Efficacy and safety of home-based transcranial direct current stimulation as adjunct treatment for cognitive improvement in major depressive disorder: A double-blind, randomized, m... by CW Lee, K Park, JE Ahn, Y Jang, YS Park, H Yu, D Lee, HK Ihm, J Lee, J Kim, YI Lee, S-E Lim, SS Kwon, HY Park, TH Ha, I-Y Yoon, Woojae Myung, Ji Hyun Baek

“…Conclusions Home-based tDCS for MDD demonstrated no evidence of effectiveness but was safe and well-tolerated. Further research is needed to address the technical limitations, evaluate broader cognitive functions, and extend durations to evaluate its therapeutic potential. …”
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Growth and Productivity Assessment of Short-Duration Rice (Oryza sativa L. and Upland NERICA) Genotypes in Semiarid North-Central Namibia by Simon K. Awala, Kudakwashe Hove, Vistorina Shivute, Johanna S. Valombola, Pamwenafye I. Nanhapo, Yoshihiro Hirooka, Osmund D. Mwandemele, Morio Iijima

“…However, further studies on morphological characters and drought tolerance of the IRRI genotypes are warranted to ascertain production sustainability under semiarid environments.…”
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Low prevalence of copy number variation in pfmdr1 and pfpm2 in Plasmodium falciparum isolates from southern Angola by Denise Duarte, Francisco Manuel, Ana Dias, Esmeralda Sacato, Elsa Taleingue, Elsa Daniel, Francisco Simão, Luis Varandas, Maria Lina Antunes, Fatima Nogueira

“…Increased copy number (CNV) of the P. falciparum gene plasmepsin 2 (pfpm2) have been reported to confer parasite tolerance to piperaquine (PPQ) and the multidrug resistance-1 (pfmdr1), resistance to mefloquine (MEF) and decreased susceptibility to lumefantrine (LUM). …”
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Long term safety and efficacy of ligelizumab in the treatment of Japanese patients with chronic spontaneous urticaria by Hidetoshi Takahashi, Atsushi Fukunaga, Koremasa Hayama, Takayoshi Sasajima, Ayako Fujishige, Ryohei Ichishita, Naoko Tomimatsu, Eva Hua, Vineeth Varanasi, Alis Burciu, Michihiro Hide, Thomas Severin

“…Conclusions: Treatment with ligelizumab 120 mg was well-tolerated with mild to moderate adverse events and was efficacious in Japanese patients.…”
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Improving the survival under gastric conditions of a potential multistrain probiotic produced in co-culture by Marcelo Fernando Valle-Vargas, Yesica Vanesa Rojas-Muñoz, Ruth Yolanda Ruiz-Pardo, Luisa Villamil-Díaz, María Ximena Quintanilla-Carvajal

“…Viability, survival low pH (3.00), bile salt tolerance, and antagonistic activity against the pathogen Streptococcus agalactiae were evaluated. …”
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Assessment of aluminium level in commercial pasteurized and UHT milk in Bangladesh and their potential health risks by Ishrat Jahan, Kazi Md. Al-Noman, Shabbir Ahmed, Mst. Umme Habiba, S. A. Masudul Hoque, Abu Sadeque Md. Selim, Md. Morshedur Rahman

“…The estimated daily Al intake ranged from 2.00E-03 to 3.00E-03 mg/kg body weight, contributing 1.4 to 2.1% of the provisional tolerable weekly intake. The target hazard quotient (THQ) for the contaminated samples ranged from 0.045 to 0.070 (THQ < 1), suggesting that the Al levels pose no significant health risk. …”
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Genomic scans for selection and runs of homozygosity in southern Italian turkey populations by Medhat S. Saleh, Vincenzo Landi, Martijn F.L. Derks, Gerardo Centoducati, Martien A.M. Groenen, Pasquale De Palo, Elena Ciani, Nicola Pugliese, Elena Circella, Antonio Camarda

“…Basilicata and Apulian (BAS-APU) turkeys, a native population in the Basilicata and Puglia regions of southern Italy, are known for their high meat quality and tolerance to local conditions. Understanding the genomic patterns of BAS-APU turkeys is critical for effective breeding and preservation strategies. …”
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Comparative efficacy of <i>Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium infantis, Lactobacillus rhamnosus</i> composition and prucalopride in treatment of const... by V. T. Ivashkin, O. M. Drapkina, A. A. Sheptulin, O. S. Shifrin, Ye. A. Poluektova, S. Yu. Kuchumova

“…Florasan-D is better tolerated by patients due to gradual increase of stool frequency during treatment course.…”
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Efficacy and Safety of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting Transforming Growth Factor-β and Programmed Death-Ligand 1, Plus Chemotherapy in Patients With Stage... by Christian Rolfo, MD, PhD, Laurent Greillier, MD, PhD, Remi Veillon, MD, PhD, Firas Badin, MD, MBA, Francois Ghiringhelli, MD, PhD, Nicolas Isambert, MD, PhD, Astrid Paulus, MD, PhD, Surendra Pal Chaudhary, MD, Yulia Vugmeyster, PhD, Masashi Sato, MSc, Sandrine Hiret, MD, PhD

“…The primary objective of this study was to evaluate the safety and tolerability of bintrafusp alfa with chemotherapy. Results: Four serious and one nonserious treatment-emergent adverse events were considered dose-limiting toxicities, none of which were assessed as related to bintrafusp alfa by the investigator. …”
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Dapsone Alters Phenotypical and Functional Properties of Human Neutrophils In Vitro by Sara Rakočević, Vanja Mališ, Ljiljana Kozić, Anđela Dubovina, Marija Drakul, Dejan Bokonjić, Miodrag Čolić, Dušan Mihajlović

“…We found that dapsone at the concentration of 50 μg/mL induced a significant neutrophil apoptotic rate during 6 h and 18 h, while other concentrations were well tolerated compared to control non-treated cells. However, dapsone significantly decreased the induced oxidative burst of neutrophils at all non-cytotoxic concentrations. …”
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Towards Better Perovskite Absorber Materials: Cu+ Doping Improves Photostability and Radiation Hardness of Complex Lead Halides by Marina I. Ustinova, Maxim N. Sarychev, Nikita A. Emelianov, Yiqun Li, Yuling Zhuo, Tongjun Zheng, Sergey D. Babenko, Evgeniy D. Tarasov, Pavel P. Kushch, Nadezhda N. Dremova, Galina A. Kichigina, Alexandra V. Rasmetyeva, Andrey I. Kukharenko, Dmitry P. Kiryukhin, Ernst Z. Kurmaev, Xueqing Xu, Pavel A. Troshin, Lyubov A. Frolova, Ivan S. Zhidkov

“…Indeed, while Cs0.12FA0.88PbI3 degrades mostly with segregation of δ‐phase of FAPbI3 forming a Cs‐rich perovskite phase, the Cs0.12FA0.88Pb0.99Cu0.01I2.99 films tend to expel δ‐CsPbI3 and produce FA‐rich perovskite phase, which shows impressive tolerance to both γ‐rays and high energy electrons. …”
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Pre-gestational diabetes in a young woman with a pathogenic INSR missense mutation, p.(Met1180Lys) by Emma L Prehn, Mairéad Crowley, David Fennell, Brendan T Kinsley, Kevin Colclough, Maria M Byrne

“…She reported nocturnal hypoglycaemia and a 5-h oral glucose tolerance test revealed post-prandial hyperinsulinaemic hypoglycaemia at 210 min. …”
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Acute Infusion-Related Side Effects of Amphotericin B Lipid Complex (ABLC) in Oncohematological Patients: Real-World Data from Brazilian Reference Centers by Francelise Bridi Cavassin, Marcello Mihailenko Chaves Magri, Ariela Victoria Borgmann, Isabela Dombeck Floriani, Marina Rachid Barreto, Tania Zaleski, Fabianne Altruda de Moraes Costa Carlesse, Giovanni Luís Breda, Fábio de Araújo Motta, Diego Rodrigues Falci, Ana Verena Almeida Mendes, Hugo Paz Morales, Patrícia Silva Montes, Mariane Taborda, Talita Teles Teixeira Pereira, João Luiz Baú-Carneiro, Flávio Queiroz-Telles

“…Therefore, services providing amphotericin B (AMB) must reinforce protocols or implement new measures that optimize tolerability and safety during the treatment of patients with oncohematological disease, with special attention to patients with neutropenia, prioritizing the liposomal formulation of AMB whenever possible.…”
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An online intervention relationship enhancement couple therapy program versus systematic desensitization on sexual performance anxiety in women undergoing infertility treatment wit... by Maryam Afzal Dehkordi, Tahmineh Farajkhoda, Mahdi Khanabadi, Farimah Shamsi

“…Psychological interventions are options for couples who do not tolerate psychiatric medications or like psychotherapy with pharmacotherapy. …”
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Real world experience with [99mTc]Tc-HYNIC-iPSMA SPECT prostate cancer detection: interim results from the global NOBLE registry by Pete Tually, Virginia García Quinto, Yehia Omar, Fuad Novruzov, Ryan Yudistiro, Mike Sathekge, Geoffrey Currie, Paul Galette, Neel Patel, Tracey Brown, Gabriel Bolland, Rebecca Lo Bue, David Cade

“…The objective of this registry was to collect and evaluate [99mTc]Tc-HYNIC-iPSMA patient data and images to establish the safety and tolerability, and clinical utility of this agent in imaging at different stages of PC. …”
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A plant endophytic bacterium Burkholderia seminalis strain 869T2 increases plant growth under salt stress by affecting several phytohormone response pathways by Hau-Hsuan Hwang, Yu-Ting Huang, Pei-Ru Chien, Fan-Chen Huang, Chih-Lin Wu, Liang-Yu Chen, Shih-Hsun Walter Hung, I-Chun Pan, Chieh-Chen Huang

“…Conclusions The plant endophytic bacterium strain B. seminalis 869T2 may affect various phytohormone responses and reduce oxidative stress damage to increase salt and drought stress tolerances of host plants.…”
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Positive impacts of typical desert photovoltaic scenarios in China on the growth and physiology of sand-adapted plants by Ruibing Meng, Ruibing Meng, Ruibing Meng, Zhongju Meng, Zhongju Meng, Zhongju Meng, Xiaomeng Ren, Jiale Cai, Jiale Cai, Jiale Cai, Xufang Tong, Xufang Tong, Xufang Tong

“…Through membership function analysis, the plant’s tolerance levels at various positions around the PV panels ranked under panels &gt; before panels &gt; behind panels &gt; CK. …”
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High light availability offsets low naturalness regarding diversity but cannot compensate for reduced ecological value: A case study of near-natural forests and tree plantations in... by Khanh Vu Ho, Mirjana Ćuk, Andraž Čarni, Dragana Vukov, Miloš Ilić, László Erdös

“…Most of the diagnostic species in the Quercus-Tilia forests were forest specialist plant species, while those in Populus alba forests were species associated with warmer and drier habitats, whereas the plantations hosted diagnostic species with broader ecological tolerances. Native species richness, total species diversity, and functional and phylogenetic diversity were similar in the four studied habitats, which can be explained by the combined effects of light regime and naturalness. …”
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Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice by Brecht Attema, Montserrat A. de la Rosa Rodriguez, Evert M. van Schothorst, Sander Grefte, Guido JEJ. Hooiveld, Sander Kersten

“…During high-fat feeding, SLC25A47 ablation also did not influence any metabolic parameters, apart from a minor improvement in glucose tolerance. In fasted mice, SLC25A47 ablation was associated with modest, reproducible, and likely indirect reductions in plasma triglycerides and glycerol. …”
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Study protocol on risk factors for the diagnosis of gestational diabetes mellitus in different trimesters and their relation to maternal and neonatal outcomes (GDM-RIDMAN) by Khalida Ismail, Boon How Chew, Iliatha Papachristou Nadal, Angus Forbes, Nurul Iftida Basri, Rozita Zakaria, Pamela Phui Har Yap, Veronika Rysinova, Intan Nureslyna Samsudin, Nurain Mohd Noor, Ziti Akthar Supian, Haslinda Hassan, Fuziah Paimin, Siti Rohani Mohamed Alias, Norizzati Bukhary Ismail Bukhary, Madeleine Benton

“…The estimated required sample size is 876 complete records (292 cases, 584 control, at a ratio of 1:2). Oral glucose tolerance test results will be used to identify glucose dysregulation, and maternal and neonatal outcomes include maternal weight gain, pre-eclampsia, polyhydramnios, mode of delivery, preterm or postdate birth, complications in labour, birth weight, gestational age at birth, Apgar score, congenital anomaly, congenital hypothyroidism, neonatal death or stillbirth, hypoglycaemia and hyperbilirubinaemia. …”
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