the prognosis and diagnosis of gastric cancer. …”
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Foxp3 Expression in Liver Correlates with the Degree but Not the Cause of Inflammation by Matthaios Speletas, Nikoletta Argentou, Georgios Germanidis, Themistoclis Vasiliadis, Konstantinos Mantzoukis, Kalliopi Patsiaoura, Pavlos Nikolaidis, Vaios Karanikas, Konstantinos Ritis, Anastasios E. Germenis

“…Liver biopsies obtained from 69 individuals (26 chronic HBV hepatitis, 14 chronic HCV hepatitis, 11 nonalcoholic fatty liver disease, 8 autoimmune diseases, 2 methotrexate-related toxicity, and 8 controls) were examined, by qRT-PCR, for the mRNA expression of Foxp3, IL-10, TGF-β1, Fas, FasL, TRAIL, caspase-3, TNF-α, IFN-γ, and IL-1β. …”
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Implications of the Intestinal Microbiota in Diagnosing the Progression of Diabetes and the Presence of Cardiovascular Complications by Alina Mihaela Leustean, Manuela Ciocoiu, Anca Sava, Claudia Florida Costea, Mariana Floria, Claudia Cristina Tarniceriu, Daniela Maria Tanase

“…Dysbiosis causes activation of proinflammatory mechanisms, metabolic toxicity, and insulin resistance. Trimethylamine N-oxide (TMAO) is a microbial organic compound generated by the large intestine, and its concentration increases in the blood after ingestion of foods rich in L-carnitine and choline, such as red meat, eggs, and fish. …”
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Psoralidin: emerging biological activities of therapeutic benefits and its potential utility in cervical cancer by Tanya Tripathi, Apoorva Chaudhary, Divya Janjua, Udit Joshi, Nikita Aggarwal, Chetkar Chandra Keshavam, Alok Chandra Bharti

“…Recent studies have emphasized the use of phytochemicals for cancer prevention due to their low toxicity. Psoralidin, a bioactive compound extracted from the seeds of the medicinal plant Psoralea corylifolia, showcases the potential for promoting health benefits. …”
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Marine Antifouling for Underwater Archaeological Sites: TiO2 and Ag-Doped TiO2 by Silvestro A. Ruffolo, Andrea Macchia, Mauro F. La Russa, Lorenzo Mazza, Clara Urzì, Filomena De Leo, Marianna Barberio, Gino M. Crisci

“…On the other hand, the most used antifouling paints, especially for ship hulls, show considerable toxicity level. Since submerged archaeological sites are often included in environmental protected areas, more eco-friendly products must be used. …”
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p97 Inhibitors Possessing Antiviral Activity Against SARS-CoV-2 and Low Cytotoxicity by Rui Ding, Tiffany C. Edwards, Prithwish Goswami, Daniel J. Wilson, Christine D. Dreis, Yihong Ye, Robert J. Geraghty, Liqiang Chen

“…<b>Conclusions:</b> These compounds are structurally novel p97 inhibitors that display low toxicity and possess promising antiviral activity against SARS-CoV-2 and potentially other viruses. …”
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Therapeutic applications of novel drug delivery systems of liquorice: An updated review on recent advancements by Sanshita, Taneja Ayushi, Sangnim Tanikan, Huanbutta Kampanart, Sindhu Rakesh K., Singh Inderbir

“…In recent times, individuals are focusing more on natural substances, primarily due to their safety and non-toxicity. Also, there is an increasing demand by industries for the phytoconstituents that might be incorporated in pharmaceuticals, cosmetics, dietary products and nutraceuticals. …”
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Therapeutic Angiogenesis Using Basic Fibroblast Growth Factor in Combination with a Collagen Matrix in Chronic Hindlimb Ischemia by Jianyin Zhou, Yilin Zhao, Jinling Wang, Sheng Zhang, Zhengjin Liu, Maochuan Zhen, Yun Liu, Pingguo Liu, Zhenyu Yin, Xiaomin Wang

“…The morphology, porosity and toxicity of CM were examined. The bFGF releasing profile and bioactivity of released bFGF were assessed. bFGF-CM was intramuscularly implanted into the rabbit ischemic hindlimb model. …”
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Synthesis, Molecular Docking, MEP and SAR Analysis, ADME-Tox Predictions, and Antimicrobial Evaluation of Novel Mono- and Tetra-Alkylated Pyrazole and Triazole Ligands by Y. Kaddouri, B. Bouchal, F. Abrigach, M. El Kodadi, M. Bellaoui, R. Touzani

“…ADME-Tox studies suggested that compounds 12 and 13 exhibit better toxicity profiles than the commercial antibiotic streptomycin. …”
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Discovery of Quinazolone Pyridiniums as Potential Broad-Spectrum Antibacterial Agents by Jie Dai, Qianyue Li, Ziyi Li, Zhonglin Zang, Yan Luo, Chenghe Zhou

“…The highly active <b>19a</b> with rapid bactericidal properties displayed imperceptible resistance development trends, negligible hemolytic toxicity, and effective biofilm inhibitory effects. …”
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