On Farm Evaluation of Eucalyptus globulus Labill Leaf and Chenopodium ambrosioides L. Whole Plant Powder against Storage Insect Pests in Stored Maize at Sokoru District in Jimma Zo... by Lelise Tilahun Dufera, Abebe Yimer Tadesse, Waktole Sori Gobena, Chala Gowe Kuyu

“…It is recommended that further research should be done to check if the increasing rate of application increases protection duration of these botanicals and the toxicity of Chenopodium ambrosioides L. should be further studied to use it as a storage insect protectant of maize grains intended for food purpose.…”
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Metal‐based nanomaterials and nanocomposites as promising frontier in cancer chemotherapy by Sunil Kumar, Monu Kumar Shukla, Abhishek Kumar Sharma, Gururaj K. Jayaprakash, Rajiv K. Tonk, Dinesh K. Chellappan, Sachin Kumar Singh, Kamal Dua, Faheem Ahmed, Sanjib Bhattacharyya, Deepak Kumar

“…NMs are being modified to overcome issues, such as toxicity, lack of selectivity, increase drug capacity, and bioavailability, for a wide spectrum of cancer therapies. …”
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Indoor and Outdoor Exposure to PM2.5 during COVID-19 Lockdown in Suburban Malaysia by Eliani Ezani, Peter Brimblecombe, Zulfa Hanan Asha’ari, Amirul Aiman Fazil, Sharifah Norkhadijah Syed Ismail, Zamzam Tuah Ahmad Ramly, Md Firoz Khan

“…Unfortunately, little is known about the toxicity of indoor particles and the types of exposures that result where people increase the amount of time they spend working from home or staying indoors, especially during periods of lockdown.…”
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Transcriptional Systems Vaccinology Approaches for Vaccine Adjuvant Profiling by Diogo Pellegrina, Heather L. Wilson, George K. Mutwiri, Mohamed Helmy

“…Here, we review some of the challenges in adjuvant studies, such as predicting adjuvant activity and toxicity when administered alone or in combination with antigens, or classifying adjuvants in groups with similar properties, while underscoring the significance of transcriptomics in systems vaccinology approaches to propel vaccine development forward.…”
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Novel antibiotics against Staphylococcus aureus without detectable resistance by targeting proton motive force and FtsH by She Pengfei, Yang Yifan, Li Linhui, Li Yimin, Xiao Dan, Guo Shaowei, Huang Guanqing, Wu Yong

“…The compounds exhibited excellent in vivo pharmacokinetics, toxicity profiles, and antimicrobial activities in the abscess model as well as the peritonitis‐sepsis model. …”
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MicroRNA-155 modulates methotrexate-induced spatial memory impairment by disruption of the blood-brain barrier integrity by Yu-Chieh Chen, Li-Tung Huang, Hong-Ren Yu, Jiunn-Ming Sheen

“…The aim of the study was to evaluate the role of miR-155 in the pathogenesis of MTX-induced cognitive impairment, mainly focused on the interplay of blood-brain barrier (BBB) integrity and MTX toxicity. Main methods: We use young rat model mimicking children leukemia treatment protocol, focusing on the systemic MTX effect on the central nervous system by intraperitoneal (IP) MTX injection. …”
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Maytansinoids in cancer therapy: advancements in antibody–drug conjugates and nanotechnology-enhanced drug delivery systems by Matteo Perra, Ines Castangia, Matteo Aroffu, Federica Fulgheri, Rita Abi-Rached, Maria Letizia Manca, Hernán Cortés, María Luisa Del Prado-Audelo, Carla Nomura-Contreras, Alejandra Romero-Montero, Dietrich Büsselberg, Gerardo Leyva-Gómez, Javad Sharifi-Rad, Daniela Calina

“…Preclinical and clinical studies show that AMCs, including FDA-approved drugs like Kadcyla and Elahere, effectively inhibit tumor growth while reducing systemic toxicity. Key developments include improved synthesis methods, linker chemistry and payload design. …”
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Improving Individualized Salbutamol Treatment: A Population Pharmacokinetic Model for Oral Salbutamol in Virtual Patients by Lara Marques, Nuno Vale

“…We also identified individual characteristics associated with increased salbutamol toxicity risk, indicating the need for dose adjustment or alternative administration. …”
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Prednisone inhibits osteosarcoma cell by regulating the Wnt/β-catenin signaling pathway by Yo Zhang, Hongmei Zhang, Shanshan Yang, Xiufeng Gao, Wenhao Guo

“…The results showed prednisone could inhibit the proliferation in osteosarcoma cells and exhibit lower proliferation toxicity towards normal bone cells compared to cisplatin by 17.5% (p<0.001). …”
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Construction of Shoot Apical Meristem cDNA Yeast Library of <i>Brassica napus</i> L. and Screening of Proteins That Interact with the Inflorescence Regulatory Factors BnTFL1s by Lingxiong Zan, Haidong Liu, Xutao Zhao, Dezhi Du, Kaixiang Li

“…Additionally, the bait vector pGBKT7-BnTFL1s was transformed into yeast cells alongside positive and negative controls, demonstrating no toxicity to the yeast cells and no self-activation. …”
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Inhibition of transcriptional regulation of detoxification genes contributes to insecticide resistance management in Spodoptera exigua by Bo Hu, Yuping Deng, Tao Lu, Miaomiao Ren, Kuitun Liu, Cong Rao, Hailiang Guo, Jianya Su

“…Bioassay results showed that sofalcone significantly enhanced the toxicity (more than 3-fold) of chlorpyrifos and lambda-cyhalothrin against S. exigua larvae. …”
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Effects of aluminum on metabolism of reactive oxygen species and reactive nitrogen species in root tips of different Eucalyptus species by Zilong Ouyang, Bing Liu, Tangkan Li, Tiandao Bai, Weichao Teng

“…The tolerance of E. urophylla and E. urophylla × E. grandis to Al stress was stronger than that of E. grandis and E. tereticornis. Differences in Al toxicity tolerance were related to long-term selection of the original habitat of the species; moreover, the Al tolerance was hereditary. …”
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Identifying common pathways for doxorubicin and carfilzomib-induced cardiotoxicities: transcriptomic and epigenetic profiling by Conagh Kelly, Dylan J. Kiltschewskij, Angeline J.W. Leong, Tatt Jhong Haw, Amanda J. Croft, Lohis Balachandran, Dongqing Chen, Danielle R. Bond, Heather J. Lee, Murray J. Cairns, Aaron L. Sverdlov, Doan T. M. Ngo

“…Abstract Cancer therapy-related cardiovascular toxicity (CTR-CVT) is now recognised as one of the leading causes of long-term morbidity and mortality in cancer patients. …”
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DNA methylation and immune evasion in triple-negative breast cancer: challenges and therapeutic opportunities by Wen-yu Cai, Xin-xian Cai, Yi-ran Fei, Rui Ye, Ding-ming Song, Dan Hu, Wan-wan Zhang, Ming-fei Xia, Xiao-xiao Yang

“…We discuss the underlying mechanisms that enable these therapeutic synergies, preclinical and clinical evidence supporting the approach, and the challenges posed by tumor heterogeneity, drug resistance, and toxicity. Finally, we explore the potential for personalized treatment strategies incorporating multi-omics data to optimize therapeutic outcomes. …”
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Determination of the Selected Heavy Metal Content and Its Associated Health Risks in Selected Vegetables Marketed in Bahir Dar Town, Northwest Ethiopia by Biset Asrade, Gebremariam Ketema

“…However, they are a major source of heavy metals, which contain both essential and toxic heavy metals over a wide range of concentrations. …”
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Ameliorated Impact of Fenugreek Seed Extract on Some Blood Cellular and Biochemical Parameters in Female Albino Rats Exposed to Lead Acetate by Rozhya Abduljalil Naser, Rabar Yousif Mameik, Nazar M. Shareef Mahmood, Kurdo Bapir Chato

“…It has a several diverse-organ toxicant effect in various healthy issues included diseases of the hepatic, renal, and other body systems. …”
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Cytopenia among CML Patients on Imatinib in Kenya: Types, Grades, and Time Course by Angela McLigeyo, Jamilla Rajab, Mohammed Ezzi, Peter Oyiro, Yatich Bett, Andrew Odhiambo, Matilda Ong’ondi, Sitna Mwanzi, Mercy Gatua, NAOthieno- Abinya

“…Patients on imatinib treatment may develop cytopenia due to drug toxicity. This study aimed to determine the types, grades, and time course of cytopenia in CML patients on imatinib at a Nairobi hospital. …”
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Effects of fiber engraving laser on metallurgical, surface topography, and corrosion properties of AZ80 magnesium-based alloy by Narges Ahmadi, Homam Naffakh-Moosavy, Seyed Mohammad Mahdi Hadavi, Fatemeh Bagheri

“…Magnesium, a lightweight metal similar to natural bone, shows no toxicity and can aid in hard tissue recovery when implanted in the human body. …”
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From guideline to practice: three years of ICH S11 insights and recommendations by Diana Tavares, Hsiao-Tzu Chien, Hsiao-Tzu Chien, Maria Elzbieta Sheean, Peter Theunissen, Peter Theunissen, Peter van Meer, Peter van Meer, Peter van Meer, Karen Van Malderen

“…A thorough consideration of developmental aspects of the product’s pharmacological target, the clinical relevance of notable toxicity findings, and the clinical context of the medicine’s use fosters effective dialogue and improves regulatory alignment. …”
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Rationale and design of the multicenter, national, randomized, open labeled phase III trial: allogeneic stem cell transplantation as a potential curative treatment for patients wit... by Annemarie Glöckner, Stefan Schönland, Hermann Einsele, Nicolaus Kröger

“…Discussion The present clinical study is designed to evaluate the superiority of allogeneic stem cell transplantation compared to conventional therapy (triplet chemotherapy) for the difference in overall survival at 5 years, toxicity and quality of life in patients with multiple myeloma who have relapsed or progressed after first-line autologous stem cell therapy. …”
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