Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients by Joanna Bartosińska, Ewelina Zakrzewska, Dorota Raczkiewicz, Joanna Purkot, Anna Michalak-Stoma, Małgorzata Kowal, Dorota Krasowska, Grażyna Chodorowska, Krzysztof Giannopoulos

“…Programmed death 1 (PD-1), a coinhibitory receptor, plays an important role in immune regulation and maintaining peripheral tolerance. The aim of the study was to compare the expression of PD-1 on the peripheral T cells between psoriatic patients and healthy controls. …”
Get full text

Novel pain management strategy for uterine fibroid embolization by Elaine Ho, Kiat Tsong Tan

“…Fentanyl and midazolam are commonly provided for sedation and pain relief, but are not tolerated by all patients. This report outlines a novel pain management strategy for uterine fibroid embolization in a patient who could not receive either opioids or benzodiazepines. …”
Get full text

Irinotecan Plus S-1 Followed by Hepatectomy for a Patient with Initially Unresectable Colorectal Liver Metastases, Who Showed Severe Drug Rash with Oxaliplatin Plus 5-FU and Leucov... by Hiroyuki Komori, Toru Beppu, Yasuo Sakamoto, Yuji Miyamoto, Hiromitsu Hayashi, Katsunori Imai, Hidetoshi Nitta, Masayuki Watanabe, Hideo Baba

“…We subsequently replaced with Irinotecan plus S-1 (IRIS) chemotherapy which was well tolerated and resulted in a partial response after 3 cycles. …”
Get full text

Sirtuin 1: A Dilemma in Transplantation by Sara Assadiasl, Nuala Mooney, Bahareh Mohebbi, Yousef Fatahi, Narjes Soleimanifar

“…Moreover, despite the findings of sirtuin 1 implication in thymic tolerance induction and T regulatory (Treg) cells survival, there is also evidence for its involvement in Treg suppression and in T helper 17 cells differentiation. …”
Get full text

Analysis of the Expression and Function of Immunoglobulin-Like Transcript 4 (ILT4, LILRB2) in Dendritic Cells from Patients with Systemic Lupus Erythematosus by Paola del Carmen Guerra-de Blas, Yael Sebastián Villaseñor-Talavera, Daniela de Jesús Cruz-González, Lourdes Baranda, Lesly Doníz-Padilla, Carlos Abud-Mendoza, Roberto González-Amaro, Adriana Elizabeth Monsiváis-Urenda

“…Dendritic cells (DC) play an important role in the development and maintenance of immune tolerance. Although the inhibitory receptor ILT4/LILRB2 has been related with the tolerogenic phenotype of DC, the possible role of this receptor in the breakdown of DC tolerogenic function in systemic lupus erythematosus (SLE) has not been elucidated. …”
Get full text

Sesame (Sesamum indicum L.) Growth and Yield as Influenced by Preemergence Herbicides by W. J. Grichar, P. A. Dotray, D. R. Langham

“…Studies were conducted during the 2007 and 2008 growing seasons under weed-free conditions in South Texas and the High Plains region of Texas to evaluate preemergence herbicides for sesame tolerance. No reduction in sesame stand was noted with any herbicide at south Texas location; however, at the High Plains location, linuron at the 2X rate reduced stand counts 28 days after treatment (DAT) in 2007 and diuron reduced sesame stand 147 DAT in 2008 when compared with the untreated check. …”
Get full text

Photoredox/Cr-catalyzed enantioselective radical-polar crossover transformation via C-H functionalization by Si-Yuan Tang, Zhan-Jie Wang, Yu Ao, Ning Wang, Huan-Ming Huang

“…The asymmetric radical-polar crossover transformation could build two chiral centers simultaneously and demonstrates broad substrate tolerance, accommodating various drug-derived aldehydes, (hetero)aromatics, and 1,3-diene derivatives. …”
Get full text

Drugs of Abuse Can Entrain Circadian Rhythms by Ann E. K. Kosobud, Andrea G. Gillman, Joseph K. Leffel, Norman C. Pecoraro, G. V. Rebec, William Timberlake

“…This could be the basis for known daily variations in drug metabolism, tolerance, and sensitivity to drug reward. These rhythms could also take the form of daily periods of increased motivation to seek and take drugs, and thus contribute to abuse, addiction and relapse.…”
Get full text

A Modeling Strategy for Predicting the Response of Steel Plate-Concrete Composite Walls by Mohammad Sadegh Barkhordari

“…Usually at the base of the wall, these structures tolerate inelastic deformations subjected to strong ground motions. …”
Get full text

Integrasi Pendidikan Islam Multikultural dalam Sistem Sosial Pesantren Hidayatullah Bengkulu dan Implikasinya terhadap Pelestarian Budaya Lokal by Putra Yopande, Rendi Rendi, Rahmad Dedek, Asiyah Asiyah

“…Research Implications – The integration of multicultural values through local cultural practices strengthens students' connection to their heritage, fostering inclusivity and tolerance. The study promotes respect for cultural diversity and appreciation for local traditions amidst globalizations. …”
Get full text

The Interplay between Defensins and Microbiota in Crohn’s Disease by Lorena Coretti, Alessandro Natale, Mariella Cuomo, Ermanno Florio, Simona Keller, Francesca Lembo, Lorenzo Chiariotti, Raffaela Pero

“…Indeed, a reduced immune tolerance to components of the intestinal commensal microbiota and inflammation of the intestinal barrier typifies patients with CD. …”
Get full text

Islam kontemporer dan moderasi beragama: studi kasus radikalisasi di Sumatera Utara by Muthiatul Khairiyah, Amru Abdul Wadud, Amriansyah Pohan, Rizkiyah Purnama

“…Moderate Islam, which emphasizes tolerance, peace and respect for differences, is an important foundation for preventing violence in the name of religion. …”
Get full text

Increased Serum ANGPTL8 Concentrations in Patients with Prediabetes and Type 2 Diabetes by Yanhua Yin, Xiaoying Ding, Liang Peng, Yanqiang Hou, Yunxia Ling, Mingyu Gu, Yufan Wang, Yongde Peng, Haiyan Sun

“…Serum ANGPTL8 levels were determined using ELISA in 22 subjects with NGT (normal glucose tolerance), 74 subjects with IGR (impaired glucose regulation), and 33 subjects with T2DM (type 2 diabetes mellitus). …”
Get full text

Modeling of Functionally Graded Material Shells by Khalil Sihame, Elmhaia Oussama, Hamdaoui Abdellah, Braikat Bouazza, Hu Heng, Boukamel Adnane, Damil Noureddine

“…This method is particularly effective for tracking the solution curve through systematic matrix inversion and tolerance adjustments. By applying this robust algorithm within the framework of Kirchhoff-Love theory, we analyze how the properties of FGM shells vary smoothly from metal at the base to ceramic at the surface, crucial for applications in aeronautics and civil engineering where stability under load is paramount. …”
Get full text

Armodafinil versus Modafinil in Patients of Excessive Sleepiness Associated with Shift Work Sleep Disorder: A Randomized Double Blind Multicentric Clinical Trial by D. V. Tembe, A. Dhavale, H. Desai, D. N. Mane, S. K. Raut, G. Dhingra, U. Sardesai, S. Saoji, M. Rohra, V. G. Shinde, M. Padsalge, A. Paliwal, K. Abbasi, P. Devnani, S. Papinwar, S. Phadke, H. Mehta, V. Bhailume

“…Safety was assessed by incidence of adverse events, change in laboratory parameters, ECG, and global assessment of tolerability. Results. Both modafinil and armodafinil significantly improved sleepiness mean grades as compared to baseline (𝑃<.0001). …”
Get full text

Uncertainty-Aware Sensor Deployment Strategy in Mixed Wireless Sensor Networks by Yan Chang, Shukui Zhang, Yang Zhang, Jianxi Fan, Jin Wang

“…Usually the sensor locations are precomputed based on “perfect” sensor detection model, whereas sensors may not always provide reliable information, either due to operational tolerance levels or environmental factors. Therefore, it is very important to take into account this uncertainty in the deployment process. …”
Get full text

24-Epibrassinolide, a Phytosterol from the Brassinosteroid Family, Protects Dopaminergic Cells against MPP+-Induced Oxidative Stress and Apoptosis by Julie Carange, Fanny Longpré, Benoit Daoust, Maria-Grazia Martinoli

“…Brassinosteroids (BRs) are phytosterols recognized to promote stress tolerance of vegetables via modulation of the antioxidative enzyme cascade. …”
Get full text

Fossil fish assemblage of the Laguna Formation, Philippines: unveiling the uniqueness of Pleistocene freshwater ecosystems in Southeast Asia by Tomáš Přikryl, Abigael Castro, Allan Gil Fernando, Jaan Ruy Conrad Nogot, Clarence Magtoto, Kevin Garas, Dominique Mediodia, Chien-Hsiang Lin

“…Despite all recognized taxa being tolerant to changes in salinity, the environment is inferred to have been freshwater, analogous to modern Taal Lake, where a freshwater sardine thrives. …”
Get full text

High-Q Fabry-Pérot Cavity Based on Micro-Lens Array for Refractive Index Sensing by Qi Wang, Xuyang Zhao, Man Luo, Yuxiang Li, Junjie Liu, Xiang Wu

“…A strong mode-profile restriction of the micro-lens simultaneously reduced the mode volume and enhanced the Q factor, exhibiting high tolerance to non-parallelism of mirrors compared with that of the plane-plane FP (PP-FP) microcavities. …”
Get full text

The impact of temperature on cotton yield and production in Xinjiang, China by Yongyan Zhao, Yumeng Zhu, Shouli Feng, Ting Zhao, Luyao Wang, Zhihong Zheng, Nijiang Ai, Xueying Guan

“…To mitigate cold damage, breeding cold-tolerant cotton varieties and developing innovative cultivation technologies are critical for sustaining cotton production in Xinjiang.…”
Get full text