Visual Analysis of Research Progress on the Impact of Cadmium Stress on Horticultural Plants over 25 Years by Zhouli Liu, Benyang Hu, Yi Zhao, Shuyan Zhang, Xiangbo Duan, Hengyu Liu, Luyang Meng

“…The network of collaborations among authors and institutions in the WOS database seemed denser compared to that in the CNKI database. (3) International research hotspots have focused on accumulation, tolerance and oxidative stress, while domestically, the focus has been on antioxidant enzymes, growth and seed germination. …”
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Effect of Acupuncture Exercise Therapy On Isokinetic Muscle Strength and Exercise Ability of Patients after Anterior Cruciate Ligament Reconstruction by Wen YAN, Jiaying MURONG, Shuyi CUI, Wanwen HE, Xun ZHUANG

“…After operation, the observation group was given acupuncture exercise therapy, acupuncture at the knee pain points on the healthy side of the patients, and then the acupuncture was performed with the method of twirling, smoothing, toning and catharsis (the frequency was 120 times a minute, with the tolerance of the patients as the degree, one minute a time). …”
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SPA14 liposomes combining saponin with fully synthetic TLR4 agonist provide adjuvanticity to hCMV vaccine candidate by Ernesto Luna, Sophie Ruiz, Marie Garinot, Cyril Chavagnac, Pankaj Agrawal, John Escobar, Laurent Revet, Marie-Jeanne Asensio, Fabienne Piras, Francis G. Fang, Donald R. Drake, Bachra Rokbi, Daniel Larocque, Jean Haensler

“…When tested as an adjuvant in vivo with human cytomegalovirus glycoprotein B (gB) and pentamer complex (PC) as test antigens, SPA14 was generally well tolerated and as active as AS01B for the induction of long-lasting CMV-neutralizing antibodies in mice and non-human primates (NHPs). …”
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The role of skill and expertise and organizational resources along with the relevant components in the competitive environment of the organization (case study: Tehran Province Muni... by Mehdi Aghighi, Rashid Zolfegari Zaferani, Behzad Mashali

“…A good citizen of the organization has a variety of behaviors such as accepting and assuming additional duties, following the regulations and procedures of the organization, maintaining and developing a positive attitude, and tolerating dissatisfaction and problems of the organization (Shamsi, 2020). …”
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Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotherapy for methamphetamine use disorder (the KAPPA trial) by Jonathan Brett, Celia Morgan, Nadine Ezard, Brendan Clifford, Krista J Siefried, Robert May, Liam Acheson, Kathryn Fletcher, Harriet MacDonald, Gillinder Bedi, Alexandre Guerin, Elizabeth Knock, Michael Millard, Jess Doumany

“…A 4-week course with three subcutaneous ketamine doses (0.75 mg/kg to 0.9 mg/kg, titrated according to tolerability) at weekly intervals and four sessions of cognitive behavioural therapy (one at treatment initiation and three within 24–48 hours following each ketamine administration session) will be delivered. …”
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Wu-Mei-Wan enhances brown adipose tissue function and white adipose browning in obese mice via upregulation of HSF1 by Shen Chen, Kexin Nie, Hongzhan Wang, Yang Gao, Xinyue Jiang, Hao Su, Zhi Wang, Yueheng Tang, Fuer Lu, Hui Dong, Jingbin Li

“…Both low-dose WMW and high-dose WMW treatments led to reduced weight gain and improved glucose tolerance, with low-dose WMW showing more pronounced effects. …”
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Anlotinib in combination with metronomic chemotherapy in HER2-negative metastatic breast cancer: an observational and retrospective study by Jiaxuan Liu, Jiayang Zhang, Huiping Li, Guohong Song, Lijun Di, Hanfang Jiang, Ying Yan, Huan Wang, Jing Wang, Xiaoran Liu, Bin Shao, Qiao Li

“…Within the context of real-world clinical practice, anlotinib in combination with metronomic chemotherapy provides a well-tolerated and effective treatment option for HER2-negative MBC, which warrants further investigation in the future.…”
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Efficacy and safety of SHEN26, a novel oral small molecular RdRp inhibitor for COVID-19 treatment: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical... by Jiangtao Bai, Tetsuya Asakawa, Wenfang Yuan, Yuanlong Lin, Hao Ju, Dandan Xu, Mingming Yang, Shuo Li, Guanguan Li, Deyin Guo, Hongzhou Lu, Xumu Zhang

“…Abstract Background SHEN26 (ATV014) is an oral RNA-dependent RNA polymerase (RdRp) inhibitor with potential anti-SARS-CoV-2 activity. Safety, tolerability, and pharmacokinetic characteristics were verified in a Phase I study. …”
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Impact of Dietary Intake and Cardiorespiratory Fitness on Glycemic Variability in Adolescents: An Observational Study by Mingliang Ge, Stephanie R Lebby, Shivani Chowkwale, Caleb Harrison, Grace M Palmer, Keith J Loud, Diane Gilbert-Diamond, Mary Ellen Vajravelu, Jennifer L Meijer

“…Methods: Healthy adolescents (n = 30) were recruited for a treadmill VO2 max test and to complete the following activities for 7–10 d: 1) wear a Dexcom G6 CGM, 2) complete ≥3 24-h dietary recalls, and 3) complete 1 at-home oral glucose tolerance test (OGTT, 75 g glucose). Glycemic patterns were extracted as mean glucose, the coefficient of variance, the mean amplitude of glycemic excursions, and the mean of daily differences. …”
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Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines by Anton Wellstein, Thomas Seufferlein, Alexander Kleger, Tim Eiseler, Anton Lahusen, Nora Minhöfer, Kim-André Lohse, Christine Blechner, Jessica Lindenmayer, Sabine Windhorst, Yuan-Na Lin

“…Background Pancreatic ductal adenocarcinoma (PDAC) is mostly refractory to immunotherapy due to immunosuppression in the tumor microenvironment and cancer cell-intrinsic T cell tolerance mechanisms. PDAC is described as a “cold” tumor type with poor infiltration by T cells and factors leading to intratumoral T cell suppression have thus received less attention. …”
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Dupilumab in children with eosinophilic esophagitis: a retrospective multicenter study by Mohammed Hasosah, Ghassan Sukkar, Asharf AlSahafi, Ali Zaidan, Nouf Ghous, Abdulmajed Alshahrani, Ziyad Al Zahrani, Naif Hasosah, Mansour Qurashi, Loie Goronfolah, Ali Alsharief, Nagla Kamal

“…Dupilumab had a well-tolerated safety profile, except for one patient who developed conjunctivitis. …”
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From fear to food: predation risk shapes deer behaviour, their resources and forest vegetation by Martin, Jean-Louis, Chamaillé-Jammes, Simon, Salomon, Anne, Gomez Pourroy, Devana Veronica, Schlaeflin, Mathilde, Le Saout, Soizic, Lucas, Annick, Bentaleb, Ilham, Chollet, Simon, Pattison, Jake, Martin-Blangy, Soline, Gaston, Anthony James

“…In these populations deer had a remarkable tolerance to human presence (short flight initiation and travel distances when disturbed), a willingness to consume foreign bait or to investigate baited traps, and a propensity to be active at daytime. …”
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DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells by Ignacio Melero, Ruth Conde-Garrosa, David Sancho, Santos Mañes, Alfonso R Sanchez-Paulete, Francisco J Cueto, Carlos del Fresno, Paola Brandi, Alexis J. Combes, Elena Hernández-García, Michel Enamorado, Christian P Bromley, Manuel J Gomez, Santiago Zelenay, Salvador Iborra, Matthew F. Krummel

“…DNGR-1 has been involved in both cross-presentation of dead cell-associated antigens and processes of disease tolerance, but its role in antitumor immunity has not been clarified yet.Methods B16 and MC38 tumor cell lines were inoculated subcutaneously into wild-type (WT) and DNGR-1-deficient mice. …”
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Early Subclinical Atherosclerosis in Gestational Diabetes: The Predictive Role of Routine Biomarkers and Nutrigenetic Variants by Marica Franzago, Federica Fraticelli, Marta Di Nicola, Francesco Bianco, Daniela Marchetti, Claudio Celentano, Marco Liberati, Raffaele De Caterina, Liborio Stuppia, Ester Vitacolonna

“…All women then attended a 3-year-postpartum follow-up and on that occasion performed an oral glucose tolerance test (OGTT, with 75 g oral glucose), the measurement of carotid artery intima-media thickness (cIMT), and analyses of metabolic parameters. …”
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Composition and the predicted functions of fungal communities and the key drivers in acidic soils of Jiaodong Peninsula, China by Jing Liu, Zafran Gul Wazir, Guoqin Hou, Guizhen Wang, Fangxu Rong, Yuzhi Xu, Kai Liu, Mingyue Li, Aiju Liu, Hongliang Liu, Hongwen Sun

“…IntroductionSoil acidification imperils soil health and hinders the agricultural sustainability. As being more tolerant than bacteria to soil acidification, so it would be more meaningful for agricultural management and crop yield to characterize fungal community in acidic soils and manifest its key drivers.MethodThis study investigated the composition and diversity of fungal communities and its key driving factors by collecting 90 soil samples from the acidic region of Jiaodong Peninsula China, spanning 3 × 104 km2.ResultsThe results indicated that most soil pH values ranged from 5.01 to 6.42, and the exchangeable acidity (EA) content raised significantly (p < 0.01) along with soil acidic degree increasing. …”
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A generative whole-brain segmentation model for positron emission tomography images by Wenbo Li, Zhenxing Huang, Hongyan Tang, Yaping Wu, Yunlong Gao, Jing Qin, Jianmin Yuan, Yang Yang, Yan Zhang, Na Zhang, Hairong Zheng, Dong Liang, Meiyun Wang, Zhanli Hu

“…Additionally, clinical tolerance rates, which are determined by the tumor background ratio, have confirmed the ability of the method to distinguish highly metabolic regions accurately from normal regions, reinforcing its clinical applicability. …”
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Genome-wide identification of the Sec14 gene family and the response to salt and drought stress in soybean (Glycine max) by Jinyu Zhang, Liying Zou, Li Wang, Dongchao Zhang, Ao Shen, Yongqi Lei, Maoni Chao, Xinjuan Xu, Zhiwei Xue, Zhongwen Huang

“…Conclusions This study provides a systematic and comprehensive examination of the Sec14 gene family in soybean, which will facilitate further functional research into their roles in response to salt and drought tolerance.…”
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Partial Stereotactic Ablative Radiotherapy Boost Before Conventional Radiotherapy (P‐SABR) for Large (> 5 cm) Unresectable Stage III Nonsmall Cell Lung Cancer by Yun Bai, Xianshu Gao, Shangbin Qin, Shanshi Li, Mingwei Ma, Xi Cao, Feng Lyu, Jiayan Chen, Xin Qi, Siwei Liu, Yan Gao, Hongzhen Li, Xiaomei Li, Xiaoying Li, Xueying Ren, Lei Huang

“…Conclusions The P‐SABR treatment has shown a high rate of LC and tolerable toxicity in patients with large unresectable stage III NSCLC.…”
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Long-term safety and sustained efficacy of bimekizumab in patients with ankylosing spondylitis (radiographic axial spondyloarthritis): 5-year results from BE AGILE (phase 2b) and i... by Sofia Ramiro, Désirée van der Heijde, Atul Deodhar, Xenofon Baraliakos, Denis Poddubnyy, Lianne S Gensler, Helena Marzo-Ortega, Natasha de Peyrecave, Victoria Navarro-Compán, Tetsuya Tomita, Carmen Fleurinck, Ute Massow, Thomas Vaux

“…Objective Assess long-term safety, tolerability and efficacy of bimekizumab in ankylosing spondylitis (radiographic axial spondyloarthritis (r-axSpA)).Methods Patients with active r-axSpA completing the dose-ranging 48-week randomised controlled trial could enrol in the open-label extension, where patients received bimekizumab 160 mg every 4 weeks. …”
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Multidimensional 1-Year Outcomes After Intensive Care Admission for Multisystem Inflammatory Syndrome in Children by Thomas C. Seijbel, BSc, Levi Hoste, MD, Corinne M. P. Buysse, MD, PhD, Karolijn Dulfer, PhD, Filomeen Haerynck, MD, PhD, Matthijs de Hoog, MD, PhD, Naomi Ketharanathan, MD, PhD

“…Although most patients had normal functional performance scores (Pediatric Cerebral Performance Category, Pediatric Overall Performance Category, and Functional Status Score), 62% still experienced physical sequelae: fatigue (40%), headaches (27%), and decreased exercise tolerance (19%). Cognitive, behavioral, and psychological problems were reported in 14%, 13%, and 23%, respectively. …”
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