Design and In Silico and In Vitro Evaluations of a Novel Nicotinamide Derivative as a VEGFR-2 Inhibitor by Ibrahim H. Eissa, Muhammad Abd ElGayed Bkrah, Reda G. Yousef, Hazem Elkady, Eslam B. Elkaeed, Bshra A. Alsfouk, Ibrahim M. Ibrahim, Ahmed M. Metwaly, Dalal Z. Husein

“…Furthermore, compound 10 demonstrated a lower level of toxicity towards Vero cell lines, with an IC50 value of 127.3 μM. …”
Get full text

Defective homologous recombination and genomic instability predict increased responsiveness to carbon ion radiotherapy in pancreatic cancer by Brock J. Sishc, Janapriya Saha, Elizabeth M. Alves, Lianghao Ding, Huiming Lu, Shih-Ya Wang, Katy L. Swancutt, James H. Nicholson, Angelica Facoetti, Arnold Pompos, Mario Ciocca, Todd A. Aguilera, Michael D. Story, Anthony J. Davis

“…These findings suggest that PDAC tumors with HR pathway mutations or high replication stress are more likely to benefit from CIRT while minimizing normal tissue toxicity.…”
Get full text

Beneficial arthropods threatened by synthetic agricultural pesticides around the southeast slopes of Mount Cameroon by Daniel Brice Nkontcheu Kenko, Agathe Lambou Fotio, Kenfack Donhachi Aimerance, Derick Atemlefac Acha, Miranda Egbe Awo, Eric Bertrand Fokam

“…Data on pesticide usage (active ingredients, interval, dosage, number of applications), and ecotoxicology (LD50 and environmental behaviour) were collected from field surveys and the IUPAC databases, respectively, then imported into PRIMET to assess the level of risk expressed in Exposure Toxicity Ratio (ETR). Tomato was the main crop of the area while insecticides were the main pesticide category utilised in the study area. …”
Get full text

Evaluation of community behavior regarding the risk of plastic micro-pollution on the environment health by D. Utari, N.I. Hawa, G. Fizumli, H. Agustina

“…This research aims encourage greater awareness of environmental condition to minimize toxicity resulting from the negative impacts of plastic waste.…”
Get full text

Insulin Facilitates the Recovery of Myocardial Contractility and Conduction during Cardiac Compression in Rabbits with Bupivacaine-Induced Cardiovascular Collapse by Solmon Yang, Tserendorj Uugangerel, In-ki Jang, Hyung-chul Lee, Jong Min Kim, Byeong-Cheol Kang, Chong Soo Kim, Kook-Hyun Lee

“…We hypothesizes that insulin therapy would be effective in resuscitating bupivacaine-induced cardiac toxicity in rabbits. Twelve rabbits were tracheally intubated and midline sternotomy was performed under general anesthesia. …”
Get full text

Sedum alfredii Hance: A cadmium and zinc hyperaccumulating plant by Mingying Liu, Ying Feng, Miao Wang, Xinglin Sun, Chen Yinfei Qi, Xiaoe Yang, Dayi Zhang

“…The hyperaccumulating ecotype Sedum alfredii Hance is one of few Cd hyperaccumulators with Cd contents in leaves and stems up to 9000 mg/kg (dry weight, DW) and 6500 mg/kg (DW) respectively without displaying significant toxicity symptoms as reported in 2004. Numerous studies have been conducted to uncover the mystery of its hypertolerance and hyperaccumulation using high-throughput sequencing, biochemical and molecular techniques, mainly pointing to the root-microorganism interaction, restrained Cd storage in roots, efficient root-shoot translocation, effective cellular detoxification, and phloem-mediated metal remobilization. …”
Get full text

Fabrication of metal organic framework/Polyoxometalate-TiO2 based DSCCs with enhanced electron lifetime and reduced recombination of charge carriers sensitized with cabbage/spinach... by William Moloto, Pontsho Mbule, Edward Nxumalo, Bulelwa Ntsendwana

“…However, considering practical requirements of DSSCs, the natural dye-based devices satisfy most of the criteria such as affordability, ease of extraction, multiple wavelengths that can be absorbed with large coefficient, non-toxicity, and wide availability.…”
Get full text

Eradication of Krebs-2 primary ascites via a single-injection regimen of cyclophosphamide and double-stranded DNA by E. A. Potter, E. V. Dolgova, A. M. Minkevich, V. P. Nikolin, N. A. Popova, Ya. R. Efremov, S. I. Baiborodin, V. A. Rogachev, A. S. Proskurina, O. S. Taranov, E. I. Vereschagin, A. A. Ostanin, E. R. Chernykh, N. A. Kolchanov, S. S. Bogachev

“…We observed an increase in the average life span of Krebs-2- transplanted mice on a single-injection regimen, which was consistent with reduced toxicity of such treatment.…”
Get full text

Preclinical use of a clinically-relevant scAAV9/SUMF1 vector for the treatment of multiple sulfatase deficiency by Maximiliano Presa, Rachel M. Bailey, Somdatta Ray, Lauren Bailey, Saurabh Tata, Tara Murphy, Pierre-Alexandre Piec, Harold Combs, Steven J. Gray, Cathleen Lutz

“…The treated mice show wide distribution of the SUMF1 gene, no signs of toxicity or neuropathy, improved vision and cardiac function, and no behavioral deficits. …”
Get full text

Design and Fabrication of MoCuO_x Bimetallic Oxide Electrodes for High-Performance Micro-Supercapacitor by Electro-Spark Machining by Ri Chen, Siqi Lv, Yunying Xu, Zicong Lin, Guoying Zhang, Jian Wang, Bocheng Wang, Wenxia Wang, Igor Zhitomirsky, Yong Yang

“…Transition metal oxides, distinguished by their high theoretical specific capacitance values, inexpensive cost, and low toxicity, have been extensively utilized as electrode materials for high-performance supercapacitors. …”
Get full text

Visceral Leishmaniasis Clinical Management in Endemic Districts of India, Nepal, and Bangladesh by Megha Raj Banjara, Siddhivinayak Hirve, Niyamat Ali Siddiqui, Narendra Kumar, Sangeeta Kansal, M. Mamun Huda, Pradeep Das, Suman Rijal, Chitra Kumar Gurung, Paritosh Malaviya, Byron Arana, Axel Kroeger, Dinesh Mondal

“…Physician awareness of renal or liver toxicity as Miltefosine side effects was lower in Bangladesh. …”
Get full text

A novel conditional active biologic anti-EpCAM x anti-CD3 bispecific antibody with synergistic tumor selectivity for cancer immunotherapy by Gerhard Frey, Ana Paula G. Cugnetti, Haizhen Liu, Charles Xing, Christina Wheeler, Hwai Wen Chang, William J. Boyle, Jay M. Short

“…Xenograft studies showed that the efficacy of CAB bispecific antibodies is similar to that of a non-CAB anti-EpCAM bispecific antibody, but they have markedly reduced toxicity in non-human primates, indicating an unprecedentedly widened therapeutic index of over 100-fold. …”
Get full text

Antitumor Effect of Demethylzeylasteral (T-96) on Triple-Negative Breast Cancer via LSD1-Mediate Epigenetic Mechanisms by Zhengjie Shen, Yongjuan Gu, Ruiyang Jiang, Heya Qian, Siyuan Li, Lixian Xu, Wenzhe Gu, Yun Zuo

“…And T-96 could significantly inhibit tumor growth without showing marked toxicity. Conclusions & Implications. The results illustrated that T-96 exerted antitumor activity in highly metastatic TNBC by inactivating the LSD1 function.…”
Get full text

Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials by Zubair Hussain, Yueteng Zhang, Lu Qiu, Shanshan Gou, Kangdong Liu

“…Consequently, these actions may contribute to reduced toxicity and enhanced treatment efficacy in immunotherapy. …”
Get full text

Perch Hydrolysates from Upcycling of Perch Side Streams Accelerate Wound Healing by Enhancing Fibroblasts to Secrete Procollagen I, Fibronectin, and Hyaluronan by Jia-Feng Chang, Chih-Yu Hsieh, Ling-Ni Chen, Mao-Hsiang Lee, Yi-Han Ting, Chi-Yu Yang, Chih-Cheng Lin

Get full text

Polydatin-Induced Shift of Redox Balance and Its Anti-Cancer Impact on Human Osteosarcoma Cells by Alessio Cimmino, Magda Gioia, Maria Elisabetta Clementi, Isabella Faraoni, Stefano Marini, Chiara Ciaccio

“…Importantly, PD exhibits minimal toxicity to non-tumorigenic cells (hFOB), suggesting a favorable therapeutic profile. …”
Get full text

One Nudge Can Be Enough:Reducing Cigarette ButtLittering in Public Areas by Artsiom Klunin, Matúš Sloboda, Emília Sičáková-Beblavá, Patrik Pavlovský

“…In the second quasi-experiment, a standalone salience nudge (crime scene) was first implemented, followed by a combination of the initial (crime scene) and follow-up salience (toxicity) nudges to nudge smokers from cigarette butt littering in public space. …”
Get full text

Advanced progress in the genetic modification of the oncolytic HSV-1 virus by Mi Zhou, Mi Zhou, Mi Zhou, Zhenyu Shen, Zhenyu Shen, Zhenyu Shen

“…The HSV-1 genome can be modified through genetic engineering in two main ways: first, by reducing infectivity and toxicity to normal cells via limited replication and assembly, altered protein-virus receptor binding, and minimized immune evasion; second, by enhancing anticancer activity through disruption of tumor cell metabolism, induction of autophagy, improved immune recognition, and modification of the tumor microenvironment. …”
Get full text

Cardiotoxicity of polystyrene nanoplastics and associated mechanism of myocardial cell injury in mice by Ziyi Xiong, Qiling Kong, Juan Hua, Qi Chen, Dandan Wang

“…We aimed to investigate the toxic effects of polystyrene NPs on the heart and the associated mechanisms. …”
Get full text

Cybertoxicology, molecular docking, and experimental verification reveal the mechanism of action of chlorpyrifos on skin damage by Weibin Du, Wenxiang Zeng, Zhenwei Wang, Huahui Hu, Hongfeng Ruan, Gang Qu

“…However, there is currently no relevant research revealing the toxic effects of CPF exposure on the skin, then it is necessary to comprehensively understand the toxic effects and mechanisms. …”
Get full text