Solely MRI-Guided Cardiac Catheterization for Assessment of Pulmonary Hypertension in a Pregnant Lady with Undiagnosed Congenital Heart Disease by Aphrodite Tzifa, Ioannis Polymerou, Dimitra Loggitsi

“…Pregnancy in women with complex congenital heart disease (CHD) can be poorly tolerated. Amongst pregnant women with CHD and pulmonary hypertension (PH), the mortality rate can be as high as 30%. …”
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Spiraea cantoniensis Reeve's Spiraea, Bridal-Wreath by Edward Gilman

“…Additionally, it addresses the plant’s moderate drought tolerance, soil preferences, and minimal pest issues, making it a versatile and attractive option for various garden settings. …”
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Indigofera cylindrica Indigo by Edward Gilman

“…The document details the plant’s growth habits, soil and light requirements, and its moderate drought tolerance. It also highlights the plant’s uses in landscaping, such as specimen planting, border planting, and container gardening. …”
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Potential pharmacological effect of Quercetin Phytosome™ in the management of hyperuricemia: results from real-life clinical studies by Francesco Di Pierro, Francesco Di Pierro, Francesco Di Pierro, Fazle Rabbani, Meherullah Tareen, Roohi Nigar, Amjad Khan, Nicola Zerbinati, Maria L. Tanda, Massimiliano Cazzaniga, Alexander Bertuccioli, Alexander Bertuccioli, Paolo Falasca, Gabriele Damiani, Nicola Villanova

“…In Cohort 3, QP led to a 13.7% decrease in uric acid and a 20.8% reduction in triglycerides (p < 0.01), with no significant uric acid changes in the BM-treated group. QP was well tolerated across all cohorts, with minimal, transient side effects.ConclusionQP supplementation demonstrates a significant hypouricemic effect. …”
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Real-World Data for Lenvatinib in Radioiodine-Refractory Differentiated Thyroid Cancer (RELEVANT): A Retrospective Multicentric Analysis of Clinical Practice in Austria by G. Rendl, B. Sipos, A. Becherer, S. Sorko, C. Trummer, M. Raderer, W. Hitzl, M. Ardelt, H. J. Gallowitsch, C. Pirich

“…Dose reductions are commonly performed due to decreased tolerability and adverse effects. This retrospective multicenter study analyzed overall survival (OS) and progression-free survival (PFS) and tolerability in the Austrian patient population treated with lenvatinib. …”
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Nutritional Counseling During Chemotherapy Treatment: A Systematic Review of Feasibility, Safety, and Efficacy by Shalet James, Alexie Oppermann, Kaitlin M. Schotz, Mackenzie M. Minotti, Gautam G. Rao, Ian R. Kleckner, Brenton J. Baguley, Amber S. Kleckner

“…Many studies showed between-group differences favoring the intervention group for body weight (8/24, gain or loss, according to goals), nutritional status (8/9), quality of life (3/10 without and 6/9 with exercise), cancer-related fatigue (7/10), chemotherapy tolerance (6/11), and treatment responses (3/13). In conclusion, nutritional interventions were feasible and safe for patients undergoing chemotherapy and demonstrated preliminary efficacy to improve nutritional status, fatigue, chemotherapy tolerance, and other outcomes.…”
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Decanoic acid-enriched ketogenic diet in refractory epilepsy by Hui Jin Shin, Seonae Ryu, NaRae Lee, Eunjoo Lee, Ara Ko, Hoon-Chul Kang, Joon Soo Lee, Se Hee Kim, Heung Dong Kim, Heung Dong Kim

“…The study compared seizure reduction rate, tolerability, and safety of the two diets.ResultsFifteen patients were enrolled. …”
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Poor efficacy of the combination of clarithromycin, amikacin, and cefoxitin against Mycobacterium abscessus in the hollow fiber infection model by Etienne Vignaud, Sylvain Goutelle, Charlotte Genestet, Jérôme Guitton, Sabine Cohen, Chloé Bourg, Aurore Durand, Laura Lebouteiller, Albin Bernard, Caroline Richet, Oana Dumitrescu, Elisabeth Hodille

“…Moreover, increasing clarithromycin concentrations stabilized the amikacin-tolerance level: amikacin minimal inhibitory concentration of amikacin-tolerant strains increased over time using blood concentrations while it remained stable using lung concentrations. …”
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Ectopic Fat Deposition on Insulin Sensitivity: Correlation of Hepatocellular Lipid Content and M Value by Beverly S. Hong, Ying Li, Shuiqing Lai, Juan Liu, Hongyu Guan, Weijian Ke, Xiaoying He, Yanbing Li

“…Fifty-nine men and women were enrolled in this study: 29 with normal glucose tolerance (NGT), 17 with impaired glucose tolerance (IGT), and 13 with type 2 diabetes mellitus (T2DM). …”
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Protocol for a first-in-human feasibility study of T regulatory cells (TR004) for inflammatory bowel disease using (ex vivo) Treg expansion (TRIBUTE) by Jennifer Clough, Peter Irving, A Toby Prevost, Graham M Lord, Joana Vasconcelos, James B Canavan, Beverley Rodger, D Macallan

“…Eligible participants are those who are at least 18 years old, have a diagnosis of active moderate to severe CD and have failed to respond to or tolerate at least two prior lines of standard medication. …”
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Peripheral Regulatory Cells Immunophenotyping in Kidney Transplant Recipients with Different Clinical Profiles: A Cross-Sectional Study by Janette Furuzawa-Carballeda, Guadalupe Lima, Perla Simancas, Dolores Ramos-Bello, Margaret Simancas, Ian C. Bostock, Mario Vilatobá, Bernardo Gabilondo, Julio Granados, Luis Morales-Buenrostro, Josefina Alberú, Luis Llorente

“…The findings of this exploratory study might suggest that in ELTGF patients, peripheral tolerance mechanisms could be directly involved in the maintenance of a quiescent immunologic state and graft function stability.…”
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De novo assembly and analysis of the transcriptome of the Siberian wood frog Rana amurensis by D. N. Smirnov, S. V. Shekhovtsov, A. A. Shipova, G. R. Gazizova, E. I. Shagimardanova, N. A. Bulakhova, E. N. Meshcheryakova, T. V. Poluboyarova, E. E. Khrameeva, S. E. Peltek, D. I. Berman

“…The Siberian wood frog Rana amurensis Boulenger, 1886 is the most hypoxia-tolerant amphibian. It can survive for several months in an almost complete absence of oxygen. …”
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Reduction of Scarce Materials in Silicon Heterojunction Solar Cells and Implications on the Performance in the Field by Sebastian Pingel, Ioan Voicu Vulcanean, Timo Wenzel, Winfried Wolke, Vasileios Georgiou-Sarlikiotis, Philipp Schmid, Henning Nagel, Ulli Kräling, Martin Bivour, Anamaria Steinmetz

“…In summary cell technologies with small busbar-pitch are more tolerant for low-silver metallization. In the second part the impact of the transparent conductive oxide (TCO) was addressed. …”
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Safety of Potato Consumption in Slovak Region Contaminated by Heavy Metals due to Previous Mining Activity by Janette Musilova, Judita Bystricka, Alena Vollmannova, Beata Janotova, Matyas Orsak, Lubos Harangozo, Alzbeta Hegedusova

“…At current average consumption levels of potatoes, tolerable weekly intake (TWI) or tolerable daily intake (TDI) for observed heavy metals was not exceeded.…”
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High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT) by Yuxuan Ding, Yong Feng, Yangfan Ye, Jiayi Shen, Chang Guo, Xia He, Liangjun Zhu, Lijun Wang

“…IntroductionMicrosatellite stable (MSS) colorectal cancer with liver metastases (CLRM) responds poorly to immunotherapy, and various approaches to break immune tolerance have been tried. Radiotherapy in combination with immune checkpoint inhibitors is one of promising therapies, and the choice of radiotherapy and immunotherapy modalities is also a hot issue.MethodsHere, we report on a Phase I trial treating nine patients with MSS CLRM using a combination of high and low dose radiotherapy and immune checkpoint inhibitors (ICIs).ResultsThe primary endpoint of the trial was the safety and tolerability of this combination treatment modality. …”
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TrkB Receptor Antagonism Enhances Insulin Secretion and Increases Pancreatic Islet Size in Rats Fed a Cafeteria-Style Diet by Jorge Agustín Velasco-Gutierrez, Elena Roces de Alvarez-Buylla, Sergio Montero, Alejandrina Rodríguez-Hernández, Saraí Limón Miranda, Karmina Martínez-Santillan, María del Rosario Álvarez-Valadez, Mónica Lemus, Alejandra Flores-Silva, Adolfo Virgen-Ortiz

“…After 4 months of intervention, the glucose and insulin tolerance curves, serum insulin levels, body fat and hematoxylin-eosin staining pancreas were evaluated. …”
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First Report on Association of Hyperuricemia with Type 2 Diabetes in a Vietnamese Population by Tran Quang Binh, Pham Tran Phuong, Nguyen Thanh Chung, Bui Thi Nhung, Do Dinh Tung, Tran Quang Thuyen, Duong Tuan Linh, Bui Thi Thuy Nga, Nguyen Anh Ngoc, Le Danh Tuyen

“…Associations between hyperuricemia and hyperglycemia (isolated impaired fasting glucose (IFG), isolated impaired glucose tolerance (IGT), combined IFG-IGT, and type 2 diabetes (T2D)) were evaluated by multinomial logistic regression analysis in several models, adjusting for the confounding factors including socioeconomic status, lifestyle factors, and clinical measures. …”
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Oral nutritional supplements for gastric cancer – the review of current evidence by A. L. Potapov, V. E. Khoronenko, E. V. Gameeva, Zh. V. Khailova, A. D. Dorozhkin, V. Yu. Scoropad

“…After discharge from the hospital ONS can decelerate the progression of malnutrition, improve the tolerance of adjuvant chemotherapy and improve the quality of life. …”
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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation by Iona Davies, Alice E. Adriaenssens, William R. Scott, David Carling, Kevin G. Murphy, James S. Minnion, Stephen R. Bloom, Ben Jones, Tricia M-M. Tan

“…Conclusions: Although GIP108 chronic treatment improved glucose tolerance, it also resulted in partial desensitisation of the pancreatic islet GIPR. …”
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DHX37 Impacts Prognosis of Hepatocellular Carcinoma and Lung Adenocarcinoma through Immune Infiltration by Yanni Xu, Qiongchao Jiang, Hejun Liu, Xiaoyun Xiao, Dinghong Yang, Phei Er Saw, Baoming Luo

“…In LIHC and LUAD, DHX37 expression showed significant positive correlations with markers of Tregs, myeloid-derived suppressor cells (MDSCs), and T cell exhaustion, contributing to immune tolerance. Conclusion. These results indicate that DHX37 can serve as a prognostic biomarker in LIHC and LUAD while having an important role in immune tolerance by activating the function of Tregs, MDSC, and T cell exhaustion.…”
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