Health Risk Assessment of Potentially Toxic Elements Contamination of Commonly Consumed Fruits in Bahir Dar Town, Northwest Ethiopia by Biset Asrade Mekonnen, Muluabay Getie Yizengaw, Haile Kassahun, Gebremariam Ketema

“…The ADI of potentially toxic elements was found to be lower than the maximum permitted tolerable daily intake in the studied fruits, and the HI values (mgday-1 kg-1) of all studied potentially toxic elements were lower than one in banana and orange, except mango (3.69). …”
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Discovery and Characterization of Novel Esterases with Ethyl Carbamate-Hydrolyzing Activity by LIU Qingtao, ZHU Sibao, WANG Tianwen, LI Chuang, QIAN Senhe, ZHANG Wenqing, CHENG Fan, TIAN Shufang

“…The EC-degrading esterases had good ethanol tolerance, which not only enrich the EC-hydrolyzing enzyme library, but also provide a new method for controlling the EC content in traditional fermented foods with low alcohol content.…”
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Safety of Levodopa-Carbidopa Intestinal Gel Treatment in Patients with Advanced Parkinson’s Disease Receiving ≥2000 mg Daily Dose of Levodopa by Cindy Zadikoff, Werner Poewe, James T. Boyd, Lars Bergmann, Horia Ijacu, Pavnit Kukreja, Weining Z. Robieson, Janet Benesh, Angelo Antonini

“…Patients who require ≥2000 mg/day LCIG exhibited a safety profile comparable to the established safety/tolerability of LCIG with similar clinical improvements. …”
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Short-Term Effects of a Novel Eye Mask Producing Heat and Vibration for the Treatment of Meibomian Gland Dysfunction: A Pilot Study by Luca Vigo, Marco Pellegrini, Francesco Carones, Vincenzo Scorcia, Giuseppe Giannaccare

“…This eye mask represents a novel well tolerated tool in the armamentarium of MGD treatments. …”
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Hybrid stochastic and robust optimization of a hybrid system with fuel cell for building electrification using an improved arithmetic optimization algorithm by Fude Duan, Mahdiyeh Eslami, Mustafa Okati, Dheyaa J. Jasim, Arsalan Khadim Mahmood

“…Furthermore, the hybrid UT-IGDT-RA outcomes found that the stochastic scenarios incorporated to simulate a range of uncertainties beyond the conventional IGDT-RA based-nominal scenario, and it provides a broader range of robust solutions, enabling operators to align strategies with their risk tolerance and improves system flexibility, and decision-making precision in the face of uncertainties.…”
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Damage Identification in Large-Scale Structures Using Time Series Analysis and Improved Sparse Regularization by Huihui Chen, Xiaojing Yuan

“…Compared to the moth-flame optimization (MFO) algorithm and traditional regularization methods, for both noise-free and noise polluted data, the iteration curves illustrate that the proposed method can achieve convergence within about 200 iterations, while the MFO algorithm is always trapped into local optima; meanwhile, the traditional regularization method needs more iterations or even cannot meet the preset tolerance. Furthermore, regarding the numerical example, the damage identification results show that the max identification errors of the proposed method are 6% among the three cases under noise-free and noise-polluted data, while the max identification errors for MFO and the regularization method are 15% and 10%, respectively. …”
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Care, conflict, and coexistence: Human–wildlife relations in community forests by Madison Stevens, Shalini Rawat, Terre Satterfield

“…Our findings indicate high prevalence of HWC and associated hardships (mentioned by 71% of survey participants), alongside high expressed ethics of care, tolerance, and responsibility for wild animals (60%). …”
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CURRENT APPROACH TO DEVELOPMENT OF BIOSIMILAR PRODUCTS CONTAINING MONOCLONAL ANTIBODIES AS AN ACTIVE SUBSTANCE – NON-CLINICAL AND CLINICAL STUDIES OF THE FIRST RUSSIAN RITUXIMAB BI... by S. M. Alekseev, K. D. Kaplanov, R. A. Ivanov, E. V. Chernyaeva

“…Acellbia is non-inferior to MabThera in terms of efficacy, pharmacokinetics, pharmacodynamics and immunogenicity. Acellbia was well tolerated, with the safety profile comparable with MabThera’s parameters.…”
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Genomic analysis and potential polyhydroxybutyrate (PHB) production from Bacillus strains isolated from extreme environments in Mexico by Alvaro Ríos Sosa, Lilia A. Prado Barragán, Alvaro Ríos Reyes, Elva T. Aréchiga Carvajal

“…The strains had growth temperatures ranging from 35 to 50 °C and pH tolerance values ranging from 3 to 9. The best PHB-producing strain, B. cereus MSF4, produced 0.43 g/kg PHB on orange peels, followed by B. inaquosorum MSD1 at 0.40 g/kg, B. cereus S07C at 0.23 g/kg and P. dendritiformis at 0.26 g/kg. …”
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Assessment of fluoride bio-accessibility in early childhood diets by Jelena Kronic, Ralph M. Duckworth, Claudio Angione, Steven M. Levy, Fatemeh Vida Zohoori

“…IntroductionCurrently available dietary recommendations for fluoride provided as “adequate intake” (AI) and “tolerable upper intake level” (UL) assume 100% fluoride availability for utilization by the body, which is often not the case. …”
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SLC6A4 5HTTLPR Polymorphism Affects Insulin Secretion in Patients with Polycystic Ovary Syndrome by Barbara Šenk, Katja Goričar, Nika Aleksandra Kravos, Mojca Jensterle Sever, Andrej Janež, Vita Dolžan

“…A cross-sectional study included 65 female patients with PCOS followed up at the endocrine outpatient clinic of the University Medical Center Ljubljana and a control group of 94 young healthy female blood donors. Oral glucose tolerance test was performed only in PCOS patients and basal- and glucose-stimulated blood glucose and insulin levels were measured. …”
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Predicting Gestational Diabetes Mellitus in the first trimester using machine learning algorithms: a cross-sectional study at a hospital fertility health center in Iran by Somayeh Kianian Bigdeli, Marjan Ghazisaedi, Seyed Mohammad Ayyoubzadeh, Sedigheh Hantoushzadeh, Marjan Ahmadi

“…Based on the glucose tolerance test (GTT) results, the RF model achieved the best performance in GDM prediction, with 89% accuracy, 86% precision, 92% recall, and 94% AUC, using demographic variables, medical history, and clinical findings. …”
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An Adaptive Finite Resolution Selection Scheme for RIS Assisted NOMA Networks by Shady M. Ibraheem, Mona Shokair, Mohamed E. Nasr, Nancy Alshaer

“…Furthermore, the impact of network parameters on the throughput and asymptotic average sum rate is discussed in both delay-limited and delay-tolerant transmission modes, respectively. Monte Carlo simulations emphasize the accuracy of the analytical work and investigate that: 1) The proposed GADPS scheme is more flexible than conventional RIS-NOMA scheme; 2) By joint optimization of RIS selection and phase shifting, the proposed GADPS scheme is capable of achieving superior performance over GARPS and conventional RIS-NOMA schemes with a superior diversity gain; 3) The throughput performance of the proposed GADPS scheme outperforms GARPS, conventional RIS-NOMA and other relay-assisted NOMA schemes, whereas full-duplex (FD) relay selection NOMA schemes suffer from throughput floor values; 4) By increasing the number of reflecting elements of RIS, the proposed GADPS scheme achieves the enhanced average sum rate performance over benchmark schemes in all scenarios of relative distance difference between users and the selected RIS.…”
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A comparative longitudinal study between bilateral and unilateral totally extraperitoneal repair among patients with unilateral inguinal hernia at a tertiary care hospital in easte... by Bikash Kumar Sah, Jatin Goel, Vijay Pratap Sah, Bhawani Khanal, Abhijeet Kumar, Rakesh Kumar Gupta

“…Young to middle-aged patients can easily tolerate the longer operative time at the cost of slightly more blood loss. …”
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Novel hormonal agents in men with metastatic castration resistant prostate cancer and reduced performance status: Experiences of a specialized single center by Thomas Büttner, Philipp Lossin, Stefan Latz, Carolin Jacobs, Philipp Krausewitz, Stefan Hauser

“…While hope for NHA treatment persists, particularly given its oral administration and tolerability, careful consideration and discussion with patients regarding treatment expectations and palliative care goals are warranted in this challenging patient population.…”
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Exploring Clec9a in dendritic cell-based tumor immunotherapy for molecular insights and therapeutic potentials by Zubair Hussain, Yueteng Zhang, Lu Qiu, Shanshan Gou, Kangdong Liu

“…Furthermore, it discusses the role of Clec9a in the induction and functional activation of Clec9a+ cDC1s, with a particular focus on addressing the challenges related to off-target effects and immune tolerance in the development of tumor vaccines. Additionally, this review explores the potential of Clec9a-targeted approaches to enhance the immunogenicity of tumor vaccines and addresses the utilization of Clec9a as a delivery target for specific agonists (such as STING agonists and αGC) to enhance their therapeutic effects. …”
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Impact of predictive selection of LbCas12a CRISPR RNAs upon on‐ and off‐target editing rates in soybean by Linda Rymarquis, Chenxi Wu, Diane Hohorst, Miguel Vega‐Sanchez, Thomas E. Mullen, Vijetha Vemulapalli, Douglas R. Smith

“…Examination of the edited off‐target sites revealed that LbCas12a was highly tolerant to mismatches between the crRNA and target site in bases 21–23 relative to the start of the protospacer, but even a single mismatch in the first 20 nt drastically reduced the editing rate. …”
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Treatment of Hepatitis C Post-Liver Transplantation Could Mitigate Discard Rates of Hepatitis C-Positive Deceased Donor Livers and Expand the Donor Pool by Jennifer Keller, Gary Marklin, Obi Okoye, Roshani Desai, Tej Sura, Ajay Jain, Chintalapati Varma, Mustafa Nazzal

“…However, the subsequent introduction of direct acting antiviral medications (DAA) against hepatitis C led to improvements in morbidity and better medication tolerance. DAA therapy allowed for an increase in treatment rates of hepatitis C in patients on the liver transplant waiting list. …”
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Assessing the Role of Incubation Temperature as a Barrier to Successful Establishment of Coho Salmon (Oncorhynchus kisutch) in a Rapidly Warming Arctic by Elizabeth D. Lindley, Karen M. Dunmall, Peter A. H. Westley

“…Broadly, our findings suggest that spawning sites within thermal tolerances that can support the survival and development of coho salmon exist in the North American Arctic. …”
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Clinical trials since 2020 of rapid anti-suicidal ideation effects of ketamine and its enantiomers: a systematic review by Sumra Sajid, J. John Mann, Michael F. Grunebaum

“…IN and IV ketamine/S-ketamine administration appears to be well tolerated. R-ketamine appears to produce fewer side effects, but additional clinical research is needed to clarify its antidepressant and anti-SI effects in humans. …”
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