From Isolation to Application: Utilising Phage‐Antibiotic Synergy in Murine Bacteremia Model to Combat Multidrug‐Resistant Enterococcus faecalis by Fatma Al‐zahraa A. Yehia, Galal Yahya, Eslam M. Elsayed, Javier Serrania, Anke Becker, Salwa E. Gomaa

“…This phage specifically lysed 42% of HLGR isolates. vB_EfaS_SZ1 demonstrated beneficial traits, including thermal stability, acid–base tolerance, a short latent period, and a large burst size. …”
Get full text

Soil–Plant Characterization in Agrosilvopastoral System Established in a Fe-Mn Abandoned Mine After Long-Term Closure by Erika S. Santos, Maria Manuela Abreu, Sabina Rossini-Oliva

“…Only the concentrations of Fe and K in the shoots of some herbaceous samples exceeded the maximum tolerable levels for cattle and sheep, so the risk to animals can be considered small since other sources are present in animal feed. …”
Get full text

Acute metabolic decompensation after liver transplant in a patient with maple syrup urine disease by Shao Ching Tu, Marium Khan, Katie Wolfe, Sakil S. Kulkarni, Elizabeth Toolan, Dorothy K. Grange

“…Liver transplant is an effective therapy for MSUD, and patients can usually tolerate a regular diet after transplant without symptomatic metabolic decompensation. …”
Get full text

Turn TRAIL Into Better Anticancer Therapeutic Through TRAIL Fusion Proteins by Yan Wang, Xin Qian, Yubo Wang, Caiyuan Yu, Li Feng, Xiaoyan Zheng, Yaya Wang, Qiuhong Gong

“…Recombinant soluble TRAIL and agonistic antibodies against TRAIL receptors have demonstrated safety and tolerability in clinical trials. However, they have failed to exhibit expected clinical efficacy. …”
Get full text

CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression by Agapitos Patakas, Bochong Li, Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Hannah M Findlay, Timothy B London

“…In primates, we observed a long serum half-life, deep and sustained depletion of normal B cells, and remarkable tolerability, in particular, reduced cytokine release when CLN-978 was administered subcutaneously.Conclusions CLN-978 warrants further exploration. …”
Get full text

Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes Susceptibility by Chenyue Qian, Heming Guo, Xiaohong Chen, Aiming Shi, Sicheng Li, Xin Wang, Jie Pan, Chen Fang

“…The programmed death- (PD-) 1/PD-1 ligand (PD-L) pathway plays an important role in regulating T cell activation and maintaining peripheral tolerance. Accumulated studies showed that PD-1/PD-L1 pathway was involved in the development of type 1 diabetes (T1DM). …”
Get full text

Ecogenomic insights into the resilience of keystone Blastococcus Species in extreme environments: a comprehensive analysis by Imed Sbissi, Farah Chouikhi, Faten Ghodhbane-Gtari, Maher Gtari

“…Ecogenomic assessments highlighted the genus's capabilities in substrate degradation, nutrient transport, and stress tolerance, particularly on stone surfaces and archaeological sites. …”
Get full text

Efficacy and Safety of Low-Dose Peginterferon Alpha-2a Plus Ribavirin on Chronic Hepatitis C by Zehui Yan, Ke Fan, Xiaohong Wang, Qing Mao, Guohong Deng, Yuming Wang

“…The peg-IFN α-2a 90 μg/week plus ribavirin is as effective as, and better tolerated than, peg-IFN α-2a standard dose with ribavirin in the treatment of chronic hepatitis C. …”
Get full text

Cutin formation in tomato is controlled by a multipartite module of synergistic and antagonistic transcription factors by Yuan Shi, Changhao Deng, Xiangyin Lu, Yan Wang, Yaowen Pan, Deding Su, Wang Lu, Yuxiang Lin, Rui Li, Junnan Han, Yanwei Hao, Yi Chen, Ghassen Abid, Julien Pirrello, Mondher Bouzayen, Yudong Liu, Zhengguo Li, Baowen Huang

“…Plants deficient in SlGRAS9, SlZHD17, or SlMBP3 exhibit thickened cuticles and a higher accumulation of cutin monomers, conferring extended fruit shelf life and higher tolerance to postharvest fungal infection. SlGRAS9 regulation of cutin is mediated by SlZHD17, a negative regulator of SlCYP86A69. …”
Get full text

The Expression Level of mRNA, Protein, and DNA Methylation Status of FOSL2 of Uyghur in XinJiang in Type 2 Diabetes by Jun Li, Siyuan Li, Ying Hu, Guolei Cao, Siyao Wang, Partab Rai, Xiaoli Wang, Kan Sun

“…One hundred Uyghur subjects where divided into two groups, T2DM and nonimpaired glucose tolerance (NGT) groups. DNA methylation of FOSL2 was also analyzed by MassARRAY Spectrometry and methylation data of individual units were generated by the EpiTyper v1.0.5 software. …”
Get full text

Attenuation and Immunogenicity of a Live High Pathogenic PRRSV Vaccine Candidate with a 32-Amino Acid Deletion in the nsp2 Protein by Wenhui Lu, Baoli Sun, Jianyue Mo, Xiduo Zeng, Guanqun Zhang, Lianxiang Wang, Qingfeng Zhou, Ling Zhu, Zhili Li, Qingmei Xie, Yinzuo Bi, Jingyun Ma

“…Following PRRSV experimental challenge, pigs inoculated with a single dose of QY1 P100 developed no significant clinic symptoms and well tolerated lethal challenge, while QY1 P80 group still developed mild fever in the clinic trial after challenge. …”
Get full text

The Influence of Ouabain on Human Dendritic Cells Maturation by C. R. Nascimento, R. C. Valente, J. Echevarria-Lima, C. F. L. Fontes, L. de Araujo-Martins, E. G. Araujo, V. M. Rumjanek

“…Collectively, our results suggest that DCs respond to Ouabain maturating into a distinct category, possibly contributing to the balance between immunity and tolerance.…”
Get full text

Introducing the Index of Response to Stimulation (IRES): A Novel Metric for Assessing Vagus Nerve Stimulation Outcomes in Drug-Resistant Epilepsy by Flavius-Iuliu Urian, Corneliu Toader, Razvan-Adrian Covache Busuioc, Antonio-Daniel Corlatescu, Horia Petre Costin, Gabriel Iacob, Alexadru Vlad Ciurea

“…Therapy settings were adjusted biweekly to optimize efficacy and patient tolerance. <i>Results</i>: There were improvements in the control of the seizures, measured in terms of increased IRES scores. …”
Get full text

A Wireless Power Conversion Chain With Fully On-Chip Automatic Resonance Tuning System for Biomedical Implants by Mohammad Javad Karimi, Menghe Jin, Catherine Dehollain, Alexandre Schmid

“…The measurement results demonstrate that this system provides tolerance up to mismatches equivalent to 75 pF capacitance variation in LC tank, &#x00B1;15&#x0025; LC variation in this design. …”
Get full text

PTPIP51: A New Interaction Partner of the Insulin Receptor and PKA in Adipose Tissue by M. A. Bobrich, S. A. Schwabe, A. Brobeil, M. Viard, M. Kamm, F. C. Mooren, K. Krüger, C. Tag, M. Wimmer

“…After ten weeks, we measured glucose tolerance of the mice. Adipose tissue samples were analyzed by immunofluorescence and Duolink proximity ligation assay to quantify interactions of PTPIP51 with either insulin receptor (IR) or PKA. …”
Get full text

Endovascular Treatment of Infrarenal Abdominal Aortic Aneurysm with Short and Angulated Neck in High-Risk Patient by Stylianos Koutsias, Georgios Antoniou, Christos Karathanos, Vassileios Saleptsis, Konstantinos Stamoulis, Athanasios D. Giannoukas

“…Patients with extensive aneurysmal disease typically have more comorbidities and may not tolerate extensive surgical trauma (Sarac et al. 2002). …”
Get full text

Benchmarking the identification of a single degraded protein to explore optimal search strategies for ancient proteins by Rodriguez Palomo, Ismael, Nair, Bharath, Chiang, Yun, Dekker, Joannes, Dartigues, Benjamin, Mackie, Meaghan, Evans, Miranda, Macleod, Ruairidh, Olsen, Jesper V., Collins, Matthew J.

“…We also explored alternative strategies, including open search that allows for the global identification of PTMs based upon wide precursor mass tolerance and de novo sequencing to boost sequence coverage. …”
Get full text

Foliar spraying melatonin reduces the threat of chromium-contaminated water to wheat production by improving photosynthesis, limiting Cr translocation and reducing oxidative stress by Chuanjiao Sun, Libing Xu, Qiang Gao, Shuzhen Sun, Xiaoxue Liu, Zigang Zhang, Zhongwei Tian, Tingbo Dai, Jianyun Sun

“…Recent studies suggest that melatonin (MT) could enhance crop tolerance to Cr pollution. This study aimed to investigate the effects of foliar spraying MT on alleviating Cr toxicity and accumulation in wheat irrigated with K2Cr2O7 solution at concentrations of 5, 10, and 20 mg/kg Cr in the soil. …”
Get full text

A 2-Year, Phase IV, Multicentre, Observational Study of Ranibizumab 0.5 mg in Patients with Neovascular Age-Related Macular Degeneration in Routine Clinical Practice: The EPICOHORT... by Sergio Pagliarini, Stephen Beatty, Blandina Lipkova, Eduardo Perez-Salvador Garcia, Stefaan Reynders, Margarita Gekkieva, Abdelkader Si Bouazza, Stefan Pilz

“…Ranibizumab was generally well tolerated with low incidence of selected AEs (0%–1.9%). …”
Get full text

Nutritional composition, toxicity, and the effects of Parkia biglobosa on the metabolic, somatic and oxidative parameters related to liver and kidney function of obese rats by Mirela Gouveia-Nhanca, Maria Luiza Rolim Bezerra, Yuri Mangueira do Nascimento, Evandro Ferreira da Silva, Josean Fechine Tavares, Gonçalo Mendes da Conceição, Rubens Teixeira de Queiroz, Luis António Tavares, Adriano Francisco Alves, Jailane de Souza Aquino

“…Results: Parkia biglobosa intake reduced the adiposity index; improved glucose tolerance, insulin resistance, leptinemia and lipid metabolism parameters, which impacted the minimization of hepatic steatosis and improved oxidative parameters in the kidney and liver in obese rats (OPB). …”
Get full text