The Second Canadian Symposium on Hepatitis C Virus: A Call to Action by Jason Grebely, Marc Bilodeau, Jordan J Feld, Julie Bruneau, Benedikt Fischer, Jennifer F Raven, Eve Roberts, Norma Choucha, Rob P Myers, Selena M Sagan, Joyce A Wilson, Frank Bialystok, D Lorne Tyrrell, Michael Houghton, Mel Krajden, on behalf of the National CIHR Research Training Program in Hepatitis C

“…Within the next three to 10 years, it is expected that tolerable, short-duration (12 to 24 weeks) therapies capable of curing >90% of those who undergo treatment will be approved. …”
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The Populus MYB transcription factor PSAR1 negatively regulates salt stress and is a repressor of ABA signaling by Qing Fang, Caiyun Zhang, Jingjie Liu, Zhi Zeng, Yanke Lu

“…A markedly diminished tolerance to salt stress was observed in the engineered Arabidopsis overexpressing PSAR1 (OeLAs) compared with Wt (wild-type) plants. …”
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Unique Genotypic Differences Discovered among Indigenous Bangladeshi Rice Landraces by Nusrat Yesmin, Sabrina M. Elias, Md. Sazzadur Rahman, Taslima Haque, A. K. M. Mahbub Hasan, Zeba I. Seraj

“…In some cases, the clustering matched with properties like aromaticity, stickiness, salt tolerance, and photoperiod insensitivity. The results will help breeders to work towards the proper utilization of these landraces for parental selection and linkage map construction for discovery of useful alleles.…”
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Severe Erosive Pill Esophagitis Induced by Crizotinib Therapy: A Case Report and Literature Review by Patrick Jung, Kyle J. Fortinsky, Zane R. Gallinger, Piero Tartaro

“…Most importantly, this case highlights nonpharmacologic ways to improve tolerability and decrease adverse effects of a highly effective chemotherapeutic agent.…”
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Dendrimer functionalized folate-targeted gold nanoparticles for luciferase gene silencing in vitro: A proof of principle study by Mbatha Londiwe Simphiwe, Maiyo Fiona Chepkoech, Singh Moganavelli

“…Nanocomplexes bound and protected siRNA against degrading RNases, and were well tolerated by the cells. The Au:G5D:FA nanocomplexes elicited excellent gene silencing in folate receptor expressing HeLa-Tat-Luc cells, decreasing significantly in the presence of excess FA ligand, indicating nanocomplex uptake by the mechanism of receptor mediation. …”
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Prophylactic use of recombinant ADAMTS-13 during pregnancy for congenital thrombotic thrombocytopenic purpura by Éloïse Colliou, Agnès Ribes, Clotilde Gaible, Mathilde Marlas, David Ribes, Isabelle Labadens, Paul Guerby, Stanislas Faguer

“…No flare-up of cTTP occurred during the pregnancy, and rADAMTS-13 was tolerated well. No anti–ADAMTS-13 antibodies developed. …”
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Dynamic Sensor Scheduling for Thermal Management in Biological Wireless Sensor Networks by Yahya Osais, F. Richard Yu, Marc St-Hilaire

“…The solution of the model gives an optimal policy that when executed will result in the maximum possible network lifetime under a constraint on the maximum temperature level tolerable by the patient's body. In order to obtain the optimal policy in a lesser amount of time, two specific types of states are aggregated to produce a considerably smaller MDP model equivalent to the original one. …”
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Adverse Effects of Proton Pump Inhibitors on Platelet Count: A Case Report and Review of the Literature by Subhajit Mukherjee, Tanima Jana, Jen-Jung Pan

“…PPIs in general have an excellent long-term safety profile and are well-tolerated. However, studies have shown some adverse reactions (e.g., osteoporosis, Clostridium difficile-associated diarrhea, Vitamin B12 and iron deficiency, and acute interstitial nephritis) on long-term PPI use. …”
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Gastric Linitis Plastica and Peritoneal Carcinomatosis as First Manifestations of Occult Breast Carcinoma: A Case Report and Literature Review by Mara Mantiero, Giovanni Faggioni, Alice Menichetti, Matteo Fassan, Valentina Guarneri, Pierfranco Conte

“…After 20 months, the same therapy is still ongoing and well tolerated, while the patient is in good condition with improvement of the dysphagia. …”
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Therapy of Osteoporosis in Men with Teriparatide by Natalie E. Cusano, Aline G. Costa, Barbara C. Silva, John P. Bilezikian

“…Teriparatide is well tolerated with a good safety profile.…”
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Positive Macroscopic Approximation for Fast Attribute Reduction by Zheng-Cai Lu, Zheng Qin, Qiao Jing, Lai-Xiang Shan

“…This paper proposes a novel model called macroscopic approximation, considering all the target concepts as an indivisible whole to be approximated by rough set boundary region derived from inconsistent tolerance blocks, as well as an efficient approximation framework called positive macroscopic approximation (PMA), addressing macroscopic approximations with respect to a series of attribute subsets. …”
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A New Spectrophotometric Reagent for Fe(III): 2-(2,3-Dihydroxy-4-oxocyclobut-2-enylidene) Hydrozinecarbothiamide and Its Application in Real Samples by Mahboubeh Saeidi, Reihaneh Aboutalebi, Ali Darehkordi

“…The method is optimized in terms of the pH value, amount of reagent required, ionic strength, and stability of the complex, sensitivity, linearity, and tolerance limits of various foreign ions. The complex is a red-brown chelate, with 𝜆max=465 nm at pH = 3 (𝜀=1.95×103 L⋅mol−1⋅cm−1). …”
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Rat Sarcoma Virus Family Genes in Acute Myeloid Leukemia: Pathogenetic and Clinical Implications by Shaimaa Khattab, Adriatik Berisha, Natalia Baran, Pier Paolo Piccaluga

“…Despite extensive efforts to find targeted therapy for <i>RAS</i>-mutated AMLs, no effective and tolerable RAS inhibitor has received approval for use against AMLs. …”
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An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders by Mohammed Alghamdi, Doaa Alasmari, Amjad Assiri, Ehab Mattar, Abdullah A. Aljaddawi, Sana G. Alattas, Elrashdy M. Redwan

“…A defect in the clearance system either in terms of efficiency or capacity may occur due to massive cell death, which may result in the accumulation and leakage of PAD enzymes and the citrullinated peptide from the necrotized cell which could be recognized by the immune system, where the immunological tolerance will be avoided and the autoimmune disorders will be subsequently triggered. …”
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Liminality Rituals of Interfaith Families: Symbolic Interactionism and MaqÄshid Sharia Perspectives by Muhammad Chairul Huda, Ilyya Muhsin

“…In the ritual act of liminality in the life cycle, interfaith families in Salatiga City had a fairly large tolerance. It was marked by the freedom of family members to perform rituals, whether they came from tradition or religion. …”
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Methimazole-Induced Cholestatic Jaundice: A Rare Case and Literature Review by Ahmed Mohamed Nefzi, Dhouha Cherif, Habiba Dabbebi, Haythem Yacoub, Hajer Hassine, Hela Kchir, Khadija Bellil, Nadia Maamouri

“…It typically exhibits a well-tolerated profile, with common side effects including gastrointestinal disorders and rash. …”
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Preparation and Evaluation of Intravaginal Ring Containing Drospirenone by Ying Zhang, Chun-Xiao Li, Mei-Ying Ning, Xue-Yan Duan, Ying Liu

“…Biocompatibility of reservoir system was evaluated by tolerability on tissue level in rats. It was found that, under strong light exposure, high temperature, and high humidity conditions, drospirenone and excipients had no significant interactions. …”
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Effect of Hemoadsorption for Cytokine Removal in Pneumococcal and Meningococcal Sepsis by Francesca Leonardis, Viviana De Angelis, Francesca Frisardi, Chiara Pietrafitta, Ivano Riva, Tino Martino Valetti, Valentina Broletti, Gianmariano Marchesi, Lorenza Menato, Roberto Nani, Franco Marson, Mirca Fabbris, Luca Cabrini, Sergio Colombo, Alberto Zangrillo, Carlo Coniglio, Giovanni Gordini, Lucia Stalteri, Giovanni Giuliani, Vittorio Dalmastri, Gaetano La Manna

“…Therapy proved to be safe and well tolerated. From this first experience, extracorporeal cytokine removal seems to be a valid and safe therapy in the management of meningococcal and pneumococcal diseases and may contribute to the patient stabilization and prevention of severe sequelae. …”
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Mitigating biomass recalcitrance for plant‐based bioenergy production by Vincent Ninkuu, Zhixin Liu, Yaping Zhou, Enzhi Guo, Xiao Song, Peibo Gao, Yajia Xie, Xuwu Sun

“…Abstract The emission of greenhouse gases, particularly carbon dioxide, predominantly from fossil fuel combustion has received critical warnings several times as their levels exceed the tolerable limits in view of global warming. This calls for a paradigm shift from a fossil fuel‐based source to a less hazardous bioenergy source. …”
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Reusable and robust fuzzy extractor for CRS-dependent sources by Yucheng Ma, Peisong Shen, Xue Tian, Kewei Lv, Chi Chen

“…These instantiations result in the first reusable and robust fuzzy extractor for CRS-dependent sources that can tolerate linear errors.…”
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