Considerations in assessing blood glucose in mice: coping with interferences of intraperitoneal injection, noise, fasting, housing and blood sampling by Si-Li Zheng, Xue-Lian Wang, Pin Wang, Jin Chen, Chao-Yu Miao

“…Blood glucose measurements by glucose meters and insulin tolerance tests (ITT) were performed. Results Both IP injection and noise independently raised blood glucose levels in conscious mice, while neither of these two interferences affected blood glucose levels in mice under good anesthesia. …”
Get full text

The genomes of Scedosporium between environmental challenges and opportunism by Francesco Venice, Federica Spina, Domenico Davolos, Stefano Ghignone, Giovanna Cristina Varese

“…The genus Scedosporium (Microascaceae) includes fungi with high tolerance to environmental pollution, whilst some species can be considered major human pathogens, such as Scedosporium apiospermum and Scedosporium boydii. …”
Get full text

Influence of Dietary Chromium and Vitamin E Supplementation on Performance, Metabolism, and Physiology of Broilers Subjected to Cyclic Heat Stress by ML X Júnior, RD Bernardes, CH Oliveira, KMM Dias, BF Almeida, SO Borges, FS Dalólio, KM Gomes, CJ Rodrigues, AA Calderano

“…In conclusion, Cr and VitE, individually or combined, benefitted performance, glucose and thyroid hormone levels, immune and oxidative response, and heat stress tolerance.…”
Get full text

Efficacy and safety of camrelizumab combined with chemotherapy as second-line treatment for locally advanced, recurrent, or metastatic esophageal squamous cell carcinoma by Yinfang Gu, Xiaofang Zou, Junlin Zhu, Guowu Wu

“…Conclusion Second-line treatment with camrelizumab combined with chemotherapy is well-tolerated and associated with favorable oncological outcomes in patients with locally advanced, recurrent, or metastatic ESCC. …”
Get full text

The Validity Of 75gms OGTT For Detection Of GDM Keeping 100gms OGTT As Gold Standard by Shazia Mehreen, Muhammad Usman, Kashif Rauf, Saima Naz, Muhammad Abdul Rab Faisal Sultan, Muhammad Akram Randhawa

“… Objective: To determine the validity of 75gms (Oral Glucose Tolerance Test) OGTT for the detection of GDM keeping 100gms OGTT as the gold standard. …”
Get full text

Adaptation Strategies for Hemp in Alkaline Salt Environments: Fertilizer Management for Nutrient Uptake and Optimizing Growth by Yunshu Ye, Haoyu Wang, Panpan Zhang, Yuhong Zhang

“…This optimal combination maintains the K⁺/Na⁺ ratio in leaves above 1.2 and regulated Ca²⁺/Mg²⁺ homeostasis, maintaining a ratio of 2.8–3.2, indicating improved salt tolerance. Notably, excessive fertilizer applications (>400 mg·L⁻¹ total nutrients) exacerbated salt injury, reducing biomass accumulation by 25–30% and disrupting ion homeostasis. …”
Get full text

An OSNR Monitoring Scheme based on Mean and Variance Value of Signal Amplitude by CHEN Fang, LI Zifan, ZHU Yanyuan, LI Bozhong, LONG Han, WU Jianjun, DUAN Mingxiong

“…For optical fiber communication systems, stable operation can only be ensured if the OSNR at the receiver end exceeds the receiver's OSNR receiving tolerance. The larger the value, the better the system stability. …”
Get full text

Characterization of Novel Nonobese Type 2 Diabetes Rat Model with Enlarged Kidneys by Ayaka Domon, Kentaro Katayama, Yuki Tochigi, Hiroetsu Suzuki

“…The cumulative incidence of DM in DEK males at the age of 30 weeks was 44.8%. Oral glucose tolerance tests showed glucose intolerance and decreased insulin secretion in response to glucose loading in affected males, features which were exacerbated with age. …”
Get full text

Prediabetes: Challenges, Novel Solutions, and Future Directions by Monique E Francois, Katie M Oetsch

“…It is projected that by 2040, almost 8% of the global population will have prediabetes, with approximately 70% progressing to T2D within their lifetime. Abnormal glucose tolerance increases the risk of associated complications, including cardiovascular disease, stroke, and microvascular diseases, all of which are major contributors to the global healthcare burden. …”
Get full text

Pain medication tapering for patients with Persistent Spinal Pain Syndrome Type II, treated with Spinal Cord Stimulation: A RCT-study protocol of the PIANISSIMO study. by Maarten Moens, Cleo Lina Crunelle, Koen Putman, Elke Wuyts, Frenn Bultinck, Hubert Van Puyenbroeck, PIANISSIMO consortium, Lisa Goudman

“…<h4>Discussion</h4>Within the PIANISSIMO project we propose a way to reduce the risks of adverse events, medication-induced hyperalgesia, tolerance, and dependence by providing pain medication tapering before SCS. …”
Get full text

Role of polyethylene glycol to alleviate lead stress in Raphanus sativus by Muhammad Sajid, Shakil Ahmed, Rehana Sardar, Aamir Ali, Nasim Ahmad Yasin

“…Hence, it becomes necessary to elucidate the beneficial role of PEG in developing approaches for improving plant growth and stress tolerance.…”
Get full text

Metastatic pancreatic cancer now in remission: a case report and literature review by Charles W. Shi, Thomas J. VanderMeer, Anita Pudusseri

“…However, in our case, the patient only tolerated 6 cycles and was still highly responsive. …”
Get full text

A Randomized Multicenter Study Comparing a Tacrolimus-Based Protocol with and without Steroids in HCV-Positive Liver Allograft Recipients by Ulf Neumann, Didier Samuel, Pavel Trunečka, Jean Gugenheim, Giorgio Enrico Gerunda, Styrbjörn Friman

“…Completion rates (45 versus 82%) indicated poorer tolerability with TAC/DAC than with TAC/STR. Steroid-free immunosuppression had no real impact on HCV viral load. …”
Get full text

Genome variability of domestic tomato varieties: data from AFLP analysis by A. V. Kulakova, E. A. Dyachenko, A. V. Shchennikova, O. N. Pyshnaya, E. A. Dzhos

“…Introgressive tomato breeding uses related wild Solanum species to improve cultivars for stress tolerance and fruit quality traits. The aim of this work was to evaluate the genome variability of 59 cultivars and perspective breeding lines of S. lycopersicum and 11 wild tomato species using the AFLP method. …”
Get full text

The role of climate change and niche shifts in divergent range dynamics of a sister-species pair by Summers, Jeremy, Lukas, Dieter, Logan, Corina J, Chen, Nancy

“…Species ranges are set by limitations in factors including climate tolerances, habitat use, and dispersal abilities. Understanding the factors governing species range dynamics remains a challenge that is ever more important in our rapidly changing world. …”
Get full text

Evaluating the Effect on Total Daily Insulin Dose in Adult Patients with Type 1 Diabetes Managed with Metformin and/or GLP-1 or GLP-1/GIP Receptor Agonists by Mayeesha Ahmed, Emily Pierson, Molly Webster

“…Data points were collected on starting dates of the first and second (if applicable) non-insulin agents, and the first office visit of at least 3 months on maximum tolerated doses. The primary endpoint was change in total daily insulin dose (TDD). …”
Get full text

Clinical Outcomes of Sequential Intrastromal Corneal Ring Segments and an Extended Range of Vision Intraocular Lens Implantation in Patients with Keratoconus and Cataract by C. Lisa, R. Zaldivar, A. Fernández-Vega Cueto, R. M. Sanchez-Avila, D. Madrid-Costa, J. F. Alfonso

“…In addition, this approach provides an increase of tolerance to defocus.…”
Get full text

DArTseq-based silicoDArT and SNP markers reveal the genetic diversity and population structure of Kenyan cashew (Anacardium occidentale L.) landraces. by Dennis Wamalabe Mukhebi, Pauline Wambui Gachanja, Diana Jepkoech Karan, Brenda Muthoni Kamau, Pauline Wangeci King'ori, Bicko Steve Juma, Wilton Mwema Mbinda

“…Understanding cashew genomics through the application of SilicoDArT and SNP markers is crucial for advancing cashew genomic breeding programs aimed at improving yield and nut quality, and enhancing resistance or tolerance to biotic and abiotic stresses. Our study presents an overview of the genetic diversity of cashew landraces in Kenya and demonstrates that DArT systems are a reliable tool for advancing genomic research in cashew breeding.…”
Get full text

NS5A replication complex inhibitor daclatasvir in the basis of chronic hepatitis C interferon-free therapy by M. V. Mayevskaya, M. S. Zharkova, V. T. Ivashkin

“…A safety profile and tolerability of daclatasvir is good, comparable to placebo group. …”
Get full text

Mild drought conditions at the tillering stage promote dry matter accumulation and increase grain weight in drip-irrigated spring wheat (Triticum aestivum L.) by Yilin Ma, Jingyi Cai, Shuting Bie, Ziqiang Che, Guiying Jiang, Jianguo Liu

“…IntroductionIn order to elucidate the physiological mechanism of post-flowering assimilate transport regulating the formation of yields in arid regions and to provide technological support for further water-saving and high yields in the wheat region in Xinjiang, we conducted a study on the effects of different fertility periods and different degrees of drought and re-watering on the post-flowering dry matter accumulation and transport of spring wheat and the characteristics of grain filling.MethodsIn two spring wheat growing seasons in 2023 and 2024, a split-zone design was used, with the drought-sensitive variety Xinchun 22 (XC22) and drought-tolerant variety Xinchun 6 (XC6) as the main zones and a fully irrigated control during the reproductive period [CK, 75%~80% field capacity (FC)], with mild drought at the tillering stage (T1, 60%~65% FC), moderate drought at the tillering stage (T2, 45%~50% FC), mild drought at the jointing stage (J1, 60%~65% FC), and mild drought at the jointing stage (J2, 45%~50% FC) as the sub-zones. …”
Get full text