Rationale and design of Diabetes Prevention with active Vitamin D (DPVD): a randomised, double-blind, placebo-controlled study by Yoshiya Tanaka, Yosuke Okada, Tetsuya Kawahara, Gen Suzuki, Tetsuya Inazu, Shoichi Mizuno, Fumiyoshi Kasagi

“…The aim of the Diabetes Prevention with active Vitamin D (DPVD) study is to assess the effect of eldecalcitol, active vitamin D analogue, on the incidence of type 2 diabetes among individuals with pre-diabetes.Methods and analysis DPVD is an ongoing, prospective, multicentre, randomised, double-blind and placebo-controlled outcome study in individuals with impaired glucose tolerance. Participants, men and women aged ≥30 years, will be randomised to receive eldecalcitol or placebo. …”
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Serum and Salivary IgE, IgA, and IgG4 Antibodies to Dermatophagoides pteronyssinus and Its Major Allergens, Der p1 and Der p2, in Allergic and Nonallergic Children by Diego O. Miranda, Deise A. O. Silva, Jorge F. C. Fernandes, Meimei G. J. Queirós, Hamilton F. Chiba, Leandro H. Ynoue, Rafael O. Resende, Janethe D. O. Pena, Sun-Sang J. Sung, Gesmar R. S. Segundo, Ernesto A. Taketomi

“…Also, specific IgA measurements in serum and/or saliva may be useful for monitoring activation of tolerance-inducing mechanisms during allergen specific immunotherapeutic procedures, especially sublingual immunotherapy.…”
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Sulforaphane as a promising anti-caries agents: inhibitory effects on Streptococcus mutans and caries control in a rat model by Meijiao Yu, Meijiao Yu, Yu Chen, Yu Chen, Sishi Dong, Sishi Dong, Zhongxin Chen, Zhongxin Chen, Xuelian Jiang, Xuelian Jiang, Yufei Wang, Yufei Wang, Linglin Zhang, Linglin Zhang

“…The growth of S. mutans and the biofilm formation were inhibited by SFN in a dose-dependent manner through suppressing the synthesis of extracellular polysaccharide (EPS) and acid production, as well as decreasing the acid tolerance. Meanwhile, SFN significantly weakened the cariogenic properties of S. mutans at sub-inhibitory concentrations, which were further illustrated by quantitative real-time PCR (qRT-PCR). …”
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The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices by Cuiling Zhu, Ran Cui, Mingming Gao, Sharvan Rampersad, Hui You, Chunjun Sheng, Peng Yang, Hui Sheng, Xiaoyun Cheng, Le Bu, Shen Qu

“…Weight, body mass index (BMI), UA, lipid profile, liver function, and renal function were measured in all participants. Oral glucose tolerance tests were performed, and serum glucose, insulin, and C peptide were measured at 0, 30, 60, 120, and 180 min. …”
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Amrubicin Monotherapy for Patients with Platinum-Refractory Gastroenteropancreatic Neuroendocrine Carcinoma by Takayuki Ando, Ayumu Hosokawa, Hiroki Yoshita, Akira Ueda, Shinya Kajiura, Hiroshi Mihara, Sohachi Nanjo, Haruka Fujinami, Jun Nishikawa, Kohei Ogawa, Takahiko Nakajima, Johji Imura, Toshiro Sugiyama

“…Amrubicin monotherapy appears to be potentially active and well-tolerated for platinum-refractory gastroenteropancreatic NEC.…”
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Foxtail millet supplementation improves glucose metabolism and gut microbiota in rats with high-fat diet/streptozotocin-induced diabetes by Xin Ren, Linxuan Wang, Zenglong Chen, Min Zhang, Dianzhi Hou, Yong Xue, Xianmin Diao, Ruihai Liu, Qun Shen

“…Results showed that both 30% and 48% FM supplementation significantly decreased concentrations of fasting blood glucose, 60-min blood glucose, and blood triglycerides (P < 0.05); additionally, 48% FM supplementation significantly improved blood glucose tolerance and insulin resistance (P < 0.05). However, FM supplementation could not effectively repair damage to β-cells over a short period of time. …”
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Olfaction-based learned preference assessment without the use of motivational fear or motivational weight loss by Sara E. Moss, Ekaterina S. McCurdy, Natalya N. Thomas, Danielle Gulick, Angela M. Poff, Dominic P. D'Agostino

“…We assessed whether this protocol discriminated learning deficit induced by lipopolysaccharide (LPS) administration.ConclusionWe conclude that this protocol is a viable tool for assessing learning abilities in preclinical models with auditory or visual deficits, motor impairments, or an inability to tolerate motivational weight loss.…”
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Schistosoma japonicum Infection in Treg-Specific USP21 Knockout Mice by Youxiang Zhang, De-Hui Xiong, Yangyang Li, Guina Xu, Baoxin Zhang, Yang Liu, Shan Zhang, Qing Huang, Simin Chen, Fansheng Zeng, Jingyi Guo, Bin Li, Zhiqiang Qin, Zuping Zhang

“…The E3 deubiquitinating enzyme ubiquitin-specific proteolytic enzyme 21 (USP21) plays vital roles in physiological activities and is required for Treg-cell-mediated immune tolerance. Using a murine model infected with Schistosoma japonicum, we observed that there were more cercariae developed into adults and more eggs deposited in the livers of the USP21fl/flFOXP3Cre (KO) mice. …”
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Impact of Irrigation Regimes on Growth and Postharvest Quality of Pomegranates (Punica granatum L.) under Conditions of Newly Reclaimed Land by Magdi A.A. Mousa, Adel D. Al-Qurashi, Omer H.M. Ibrahim, Kamal A.M. Abo-Elyousr, Ahmed M.K. Abdel Aal, Abdel-Fattah M. El-Salhy, Tarek K.H. El-Bolok, Mohamed A.H. Ali, Esmat F. Ali, Eman A.A. Abou-Zaid

“…Farmers are encouraged to invest in crops that will grow and produce under the predicted climate change, such as global warming, limited water supplies, and drought-imposed water restrictions on agriculture. The drought-tolerant pomegranate (Punica granatum L.) is a promising horticulture crop that can be grown under arid conditions. …”
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Experience of piloting BPaLM/BPaL for DR-TB care at selected sites in Pakistan by M.A. Khan, A. Ismail, A. Ghafoor, N. Khan, N. Muzaffar, F. Zafar, A. Gupta, S. Foraida, S. Juneja, R. Fatima, A.W. Khan, S. Shahid, M.A. Khan

“…Bedaquiline, pretomanid, linezolid and moxifloxacin (BPaLM/BPaL) offers an opportunity for most DR-TB patients to benefit from a shorter, all-oral, well-tolerated and more effective treatment. METHODS: We conducted a retrospective cohort study to pilot the BPaLM/BPaL regimen at four selected sites in two provinces of Pakistan, i.e. …”
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Deletion of IRS-1 leads to growth failure and insulin resistance with downregulation of liver and muscle insulin signaling in rats by Yuka Toyoshima, Katsuyuki Nakamura, Yusuke Taguchi, Reiko Tokita, Shiho Takeuchi, Hayato Osawa, Naomi Teramoto, Hidetoshi Sugihara, Fumiaki Yoshizawa, Keitaro Yamanouchi, Shiro Minami

“…Our previous study showed that the disruption of IRS-2 impairs body growth but not glucose tolerance or insulin sensitivity in rats, which led us to hypothesize that IRS-1 plays more pivotal roles in insulin functions than IRS-2. …”
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Intradermal DNA Electroporation Induces Cellular and Humoral Immune Response and Confers Protection against HER2/neu Tumor by Alessia Lamolinara, Lorenzo Stramucci, Albana Hysi, Manuela Iezzi, Cristina Marchini, Marianna Mariotti, Augusto Amici, Claudia Curcio

“…Moreover, we tested the efficacy of intradermal vaccination against Her2/neu antigen in cellular and humoral response induction and consequent protection from a Her2/neu tumor challenge in Her2/neu nontolerant and tolerant mice. A significant delay in transplantable tumor onset was observed in both BALB/c (p≤0,0003) and BALB-neuT mice (p=0,003). …”
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Renal Transplantation in Hepatitis C Positive Patients: A Single Centre Experience by P. R. Shah, A. V. Vanikar, M. R. Gumber, H. V. Patel, V. B. Kute, S. M. Godara, H. L. Trivedi

“…We analyzed 132 HCV-positive RTx patients (group A) transplanted under tolerance induction protocol (TIP) and compared them with 79 controls (group B) transplanted using standard triple drugs. …”
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Deciphering the Molecular Mechanism of Peracetic Acid Response in Listeria monocytogenes by Marianna Arvaniti, Ahmed Gaballa, Renato H. Orsi, Panagiotis Skandamis, Martin Wiedmann

“…The investigation of the molecular mechanism of PAA response in L. monocytogenes is of utmost importance for the food industry, as residual PAA can lead to stress tolerance in pathogens.…”
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Pyrrocidines A and B demonstrate synergistic inhibition of Fusarium verticillioides growth by Lily W. Lofton, Lily W. Lofton, Quentin D. Read, Hailey L. Hamilton, Anthony E. Glenn, Jaci A. Hawkins, Trevor R. Mitchell, Scott E. Gold

“…Further, results provided evidence that FvZBD1 confers partial tolerance to pyrrocidines, particularly pyrrocidine A, and that pyrrocidine functions through FvZBD1 to effectively eliminate fumonisin biosynthesis. …”
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Environmental DNA-based assessment of multitrophic biodiversity in a typical river located in the Loess Plateau, China: Influence of PAHs and suspended sediments by Qian Li, Yulu Tian, Yongrong Hao, Chengkai Qu, Rungnapa Tagun, Hisato Iwata, Jiahua Guo

“…Fishes (Cypriniformes and Clupeiformes) demonstrated greater tolerance to PAH contamination than algae and metazoans, and their reduced richness and Shannon index were linked to the high SS loads (> 0.45 μm). …”
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Growth response, economic indices, blood profile, and organ weight of pigs fed rejected cashew kernel meal from weaner to growing phase by Ojediran Taiwo K., Aniyikaye Sarah A., Akinola Rukayat O., Emiola Isiak A.

“…From the outcome of this investigation, it can therefore be concluded that dietary inclusion of RCKM up to 15% did not trigger any deleterious effects in pigs in terms of growth performance, blood profile, reduced feed cost, increased profit, and economics of gain thus RCKM was well tolerated by the pigs without adverse physiological effects, supported optimal growth, health, and wellbeing of pigs from weaner to grower phase.…”
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Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension by Christos Papageorgiou, Efstathios Manios, Eleftheria Tsaltas, Eleni Koroboki, Maria Alevizaki, Elias Angelopoulos, Meletios-Athanasios Dimopoulos, Charalabos Papageorgiou, Nikolaos Zakopoulos

“…Positive correlations were noted between ABPM variables and Delta (1–4 Hz) oscillations during the tolerance phase; in high-alpha (10–12 Hz) oscillations during the stress unit and posttest phase; and in low-alpha (8–10 Hz) oscillations during CPT phases overall. …”
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Pilot clinical trial of neoadjuvant toll-like receptor 7 agonist (Imiquimod) immunotherapy in early-stage oral squamous cell carcinoma by Angela J. Yoon, Richard D. Carvajal, Evan M. Graboyes, John M. Kaczmar, William G. Albergotti, Alexandra E. Kejner, Scott H. Troob, Elizabeth Philipone, Jean-Sebastien Anoma, Kent E. Armeson, Elizabeth G. Hill, Mary S. Richardson, Tina R. Woods, Bhishamjit S. Chera, Farzad Nourollah-Zadeh, Byung J. Lee, Subramanya Pandruvada, Antonis Kourtidis, Christina Kingsley, Elizabeth C. O’Quinn, Stephanie Mills, Victoria C. Jordan, Mike Spencer, Danielle Fails, Trevor D. McKee, Mark Zaidi, Alan Brisendine, Shane Horn, Shikhar Mehrotra, Besim Ogretmen, Jason G. Newman

“…The treatment was well tolerated with the application site mucositis being the most common adverse event (grades 1-3), and no grade 4 life-threatening event. …”
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The Role of Lifestyle in the Prevention and Treatment of Insulin Resistance: A Review of Clinical and Intervention Studies by Daria Rybak, Olga Krupa, Kinga Furtak, Zofia Martyna Wójcik, Kuba Borys Romańczuk, Szymon Przemysław Stolarczyk, Paulina Dorota Pietrukaniec, Bartosz Omasta, Katarzyna Kamińska-Omasta, Magdalena Agata Czerska

“…The analysis included studies evaluating the impact of specific lifestyle interventions on markers of insulin resistance (IR), such as fasting insulin levels, HOMA-IR indices and glucose tolerance. Particular attention was paid to randomized controlled trials (RCTs) and meta-analyses published between 2020 and 2024.  …”
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