Development and Validation of an RP-HPLC Method for the Quantitative Analysis of Triclosan in Human Urine by Prince Karikari, James Oppong-Kyekyeku, Edmund Ekuadzi, Samuel Oppong Bekoe, Rita Opoku, Daniel Nimako Amprako, Emmanuel Addo-Yobo, Sandra Kwarteng Owusu, Bernard Arhin, Adegoke G. Falade, Ganiyu Arinola, Adeleye S. Bakarey, John I. Anetor, Kevin J. Mortimer

“…TCS has sparked widespread awareness because of its toxicity and possible negative effect on public health in recent years. …”
Get full text

Sublethal effects of copper nanoparticles on the histology of gill, liver and kidney of the Caspian roach, Rutilus rutilus caspicus by Sh. Aghamirkarimi, A. Mashinchian Moradi, I. Sharifpour, Sh. Jamili, P. Ghavam Mostafavi

“…The current study has determined the toxicity effects of copper nanoparticles on the some vital organs such as gill, liver and kidney of Caspian Roach; Rutillus rutillus caspicus. …”
Get full text

Application of Novel Amino-Functionalized NZVI@SiO2 Nanoparticles to Enhance Anaerobic Granular Sludge Removal of 2,4,6-Trichlorophenol by Zeyu Guan, Jinquan Wan, Yongwen Ma, Yan Wang, Yajie Shu

“…Moreover, adding the appropriate concentration of NZVI@SiO2-NH2 in anaerobic granular sludge treatment system can decrease the toxicity of 2,4,6-TCP to anaerobic microorganisms and improved the cumulative amount of methane production and electron transport system activity. …”
Get full text

Nanoplastics induces arrhythmia in human stem-cells derived cardiomyocytes by Shirley Pei Shan Chia, Jeremy Kah Sheng Pang, Winanto Winanto, Boon-Seng Soh

“…Further research is needed to fully elucidate the mechanisms underlying NP-induced toxicity and to develop strategies for mitigating their adverse effects. …”
Get full text

Growth and viability of juvenile humpback grouper (Cromileptes altivelis) supplemented with inorganic and organic selenium by Muhaimin Hamzah, Muhammad Agus Suprayudi, Nur Bambang Priyo Utomo, Wasmen Manalu

“…On the contrary, supplementation of selenomethionine up to 4 mg Se/kg did not show any signs of toxicity and the survival was on 86.11 to 97.22%. Feed efficiency, protein retention, lipid retention, and Se retention indicated that a dosage of 4 mg Se/kg selenomethionine supplementation was the best dosage. …”
Get full text

The effect of ozone exposure on the release of eicosanoids in guinea-pig BAL fluid in relation to cellular damage and inflammation by H. J. M. Van Hoof, F. J. Zijlstra, H-P. Voss, I. M. Garrelds, J. A. M. A. Dormans, L. Van Bree, A. Bast

“…We hypothesized that depending on the O3 exposure protocol, mainly either an oxidant damage or an inflammation will determine the O3 toxicity. We compared two different ozone exposure protocols: an acute exposure (3 ppm 2 h) for studying the oxidant damage and an exposure (1 ppm 12 h) where an inflammatory component is also probably involved. …”
Get full text

Anti-Inflammatory Activities of Some Plants of Genus Alpinia: Insights from In Vitro, In Vivo, and Human Studies by Yuliawati KM, Febriyanti RM, Sumiwi SA, Levita J

“…These plants did not show toxicity toward numerous normal cell lines (RAW 264.7, IEC-6, HepG2, MT-4, NIH-3T3, Vero cells, human peripheral blood mononuclear cells, and HaCaT) but were toxic to cancer cell lines (HT29). …”
Get full text

Investigation study of face mask consumption in Malaysia and its impact on environment by Low Chung-Yu, Bee Soo-Tueen, Law Yung-Siang, Lee Tin-Sin, Bee Soo-Ling

“…In overall, RFL washable face mask is found to provide a lower environmental impact when compared to 3-ply surgical face mask in terms of the ReCiPe midpoint and endpoint indicator, which included Global Warming Potential, Photochemical Oxidant Formation Potential, Toxicity Potential, Ecosystem Quality, Human Health and Resource Depletion.…”
Get full text

Applications of cell penetrating peptide-based drug delivery system in immunotherapy by Jing-Jing Du, Ru-Yan Zhang, Shangchi Jiang, Shanshan Xiao, Yiting Liu, Yongheng Niu, Wen-Xiang Zhao, Dongyuan Wang, Dongyuan Wang, XianShi Ma

“…Besides, inappropriate chemical modification can lead to membrane disruption and nonspecific toxicity. In this paper, we first reviewed recent advances in the CPP applications for cancer therapy via covalent or non-covalent manners. …”
Get full text

Hypoglycemic natural products with in vivo activities and their mechanisms: a review by Wenyi Ma, Longgao Xiao, Haiyang Liu, Xiaojiang Hao

“…Natural products (NPs) are a reservoir of diverse structures and bioactivities with low toxicity and less side effects. And some of them show effects on diabetic complications, which is a significant idea for drug development. …”
Get full text

Effect of Nano-Silica on Mechanical Properties and Cytotoxicity of Calcium-Silicate-Based Root Canal Filling Materials by Hao He, Bolang Hao, Xiang Xiong, Yi Cheng, Jia Lou, Zheyu He, Dongyang Li, Zhihuan Wang, Jian Qin

“…The findings of this study demonstrate that the early compressive strength of calcium-silicate-based root canal filling materials exhibits a substantial increase in response to the incorporation of NS, and that calcium-silicate-based root canal filling materials do not manifest significant levels of toxicity. NS improved hydration product formation and made efficient pore filling possible.…”
Get full text

Effects of POPs-induced SIRT6 alteration on intestinal mucosal barrier function: A comprehensive review by Guangcan Chen, Tengyang Huang, Yifeng Dai, Xia Huo, Xijin Xu

“…Persistent organic pollutants (POPs) are pervasive organic chemicals with significant environmental and ecological ramifications, extending to adverse human health effects due to their toxicity and persistence. The intestinal mucosal barrier, a sophisticated defense mechanism comprising the epithelial layer, mucosal chemistry, and cellular immunity, shields the host from external threats and fosters a symbiotic relationship with intestinal bacteria. …”
Get full text

Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes by Rauda A. Mohamed, Keat K. Ong, Noor Azilah M. Kasim, Norhana A. Halim, Siti Aminah M. Noor, Victor F. Knight, Nurul Najwa Ab. Rahman, Wan Md Zin W. Yunus

“…However, many questions remain unanswered regarding the efficacy and toxicity of this reactivator. Pralidoxime, MMB-4, TMB-4, obidoxime, and HI-6 are the examples of the established oximes, yet they are of insufficient effectiveness in some poisonings and only a limited spectrum of the different nerve agents and pesticides are being covered. …”
Get full text

Assessment of Health Risks in Wheat Crop Irrigated by Manka Canal, Dera Ghazi Khan, Pakistan by Muhammad Anwar ul Hassan, Sabiha Javied, Umair Riaz, Muneera A. Saleh, Khalid H. Alamer, Naila Siddique, Ambreen Aslam, Nabeela Noor, Qamar uz Zaman

“…Prior to irrigating crops like wheat and vegetables, it is strongly advised to treat municipal wastewater to prevent soil and dietary toxicity from heavy metals.…”
Get full text

4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies by Ashanul Haque, Khalaf M. Alenezi, Mohd. Saeed Maulana Abdul Rasheed, Md. Ataur Rahman, Saleha Anwar, Shahzaib Ahamad, Dinesh Gupta

“…The drug-likeness feature and toxicity of the molecules were evaluated using QikProp and other tools.ResultsCompounds were synthesized following a multi-step approach and characterized using multi-nuclear magnetic resonance (1H/13C-NMR) and mass spectrometry. …”
Get full text

Cytotoxic mechanisms of pemetrexed and HDAC inhibition in non-small cell lung cancer cells involving ribonucleotides in DNA by Tobias Solli Iveland, Lars Hagen, Mirta Mittelstedt Leal de Sousa, Nina Beate Liabakk, Per Arne Aas, Animesh Sharma, Bodil Kavli, Geir Slupphaug

“…Contrary to the conventional model of antifolate toxicity, which implicates futile cycles of uracil incorporation and excision in DNA, we propose that ribonucleotide incorporation in nuclear and mitochondrial DNA significantly contributes to the cytotoxicity of antifolates like pemetrexed, and likely also of fluorinated pyrimidine analogs. …”
Get full text

Neurovascular bundle sparing in hypofractionated radiotherapy maintained with realistic treatment uncertainties by Roel C. Kwakernaak, Victor J. Brand, Jesús Rojo-Santiago, Femke E. Froklage, Mischa S. Hoogeman, Steven J.M. Habraken, Maaike T.W. Milder

“…Background and purpose: Erectile dysfunction is a common side effect of radiotherapy for prostate cancer. To mitigate this toxicity, it has been suggested to limit the dose to critical nerves and vessels. …”
Get full text

Sources of Lipopeptides and Their Applications in Food and Human Health: A Review by Shuyi Chen, Sumin Chen, Xin Yu, Caijing Wan, Ying Wang, Lianxin Peng, Qiang Li

“…Lipopeptides (LPs) are widely sourced surface-active natural products with a wide range of functions and low toxicity, high potency, and good biodegradability. …”
Get full text

Electrochemical sensor doped with core-shell structured molecularly imprinted polymer proposed for therapeutic drug monitoring of trazodone hydrochloride by Amr M. Mahmoud, Nariman A. El-Ragehy, Maha A. Hegazy, Samia A. Tawfik, Ghada A. Sedik

“…Its detection is significant for ensuring effective therapeutic drug monitoring as it has a narrow therapeutic window in addition to optimize dosages, prevent toxicity, and enhance treatment outcomes. MIP with a uniform core shell structure was prepared where the shell was combined onto the surface of silica nanoparticles by copolymerizing ethylene glycol dimethacrylate together with methacrylic acid in the presence of trazodone hydrochloride. …”
Get full text

Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product by Afolabi C. Akinmoladun, Kehinde O. Oguntunde, Lawrence O. Owolabi, Omotayo B. Ilesanmi, Joan O. Ogundele, M.Tolulope Olaleye, Afolabi A. Akindahunsi

“…In this study, Trévo™, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in acetaminophen-induced hepatic toxicity in Wistar rats. Animals received Trévo™ (1.5 mL/kg, 3.0 mL/kg or 4.5 mL/kg) orally for 14 days. …”
Get full text