First-in-human phase 1 dose-escalation results with livmoniplimab, an antibody targeting the GARP:TGF-ß1 complex, as monotherapy and in combination with the anti–PD-1 antibody budi... by Toshio Shimizu, Toshio Shimizu, John Powderly, Albiruni Abdul Razak, Patricia LoRusso, Kathy D. Miller, Steven Kao, Sarah Kongpachith, Catherine Tribouley, Michelle Graham, Brian Stoll, Maulik Patel, Mohammad Sahtout, Martha Blaney, Rachel Leibman, Talia Golan, Talia Golan, Anthony Tolcher

“…Dose-limiting toxicities were limited, no maximum tolerated dose was reached, and the maximum administered dose of 1500mg was selected for dose expansion. …”
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Modulation of myeloid and T cells in vivo by Bruton’s tyrosine kinase inhibitor ibrutinib in patients with metastatic pancreatic ductal adenocarcinoma by Li Zhang, Matthew Crocker, Lawrence Fong, Lisa M Coussens, Charles D Lopez, Shamilene Sivagnanam, Meenal Sinha, Brandon Chen, Jaqueline Marquez, Alexander Cheung, Whitney Tamaki, Jacob Stultz, Kendra Todd, Courtney Betts, Madeline J Griffith, Isabelle Solman, Eric Liu, Denise Pener, Anne Fahlman, Erin Taber, Kimberly Lerner, Brindha Rajagopalan, Clarisha Ware, Mark Bridge, Johnson Vo, Hannah Dragomanovich, Julie Sudduth-Klinger, Gina Vaccaro, Margaret Tempero

“…This led to a phase 1b clinical trial to determine the safety, tolerability, and immunologic effects of ibrutinib treatment in patients with advanced PDAC.Methods Previously untreated patients with PDAC were enrolled in a phase 1b clinical trial (ClinicalTrials.gov) to determine the safety, toxicity, and maximal tolerated dose of ibrutinib when administered with the standard regimen of gemcitabine and nab-paclitaxel. …”
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TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Primary objectives were safety, tolerability, maximum tolerated dose (MTD) and recommended dose for expansion (RDE). …”
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Assessment of salicylic acid and potassium nitrate to mitigate frost stress in autumn-sown potato crop cv. Sutlej by Muhammad Wasim Haider, Syed Mohsin Abbas, Tanveer Hussain, Muhammad Tahir Akram, Umar Farooq, Mona S. Alwahibi, Mohamed S. Elshikh, Zaid Shakeel, Muhammad Nafees, Muhammad Rizwan, Rashid Iqbal

“…However, the application rate of KNO3 needs to be optimized in order to use its maximal frost stress tolerance potential.…”
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Complex resistance of spring and winter bread wheat lines to biotic and abiotic stresses by I. F. Lapochkina, N. R. Gainullin, O. A. Baranova, N. M. Kovalenko, L. A. Marchenkova, O. V. Pavlova, O. V. Mitroshina

“…Lines 33-16i, 37-16i, 32-16i and 3-16i were characterized by high salt tolerance, exceeding the average of 49.7 %. Among the winter genotypes, lines were identified with increased resistance to hypoxia (37-19w, 32-19w, 16-19w, 90-19w) and with increased salt tolerance (20-19w, 9-19w, 37-19w, 90-19w), significantly exceeding the standard cv. …”
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Upadacitinib in active non-radiographic axial spondyloarthritis: 2-year data from the phase 3 SELECT-AXIS 2 study by Filip Van den Bosch, Atul Deodhar, Denis Poddubnyy, Walter P. Maksymowych, Désirée van der Heijde, Tae-Hwan Kim, Mitsumasa Kishimoto, Xenofon Baraliakos, Xianwei Bu, Ivan Lagunes-Galindo, In-Ho Song, Peter Wung, Koji Kato, Anna Shmagel

“…Abstract Background In SELECT-AXIS 2, upadacitinib improved the signs and symptoms of active non-radiographic axial spondyloarthritis (nr-axSpA) through 52 weeks versus placebo and was well tolerated. Here, we evaluated the efficacy and safety of upadacitinib through 2 years. …”
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Towards reliable object representation via sparse directional patches and spatial center cues by Muwei Jian, Hui Yu

“…This study demonstrates that the sparse patch-based visual representation with spatial center cues is intrinsically tolerant to object positioning and understanding beyond object variations in spatial position, multiresolution, and chrominance, which has significant implications for many vision-based automatic object grabbing and perception applications, such as robotics, human‒machine interaction, and unmanned aerial vehicles (UAVs).…”
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Neurological Crisis Following Intravenous Ozone Therapy; a Case Report by Chloe Y Y Wong, Komal Saxena, John Meneer, Koshy George, Gerben Keijzers

“…Food and Drug Administration (FDA), warn against its use due to its toxic properties and lack of proven benefits at tolerable exposure levels. This case report highlights severe neurological complications, including ischemic infarcts and persistent cognitive deficits, following intravenous ozone (O3) therapy in a previously healthy patient. …”
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Phylogenetic relationships and genetic diversity of Tunisian maize landraces. by Mohamed Dhia Eddine Hammami, Delphine Madur, Zayneb Kthiri, Agustin Galaretto, Stéphane D Nicolas, Alain Charcosset, Valérie Combes, Chahine Karmous, Pedro Revilla

“…The Tunisian maize germplasm could be a basis for identifying sources of favorable alleles to improve tolerance to abiotic stresses.…”
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Coexistence between people and polar bears supports Indigenous knowledge mobilization in wildlife management and research by Katharina M. Miller, Georgina Berg, Indigenous Knowledge Keepers of Churchill, Michael Lickers, Nickia McIvor, Dominique A. Henri

“…However, in the community of Churchill, Manitoba, Canada, people live alongside polar bears with high tolerance and reciprocal respect. Through this case study, we explored human-polar bear coexistence in the community through Indigenous voices, documented social-ecological change, and mobilized recommendations as future visions to inform inclusive management and research strategies: elevate Indigenous knowledge, support proactive management and less invasive research, cultivate a culture of coexistence, improve education and safety awareness, and protect polar bears to support tourism. …”
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Automated Testing of Ultrawideband Positioning for Autonomous Driving by Benjamin Vedder, Bo Joel Svensson, Jonny Vinter, Magnus Jonsson

“…Fault injection was used to study the fault tolerance of the UWB positioning system. Addressed challenges are automatically generating test cases for real-time hardware, restoring the state between tests, and maintaining safety by preventing collisions. …”
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Integrated Instrumentation and Sensor Systems Enabling Condition-Based Maintenance of Aerospace Equipment by Richard C. Millar

“…CBM IISS imperatives identified include factors such as tolerance of the bulk of aerospace equipment operational environments, low intrusiveness, rapid reconfiguration, and affordable life cycle costs. …”
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Ethynilestradiol 20 mcg plus Levonorgestrel 100 mcg: Clinical Pharmacology by Stefano Lello, Andrea Cavani

“…Overall, EE20/LNG100 combination is safe and well tolerated, and in several studies the incidence of adverse events in the treated group was comparable to that of the placebo group. …”
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Eucalypts and Their Potential for Invasiveness Particularly in Frost-Prone Regions by Trevor H. Booth

“…The use of carefully selected frost-tolerant species and the development of genetically modified eucalypts may now open up more frost-affected areas for eucalypt plantations. …”
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Proprotein Convertase Subtilisin/Kexin Type 9: From the Discovery to the Development of New Therapies for Cardiovascular Diseases by Nicola Ferri

“…There remains, therefore, an unmet medical need to develop additional well-tolerated and effective agents to lower LDL cholesterol levels. …”
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Range and Battery Depletion Concerns with Electric Vehicles by Tomio Miwa, Hitomi Sato, Takayuki Morikawa

“…Firstly, the methodology for deriving the probabilistic distribution of the daily travel distance is developed, which enables us to analyze people’s tolerance of the risk of battery depletion. Secondly, the desired range of an EV is modeled. …”
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Long-Term Evaluation of the Use of the Transdermal Contraceptive Patch in Adolescents by Stephanie Logsdon, Jessica Richards, Hatim A. Omar

“…These results confirmed that the transdermal contraceptive patch is easy to use and an effective method of birth control that may be better tolerated by young women. It also seemed to improve contraceptive compliance in this population.…”
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Comparative Evaluation of Postoperative Incisional Negative Pressure Wound Therapy with Conventional Dressings in Patients of Proximal Tibia Fracture Managed by Dual Plating by Pranav Kothiyal, Kunal Vij, Puneet Gupta

“…Conclusion: With our study, we concluded that in high-velocity proximal tibia fractures with a lot of soft-tissue traumas, incisional NPWT is well tolerated and has shown a definitive advantage in preventing wound-related complications as compared to regular conventional dressing.…”
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FAILURE MODES AND EFFECTS ANALYSIS (FMEA) ON TRACK INFRASTRUCTURE INTEGRITY ASSESSMENT by Angga Ahmad Maulana, IGN Wiratmaja Puja, Satrio Wicaksono

“…Then 21 failure modes fall into the "unacceptable" risk level, 4 failure modes fall into the "tolerable" risk level, and 1 failure mode falls into the "acceptable" risk level. …”
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Pseudomembranous Colitis: An Update by Harpreet S Brar, Christina M Surawicz

“…Vancomycin should be reserved for severe cases where metronidazole has failed or where metronidazole cannot be tolerated or is contraindicated. Recurrent C difficile disease is a particularly vexing clinical problem. …”
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