Studying the Oncolytic Activity of <i>Streptococcus pyogenes</i> Strains Against Hepatoma, Glioma, and Pancreatic Cancer <i>In Vitro</i> and <i>In Vivo</i> by Anna N. Tsapieva, Alexander N. Chernov, Nadezhda V. Duplik, Anastasiya O. Morozova, Tatiana A. Filatenkova, Mariia A. Suvorova, Elena Egidarova, Elvira S. Galimova, Kseniya Bogatireva, Alexander N. Suvorov

“…This study aimed to investigate the oncolytic efficacy of <i>S. pyogenes</i> GUR and its M protein knockout mutant, <i>S. pyogenes</i> strain GURSA1, which was genetically constructed to minimize overall toxicity, against mouse hepatoma 22A, pancreatic cancer PANC02, and human glioma U251 cells, both <i>in vitro</i> and <i>in vivo</i>, using the C57BL/6 mouse model. …”
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<i>Vismia guianensis</i> Improves Survival of <i>Tenebrio molitor</i> and Mice During Lethal Infection with <i>Candida albicans</i> by Arthur André Castro Costa, Elizangela Pestana Motta, Aluísio Silva Oliveira, Pamela Gomes Santos, Josivan Regis Farias, Danielle Cristine Gomes Franco, Mayara Cristina Pinto Silva, Nicolle Teixeira Barbosa, Simone Batista Muniz, Luís Douglas Miranda. Silva, Lucilene Amorim Silva, Claudia Quintino Rocha, Flavia Raquel Fernandes Nascimento, Rosane Nassar Meireles Guerra

“…Two sets of experiments used <i>T. molitor</i> larvae. To evaluate toxicity, the uninfected larvae were treated with EHVG or anthraquinone. …”
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Pharmacological ascorbate combined with rucosopasem selectively radio-chemo-sensitizes NSCLC via generation of H2O2 by C.F. Pulliam, M.A. Fath, S. Sho, S.T. Johnson, B.A. Wagner, M. Singhania, A.L. Kalen, K. Bayanbold, S.R. Solst, B.G. Allen, B.N. George, J.M. Caster, G.R. Buettner, D.P. Riley, J.L. Keene, R.A. Beardsley, D.R. Spitz

“…The current study shows that the combination of newly developed MnPAM dismutase mimetic, rucosopasem manganese (RUC) with P-AscH‾ radio-sensitizes non-small cell lung cancer cells (NSCLC) and increases steady state levels of intracellular H2O2 with no additional toxicity to normal human bronchial epithelial cells (HBECs). …”
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Investigating new drugs from marine seaweed metabolites for cervical cancer therapy by molecular dynamic modeling approach by Sk Injamamul Islam, Sheikh Sunzid Ahmed, Sarower Mahfuj, Gunjan Das, Md. Mohaimenul Islam Tareq, Mazen Almehmadi, Mamdouh Allahyani, Naif Alsiwiehri, Partha Biswas, Md. Nazmul Hasan, Foysal Ahammad

“…All of the leading candidates had positive characteristics in terms of pharmacokinetics, pharmacodynamics, and toxicity. The molecular dynamics simulation of the apoprotein, control drug, and lead compounds revealed the superior structural stability and uniformity of the main drug candidates. …”
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In Vitro Antibacterial, Antioxidant, Cytotoxicity Activity, and In Silico Molecular Modelling of Compounds Isolated from Roots of Hydnora johannis by Teshome Degfie, Milkyas Endale, Muhdin Aliye, Rajalakshmanan Eswaramoorthy, Tariku Nefo Duke, Aman Dekebo

“…According to the cytotoxicity study, n-hexane extract exhibited a high level of toxicity with 28.9 ± 5.6% cell viability. Antibacterial activity was tested against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus pyogen. …”
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Plant Extracts in the Bone Repair Process: A Systematic Review by Lyvia Lopes Miranda, Vanessa de Paula Guimarães-Lopes, Luciana Schulthais Altoé, Mariáurea Matias Sarandy, Fabiana Cristina Silveira Alves Melo, Rômulo Dias Novaes, Reggiani Vilela Gonçalves

“…The absence or incomplete characterization of the animal models, treatment protocols, and phytochemical and toxicity analyses impairs the internal validity of the evidence, making it difficult to determine the effectiveness and safety of plant-derived products in bone repair.…”
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The Characterization of L-Asparaginase with Low L-Glutaminase Activity Produced by the Marine <i>Pseudomonas</i> sp. Strain GH-W2b by Woon-Jong Yu, Ha Young Lee, Yong Min Kwon, Seung Seob Bae, Grace Choi, Hyun-Ju Hwang, Dawoon Chung

“…Commercial ASNases currently used in the pharmaceutical and food industries are produced by microorganisms, such as bacteria and fungi. However, their toxicity and poor thermal stability limit their application. …”
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Lipoic acid-boronophenylalanine-derived multifunctional vesicles for cancer chemoradiotherapy by Liqun Dai, Jie Liu, Tingyu Yang, Xiaorui Yu, Yi Lu, Lili Pan, Siming Zhou, Diyun Shu, Yuanhao Liu, Wuyu Mao, Zhiyong Qian

“…Abstract Cancer remains a major health challenge, with the effectiveness of chemotherapy often limited by its lack of specificity and systemic toxicity. Nanotechnology, particularly in targeted drug delivery, has emerged as a key innovation to address these limitations. …”
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High Glucose-Induced Oxidative Stress Mediates Apoptosis and Extracellular Matrix Metabolic Imbalances Possibly via p38 MAPK Activation in Rat Nucleus Pulposus Cells by Xiaofei Cheng, Bin Ni, Feng Zhang, Ying Hu, Jie Zhao

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Preliminary efficacy and safety analysis: 12-month results in 83 patients using a novel approach of widefield radiation therapy for extensive skin field cancerization with or witho... by Andrew E. Potter, Christopher Baker, Stephen Shumack, Robert Sinclair, Walter J. Curran, David Christie, Bradley Wong, Peter Foley, Peter O’Brien, Lynda Spelman

“…The frequency of Grade 3 acute skin toxicities was low.Conclusions Registry data demonstrate the potential for widefield RT to treat patients with significant skin pathology who have exhausted other therapies and require durable, minimally invasive treatment options. …”
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A detoxified TLR4 agonist inhibits tumour growth and lung metastasis of osteosarcoma by promoting CD8+ cytotoxic lymphocyte infiltration by Ryunosuke Oyama, Akira Nabeshima, Makoto Endo, Alexey Novikov, Toshifumi Fujiwara, Capucine Phelip, Nobuhiko Yokoyama, Yoshinao Oda, Martine Caroff, Yoshihiro Matsumoto, Jerome Kerzerho, Yasuharu Nakashima

“…Systemic immune activation by Toll-like receptor 4 (TLR4) immunostimulants has shown great promise; however, current TLR4 agonists’ toxicity hinders this systemic approach in patients with osteosarcoma. …”
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Multifunctional Plumeria rubra nanoparticles: Antimicrobial, antiviral, antiparasitic and anti-inflammatory activities by Bassma H. Elwakil, Mohab H. Elsabrouty, Areej Eskandrani, Keshav Raj Paudel, Esraa Abdelhamid Moneer

“…Novel natural nanomaterials are extensively investigated nowadays due to their potential biological activities and low toxicity. In the present investigation, polyvinyl alcohol was used as a green reducing agent to synthesize Plumeria rubra nanoparticles. …”
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Exploring chitin metabolite profiles and sensitivity differences in Collembola species exposed to teflubenzuron by Saúl Fernandes, Diana Ilyaskina, Matty P. Berg, Marja H. Lamoree, Pim E.G. Leonards, Cornelis A.M. van Gestel

“…This study combines traditional toxicity tests with a metabolomic approach to examine the interspecies specific sensitivity of three Collembola species — Sinella curviseta, Ceratophysella denticulata, and Folsomia candida — to teflubenzuron. …”
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Efficacy and safety of an herbal galactagogue decoction versus powdered formulation in lactating rats by Pruksa Chotitham, Suksalin Booranasubkajorn, Saracha Pattanapholkornsakul, Pravit Akarasereenont, Pinpat Tripatara

“…Both PNF decoction and powder did not exhibit subacute toxicity to the liver and kidneys in maternal rats and pups. …”
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The Role of AChE in Swimming Behavior of Daphnia magna: Correlation Analysis of Both Parameters Affected by Deltamethrin and Methomyl Exposure by Qing Ren, Ruibin Zhao, Cheng Wang, Shangge Li, Tingting Zhang, Zongming Ren, Meiyi Yang, Hongwei Pan, Shiguo Xu, Jianping Zhu, Xun Wang

“…The unpredictable toxicity of insecticides may cause behavior disorder of biological organisms. …”
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Chromosomal Abnormalities in Allium cepa Induced by Treated Textile Effluents: Spatial and Temporal Variations by W. M. Dimuthu Nilmini Wijeyaratne, P. G. Minola Udayangani Wickramasinghe

“…Appropriate effluent treatment processes are expected to significantly reduce the toxicity of effluents before they are released to the natural environment. …”
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From botany to bedside: a review of the health benefits of Lycium barbarum as a functional food by Alois Berisha, Elena-Alexandra Alexa, Robbie Kelleher, Tao Zhang

“…This review also examines the safety profile of L. barbarum, considering its side effects, toxicity, potential contamination, and interactions with medications, emphasising the importance of balancing its health-promoting properties with cautious consumption. …”
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Separation of Inorganic Forms of Tellurium Using On-Site SPE Followed by ICP-MS or ICP-OES—The Right Solution for Water Monitoring by Katarzyna Kińska, Barbara Żelazko, Olga Gajewska, Magdalena Borowska, Monika Sadowska, Beata Krasnodębska-Ostręga

“…As both forms differ in mobility and toxicity, Te speciation should be included in water monitoring, but problems with speciation changes occurring during sampling, transport, and sample storage require the use of on-site separation of Te forms. …”
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Bifunctional copper ion/melittin incorporated hydrogel with antimicrobial and antioxidant capabilities for infected skin wound healing by Jun Yao, Xiao Li, Minjie Lin, Zhuoqi Han, Xiaonan Wang, Jingjing Guo, Bing Wu, Jiajie Xia

“…The optimised hydrogel not only reduces MEL toxicity but also amplifies its antibacterial and anti-inflammatory effects. …”
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PSMA antibody, humanized PSMA.CAR10.3, or Cetuximab increases prostate cancer localization of NF-κB p50-deficient immature myeloid cells (p50-IMC) and phagocytosis by their macroph... by Mohammad A. Alzubi, Theresa Barberi, Alan D. Friedman

“…Nevertheless, this study indicates the potential clinical utility of adding a tumor-directing antibody or CAR, including the novel, fully humanized PSMA.CAR10.3, to proinflammatory p50-IMC to optimize the activation of anti-tumor immunity in prostate cancer and other malignancies, and understanding PSMA toxicity in normal but not malignant prostate epithelium may reveal a novel therapeutic opportunity.…”
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