Heterologous Expression and Adaptive Evolution of ε-Poly-lysine Synthase Gene in <i>Corynebacterium glutamicum</i> by Long Pan, Yihang Chen, Aimei Liao, Yinchen Hou, Jihong Huang

“…Finally, through adaptive evolution of the recombinant strain, the ε-PL tolerance of the recombinant strain was increased to 1.3 g/L, and the yield of ε-PL ultimately reached 0.34 g/L, which increased by 54.55% compared to the initial strain. …”
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Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study by L. Guiducci, C. Vassalle, P. Parchi, S. Maffei

“…Oral bisphosphonates (BPs) are the most commonly used medications for osteoporosis (OP), but their poor gastrointestinal (GI) absorption and tolerance hamper compliance. Intramuscular (IM) neridronate (NE), an amino-BP, is an easy-to-administer, effective, and safe alternative to oral BPs. …”
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The TikTok Addiction Scale: Development and validation by Petros Galanis, Aglaia Katsiroumpa, Ioannis Moisoglou, Olympia Konstantakopoulou

“…Factor analysis revealed a six-factor structure, (1) salience, (2) mood modification, (3) tolerance, (4) withdrawal symptoms, (5) conflict, and (6) relapse, which accounted for 80.70% of the total variance. …”
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Effect of Multiradiance Low-Level Laser Therapy and Topical Silver Sulfadiazine on Healing Characteristics of Dermal Wounds in Marine Toads (Rhinella marina) by Kate E. Archibald, Tara Harrison, Brigid Troan, Dustin Smith, Larry J. Minter

“…Laser therapy and SSD, at the doses and dosing schedule utilized in this pilot study, appear to be safe and well-tolerated treatments in marine toads, but may not be warranted for uncomplicated skin wounds in this species.…”
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An Efficient and Accurate Adaptive Time-Stepping Method for the Landau–Lifshitz Equation by Hyundong Kim, Soobin Kwak, Moumni Mohammed, Seungyoon Kang, Seokjun Ham, Junseok Kim

“…Our proposed algorithm strategically selects an adaptive time step, ensuring that the maximum displacement falls within a predefined tolerance threshold. Furthermore, this adaptive approach allows the utilization of larger time steps near equilibrium states and results in faster computations. …”
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Genotypic Variability in Some Morpho-Physiological Traits in Different Environments and Their Relationship with Cassava (Manihot esculenta Crantz) Root Yield by Joseph Adjebeng-Danquah, Isaac Kwadwo Asante, Joseph Manu-Aduening, Richard Yaw Agyare, Vernon Edward Gracen, Samuel Kwame Offei

“…These can be used as secondary traits to select drought-tolerant genotypes. From this study, the GGE biplot was useful in identifying traits associated with specific genotypes in different environments to aid in selection. …”
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Fast Hadamard-Encoded 7T Spectroscopic Imaging of Human Brain by Chan Hong Moon, Frank S. Lieberman, Hoby P. Hetherington, Jullie W. Pan

“…<b>Conclusions</b>: With minimal gradient demands and fast acquisition times, the 2.2 min to 9 min for single- to four-slice RSI acquisitions are well tolerated by healthy subjects and tumor patients, and show results that are consistent with clinical outcomes.…”
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Perioperative or neo/adjuvant chemoimmunotherapy versus chemotherapy for resectable non-small cell lung cancer: a systematic review and network meta-analysis by Qiong Zhang, Jia Duan, Yuanmei Zhang, Lei Yang, Duo Li

“…However, these immunotherapy combinations are generally well tolerated. Conclusions The findings indicate that neoadjuvant and perioperative immunotherapy combined with chemotherapy can significantly improve overall survival in patients with resectable NSCLC compared to standard chemotherapy. …”
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Integrated metabolomic and transcriptomic analysis of anthocyanin metabolism in wheat pericarp by Jiao Wang, Lei Sun, Bo Jiao, Pu Zhao, Tianyun Xu, Sa Gu, Chenmin Huo, Jianzhou Pang, Shuo Zhou

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Indicators of environmental variability in spring bread wheat cultivars under the conditions of Tyumen Province by V. V. Novokhatin, E. V. Zuev, Т. V. Shelomentseva, Т. A. Leonova

“…Accessions with low levels of plasticity and less pronounced environmental variability indices, but tolerant to deteriorated environmental conditions: ‘Tarskaya 10’ (k-64996), ‘FPCh-Рpd-0s’ (k-65123), and ‘Novosibirskaya 44’ (k-64867), can be used to produce climateresistant cultivars.Conclusion. …”
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Music and low-frequency vibrations for the treatment of chronic musculoskeletal pain in elderly: A pilot study. by Thom A H Eshuis, Peter J C Stuijt, Hans Timmerman, Peter Michael L Nielsen, André Paul Wolff, Remko Soer

“…<h4>Conclusions</h4>The combination of music and abdominally administered vibrations was found to be safe and well tolerated by the elderly patients. However, over time, neither the low-frequency treatment group nor the high-frequency treatment group provided clinically meaningful pain relief. …”
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Optimizing bioethanol production from sweet sorghum stem juice under very high gravity fermentation and temperature stress conditions by Phon Thatiyamanee, Pattana Laopaiboon, Lakkana Laopaiboon

“…The findings from this study, particularly the optimized fermentation conditions and stress tolerance strategies, could guide the scale-up to an industrial level of bioethanol production from sweet sorghum stem juice or other feedstocks using VHG fermentation, contributing to the development of more efficient and sustainable biofuel production processes.…”
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Differential physiological and yield responses of selected mung bean (Vigna radiata (L.) R. Wilczek) genotypes to various high-temperature stress regimes by Uday Chand Jha, Sadiah Shafi, Shyam Tallury, Harsh Nayyar, Ignacio A. Ciampitti, Kadambot H. M Siddique, P. V. Vara Prasad

“…Thus, it is essential to understand the physiological and yield-related trait responses of mung bean genotypes and harness germplasm with enhanced heat tolerance to mitigate the impact of rising heat stress on mung bean yield. …”
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Study on the safety and efficacy of HIFU in the treatment of VaIN by Susu Wu, Xiang Li, Dabao Xu, Mingzhu Ye

“…All patients successfully completed the HIFU treatment, with an average treatment time of 5.99 ± 1.25 min, treatment power of 3.5 W, and average total treatment dose of 1118.99 ± 316.20 J. Patients tolerated the treatment well, experiencing only slight pain with VAS score of 3. …”
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Exploring the Role of Social Workers in Addressing Health Disparities Among Maginalised Population in Kabale District. by Asasira, Precious

“…Based on the results from the study, 100% of the respondents agreed that there are some roles of Social Workers in addressing the health disparities among the marginalized population and these included social workers have a vital role in the need analysis, implementation and manage the project, social workers analyze the needs of the community with the help of community members and priorities they, the major role of the social worker in the community development begins with the organizing community on various social issues, social workers widen the betterment of individual, group, and community, social workers helps to improve tolerance among all and it leads into community development, social workers facilitate various benefits/projects provided by the government and NGOs. …”
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Isolation and Identification of Functional Bacillus Strain from Cupei of Sichuan Bran Vinegar and Evaluation of Its Fermentation Characteristics by Yuwei WU, Yu TIE, Zhixing TANG, Haiyan ZHU, Yuwei LI, Wenyou ZHU, Xinhui WANG, Liguo YIN

“…The five strains grew well at 30~40 ℃ and pH5~7 (OD600=0.23~0.52), with a certain degree of tolerance for environmental factor. Some of the Bacillus strains had a strong ability to hydrolyze protein (proteolytic ring of B. velezensis BA-9: 3.7±0.3) and starch (starch hydrolysis ring of P. cookie BA-6: 3.8±0.5). …”
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Successful Pregnancy Outcome in a Patient Treated with Pembrolizumab and Exposed to Fluoro-Deoxyglucose (¹⁸F-FDG) PET/CT: Case Report and Review of Literature by Anna Lucia Mastricci, Felice Sorrentino, Elisa Giansiracusa, Erika Zanzarelli, Graziana Silvana De Lucia, Vincenza Fernanda Fesce, Luigi Nappi, Lorenzo Vasciaveo

“…However, ICIs can impair immune tolerance, potentially increasing immune-related adverse events. …”
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Efficacy and Safety of Sacubitril/Valsartan Versus Amlodipine in Japanese Patients With Essential Hypertension: A Randomized, Multicenter, Open‐Label, Noninferiority Study (PARASOL... by Koichi Yamamoto, Daisuke Yarimizu, Ayano Shimanishi, Shunsuke Eguchi, Kazuma Iekushi, Yoichi Takami, Yoichi Nozato, Kazuomi Kario, Hiromi Rakugi

“…These results suggested that the blood pressure‐lowering effect of sacubitril/valsartan is comparable to that of amlodipine, with no marked differences in tolerability between the two groups. Sacubitril/valsartan, a potent antihypertensive drug comparable to amlodipine, is expected to improve blood pressure control in clinical practice.…”
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Advancements in hazardous gases detection: Using dual structures of photonic crystal fiber-based sensor by Pratishtha Pandey, Sapana Yadav, Adarsh Chandra Mishra, D.K. Dwivedi, Pooja Lohia, R.K. Yadav, Upendra Kulshrestha, Vipin Kumar, Prabhu Paramasivam, R. Bousbih, M. Khalid Hossain

“…In order to enhance both the fabrication tolerance and sensing performance of the proposed sensors, investigations have been conducted on the diameter of circular and elliptical-shaped air holes, as well as the dimensions of struts and the core size. …”
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In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection by Yuta Suzuki, Takayuki Miyazaki, Yoko Ida, Tatsuya Suzuki, Yumi Itoh, Shuto Nakao, Keita Kondo, Kenji Kubara, Keisuke Nishioka, Hiroki Muto, Ryuji Watari, Toshifumi Hirayama, Dai Kakiuchi, Shinya Sato, Satoshi Inoue, Yoshifumi Uemoto, Yohei Mukai, Atsushi Hoshino, Toru Okamoto, Junji Matsui

“…Systemic delivery of mRNA in mice resulted in a dose-dependent expression of 3N39v4 in plasma (20–261 μg/mL at 1–10 mg/kg) with sufficient tolerability. An improved pharmacokinetic profile of the produced protein was compared to injection of the 3N39v4 protein. …”
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