Medical student experiences of Case-Based Learning (CBL) at a multicultural medical school by Catherine Bruen, Jan Illing, Ronan Daly, Frances Meagher, Caroline Delany, Gozie Offiah, Sally Doherty, Ellen Stuart, Martina Crehan, Helen Kelly

“…We identified six learning points to highlight features of CBL that support active learning: CBL increased contact with peers and facilitated student bonding; students need to feel psychologically safe to participate; prior learning can enhance confidence to participate; facilitators need to be aware of their role, know about psychological safety, and manage student participation including the dominant voice; some students have a lower tolerance of uncertainty and need additional clarity at the end either via the facilitator or additional notes that provide the key learning points to take away; students became more engaged when a case is aligned to a real patient case giving it authenticity. …”
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Plaider la « bonne gouvernance sécuritaire » au Maroc : Domestiquer les savoirs de réforme en régime de contrainte consensuelle by Irene Lizzola

“…However, this consensus appears to be constrained, at the level of the threshold of criticism tolerated by security institutions. Thus, the confrontation between the parties is part of a regime of consensual constraint. …”
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Clinical manifestations of COVID-19 infection and its impact on the outcome in children and adolescents with benign and malignant hematological disease in Egypt: a single-center ex... by Fatma Soliman Elsayed Ebeid, Aya Mostafa, Sondos M. Magdy, Haidy Moahmed Abd El Kader, Amal Abdel Azim Lotfy, Nihal Hussien Aly

“…Conclusion The current study showed that COVID-19 was higher among patients with hematological malignancies than those with benign hematological disease. COVID-19 was tolerable among the studied patients with underlying hematological disease where 94.1% of the COVID-19-positive patients survived. …”
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Effect of Lingnan Painless Apitherapy combined with McKenzie Therapy on Patients with Lumbar Disc Herniation by Hongbo WU, Xinghua CHEN, Ruike ZHANG, Qinglu LUO, Yongming CHENG

“…Objective:To observe the clinical efficacy of Lingnan painless apitherapy combined with McKenzie therapy on patients with lumbar disc herniation(LDH).Methods:A total of 80 patients with LDH who were treated in the department of rehabilitation medicine of the fifth affiliated hospital of Guangzhou medical university from February 2019 to June 2020 were randomly divided into the control group and the observation group according to the random number table method, with 40 cases in each group.The control group received magnetic thermal-vibration therapy and McKenzie therapy.The Japanese magnetic thermal-vibration therapy instrument(TM-3200)was used in the magnetic thermotherapy, the appropriate intensity(high, hot, warm and low temperature)was selected according to the patient's feeling and symptoms, 20 minutes each time, once a day, seven times a week, continuous treatment for two weeks.In addition, the patients with LDH received McKenzie therapy, which was assisted by the therapist or the patient actively completed the flowing training, such as prone position stretching, prone position stretching combined with compression, standing position lateral movement and so on.Each step rested for one minute, once every two days, continuous treatment for two weeks.The observation group received Lingnan painless apitherapy on the basis of treatment in the control group after half an hour's rest.Before treatment, the patients were given apitherapy tolerance test, performing apitherapy with one bee on each Zusanli acupoints on both sides.After apitherapy for 15 minutes, if there was no adverse reaction, the patients were given painless apitherapy with a quiet and comfortable environment, every other day.In this treatment, both sides of Huatuo Jiaji acupoints on the lumbar spinous processes were selected, and Huatuo Jiaji acupoints on both sides of the 5th lumbar spinous process were selected in the first treatment, one acupoint on the left and one on the right.After that, two acupoints were added each time, and each acupoint was treated by one bee.According to the order of Jiaji points on the 4th, 3rd, 2nd and 1st lumbar vertebrae, the number of bee needles increased to 10 bees.Before treatment and two weeks after treatment, visual analogue scales(VAS)was used to evaluate the pain degree, Oswestry disability index(ODI)was used to assess the lumbar spine dysfunction, and TCM syndrome score was used to evaluate the therapeutic effect, and the clinical efficacy was evaluated by <italic>the diagnosis and curative effect standards of TCM diseases</italic>.Results:Before treatment, there was no significant difference in the VAS score, ODI score and TCM syndrome score between the observation group and the control group(<italic>P</italic>&gt;0.05).Compared with treatment before, the VAS score, ODI score and TCM syndrome score after treatment for two weeks of the two groups were significantly reduced, with a statistically significant difference(<italic>P</italic>&lt;0.05).Compared with the control group, the VAS score and TCM syndrome score of the observation group were lower than those of the control group, with a statistically significant difference(<italic>P</italic>&lt;0.05), but there was no considerable difference in ODI score between the two groups(<italic>P</italic>&gt;0.05), and the clinical efficacy of the observation group(95%)was significantly higher than that of the control group(80%)(<italic>P</italic>&lt;0.05).Conclusion:Lingnan painless apitherapy combined with McKenzie therapy can significantly improve the pain degree and lumbar spine dysfunction of patients with LDH, which have a good effect and it is worthy of clinical promotion.However, it's necessary to develop large-sample randomized controlled trials and follow-up, to provide more reliable basis for clinical treatment of LDH.…”
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The Role of Intravenous Selexipag in Managing PAH and Bridging Gaps in Oral Treatment: A Narrative Review by Goren S, Kidwai N, Aronow WS, Lanier GM

“…A Phase III clinical trial confirmed that switching between oral and IV selexipag was safe, with comparable efficacy and tolerability, though it was limited by small sample size and short duration. …”
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Brimonidine as an additional treatment for moderate glaucoma by I.R. Gazizova, V.E. Korelina

“…This medication is well tolerated.</i> </p> <p> <i><b>Keywords</b>: glaucoma, IOP, visual field, perimetry, tonometry, neuroprotection.…”
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Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naï... by David J Diemert, Maria Zumer, Mark Bova, Christina Gibbs-Tewary, Elissa M Malkin, Doreen Campbell, Lara Hoeweler, Guangzhao Li, Maria Elena Bottazzi, Peter J Hotez, Jeffrey M Bethony

“…<h4>Results</h4>Na-GST-1/Alhydrogel administered with or without CpG 10104 was well-tolerated. The most common solicited adverse events were mild injection site tenderness and pain, and mild headache. …”
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Distribution of sasX, mupA, and qacA/B genes and determination of genetic relatedness of epidemic methicillin-resistant Staphylococcus aureus strains associated with bloodstream in... by Rui Zhao, Bingyu Du, Lingling Hu, Chenxi Li, Fen Xue, Xing Wang, Changhong Jiang, Jinghua Wang, Yanfeng Zhao

“…This study investigates the prevalence of the sasX, mupA, and qacA/B genes among MRSA isolates from bloodstream infections in southern China and analyzes their genetic relatedness.MethodsA polymerase chain reaction (PCR) assay was developed to detect the presence of the sasX gene, which is associated with nasal colonization, immune evasion, and virulence, the mupirocin resistance gene mupA, and the chlorhexidine tolerance gene qacA/B in a total of 77 MRSA isolates. …”
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High-fat diet promotes gestational diabetes mellitus through modulating gut microbiota and bile acid metabolism by Lei Yao, Xuefei Zhou, Xianqi Jiang, Hao Chen, Yuanliang Li, Xiao Xiong, Yan Tang, Haogang Zhang, Pengfei Qiao

“…Body weight, average feed intake, blood glucose, insulin levels and oral glucose tolerance test was performed among each groups. Expression levels of Fxr, Shp and Fgf15 mRNA and protein were detected by quantitative reverse transcription polymerase chain reaction and western blot, respectively.ResultsOur data indicated that high fat diet (HFD) was linked with higher prevalence of GDM, and HFD was positively associated with poor prognosis in GDM patients. …”
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Quantifying diversity and growth form distribution of scleractinian corals, in Mangrove Bay, El Qoseir, Egypt by Theres Koch, Angelina Ivkić, Lewis Jones, Victor Scharnhorst, Constanze Stix, Antonia Auer, Theda Schöchtner, Gözde Özer, Simon Steinwender, Joseph Wallace Daurella, Martin Zuschin

“…Within the northern Red Sea, coral reef communities appear to be faring relatively better than global trends and continue to exhibit remarkable diversity and thermal tolerance. However, recent reports of coral bleaching in the region highlight the urgent need for comprehensive ecological surveys to provide a baseline for long-term monitoring of biodiversity and potential species loss. …”
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GIS-based modeling and analytical approaches for groundwater quality suitability for different purposes in the Egyptian Nile Valley, a case study in Wadi Qena by Hanaa A. Megahed, Abd El-Hay A. Farrag, Amira A. Mohamed, Mahmoud H. Darwish, Mohamed A. E. AbdelRahman, Heba El-Bagoury, Paola D’Antonio, Antonio Scopa, Mansour A. A. Saad

“…Comparative analysis against standard quality guidelines indicated that most groundwater samples exceeded safe levels for major constituents, TDS, TH, pH, and EC, making them unsuitable for drinking but potentially suitable for irrigation of high salt-tolerant crops. The results of hydrochemical analysis maps and analytical diagrams of groundwater samples revealed that the water was characterized by natural to alkali and the total dissolved solids (TDS) increasing from the Nubian to Quaternary and high ranges of sodium absorption (SAR). …”
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Salvage Magnetic Resonance Imaging–guided Transurethral Ultrasound Ablation for Localized Radiorecurrent Prostate Cancer by Mikael Anttinen, Pietari Mäkelä, Pertti Nurminen, Heikki Pärssinen, Simona Malaspina, Teija Sainio, Mikael Högerman, Pekka Taimen, Roberto Blanco Sequeiros, Peter J. Boström

“…Further studies should refine patient selection and treatment parameters to improve safety and tolerability. Patient summary: In this study, we examined a new treatment called magnetic resonance imaging–guided transurethral ultrasound ablation for prostate cancer that has returned after radiation therapy. …”
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A humanized anti-MSLN×4-1BB bispecific antibody exhibits potent antitumour activity through 4-1BB signaling activation and fc function without systemic toxicity by Da-yan Zhang, Zhi-hua Zhang, Wen-ting Liu, Wei-ming Zhou, Peng-fei Zhou, Juan-juan Wei, Xue-jing Dai, Xiao-li Zeng, Yu-qiong Zhou, Han-wang Li, Heng Zhang, Ao-lin Shen, Lian-sheng Cheng, Guo-dong Shen, Yi-fu He

“…Furthermore, HK013-G1 did not induce nonspecific production of proinflammatory cytokines and showed good tolerability up to the highest tested dose (30 mg/kg weekly) for 5 weeks, with no HK013-G1-related adverse effects observed in cynomolgus monkeys. …”
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Antiviral efficacy of fluoxetine in early symptomatic COVID-19: an open-label, randomised, controlled, adaptive platform trial (PLATCOV)Research in context by Podjanee Jittamala, Simon Boyd, William H.K. Schilling, James A. Watson, Thundon Ngamprasertchai, Tanaya Siripoon, Viravarn Luvira, Elizabeth M. Batty, Phrutsamon Wongnak, Lisia M. Esper, Pedro J. Almeida, Cintia Cruz, Fernando R. Ascencao, Renato S. Aguiar, Najia K. Ghanchi, James J. Callery, Shivani Singh, Varaporn Kruabkontho, Thatsanun Ngernseng, Jaruwan Tubprasert, Wanassanan Madmanee, Kanokon Suwannasin, Amornrat Promsongsil, Borimas Hanboonkunupakarn, Kittiyod Poovorawan, Manus Potaporn, Attasit Srisubat, Bootsakorn Loharjun, Walter R.J. Taylor, Farah Qamar, Abdul Momin Kazi, M. Asim Beg, Danoy Chommanam, Sisouphanh Vidhamaly, Kesinee Chotivanich, Mallika Imwong, Sasithon Pukrittayakamee, Arjen M. Dondorp, Nicholas P.J. Day, Mauro M. Teixeira, Watcharapong Piyaphanee, Weerapong Phumratanaprapin, Nicholas J. White

“…Fluoxetine was well tolerated, there were no serious adverse events and only one grade 3 adverse event in the intervention arm. …”
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Does pregabalin offer potential as a first-line therapy for generalized anxiety disorder? A meta-analysis of efficacy, safety, and cost-effectiveness by Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Narcis Cardoner, Luis Gutiérrez-Rojas, Luis Gutiérrez-Rojas, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Pilar Saiz, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Guillermo Lahera, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Miguel Ángel Álvarez-Mon, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, Pino Alonso Ortega, María Pérez-Páramo

“…Pregabalin was associated with higher cost-effectiveness (MD 0.02, 95% CI 0.01, 0.03).ConclusionPregabalin is an effective and well-tolerated treatment for generalized anxiety disorder, showing superior efficacy and safety compared with first-line medications.Systematic Review RegistrationPROSPERO CRD42024556152.…”
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Correlation between aboveground vegetation composition and soil seed bank of Raudhat desert habitat: a case study of Raudhat Alkhafs, Saudi Arabia by Asma A. Al-Huqail, Hanan F. Al-Harbi, Abdullah M. Alowaifeer, Mohamed A. El-Sheikh, Abdulaziz M. Assaeed, Turki S. Alsaleem, Hazem S. Kassem, Omar M. Azab, Basharat A. Dar, Jahangir A. Malik, Ahmed M. Abd-ElGawad

“…Therophytes are distinguished as major (45.8%) because of their ability to tolerate arid environments, high reproduction rate, ecological flexibility, and genetic plasticity. …”
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Autoinducer-2 enhances the defense of Vibrio furnissii against oxidative stress and DNA damage by modulation of c-di-GMP signaling via a two-component system by Heng Zhang, Wenjin Zhao, Wenguang Yang, Huimin Zhang, Xinyu Qian, Kai Sun, Qiao Yang, Xihui Shen, Lei Zhang

“…AI-2 perception by the AsrK-AsrR system remarkably reduces intracellular c-di-GMP levels and enhances tolerance of V. furnissii to oxidative stress and DNA damage by upregulating the transcription of universal stress proteins including UspA1, UspA2, and UspE. …”
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Safety and efficacy of the therapeutic DNA-based vaccine VB10.16 in combination with atezolizumab in persistent, recurrent or metastatic HPV16-positive cervical cancer: a multicent... by Hannelore Denys, Frederik Marmé, Frederic Forget, Lukas Rob, Pawel Blecharz, Kristina Lindemann, Peter Hillemanns, Linn Wölber, Theresa Link, Jean-Francois Baurain, Mariusz Bidziński, Linn Woelber, Michal ZikÁN, Josef Chovanec, Christian Dannecker, Stéphanie Henry, Hannelore G Denys, Velko Minchev, Anders Rosholm, Kaja C G Berg, Roberto S Oliveri, Marchela Koleva, Bozhil Robev

“…HPV16-specific T-cell responses were analyzed in 36 of 47 patients with an increase observed in 22/36 (61%).Conclusions The therapeutic DNA-based vaccine VB10.16 combined with atezolizumab was safe and well tolerated showing a promising clinically meaningful efficacy with durable responses in patients with persistent, r/m HPV16-positive cervical cancer, especially if PD-L1-positive.…”
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Molecular mapping and validation of quantitative trait loci for content of micronutrients in wheat grain by Xiangdong Chen, Junchao You, Nannan Dong, Di Wu, Die Zhao, Rui Yong, Wenjing Hu

“…Some genes in these two regions were involved in stress tolerance, growth development, Zn synthesis in plants. …”
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Efficacy of PARPi re-maintenance therapy for recurrent ovarian cancer by Yulin Wang, Yunjie Yang, Binghong Guo, Binghong Guo, Xiaoyan Li, Renakezi Tuersun, Ye Cao, Jundong Li, Jihong Liu, Su Li, Tao Liu, Yongwen Huang

“…Re-treatment with PARPi was well-tolerated.…”
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