Inhibition of MEK1 Signaling Pathway in the Liver Ameliorates Insulin Resistance by Atsunori Ueyama, Nobuhiro Ban, Masanori Fukazawa, Tohru Hirayama, Minako Takeda, Tatsuo Yata, Hiroyasu Muramatsu, Masaki Hoshino, Marii Yamamoto, Masao Matsuo, Yuka Kawashima, Tatsuhiko Iwase, Takehisa Kitazawa, Youichi Kushima, Yuichiro Yamada, Yoshiki Kawabe

“…Both compounds decreased blood glucose and improved glucose tolerance in doses sufficient to sustain inhibition of extracellular signal-regulated kinase (ERK)1/2 phosphorylation downstream of MEK in insulin-responsive tissues in db/db mice. …”
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A Randomized Controlled Trial of Chinese Medicine on Nonmotor Symptoms in Parkinson’s Disease by Ka-Kit Chua, Adrian Wong, Kam-Wa Chan, Yin-Kei Lau, Zhao-Xiang Bian, Jia-Hong Lu, Liang-Feng Liu, Lei-Lei Chen, Ka-Ho Chan, Kim-Pong Tse, Anne Chan, Ju-Xian Song, Justin Wu, Li-Xing Zhu, Vincent Mok, Min Li

“…In conclusion, long-term administration of JLT is well tolerated and shows significant benefits in improving NMS including mood, cognition, and constipation.…”
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Tryptophan as a biomarker of pregnancy-related immune expression and modulation: an integrative review by Stephanie Prescott, Stephanie Prescott, Natasa Billeci, Melissa Gotcher, Sapna Patel, Addison Almon, Hailey Morgan, Danielle Abukhalaf, Maureen Groer

“…The immunomodulatory role of TRP and its metabolites through the indoleamine 2,3-dioxygenase (IDO) pathway is particularly relevant to pregnancy due to its potential influence on maternal and fetal immune tolerance and the mother's health.MethodsA targeted literature search was conducted via PubMed, Web of Science, and Embase, focusing on maternal serum TRP levels in pregnancy. …”
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In-depth proteomic profiling identifies potentiation of the LPS response by 7-ketocholesterol by Iain R. Phair, Magdalena Sovakova, Noor Alqurashi, Raid B. Nisr, Alison D. McNeilly, Douglas Lamont, Graham Rena

“…In this context, our findings suggest that drugs targeting atherogenic markers induced by 7-KC might be well tolerated, as they will not necessarily be expected to be immunosuppressive.…”
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Isolated Pauci-Immune Pulmonary Capillaritis Associated with Hydrocarbon Inhalation and Marijuana Smoking: An Unusual Case of Severe Hypoxemia by Jason S. Oh, Uni Wong, Divyansh Bajaj, Stella E. Hines

“…His hypoxemia made little improvement after conventional ventilator support and broad-spectrum antibacterial therapy and he was considered too unstable to tolerate diagnostic bronchoscopy with bronchoalveolar lavage. …”
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Seed banking impacts native Acacia ulicifolia seed microbiome composition and function by Dylan Russell, Vaheesan Rajabal, Matthew Alfonzetti, Marlien M. van der Merwe, Rachael V. Gallagher, Sasha G. Tetu

“…Conclusion Overall, these results suggest that epiphytic seed microbiomes may undergo significant changes during the storage process, selecting for bacteria tolerant to storage conditions, and potentially reducing the population of plant-growth promoting bacteria on seeds.…”
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Plant Growth-Promoting and Herbicidal Bacteria as Potential Bio-Based Solutions for Agriculture in Desertic Regions by Patricio Muñoz-Torres, Wilson Huanca-Mamani, Steffany Cárdenas-Ninasivincha, Yola Aguilar, Antonio Quezada, Franco Bugueño

“…These bacteria possess in vitro plant growth-promoting traits, the ability to produce hydrolytic enzymes, and the capacity to inhibit phytopathogenic fungi. Moreover, they can tolerate different concentrations of NaCl and boron, making them suitable for developing new agricultural bioproducts for arid environments. …”
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Star Identification Algorithm Based on Dynamic Distance Ratio Matching by Ya Dai, Chenguang Shi, Liyan Ben, Hua Zhu, Rui Zhang, Shufan Wu, Sixiang Shan, Yu Xu, Wang Zhou

“…Therefore, it exhibits better tolerance to positional noise, magnitude noise, and false stars, particularly demonstrating higher robustness against focal length variations.…”
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A Single 60 mg Dose of Denosumab Might Improve Hepatic Insulin Sensitivity in Postmenopausal Nondiabetic Severe Osteoporotic Women by Elena Passeri, Stefano Benedini, Elena Costa, Sabrina Corbetta

“…This is a prospective study on the effect of a subcutaneously injected single 60 mg dose of denosumab in 14 postmenopausal severe osteoporotic nondiabetic women evaluated at baseline and 4 and 12 weeks after their first injection by an oral glucose tolerance test. Results. A single 60 mg dose of denosumab efficiently inhibited serum alkaline phosphatase while it did not exert any significant variation in fasting glucose, insulin, or HOMA-IR at both 4 and 12 weeks. …”
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Case report: Long-term efficacy and safety of semaglutide in the treatment of syndromic obesity in Prader Willi syndrome - case series and literature review by Andrijana Koceva, Andrijana Koceva, Katarina Mlekuš Kozamernik, Katarina Mlekuš Kozamernik, Andrej Janež, Andrej Janež, Rok Herman, Rok Herman, Simona Ferjan, Simona Ferjan, Mojca Jensterle, Mojca Jensterle

“…Semaglutide treatment at dosages from 0.5 mg to 2 mg weekly demonstrated variable efficacy, from preventing further weight gain in patient 1, to achieving weight loss of up to 14.4% and 11% relative to baseline, in Patient 2 and Patient 3. It was well tolerated, even after metabolic surgery.ConclusionLong-term randomized placebo-controlled trials with larger sample sizes are needed to provide stronger evidence on the long-term efficacy and safety of semaglutide for obesity treatment in PWS as well as explore the potential synergistic effects of GLP-1 RA treatment combined with other therapeutic interventions.…”
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Position Paper by Canadian Dental Sleep Medicine Professionals Regarding the Role of Different Health Care Professionals in Managing Obstructive Sleep Apnea and Snoring with Oral A... by Luc Gauthier, Fernanda Almeida, Patrick Arcache, Catherine Ashton-McGregor, David Côté, Helen Driver, Kathleen Ferguson, Gilles Lavigne, Philippe Martin, Jean-François Masse, Florence Morisson, Jeffrey Pancer, Charles Samuels, Maurice Schachter, Frédéric Sériès, Glendon Sullivan

“…OAs offer an effective, first-line treatment option for patients with mild to moderate OSA who prefer an OA to continuous positive airway pressure (CPAP) therapy, or for severe OSA patients who cannot tolerate CPAP, are inappropriate candidates for CPAP or who have failed CPAP treatment attempts. …”
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Effectiveness of Solution-oriented Group Counseling on Improving Job Burnout and Resilience of Working Women Referring to Counseling Centers in Bushehr City by Farzad Poorgholamy, Setareh Mohannaee, Nafisseh Shamoradi, Mitra Razavi Klishadi, Bamshad Eskandari

“…Furthermore, the experimental group demonstrated improvements in various aspects of resilience, such as competence, personal strength, trust in personal instincts, tolerance of negative emotions, positive acceptance of emotions, safe relationships, and control of security, compared to the control group. …”
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Graphene-Metamaterial Based Tunable Broadband Polarization Insensitive Absorber for Terahertz Antenna Design by Rummanur Rahad, Abu S. M. Mohsin, Mohammed Belal Hossain Bhuian, Md. Mosaddequr Rahman

“…The absorber exhibits wideband tunability, polarization insensitivity, and robust tolerance to structural variations, making it a promising candidate for diverse applications in the terahertz (THz) band especially in the antenna regime. …”
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The combined effect of metformin and mirabegron on diet‐induced obesity by Xin‐Yuan Zhao, Ying Liu, Xuan Zhang, Ben‐Chi Zhao, George Burley, Zhi‐Can Yang, Yi Luo, An‐Qi Li, Ruo‐Xin Zhang, Zhi‐Ying Liu, Yan‐Chuan Shi, Qiao‐Ping Wang

“…Additionally, Met/Mir improved glucose tolerance and insulin sensitivity. These benefits of Met/Mir were associated with increased EE, activated brown adipose tissue thermogenesis, and white adipose tissue browning. …”
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A Spiritual Care Program for Patients With Cancer and Psychosomatic Disorders in Iran: A Protocol Study by Rahmatollah Marzband, Seyed Hamzeh Hosseini, Zeinab Hamzehgardeshi, Mahmood Moosazadeh, Mohammad Eslamijouybari, Tahereh Yaghoubi, Marzieh Azizi, Fereshteh Araghian Mojarad, Ehsan Abedini

“…They will be assessed before and after the intervention by using the hospital anxiety and depression scale, distress tolerance scale, hospital service satisfaction questionnaire, and spiritual well-being questionnaire. …”
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Circulating Sclerostin and Irisin Are Related and Interact with Gender to Influence Adiposity in Adults with Prediabetes by Theerawut Klangjareonchai, Hataikarn Nimitphong, Sunee Saetung, Nuttapimon Bhirommuang, Rattanapan Samittarucksa, Suwannee Chanprasertyothin, Rattana Sudatip, Boonsong Ongphiphadhanakul

“…A cross-sectional study included 98 adults with impaired fasting glucose and/or impaired glucose tolerance. 75 gm OGTT was performed in all subjects. …”
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Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat by Caroline E. Rasmussen, Jette Nowak, Julie M. Larsen, Emma Moore, David Bell, Kai Chiu Liu, Nanna Skall Sorensen, Wendela A. Kappers, Thomas Krogh-Meibom, Hanne Offenberg

“…A small number of animals developed ADAs, and the proportion of animals surviving until scheduled termination was >80%. N8-GP was well tolerated, and the immune-deficient rat proved suitable for testing long-term toxicity of human proteins that are immunogenic in animals.…”
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Intrahepatic Lipid Content and Insulin Resistance Are More Strongly Associated with Impaired NEFA Suppression after Oral Glucose Loading Than with Fasting NEFA Levels in Healthy Ol... by Francis M. Finucane, Stephen J. Sharp, Mensud Hatunic, Alison Sleigh, Ema De Lucia Rolfe, Avan Aihie Sayer, Cyrus Cooper, Simon J. Griffin, David B. Savage, Nicholas J. Wareham

“…We performed a cross-sectional analysis of 70 healthy participants in the Hertfordshire Physical Activity Trial (39 males, age 71.3 ± 2.4 years) who underwent oral glucose tolerance testing with glucose, insulin, and NEFA levels measured over two hours. …”
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Investigation on Circadian Regulation of Four-Primary LED Display Differed in People by GA by Wenhui Li, Junying Li, Yating Feng, Yi Lin, Haoyang Liu, Ruoping Lian, Qinzhen Lin, Jingyi Cui, Zixin Huang, Yaling Chai, Ziquan Guo, Lili Zheng, Zhong Chen

“…Then, the genetic algorithm is adopted for performing the spectral optimization of four-primary LED display while many constraint conditions are set, such as CCT values (2700 K and 6500 K), CCT tolerance, and color distance (<italic>D</italic>_uv &lt; 0.01) in the CIE 1960 UCS color space. …”
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THE PGR NETWORKS IN FRANCE: COLLABORATION OF USERS AND THE GENETIC RESOURCE CENTRE ON SMALL GRAIN CEREALS by A. Didier, L. Bardy, E. Boulat, J. Koenig, A. Lapierre, F. Exbrayat, J. Bordes, F. Balfourier

“…Nevertheless, these resources remain underestimated if we focus on abiotic stress tolerance or new agricultural techniques, which consider productivity with regard to the environment. …”
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