The activity of a herbal medicinal product of Phyllanthus niruri and Silybum marianum powdered extracts (Heptex®) in patients with apparent risk factors for nonalcoholic steatohepa... by Mohamed Kamal Shaker, Mohamed Hassany, Basem Eysa, AbdulMoneim Adel, Ahmed Zidan, Shahnaz Mohamed

“…Conclusion Heptex® capsules were safe and well tolerated over a treatment period of 36 weeks. However, the hepatoprotective effect in patients at risk of NASH still needs further assessment using more accurate investigation tools, a larger sample size, and/ or higher doses of the combination. …”
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Embedding the patient voice into research on spontaneous preterm birth-themes from a Preterm Birth Advisory Council. by Gillian Corbett, Mandy Daly, Dylan Keegan, Patricia Horgan, Catriona Keyes, Larissa Luethe, Siobhan Corcoran, Fionnuala M McAuliffe

“…The most important aspect of an intervention is its clinical efficacy. High tolerance thresholds were described in sacrifice for a positive pregnancy outcomePreterm Birth Preventative care as a patient-led care model. …”
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Distinct dynamic regulation of pectoralis muscle metabolomics by insulin and the promotion of glucose-lipid metabolism with extended duration by Xiangli Zhang, Pengfei Du, Ziyang Wang, Yao Zhu, Xuemeng Si, Wen Chen, Yanqun Huang

“…Glycolipid concentrations were measured using kits, and the expression of key genes involved in glucose metabolism was assessed via quantitative real-time PCR (qRT-PCR). The insulin tolerance test, performed by injecting 5 IU/kg body weight of insulin, demonstrated a rapid drop in blood glucose levels from 0 to 15 min, with a consistent reduction observed at 120 min (P < 0.01). …”
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Heme-Iron OptiFer® in the Treatment of Iron Deficiency Anemia During Pregnancy by Ibrahim A. Abdelazim, Mohannad AbuFaza, Soud M. Al-Ajmi, Osama O. Amer, Svetlana Shikanova, Bakyt Karimova

“… OBJECTIVES: This study designed to compare the efficacy, and tolerability of heme-iron OptiFer® to ferrous fumarate in the treatment of iron deficiency anemia during pregnancy. …”
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Serum Ferritin Levels in Pregnancy and Their Association with Gestational Diabetes Mellitus: A Prospective Longitudinal Study by Qin Z, Du Y, Wang Z, Qin X, Wu H, Yu X, Zhao C, Mo L, Huang B

“…We measured SF levels in the1st, 2nd, and 3rd trimesters, as well as plasma malondialdehyde (MDA) and C-reactive protein (CRP) in the 1st trimester, blood glucose levels in the oral glucose tolerance test (OGTT), and glycosylated hemoglobin (HbA1c) in the 2nd trimester. …”
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Interplay of NF-κB and PPAR-γ transcription factors in patients with juvenile systemic lupus erythematosus by Ozgur Kasapcopur, Sezgin Sahin, Amra Adrovic, Kenan Barut, Sinem Durmus, Remise Gelisgen, Hafize Uzun

“…Objective Juvenile SLE (jSLE) is an autoimmune disease characterised by the presence of high levels of autoantibodies, predominantly targeting nuclear antigens, resulting in a breakdown of self-tolerance. However, its pathogenesis is multifactorial and poorly understood. …”
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Efficacy and retention rate of secukinumab in psoriatic arthritis across different clinical phenotypes: insights from the Italian GISEA Registry by Giuseppe Lopalco, Maria Morrone, Fabiola Atzeni, Chiara Bazzani, Francesco Paolo Bianchi, Francesco Paolo Cantatore, Roberto Caporali, Antonio Carletto, Alberto Cauli, Maria Sole Chimenti, Sergio Colella, Fabrizio Conti, Addolorata Corrado, Ennio Giulio Favalli, Alberto Floris, Marco Fornaro, Rosario Foti, Roberta Foti, Elena Fracassi, Bruno Frediani, Stefano Gentileschi, Roberto Gorla, Elisa Gremese, Emanuela Praino, Roberta Ramonda, Cinzia Rotondo, Marco Sebastiani, Angelo Semeraro, Gianfranco Ferraccioli, Giovanni Lapadula, Florenzo Iannone

“…Higher age (aHR = 0.98, 95% confidence interval (CI): 0.96–0.99, p  = 0.007) and lower baseline DAPSA scores (aHR = 1.02, 95% CI: 1.01–1.03, p  = 0.014) were associated with greater persistence of SECU treatment. SECU was well tolerated, with no serious adverse events. Conclusion: SECU showed sustained clinical improvements in both peripheral and axial involvement of PsA patients over 24 months, with higher persistence observed in mixed PsA patients. …”
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Translation, content validity and internal structure of the Brazilian version of the Adolescent Resilience Questionnaire (B-ARQ). by Genara Brum Gomes, Luisa Gatti-Reis, Matheus França Perazzo, Marisa Alves Araújo, Flávio Freitas Mattos, Deirdre Gartland, Saul Martins Paiva, Isabela Almeida Pordeus

“…The internal consistency was estimated with McDonald's Omega for each factor: Confidence (ω = 0.480), Negative Cognition (ω = 0.588), Empathy/tolerance (ω = 0.295), Emotional insight (ω = 0.425), Social Skill (ω = 0.235), Family Domain Connectedness (ω = 0.785), Family Domain Availability (ω = 0.847), Peers Domain Connectedness (ω = 0.719), Peers Domain Availability (ω = 0.402), School Domain Supportive environment (ω = 0.677), School Domain Connectedness (ω = 0.013), Community Domain Connectedness (ω = 0.791). …”
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Safeguarding and using global banana diversity: a holistic approach by Ines Van den houwe, Rachel Chase, Julie Sardos, Max Ruas, Els Kempenaers, Valentin Guignon, Sebastien Massart, Sebastien Carpentier, Bart Panis, Mathieu Rouard, Nicolas Roux

“…The evaluation of desirable agronomic traits inherent in Musa spp. are investigated by a high-throughput phenotyping platform, which helps breeding programs to select cultivars resistant or tolerant to biotic and abiotic stresses. Genomic and bioinformatic studies of several banana wild relatives greatly enhance our understanding of Musa genetic diversity, links to important phenotypic traits and bring new methods for management of the collection. …”
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Aflatoxin M1 Concentrations, Adulterants, Microbial Loads, and Physicochemical Properties of Raw Milk Collected From Nekemte City, Ethiopia by Leila Nasir, Habtamu Fekadu Gemede

“…The results of this study also revealed that the concentration of AFM1 in 7 (58%) of the 12 milk samples was above the European Union’s (EU) maximum tolerance limit (0.05 g/L). The present study also revealed that of the investigated adulterants, only the addition of water had positive effects on three milk samples, while the remaining adulterants were not detected in any of the milk samples. …”
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Changes in oxygen uptake kinetics after exercise caused by differences in loading pattern and exercise intensity by Yuri Ichikawa, Tomoko Maeda, Tetsuya Takahashi, Kohei Ashikaga, Shiori Tanaka, Yuki Sumi, Haruki Itoh

“…Submaximal exercise tests may be considered as convenient methods for evaluating exercise tolerance in patients with cardiac failure.…”
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Safety and efficacy of anti-CD30 CAR-T cell therapy in relapsed/refractory classic Hodgkin lymphoma: a systematic review and meta-analysis by Fanqiao Meng, Maoyuan Xiang, Yu Liu, Dongfeng Zeng

“…The grade ≥ 3 AEs was 66% (95%CI 0.06–0.98, I2 = 93%, P = 0.70), 34% (95%CI 0.07–0.78, I2 = 85%, P = 0.51) in neutropenia and thrombocytopenia, respectively. All AEs were tolerable and resolved with treatment. Conclusion Current evidence suggests that anti-CD30 CAR-T cell therapy is effective and safe in treating R/R cHL and is worth considering as a viable therapeutic option.…”
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The differences in symptom networks of depression, anxiety, and sleep in college students with different stress levels by Wei Li, Shuhui Huo, Fei Yin, Zhengyu Wu, Xueqi Zhang, Zhengjun Wang, Jianqin Cao

“…A total of 7,845 participants (2,447 males and 5,398 females) were assessed using the Psychological Stress Tolerance Index (PSTR), the General Health Questionnaire-20 (GHQ-20), and the Self-Rating Scale of Sleep (SRSS). …”
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Efficacy of Curcumin on Treating Cancer Anorexia-Cachexia Syndrome in Locally or Advanced Head and Neck Cancer: A Double-Blind, Placebo-Controlled Randomised Phase IIa Trial (CurCh... by Tawasapon Thambamroong, Kasan Seetalarom, Siriwimon Saichaemchan, Yanisa Pumsutas, Naiyarat Prasongsook

“…Curcumin was safe and well tolerated. This constitutes an unmet need for clinical trials. …”
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Stage-specific milk yield losses and associated sweating, respiration, and rectal temperature responses under varying temperature-humidity index thresholds in lactating and dry cow... by P.A. Tu, Y.H. Yeh, Y.H. Chen, J.W. Shiau, T.Y. Lin, Thomas Banhazi, M.K. Yang

“…Therefore, comprehensive strategies, including not only cooling measures but also dietary adjustments and genetic improvements for heat tolerance, are required to help these animals regulate their body temperature and avoid HS. …”
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Physiological and transcriptome analysis reveals the mechanism of Gymnocarpos przewalskii response to drought stress by Chao Du, Xinyu Ni, Mengjiao Yan, Qinghan Meng, Junying He

“…Conclusions High forage quality and drought stress tolerance were observed in G. przewalskii. In response to drought stress, G. przewalskii orchestrates reactive oxygen species scavenging, proline biosynthesis, and other intricate physiological processes, with substantial contributions from plant hormones and transcription factors. …”
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Effect of a Sodium and Calcium DL-β-Hydroxybutyrate Salt in Healthy Adults by Tobias Fischer, Ulrike Och, Ira Klawon, Tim Och, Marianne Grüneberg, Manfred Fobker, Ursula Bordewick-Dell, Thorsten Marquardt

“…More information on the kinetics of intake, safety, and tolerance of these products is needed. Methods. In a one-dose kinetic study, six healthy subjects received an intervention (0.5 g/kg bw) using a commercially available ketone body supplement. …”
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Effects of poultry by-product meal and complete replacement of fish oil with alternative oils on growth performance and gut health of rainbow trout (Oncorhynchus mykiss): a FEEDNET... by Imam Hasan, Simona Rimoldi, Biagina Chiofalo, Marianna Oteri, Micaela Antonini, Rosangela Armone, Violeta Kalemi, Laura Gasco, Genciana Terova

“…The combination of PBM and natural algae oil was well tolerated by the trout and showed no negative effects on gut health. …”
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Reduction on Proinflammatory Cytokines after Application of Transcutaneous Electrical Nerve Stimulation (TENS) in Patients with a Breast Cancer: A Nonrandomized, Open, and Single-A... by Tábata Cristina do Carmo Almeida, Simone Meneghette Zatta, Laércio da Silva Paiva, Luís Eduardo Werneck de Carvalho, Jean Schoueri, Luiz Carlos de Abreu, Fernando Luiz Affonso Fonseca, Fernando Adami

“…All patients will be submitted to TENS intervention (Ibramed, Model Neurodyn III, parameters: VIF—turn on, frequency—2-247 Hz, pulse size—50-500 μs, and intensity (mA)—maximum tolerated by the patient), and the data will be analyzed in the pre- and postintervention of each patient. …”
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Incremental Lifetime Cancer Risk of PAHs in PM2.5 via Local Emissions and Long-Range Transport during Winter by Shahzada Amani Room, Chia En Lin, Shih Yu Pan, Ta Chih Hsiao, Charles C.-K. Chou, Kai Hsien Chi

“…The incremental lifetime cancer risk (ILCR) of Cr6+ was higher in metal (2.60 × 10‒5) but did not exceed its tolerable limits.…”
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