Molecular cloning and expression dynamics of Atrogin-1 in muscle tissue of Russian sturgeon (Acipenser gueldenstaedtii) under high salt stress by Yong-Juan Mo, Yi-Li Gao, Shi-Jjian Xu, Bin Wang, Jingping Wu, Peng Yu, Ming Li, Xiangtao Kang, Zhi-Qiang Han

“…This research is anticipated to inform aquaculture practices and shed light on the selection of germplasm resources for the development of salt-tolerant Russian sturgeon strains.…”
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Monitoring of hepatitis E virus infection and replication by functional tagging of the ORF2 protein by Maliki Ankavay, Nathalie Da Silva, Angela Pollán, Noémie Oechslin, Katja Dinkelborg, Patrick Behrendt, Darius Moradpour, Jérôme Gouttenoire

“…Results: Short sequence insertions (5 amino acids) were tolerated at four distinct sites in the C-terminal region of the ORF2 protein, without significantly affecting viral capsid expression and subcellular localization as well as virus production. …”
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Evaluation of the rainfed and irrigated conditions on biomass and essential oil yield of German chamomile (Matricaria chamomilla) in response to melatonin foliar application by Hossein Gorgini Shabankareh, Mohammad Reza Asgharipour, Ali Salehi Sardoei, Ahmad Reza Kamaliun, Hamid Mohammadi, Mansour Ghorbanpour

“…Based on these findings, combining rainfed cultivation with melatonin application is a promising and environmentally friendly strategy to enhance drought tolerance, growth, and biochemical content in German chamomile.…”
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Combined metabolomic and transcriptomic analysis to reveal the response of rice to Mn toxicity stress by Feng Li, Yushuang Yao, Jiapeng Ma, Zhengwei Wu, Dianfeng Zheng, Yingbin Xue, Ying Liu

“…These results enhance our understanding of the molecular processes underlying the responses of rice to Mn toxicity stress and provide a basis for breeding Mn-tolerant rice varieties.…”
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Comparative Analysis of Adverse Drug Reactions Associated with Fluoroquinolones and Other Antibiotics: A Retrospective Pharmacovigilance Study by Alshareef H, Alenzi KA, Albalawi BR, Alanazi RM, Albalawi NS, Alasoufi WS, Alqifari S, Ahmed R, Ali MAS

“…Although FQs are the most frequently used and generally tolerated, there are issues with their safety. This study assessed the rate, severity, seriousness, outcomes, and types of FQs adverse drug reactions (ADRs) in reports submitted to a regional spontaneous ADR database.Methods: This was a retrospective cross-sectional observational study involving all patients with reported ADRs related to FQs or other antibiotics (ABs) that were submitted to the Regional Pharmacovigilance Center (PVC) database between January 2019 and December 2022. …”
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Comprehensive safety evaluation of isatuximab in multiple myeloma using disproportionality analysis of FAERS and meta-analysis of randomized controlled trials by Muhammed Favas Karimbanathottathil, Beema T Yoosuf, M Mamatha, Dipika Bansal

“…Isatuximab therapy was generally well-tolerated and exhibited a manageable safety profile. …”
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In Vitro Probiotic Evaluation of Yeasts from Coconut and Raffia Juices by Emenike O. Irokanulo, Queen-Esther M. Yadung, Dolapo E. Orotayo, Charles O. Nwonuma, Oreoluwa S. Alonge

“…The in vitro tests used the optical density method to assay the tolerance to acid (pH 2, 3, 5), alkaline (pH 7.5, 8.0), gastric juice (30%), bile (1, 2, and 3%), and osmotic pressure (5, 10, 15, 20, 25, and 30% glucose solution). …”
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First-trimester metabolic profiling of gestational diabetes mellitus: insights into early-onset and late-onset cases compared with healthy controls by Danuta Dudzik, Vangeliya Atanasova, Coral Barbas, Jose Luis Bartha

“…In this study, we conducted a comprehensive metabolomic analysis to explore potential biomarkers for early GDM prediction.MethodsPlasma samples were collected during the first trimester from 60 women: 20 with early-onset GDM, 20 with late-onset GDM, and 20 with normal glucose tolerance. Using advanced analytical techniques, including liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-mass spectrometry (GC-MS), we profiled over 150 lipid species and central carbon metabolism intermediates.ResultsSignificant metabolic alterations were observed in both early- and late-onset GDM groups compared to healthy controls, with a specific focus on glycerolipids, fatty acids, and glucose metabolism. …”
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Sağlık Çalışanlarının Tükenmişlik Sendromu Düzeyleri İle Hedonik Tüketim Davranışları Arasındaki İlişki by Ebru Ertürk, Meral Erdirençelebi, Şerife Şen

“…Bu süreçte birey işinden kopmakta, işle ve örgütle olan bağı zayıflamakta işten ve çalışma arkadaşlarından izolasyon yaşanmakta, birey duyarsızlaşmakta, insanları ve olayları tolere edebilme gücü zayıflamakta, kurumdaki performansı ve ilişkileri bu süreçten zarar görmektedir. …”
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One-year experience with latanoprostene bunod ophthalmic solution 0.024% in clinical practice: A retrospective observational study. by Chun-Mei Hsueh, Chen-Hsin Tsai, Jou-Chen Huang, Si-Huei Lee, Tsung-Jen Wang, Siao-Pei Guo

“…Subgroup analysis of PGA use at month 12 was 1.8±2.3 mm Hg in tafluoprost group and 0.5±1.7 mm Hg in travoprost group (9.5% vs.2.6% additional IOP reduction rates, P = 0.02). Tolerable ocular adverse effects included irritation (n = 16, 19.8%), mild conjunctival hyperemia (n = 11, 13.6%), dark circles (n = 4, 4.9%) and blurred vision (n = 2, 2.5%). …”
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Vasoreactive testing prevalence and characteristics in patients with idiopathic pulmonary arterial hypertension by Goncharova Natalia, Kirill Lapshin, Aelita Berezina, Irina Zlobina, Anton Ryzhkov, Zhaneta Matakaeva, Elizaveta Andreeva, Olga Moiseeva

“…Patients with negative VRT demonstrated worse hemodynamics and exercise tolerance, higher N-terminal pro-brain-type natriuretic peptide (NT-proBNP) level, and right heart dilatation compared with VRT+. …”
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Tapinarof Improved Outcomes and Sleep for Patients and Families in Two Phase 3 Atopic Dermatitis Trials in Adults and Children by Eric L. Simpson, Adelaide A. Hebert, John Browning, Rocco T. Serrao, Howard Sofen, Philip M. Brown, Stephen C. Piscitelli, David S. Rubenstein, Anna M. Tallman

“…In two phase 3 trials (ADORING 1 and 2), tapinarof cream 1% once daily (QD) demonstrated significant efficacy and was well tolerated in patients down to age 2 years with AD. …”
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Reconstruction for Complex Oromandibular Facial Defects: The Fibula Free Flap and Pectoralis Major Flap Combination by Mohammed Qaisi, Ryan Dee, Issam Eid, James Murphy, Ignacio A. Velasco Martinez, Henry Fung

“…Two patients regained good oral intake while one patient tolerated oral intake but was PEG tube-dependent. Conclusions. …”
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Relationship between physical activity during pregnancy and maternal health outcomes: evidence from the MAASTHI cohort study in Bengaluru, India by Yamuna Ana, Floor A. van den Brand, Onno C. P. van Schayck, Giridhara R. Babu

“…We assessed presence of depressive symptoms and conducted oral glucose tolerance tests, hemoglobin and blood pressure assessments, anthropometric measurements, and collected delivery details. …”
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Patrimoine juif, pouvoir marocain by Chiara Lutteri

“…A State-sanctioned reading of interreligious history, based on peaceful coexistence and tolerance, was spread through cultural and patrimonial projects that actively participated in the survival of the King’s political centrality. …”
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Symptoms of dwarf elm (Ulmus pumila L.) health condition in the Left-bank Ukraine by Valentyna L. Meshkova, Olena A. Kuznetsova, Volodymyr P. Turenko

“…Due to its rapid growth, winter hardiness, low demand for soil fertility and moisture, tolerance of drought, resistance to gaseous pollution and soil salinization, and ability to spread under favorable conditions, U. pumila has been widely cultivated in forests, urban plantations, and along transportation right-of-ways. …”
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Determination of Vibration Properties and Reliable Frequency Estimation for Synchronous Vibrations Through Improved Blade Tip Timing Techniques Without a Once-per-Revolution Sensor by Marios Sasakaros, Luca Mann, Markus Schafferus, Manfred Wirsum

“…Specifically, the blades are identified by unique characteristics resulting from manufacturing tolerances, while the blade deflections are calculated through a novel method, which relies on the impeller’s circumferential position. …”
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A comparison of new and existing rootstocks to reduce canker of apple trees caused by Neonectria ditissima (Nectriaceae, Hypocreales) by Lucas A. Shuttleworth, Sonia Newman, Ioannis Korkos

“…Abstract The grafting of apple rootstocks on to scions confers benefits including reduced tree size/dwarfing for trellis based growing systems, increased tolerance to physiological stress, and pest and disease management. …”
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Transcranial photobiomodulation for reducing symptoms of autism spectrum disorder and modulating brain electrophysiology in children aged 2–7: an open label study by Yuli Fradkin, Joaquin A. Anguera, Alexander J. Simon, Luis De Taboada, Eugenia Steingold

“…We collected electroencephalogram (EEG) data after each treatment session from all children who tolerated wearing the EEG cap to monitor changes in brain activity.ResultsThe intervention resulted in a significant 7-point reduction in average CARS-2 scores (t = 10.23, p < .0001), along with decreased delta power and increased gamma and beta power in EEG readings. …”
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Effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand: protocol for a three-arm, pragmatic, community-based rand... by Natalie Walker, Amanda Calder, Joanne Barnes, George Laking, Varsha Parag, Chris Bullen

“…Abstract Background Combining short-acting nicotine replacement therapy with varenicline increases smoking cessation rates compared with varenicline alone, but not all people tolerate these medications or find them helpful. We aim to investigate the therapeutic potential of an analogous combination, by evaluating the effectiveness, safety, and acceptability of combining nicotine salt e-cigarettes with cytisine, compared to nicotine salt e-cigarettes or cytisine only, on smoking abstinence at six months. …”
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