Pneumocystis carinii Pneumonia in HIV — Investigate or Just Treat? by Steven Kesten

“…This strategy has not been tested in controlled clinical trials although decision analysis models have attempted to evaluated it, it's liekly reasonable to choose empirical antimicrobial therapy in specific clinical settings such as: (a) typical radiographic picture in a person with dyspnea and/or nonproductive cough. presence of HIV and a CD4 count of less than 200 cells/mm3:(b) previous PCP, typical appearance and the patient is known to tolerate standard anti-PCP medications: and (c) high clinical suspicion in a patient who refuses bronchoscopy yet desires treatment or where bronchoscopy cannot he performed. …”
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DEMOCRACY AND THE FIGHT AGAINST LEADERSHIP CORRUPTION IN SUB-SAHARAN AFRICA: IMPLICATION FOR CONTINENTAL DEVELOPMENT by TAIWO FRANCIS AYOMOBA

“…As a result, the study contends that if citizens continue to tolerate unethical behaviors by political leaders, the governance crisis caused by misuse of public resources by political leadership will worsen insecurity and underdevelopment in Nigeria, West Africa. …”
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Replacement of Cable Stays in Yonghe Bridge in Tianjin, China by Hongjiang Li

“…The measured results showed that, influenced by the accumulated tolerances of cable forces during construction, cable replacement may often lead to a further deviation of structural condition. …”
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An updated overview on the bacterial PhoP/PhoQ two-component signal transduction system by Meiqin Mao, Li He, Qingpi Yan

“…It regulates the expression of bacterial environmental tolerance genes, virulence factors, adhesion, and invasion-related genes by sensing various environmental signals in the host, including Mg2+, low pH, antimicrobial peptides, and osmotic pressure. …”
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Utility-Oriented Placement of Actuator Nodes with a Collaborative Serving Scheme for Facilitated Business and Working Environments by Chi-Un Lei, Woon Kian Chong, Ka Lok Man

“…Service fading, 3D placements, multiscenario placements, and fault-tolerant placements have been modeled in the framework. …”
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Interleukin-1 as a Common Denominator from Autoinflammatory to Autoimmune Disorders: Premises, Perils, and Perspectives by Giuseppe Lopalco, Luca Cantarini, Antonio Vitale, Florenzo Iannone, Maria Grazia Anelli, Laura Andreozzi, Giovanni Lapadula, Mauro Galeazzi, Donato Rigante

“…A complex web of dynamic relationships between innate and adaptive immunity is now evident for many autoinflammatory and autoimmune disorders, the first deriving from abnormal activation of innate immune system without any conventional danger triggers and the latter from self-/non-self-discrimination loss of tolerance, and systemic inflammation. Due to clinical and pathophysiologic similarities giving a crucial role to the multifunctional cytokine interleukin-1, the concept of autoinflammation has been expanded to include nonhereditary collagen-like diseases, idiopathic inflammatory diseases, and metabolic diseases. …”
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The Hormesis effect of cadmium on Panax notoginseng and corresponding impact on the rhizosphere microorganism by Mingpeng Liu, Xuanxiang Du, Mulan Wang, Yuewen Huo, Yanbo Zeng, Jingheng Wu, Xin Ying, Fugang Wei, Li Liu, Jianguo Tang

“…Conversely, under strong Cd stress, the richness and diversity of the rhizospheric microbial community decrease, while the abundance of cadmium-tolerant species increases, such as Deinococcus and Rhodanobacter.…”
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Antioxidant and Anti-Inflammatory Properties of Melatonin in Secondary Traumatic Brain Injury by Mariusz Sieminski, Michalina Reimus, Maria Kałas, Ewelina Stępniewska

“…Melatonin, a sleep–wake-cycle-regulating neurohormone, exerts strong antioxidant and anti-inflammatory effects and is well tolerated when used as a drug. Due to these properties, it is very reasonable to consider melatonin as a potential therapeutic molecule for TBI treatment. …”
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Peach Rust (Transchelia spp.) by Daniel Mancero-Castillo, Ali Sarkhosh, Courtney Ligon, Mercy A. Olmstead, Philip F. Harmon

“…Further studies of subtropical peach cultivars have shown differences for peach rust tolerance, measured by leaf retention, and rust incidence in the orchards (Alves et al. 2014; Citadin et al. 2010) …”
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Reprogramming of Mice Primary Hepatocytes into Insulin-Producing Cells by Transfection with Multicistronic Vectors by Haizhao Luo, Rongping Chen, Rui Yang, Yan Liu, Youping Chen, Yi Shu, Hong Chen

“…Furthermore, when transplanted into streptozotocin-induced diabetic mice, the cells markedly ameliorated glucose tolerance. Our results indicated that ectopic expression of Pdx1, Ngn3, and MafA facilitated hepatocytes-to-IPCs reprogramming. …”
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Antihyperglycemic Activity of Eucalyptus tereticornis in Insulin-Resistant Cells and a Nutritional Model of Diabetic Mice by Alis Guillén, Sergio Granados, Kevin Eduardo Rivas, Omar Estrada, Luis Fernando Echeverri, Norman Balcázar

“…Furthermore, in a nutritional model using diabetic mice, the administration of ethyl acetate extract of E. tereticornis reduced fasting glycaemia, improved tolerance to glucose, and reduced resistance to insulin. …”
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Peach Rust (Transchelia spp.) by Daniel Mancero-Castillo, Ali Sarkhosh, Courtney Ligon, Mercy A. Olmstead, Philip F. Harmon

“…Further studies of subtropical peach cultivars have shown differences for peach rust tolerance, measured by leaf retention, and rust incidence in the orchards (Alves et al. 2014; Citadin et al. 2010) …”
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Multiplex genome editing for climate-resilient woody plants by Madhab Kumar Sen, Sunil Kanti Mondal, Rohit Bharati, Lucie Severova, Karel Šrédl

“…By simultaneously targeting multiple genes, multiplex CRISPR enables efficient modification of polygenic traits that govern stress tolerance, disease resistance, and other crucial resilience factors. …”
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Calculation of the Instream Ecological Flow of the Wei River Based on Hydrological Variation by Shengzhi Huang, Jianxia Chang, Qiang Huang, Yimin Wang, Yutong Chen

“…Besides, based on the law of tolerance and ecological adaptation theory, the maximum instream ecological flow is calculated, which is the highest frequency of the monthly flow based on the GEV distribution and very suitable for healthy development of the river ecosystems. …”
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Differential effects of acute and chronic treatment with the flavonoid chrysin on anxiety-like behavior and Fos immunoreactivity in the lateral septal nucleus in rats by Germán-Ponciano León Jesús, Puga-Olguín Abraham, De Jesús Rovirosa-Hernández María, Caba Mario, Meza Enrique, Rodríguez-Landa Juan Francisco

“…Altogether, results suggest that chrysin exerts anxiolytic-like effects, however, it can produce pharmacological tolerance after repeated use, similar to benzodiazepines.…”
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Everolimus for Compassionate Use in Multiple Basal Cell Carcinomas by Laura Eibenschutz, Delia Colombo, Caterina Catricalà

“…Everolimus was well tolerated in these elderly patients. These promising preliminary data suggest that further dose-finding, controlled clinical studies are warranted to evaluate the antineoplastic effects of everolimus in patients affected by BCC who cannot or will not undergo surgery.…”
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Hepatic Lamp2a deficiency promotes inflammation of murine autoimmune cholangitis via affecting bile acid metabolism by Qingling Fan, Guanya Guo, Yinan Hu, Yi Lu, Rui Su, Jiaqi Yang, Erzhuo Xia, Shuoyi Ma, Miao Zhang, Jingbo Wang, Ting Li, Ying Han

“…Summary: Primary biliary cholangitis is characterized by breaking of immune tolerance and disorders of bile acid metabolism. Our previous study found that abnormal expression of Lamp2 was detected in PBC patients. …”
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Biometallic ions and derivatives: a new direction for cancer immunotherapy by Lin Zhao, Yajun Gui, Jing Cai, Xiangying Deng

“…However, existing therapies still face challenges, such as immune tolerance and immune escape. Biometallic ions (e.g. zinc, copper, magnesium, manganese, etc.) can assist in enhancing the efficacy of immunotherapy through the activation of immune cells, enhancement of tumor antigen presentation, and improvement of the tumor microenvironment. …”
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MHSDN: A Hierarchical Software Defined Network Reliability Framework design by Zhengbin Zhu, Qinrang Liu, Dongpei Liu, ChenYang Ge, Chong Wang

“…Finally, to speed up detection and reduce defence cost of DDoS, this research proposes the Random Forest Feature Extract (RFFE) and tolerable switch migration. Simulation shows that RFFE has achieved a faster detection speed at the cost of less detection accuracy, and MHSDN can better improve the reliability of hierarchical SDN.…”
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Allylic C–H oxygenation of unactivated internal olefins by the Cu/azodiformate catalyst system by Le Wang, Yuan She, Jie Xiao, Zi-Hao Li, Shen-Yuan Zhang, Peng-Fei Lian, Tong-Mei Ding, Shu-Yu Zhang

“…This method features a broad substrate scope and functional group tolerance, successfully applied to the synthesis of various challenging medium-sized cyclic ethers (7-10 members) and large-ring lactones (14-20 members), with high regioselectivity and stereoselectivity.…”
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